Welcome!

News Feed Item

Treatment Algorithms: Postherpetic Neuralgia - Lyrica forms the cornerstone of treatment for postherpetic neuralgia

NEW YORK, Dec. 17, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Treatment Algorithms: Postherpetic Neuralgia – Lyrica forms the cornerstone of treatment for postherpetic neuralgia

http://www.reportlinker.com/p01055536/Treatment-Algorithms-Postherpetic-Neuralgia-–-Lyrica-forms-the-cornerstone-of-treatment-for-postherpetic-neuralgia.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Therapy

Prescribing trends reveal that patients with PHN are typically initiated on monotherapy. Since no single therapy provides sufficient efficacy, physicians increasingly turn to combination therapy at later lines of treatment to optimize patient outcomes. Lyrica (pregabalin; Pfizer) leads the market, with the recent market entrant Gralise (extended-release gabapentin) struggling to make an impact.Gain insight into patient presentation, diagnosis, and treatment rates and understand which physician types are responsible for management of PHN.Quantify the PHN population across the seven major markets by pain severity (mild, moderate, and severe).Understand which drug treatments are the most commonly prescribed and how this differs across line of therapy and geographic region.Analyze the class, formulation, and brand prescribing trends in the seven major markets.Understand the response rate of patients across three lines of therapy and rates of progression from first to second and third lines of therapy.Following first-line therapy, combination therapies become the mainstay of treatment regimens for the management of PHN, as physicians attempt to optimize therapeutic outcomes. Therefore positioning treatments as adjuvant therapy represents a key opportunity for drug developers.With the vast majority of patients prescribed anticonvulsants as first-line therapy, this treatment class represents the key competition to prospective market entrants. Widespread, off-label prescribing of antidepressants also represents a significant competitive barrier within the PHN market.Lyrica (pregabalin; Pfizer) is the leading brand in the PHN market. Generally, branded products are well received in the market, accounting for the majority of treatments prescribed at first-line therapy.What drugs are the most commonly prescribed for the management of PHN in each of the seven major markets?What are the current PHN market dynamics and the competitive landscape in terms of patient numbers?How can drug developers optimize patient share and position new products appropriately within the PHN market?Which physician types are primarily responsible for PHN prescribing decisions and are therefore key targets for marketing efforts for PHN treatments?What proportion of patients responds to first-line therapy and what proportion progress to second and third lines of therapy?

OVERVIEW

Summary

EXECUTIVE SUMMARY

Datamonitor key findings

COUNTRY TREATMENT TREES

Introduction to treatment trees

Seven major markets

US

Japan

France

Germany

Italy

Spain

UK

DISEASE DEFINITION AND DIAGNOSIS

Disease definition

Etiology

Postherpetic neuralgia results from nerve damage caused by the herpes zoster virus

There are three key points of influence in the prevention of postherpetic neuralgia

Symptoms

Presentation and diagnosis

Less than two thirds of individuals with symptoms of postherpetic neuralgia present to a physician

Of individuals presenting to physicians with symptoms of PHN, 58% receive a diagnosis of PHN

Treatment rates

Across the seven major markets, 37% of diagnosed PHN patients do not receive pharmacological treatment

Influences on diagnosis and treatment rates

Identification of patients at risk of developing PHN is key to capturing the potential treatment market

Referral patterns

Patients with PHN are predominantly managed by primary care physicians/general practitioners

PATIENT SEGMENTATION

Severity of postherpetic neuralgia

The majority of patients with postherpetic neuralgia suffer from moderate to severe pain

Symptoms associated with pain in PHN

Burning sensation, shooting pain, and interrupted sleep are the key pain-associated symptoms in PHN

CURRENT TREATMENT OPTIONS

Overview of drug classes

Only five patented products are indicated for the treatment of postherpetic neuralgia

Anticonvulsants

Antidepressants

Opioids

Topical treatments

PRESCRIBING TRENDS

Class trends

Anticonvulsants are the most commonly prescribed drug class for PHN across all lines of therapy

Across the seven major markets antidepressants are frequently prescribed off-label for PHN

The US has the highest level of opioid prescribing for postherpetic neuralgia

Poor perception of efficacy leaves local anesthetics as the fourth most frequently prescribed drug class

Anxiolytic and antiarrhythmic treatments are not widely prescribed for the management of PHN

Formulation trends

Oral treatments dominate the treatment of postherpetic neuralgia at all lines of therapy

Combination therapy trends

Combination therapy is the mainstay at second and third-line therapy in order to optimize patient outcomes

Prescribing of brands versus generics

Branded products are favored for the first-line management of PHN

Changes in therapy

Lyrica monotherapy dominates the market as the top therapeutic option across all lines of therapy

Lyrica continues to dominate at second-line therapy

Treatments struggle to dominate later lines of therapy amid a vast range of different therapeutic options

