Welcome!

News Feed Item

2012: Sweeping Advances Made In MS Research

Part 1: Overview, Progress Toward Stopping MS   

NEW YORK, