|By PR Newswire||
|November 14, 2012 03:04 AM EST||
RHEINBREITBACH, Germany, November 14, 2012 /PRNewswire/ --
Synthetic human-milk-oligosaccharides reduce the risk of infections caused by hazardous pathogens
Human-milk-oligosaccharides, an important component of human mother's milk, play a fundamental role in the protection of infants against viral and bacterial infection. Preclinical studies carried out by Jennewein Biotechnologie GmbH have now shown for the first time that synthetically produced functional sugars protect humans from infectious diseases. The investigations were conducted in collaboration with the University Children's Hospital Mannheim of Heidelberg University (GER).
In collaboration with the University Children's Hospital Mannheim of Heidelberg University, Jennewein Biotechnologie GmbH carried out extensive preclinical research to demonstrate for the first time that synthetic human-milk-oligosaccharides achieve the same protective effects as natural sugars in human breast milk. The study focused on the human-milk-oligosaccharides 2'-Fucosyllactose and 3-Fucosyllactose, which are present in human breast milk at levels of up to 3.5 grams per liter and are by far the most abundant human-milk-oligosaccharides.
The researchers at Mannheim (GER) tested the sugars on human cells using various pathogens. The results demonstrate a clear protective effect, i.e. the synthetic human-milk-oligosaccharides produced by Jennewein Biotechnologie GmbH successfully bind prevalent diarrhea causing pathogens such as Campylobacter jejuni, Escherichia coli and particular Salmonella species. Furthermore, the now available results reveal that these saccharides effectively inhibit the pneumonia causing pathogen Pseudomonas aeruginosa, which is together with E. coli and Staphylococcus aureus the most common pathogen causing nosocomial infections. Moreover, Pseudomonas aeruginosa infections can cause severe, life-threatening infections in patients with underlying immunodeficiency.
Human-milk-oligosaccharides not only inhibit gastrointestinal pathogens directly, they also provide at least two further major benefits. First, they have a prebiotic or bifidogenic effect, encouraging the growth of bifidobacteria that improve digestion and suppress pathogens to maintain a healthy microbiome. Second, up to 1% of these saccharides are absorbed into the blood, where they provide a systemic protection such as reducing the risk of infection of organs such as the lungs and meninges, for example. Although there is abundant evidence for the benefits of human-milk-oligosaccharides further research is required to understand the underlying mechanisms. Jennewein Biotechnologie GmbH has taken the lead in this research and is committed to the development of innovative products based on synthetic human-milk-oligosaccharides to reduce infection rates in infants and adults.
As emphasized Prof. Dr. Schroten, Director of the University Children's Hospital Mannheim of Heidelberg University, "… this study represents asignificant milestone in the development of novel and effective non-interventional strategies to reduce the risk of human infections by pathogenic bacteria. In consideration of the continued growth of the world population and the increasing number of multidrug-resistant bacteria, this represents one of the key challenges of the 21st century."
The protective mechanism of human-milk-oligosaccharides
Mother's milk is seen as the "gold standard" for infant nutrition during the first few months of human life, not only reflecting the optimal balance of nutrients but also because of its ingredients with specific biological functions. Human-milk-oligosaccharides are the third most abundant solid component of breast milk, after lactose and fat which primarily serve as energy source. These human-milk-oligosaccharides are highly complex sugar molecules which are human specific and therefore can only be found in nature in this composition in human mother's milk.
Many scientific studies have shown that human-milk-oligosaccharides reduce the risk of infection by pathogens and have no adverse effects in humans. Soluble human-milk-oligosaccharides imitate sugar molecules that are found on the surface of all human cells to facilitate cell-to-cell communication. More than 70% of human pathogens - virus and bacteria - use these cell-surface sugar molecules to attach to, enter and infect cells. Thus, soluble human-milk-oligosaccharides in the gastrointestinal tract and in the blood act as decoys to prevent pathogens interacting with cells. Human pathogens will connect to these soluble saccharides "assuming" they connect to a host cell. The binding between pathogens and sugar molecules is irreversible and pathogens have no possibility to become resistant to soluble human-milk-oligosaccharides because they need to interact with the same molecules on the cell surface. Therefore, pathogens that do not bind to these sugars would be unable to bind to the cell surface either, and would lose their virulence.
Because human-milk-oligosaccharides have a specific role in the elimination of pathogens they are not used by human cells as an energy source. However, they retain the organoleptic properties of other sugars, i.e. they are soluble and sweet. This means that human-milk-oligosaccharides could be added to the diet in place of sucrose, for example, acting as sweeteners with no calorific value but also providing prebiotic benefits and protecting against infection.
Multiple applications for Fucosyllactose in human nutrition
The synthetic human-milk-oliogsacchrides produced by Jennewein Biotechnologie GmbH are presented as white, crystalline powders similar to sucrose, making them ideal as additives for use by the food processing industry to increase the health-promoting characteristics of innovative food products. In specialized areas, Jennewein Biotechnologie GmbH already cooperates with Pfizer Nutrition, one of the leading international infant food manufacturers. However, there are many other potential applications outside the field of infant nutrition, ranging from dairy products, breakfast cereals and beverages providing health benefits to special nutrition programs for professionals facing a high risk of infection, dietary supplements for travelers in disease-endemic areas, special diets for immunocompromized hospital patients to prevent nosocomial infections and therapeutic nutrition used to improve patients' clinical outcomes and quality of life.
About Jennewein Biotechnologie GmbH
Jennewein Biotechnologie GmbH is active in the field of industrial biotechnology and specializes in the production of complex sugar molecules using bio-organic synthesis. The main focus of the company is the production of ingredients for the food, personal care and pharmaceutical industries. Jennewein Biotechnology also produces molecules for research and development, as well as for diagnostics.
Jennewein Biotechnologie GmbH is a family-owned company, founded in 2005 with its headquarters in Rheinbreitbach (Rhineland-Palatinate, Germany). The company cooperates in research and development with leading universities and research institutes. Jennewein Biotechnologie GmbH received the Pionier-Geist award in 2007 from the Rhineland-Palatinate Ministry of Economics. The Federal Ministry of Education and Research supports Jennewein Biotechnologie GmbH in its research and development activities in the field of human-milk-oligosaccharides.
Jennewein Biotechnologie GmbH
EMail: [email protected]
In his session at 19th Cloud Expo, Claude Remillard, Principal Program Manager in Developer Division at Microsoft, contrasted how his team used config as code and immutable patterns for continuous delivery of microservices and apps to the cloud. He showed how the immutable patterns helps developers do away with most of the complexity of config as code-enabling scenarios such as rollback, zero downtime upgrades with far greater simplicity. He also demoed building immutable pipelines in the cloud ...
Jan. 19, 2017 04:15 AM EST Reads: 3,440
Using new techniques of information modeling, indexing, and processing, new cloud-based systems can support cloud-based workloads previously not possible for high-throughput insurance, banking, and case-based applications. In his session at 18th Cloud Expo, John Newton, CTO, Founder and Chairman of Alfresco, described how to scale cloud-based content management repositories to store, manage, and retrieve billions of documents and related information with fast and linear scalability. He addres...
Jan. 19, 2017 04:00 AM EST Reads: 5,352
Hardware virtualization and cloud computing allowed us to increase resource utilization and increase our flexibility to respond to business demand. Docker Containers are the next quantum leap - Are they?! Databases always represented an additional set of challenges unique to running workloads requiring a maximum of I/O, network, CPU resources combined with data locality.
Jan. 19, 2017 03:30 AM EST Reads: 381
Due of the rise of Hadoop, many enterprises are now deploying their first small clusters of 10 to 20 servers. At this small scale, the complexity of operating the cluster looks and feels like general data center servers. It is not until the clusters scale, as they inevitably do, when the pain caused by the exponential complexity becomes apparent. We've seen this problem occur time and time again. In his session at Big Data Expo, Greg Bruno, Vice President of Engineering and co-founder of StackIQ...
Jan. 19, 2017 01:15 AM EST Reads: 7,798
The cloud market growth today is largely in public clouds. While there is a lot of spend in IT departments in virtualization, these aren’t yet translating into a true “cloud” experience within the enterprise. What is stopping the growth of the “private cloud” market? In his general session at 18th Cloud Expo, Nara Rajagopalan, CEO of Accelerite, explored the challenges in deploying, managing, and getting adoption for a private cloud within an enterprise. What are the key differences between wh...
Jan. 19, 2017 01:15 AM EST Reads: 6,096
Security, data privacy, reliability, and regulatory compliance are critical factors when evaluating whether to move business applications from in-house, client-hosted environments to a cloud platform. Quality assurance plays a vital role in ensuring that the appropriate level of risk assessment, verification, and validation takes place to ensure business continuity during the migration to a new cloud platform.
Jan. 19, 2017 01:00 AM EST Reads: 1,279
"Tintri was started in 2008 with the express purpose of building a storage appliance that is ideal for virtualized environments. We support a lot of different hypervisor platforms from VMware to OpenStack to Hyper-V," explained Dan Florea, Director of Product Management at Tintri, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jan. 19, 2017 12:45 AM EST Reads: 4,692
Containers have changed the mind of IT in DevOps. They enable developers to work with dev, test, stage and production environments identically. Containers provide the right abstraction for microservices and many cloud platforms have integrated them into deployment pipelines. DevOps and containers together help companies achieve their business goals faster and more effectively. In his session at DevOps Summit, Ruslan Synytsky, CEO and Co-founder of Jelastic, reviewed the current landscape of Dev...
Jan. 19, 2017 12:00 AM EST Reads: 4,177
One of the hottest areas in cloud right now is DRaaS and related offerings. In his session at 16th Cloud Expo, Dale Levesque, Disaster Recovery Product Manager with Windstream's Cloud and Data Center Marketing team, will discuss the benefits of the cloud model, which far outweigh the traditional approach, and how enterprises need to ensure that their needs are properly being met.
Jan. 18, 2017 11:15 PM EST Reads: 4,476
The security needs of IoT environments require a strong, proven approach to maintain security, trust and privacy in their ecosystem. Assurance and protection of device identity, secure data encryption and authentication are the key security challenges organizations are trying to address when integrating IoT devices. This holds true for IoT applications in a wide range of industries, for example, healthcare, consumer devices, and manufacturing. In his session at @ThingsExpo, Lancen LaChance, vic...
Jan. 18, 2017 09:45 PM EST Reads: 6,519
WebRTC has had a real tough three or four years, and so have those working with it. Only a few short years ago, the development world were excited about WebRTC and proclaiming how awesome it was. You might have played with the technology a couple of years ago, only to find the extra infrastructure requirements were painful to implement and poorly documented. This probably left a bitter taste in your mouth, especially when things went wrong.
Jan. 18, 2017 09:30 PM EST Reads: 7,636
Big Data, cloud, analytics, contextual information, wearable tech, sensors, mobility, and WebRTC: together, these advances have created a perfect storm of technologies that are disrupting and transforming classic communications models and ecosystems. In his session at @ThingsExpo, Erik Perotti, Senior Manager of New Ventures on Plantronics’ Innovation team, provided an overview of this technological shift, including associated business and consumer communications impacts, and opportunities it m...
Jan. 18, 2017 09:30 PM EST Reads: 5,747
In their general session at 16th Cloud Expo, Michael Piccininni, Global Account Manager - Cloud SP at EMC Corporation, and Mike Dietze, Regional Director at Windstream Hosted Solutions, reviewed next generation cloud services, including the Windstream-EMC Tier Storage solutions, and discussed how to increase efficiencies, improve service delivery and enhance corporate cloud solution development. Michael Piccininni is Global Account Manager – Cloud SP at EMC Corporation. He has been engaged in t...
Jan. 18, 2017 08:15 PM EST Reads: 4,887
You have great SaaS business app ideas. You want to turn your idea quickly into a functional and engaging proof of concept. You need to be able to modify it to meet customers' needs, and you need to deliver a complete and secure SaaS application. How could you achieve all the above and yet avoid unforeseen IT requirements that add unnecessary cost and complexity? You also want your app to be responsive in any device at any time. In his session at 19th Cloud Expo, Mark Allen, General Manager of...
Jan. 18, 2017 07:30 PM EST Reads: 3,151
WebRTC is bringing significant change to the communications landscape that will bridge the worlds of web and telephony, making the Internet the new standard for communications. Cloud9 took the road less traveled and used WebRTC to create a downloadable enterprise-grade communications platform that is changing the communication dynamic in the financial sector. In his session at @ThingsExpo, Leo Papadopoulos, CTO of Cloud9, discussed the importance of WebRTC and how it enables companies to focus o...
Jan. 18, 2017 06:15 PM EST Reads: 4,202