Lidoderm and Lyrica provide models of successful PHN treatments in the US market

Patients with PHN increasingly spend longer on second and third-line therapy

Treatment outcomes

Response to therapy

Progression through lines of therapy

Compliance to therapy

BIBLIOGRAPHY

Journal papers

Websites

APPENDIX A

Physician research methodology

Physician sample breakdown

The survey questionnaire

Screener

APPENDIX B

Contributing experts

Conferences attended

TABLES

Table: Summary of drug classes and molecules used for the treatment of postherpetic neuralgia, 2012

Table: The proportion of patients across the seven major markets receiving monotherapy or combination therapy, across different lines of therapy, in the seven major markets, 2012

Table: The top 20 first-line treatments for postherpetic neuralgia across the seven major markets and the proportion of patients receiving these therapies in the individual markets, 2012

Table: The top 20 second-line treatments for postherpetic neuralgia across the seven major markets and the proportion of patients receiving these therapies in the individual markets, 2012

Table: The top 20 third-line treatments for postherpetic neuralgia across the seven major markets and the proportion of patients receiving these therapies in the individual markets, 2012

Table: Treatment response among patients with postherpetic neuralgia across the seven major markets, 2012

Table: Physicians surveyed regarding neuropathic pain across the seven major markets, 2012

FIGURES

Figure: Postherpetic neuropathic pain treatment algorithm in the US, 2012

Figure: Postherpetic neuropathic pain treatment algorithm in Japan, 2012

Figure: Postherpetic neuropathic pain treatment algorithm in France, 2012

Figure: Postherpetic neuropathic pain treatment algorithm in Germany, 2012

Figure: Postherpetic neuropathic pain treatment algorithm in Italy, 2012

Figure: Postherpetic neuropathic pain treatment algorithm in Spain, 2012

Figure: Postherpetic neuropathic pain treatment algorithm in the UK, 2012

Figure: Etiology of postherpetic neuralgia

Figure: Common sites for shingles and subsequent postherpetic neuralgia

Figure: Percentage of individuals with the symptoms of postherpetic neuralgia presenting to physicians, 2012

Figure: The diagnosis rate of individuals presenting to physicians with the symptoms of postherpetic neuralgia, 2012

Figure: The percentage of patients diagnosed with postherpetic neuralgia receiving pharmacological treatment, 2012

Figure: A screenshot of patient-centric educational material regarding postherpetic neuralgia, produced by Depomed, 2011

Figure: Percentage of postherpetic neuralgia patients across the seven major markets who are managed by different healthcare professionals during patient presentation, diagnosis, treatment, and management, 2012

Figure: Patient segmentation by severity of postherpetic neuralgia pain, across the seven major markets, 2012

Figure: Percentage of patients experiencing pain associated with the symptoms of postherpetic neuralgia, 2012

Figure: The impact of postherpetic neuralgia symptoms on patients, as rated by surveyed physicians, 2012

Figure: Proportion of patients with postherpetic neuralgia receiving different classes of therapy at three lines of therapy, across the seven major markets, 2012

Figure: The percentage of patients receiving each drug class as first-line therapy across the seven major markets, 2012

Figure: The relative proportion of therapies, by formulation, that patients are prescribed for the management of postherpetic neuralgia, 2012

Figure: The percentage of patients with postherpetic neuralgia receiving combination or monotherapy across different lines of therapy, in the seven major markets, 2012

Figure: The relative proportion of branded versus generic products prescribed for the first-line management of postherpetic neuralgia across the seven major markets, 2012

Figure: The relative percentage of branded or generic drug therapies prescribed to patients in the seven major markets, Spain, and the UK, 2012

Figure: The percentage of patients receiving branded products as first-line therapy, by drug class, across the seven major markets, 2012

Figure: The top 10 first-line treatments for postherpetic neuralgia across the seven major markets and the proportion of patients receiving these therapies in the individual markets, 2012

Figure: The top 10 second-line treatments for postherpetic neuralgia across the seven major markets and the proportion of patients receiving these therapies in the individual markets, 2012

Figure: The top 10 third-line treatments for postherpetic neuralgia across the seven major markets and the proportion of patients receiving these therapies in the individual markets, 2012

Figure: The proportion of patients receiving key FDA-approved therapies, either as monotherapy or combination therapy, for the management of postherpetic neuralgia, across all lines of therapy in the US, 2012

Figure: The mean number of weeks patients with postherpetic neuralgia spend on first, second, and third-line therapy, across the seven major markets, 2012

Figure: Percentage of postherpetic neuralgia patients responding to first-line therapy across the seven major markets, 2012

Figure: The percentage of patients who progress through three lines of pharmacotherapy across the seven major markets, 2012

Figure: Mean compliance rate across the seven major markets, by type of therapeutic regimen, 2012

Figure: Reasons for patients' non-compliance to therapy in neuropathic pain, 2012

Figure: First-line treatment of postherpetic neuralgia

Figure: Second-line treatment of postherpetic neuralgia

Figure: Third-line treatment of postherpetic neuralgia

Companies Mentioned

Choices, Devoteam SA, GlaxoSmithKline Plc, Hutchison 3G UK Limited, Schindler Holding Ltd.

