Welcome!

News Feed Item

Preclinical Investigation Shows Ground-Breaking Results on Human Infections

RHEINBREITBACH, Germany, November 14, 2012 /PRNewswire/ --

Synthetic human-milk-oligosaccharides reduce the risk of infections caused by hazardous pathogens

Human-milk-oligosaccharides, an important component of human mother's milk, play a fundamental role in the protection of infants against viral and bacterial infection. Preclinical studies carried out by Jennewein Biotechnologie GmbH have now shown for the first time that synthetically produced functional sugars protect humans from infectious diseases. The investigations were conducted in collaboration with the University Children's Hospital Mannheim of Heidelberg University (GER).

In collaboration with the University Children's Hospital Mannheim of Heidelberg University, Jennewein Biotechnologie GmbH carried out extensive preclinical research to demonstrate for the first time that synthetic human-milk-oligosaccharides achieve the same protective effects as natural sugars in human breast milk. The study focused on the human-milk-oligosaccharides 2'-Fucosyllactose and 3-Fucosyllactose, which are present in human breast milk at levels of up to 3.5 grams per liter and are by far the most abundant human-milk-oligosaccharides.

The researchers at Mannheim (GER) tested the sugars on human cells using various pathogens. The results demonstrate a clear protective effect, i.e. the synthetic human-milk-oligosaccharides produced by Jennewein Biotechnologie GmbH successfully bind prevalent diarrhea causing pathogens such as Campylobacter jejuni, Escherichia coli and particular Salmonella species. Furthermore, the now available results reveal that these saccharides effectively inhibit the pneumonia causing pathogen Pseudomonas aeruginosa, which is together with E. coli and Staphylococcus aureus the most common pathogen causing nosocomial infections. Moreover, Pseudomonas aeruginosa infections can cause severe, life-threatening infections in patients with underlying immunodeficiency.

Human-milk-oligosaccharides not only inhibit gastrointestinal pathogens directly, they also provide at least two further major benefits. First, they have a prebiotic or bifidogenic effect, encouraging the growth of bifidobacteria that improve digestion and suppress pathogens to maintain a healthy microbiome. Second, up to 1% of these saccharides are absorbed into the blood, where they provide a systemic protection such as reducing the risk of infection of organs such as the lungs and meninges, for example. Although there is abundant evidence for the benefits of human-milk-oligosaccharides further research is required to understand the underlying mechanisms. Jennewein Biotechnologie GmbH has taken the lead in this research and is committed to the development of innovative products based on synthetic human-milk-oligosaccharides to reduce infection rates in infants and adults.

As emphasized Prof. Dr. Schroten, Director of the University Children's Hospital Mannheim of Heidelberg University, " this study represents asignificant milestone in the development of novel and effective non-interventional strategies to reduce the risk of human infections by pathogenic bacteria. In consideration of the continued growth of the world population and the increasing number of multidrug-resistant bacteria, this represents one of the key challenges of the 21st century."

The protective mechanism of human-milk-oligosaccharides

Mother's milk is seen as the "gold standard" for infant nutrition during the first few months of human life, not only reflecting the optimal balance of nutrients but also because of its ingredients with specific biological functions. Human-milk-oligosaccharides are the third most abundant solid component of breast milk, after lactose and fat which primarily serve as energy source. These human-milk-oligosaccharides are highly complex sugar molecules which are human specific and therefore can only be found in nature in this composition in human mother's milk.

Many scientific studies have shown that human-milk-oligosaccharides reduce the risk of infection by pathogens and have no adverse effects in humans. Soluble human-milk-oligosaccharides imitate sugar molecules that are found on the surface of all human cells to facilitate cell-to-cell communication. More than 70% of human pathogens - virus and bacteria - use these cell-surface sugar molecules to attach to, enter and infect cells. Thus, soluble human-milk-oligosaccharides in the gastrointestinal tract and in the blood act as decoys to prevent pathogens interacting with cells. Human pathogens will connect to these soluble saccharides "assuming" they connect to a host cell. The binding between pathogens and sugar molecules is irreversible and pathogens have no possibility to become resistant to soluble human-milk-oligosaccharides because they need to interact with the same molecules on the cell surface. Therefore, pathogens that do not bind to these sugars would be unable to bind to the cell surface either, and would lose their virulence.

Because human-milk-oligosaccharides have a specific role in the elimination of pathogens they are not used by human cells as an energy source. However, they retain the organoleptic properties of other sugars, i.e. they are soluble and sweet. This means that human-milk-oligosaccharides could be added to the diet in place of sucrose, for example, acting as sweeteners with no calorific value but also providing prebiotic benefits and protecting against infection.

Multiple applications for Fucosyllactose in human nutrition

The synthetic human-milk-oliogsacchrides produced by Jennewein Biotechnologie GmbH are presented as white, crystalline powders similar to sucrose, making them ideal as additives for use by the food processing industry to increase the health-promoting characteristics of innovative food products. In specialized areas, Jennewein Biotechnologie GmbH already cooperates with Pfizer Nutrition, one of the leading international infant food manufacturers. However, there are many other potential applications outside the field of infant nutrition, ranging from dairy products, breakfast cereals and beverages providing health benefits to special nutrition programs for professionals facing a high risk of infection, dietary supplements for travelers in disease-endemic areas, special diets for immunocompromized hospital patients to prevent nosocomial infections and therapeutic nutrition used to improve patients' clinical outcomes and quality of life.

About Jennewein Biotechnologie GmbH

Jennewein Biotechnologie GmbH is active in the field of industrial biotechnology and specializes in the production of complex sugar molecules using bio-organic synthesis. The main focus of the company is the production of ingredients for the food, personal care and pharmaceutical industries. Jennewein Biotechnology also produces molecules for research and development, as well as for diagnostics.

Jennewein Biotechnologie GmbH is a family-owned company, founded in 2005 with its headquarters in Rheinbreitbach (Rhineland-Palatinate, Germany). The company cooperates in research and development with leading universities and research institutes. Jennewein Biotechnologie GmbH received the Pionier-Geist award in 2007 from the Rhineland-Palatinate Ministry of Economics. The Federal Ministry of Education and Research supports Jennewein Biotechnologie GmbH in its research and development activities in the field of human-milk-oligosaccharides.

Further information

Further information about Jennewein Biotechnology GmbH, its products and graphical material can be obtained at http://www.jennewein-biotech.de or by writing to:  

Jennewein Biotechnologie GmbH
Maarweg 32
D-53619 Rheinbreitbach
Germany
Tel.:  +49-(0)2224-989-4502
Fax.:  +49-(0)2224-988-0854
EMail: [email protected]

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
SYS-CON Events announced today that Isomorphic Software will exhibit at DevOps Summit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Isomorphic Software provides the SmartClient HTML5/AJAX platform, the most advanced technology for building rich, cutting-edge enterprise web applications for desktop and mobile. SmartClient combines the productivity and performance of traditional desktop software with the simp...
With so much going on in this space you could be forgiven for thinking you were always working with yesterday’s technologies. So much change, so quickly. What do you do if you have to build a solution from the ground up that is expected to live in the field for at least 5-10 years? This is the challenge we faced when we looked to refresh our existing 10-year-old custom hardware stack to measure the fullness of trash cans and compactors.
Extreme Computing is the ability to leverage highly performant infrastructure and software to accelerate Big Data, machine learning, HPC, and Enterprise applications. High IOPS Storage, low-latency networks, in-memory databases, GPUs and other parallel accelerators are being used to achieve faster results and help businesses make better decisions. In his session at 18th Cloud Expo, Michael O'Neill, Strategic Business Development at NVIDIA, focused on some of the unique ways extreme computing is...
The emerging Internet of Everything creates tremendous new opportunities for customer engagement and business model innovation. However, enterprises must overcome a number of critical challenges to bring these new solutions to market. In his session at @ThingsExpo, Michael Martin, CTO/CIO at nfrastructure, outlined these key challenges and recommended approaches for overcoming them to achieve speed and agility in the design, development and implementation of Internet of Everything solutions wi...
Cloud computing is being adopted in one form or another by 94% of enterprises today. Tens of billions of new devices are being connected to The Internet of Things. And Big Data is driving this bus. An exponential increase is expected in the amount of information being processed, managed, analyzed, and acted upon by enterprise IT. This amazing is not part of some distant future - it is happening today. One report shows a 650% increase in enterprise data by 2020. Other estimates are even higher....
With over 720 million Internet users and 40–50% CAGR, the Chinese Cloud Computing market has been booming. When talking about cloud computing, what are the Chinese users of cloud thinking about? What is the most powerful force that can push them to make the buying decision? How to tap into them? In his session at 18th Cloud Expo, Yu Hao, CEO and co-founder of SpeedyCloud, answered these questions and discussed the results of SpeedyCloud’s survey.
Today we can collect lots and lots of performance data. We build beautiful dashboards and even have fancy query languages to access and transform the data. Still performance data is a secret language only a couple of people understand. The more business becomes digital the more stakeholders are interested in this data including how it relates to business. Some of these people have never used a monitoring tool before. They have a question on their mind like “How is my application doing” but no id...
Actian Corporation has announced the latest version of the Actian Vector in Hadoop (VectorH) database, generally available at the end of July. VectorH is based on the same query engine that powers Actian Vector, which recently doubled the TPC-H benchmark record for non-clustered systems at the 3000GB scale factor (see tpc.org/3323). The ability to easily ingest information from different data sources and rapidly develop queries to make better business decisions is becoming increasingly importan...
The 19th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportuni...
Qosmos has announced new milestones in the detection of encrypted traffic and in protocol signature coverage. Qosmos latest software can accurately classify traffic encrypted with SSL/TLS (e.g., Google, Facebook, WhatsApp), P2P traffic (e.g., BitTorrent, MuTorrent, Vuze), and Skype, while preserving the privacy of communication content. These new classification techniques mean that traffic optimization, policy enforcement, and user experience are largely unaffected by encryption. In respect wit...
Deploying applications in hybrid cloud environments is hard work. Your team spends most of the time maintaining your infrastructure, configuring dev/test and production environments, and deploying applications across environments – which can be both time consuming and error prone. But what if you could automate provisioning and deployment to deliver error free environments faster? What could you do with your free time?
SYS-CON Events announced today that Hitrons Solutions will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Hitrons Solutions Inc. is distributor in the North American market for unique products and services of small and medium-size businesses, including cloud services and solutions, SEO marketing platforms, and mobile applications.
Smart Cities are here to stay, but for their promise to be delivered, the data they produce must not be put in new siloes. In his session at @ThingsExpo, Mathias Herberts, Co-founder and CTO of Cityzen Data, will deep dive into best practices that will ensure a successful smart city journey.
SYS-CON Events announced today that 910Telecom will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Housed in the classic Denver Gas & Electric Building, 910 15th St., 910Telecom is a carrier-neutral telecom hotel located in the heart of Denver. Adjacent to CenturyLink, AT&T, and Denver Main, 910Telecom offers connectivity to all major carriers, Internet service providers, Internet backbones and ...
SYS-CON Events announced today that eCube Systems, a leading provider of middleware modernization, integration, and management solutions, will exhibit at @DevOpsSummit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. eCube Systems offers a family of middleware evolution products and services that maximize return on technology investment by leveraging existing technical equity to meet evolving business needs. ...