To order this report:Therapy Industry: Treatment Algorithms: Postherpetic Neuralgia – Lyrica forms the cornerstone of treatment for postherpetic neuralgia

Nicolas Bombourg

Reportlinker

Email: [email protected]

US: (805)652-2626

Intl: +1 805-652-2626

SOURCE Reportlinker

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
One of the biggest challenges with adopting a DevOps mentality is: new applications are easily adapted to cloud-native, microservice-based, or containerized architectures - they can be built for them - but old applications need complex refactoring. On the other hand, these new technologies can require relearning or adapting new, oftentimes more complex, methodologies and tools to be ready for production. In his general session at @DevOpsSummit at 20th Cloud Expo, Chris Brown, Solutions Marketi...
At the keynote this morning we spoke about the value proposition of Nutanix, of having a DevOps culture and a mindset, and the business outcomes of achieving agility and scale, which everybody here is trying to accomplish," noted Mark Lavi, DevOps Solution Architect at Nutanix, in this SYS-CON.tv interview at @DevOpsSummit at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
I think DevOps is now a rambunctious teenager - it's starting to get a mind of its own, wanting to get its own things but it still needs some adult supervision," explained Thomas Hooker, VP of marketing at CollabNet, in this SYS-CON.tv interview at DevOps Summit at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
Enterprises are moving to the cloud faster than most of us in security expected. CIOs are going from 0 to 100 in cloud adoption and leaving security teams in the dust. Once cloud is part of an enterprise stack, it’s unclear who has responsibility for the protection of applications, services, and data. When cloud breaches occur, whether active compromise or a publicly accessible database, the blame must fall on both service providers and users. In his session at 21st Cloud Expo, Ben Johnson, C...
In this presentation, you will learn first hand what works and what doesn't while architecting and deploying OpenStack. Some of the topics will include:- best practices for creating repeatable deployments of OpenStack- multi-site considerations- how to customize OpenStack to integrate with your existing systems and security best practices.
"MobiDev is a software development company and we do complex, custom software development for everybody from entrepreneurs to large enterprises," explained Alan Winters, U.S. Head of Business Development at MobiDev, in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
Agile has finally jumped the technology shark, expanding outside the software world. Enterprises are now increasingly adopting Agile practices across their organizations in order to successfully navigate the disruptive waters that threaten to drown them. In our quest for establishing change as a core competency in our organizations, this business-centric notion of Agile is an essential component of Agile Digital Transformation. In the years since the publication of the Agile Manifesto, the conn...
Major trends and emerging technologies – from virtual reality and IoT, to Big Data and algorithms – are helping organizations innovate in the digital era. However, to create real business value, IT must think beyond the ‘what’ of digital transformation to the ‘how’ to harness emerging trends, innovation and disruption. Architecture is the key that underpins and ties all these efforts together. In the digital age, it’s important to invest in architecture, extend the enterprise footprint to the cl...
Leading companies, from the Global Fortune 500 to the smallest companies, are adopting hybrid cloud as the path to business advantage. Hybrid cloud depends on cloud services and on-premises infrastructure working in unison. Successful implementations require new levels of data mobility, enabled by an automated and seamless flow across on-premises and cloud resources. In his general session at 21st Cloud Expo, Greg Tevis, an IBM Storage Software Technical Strategist and Customer Solution Architec...
"We work around really protecting the confidentiality of information, and by doing so we've developed implementations of encryption through a patented process that is known as superencipherment," explained Richard Blech, CEO of Secure Channels Inc., in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
Data is the fuel that drives the machine learning algorithmic engines and ultimately provides the business value. In his session at Cloud Expo, Ed Featherston, a director and senior enterprise architect at Collaborative Consulting, discussed the key considerations around quality, volume, timeliness, and pedigree that must be dealt with in order to properly fuel that engine.
"We were founded in 2003 and the way we were founded was about good backup and good disaster recovery for our clients, and for the last 20 years we've been pretty consistent with that," noted Marc Malafronte, Territory Manager at StorageCraft, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
Effectively SMBs and government programs must address compounded regulatory compliance requirements. The most recent are Controlled Unclassified Information and the EU's GDPR have Board Level implications. Managing sensitive data protection will likely result in acquisition criteria, demonstration requests and new requirements. Developers, as part of the pre-planning process and the associated supply chain, could benefit from updating their code libraries and design by incorporating changes. In...
Two weeks ago (November 3-5), I attended the Cloud Expo Silicon Valley as a speaker, where I presented on the security and privacy due diligence requirements for cloud solutions. Cloud security is a topical issue for every CIO, CISO, and technology buyer. Decision-makers are always looking for insights on how to mitigate the security risks of implementing and using cloud solutions. Based on the presentation topics covered at the conference, as well as the general discussions heard between sessio...
IoT is rapidly becoming mainstream as more and more investments are made into the platforms and technology. As this movement continues to expand and gain momentum it creates a massive wall of noise that can be difficult to sift through. Unfortunately, this inevitably makes IoT less approachable for people to get started with and can hamper efforts to integrate this key technology into your own portfolio. There are so many connected products already in place today with many hundreds more on the h...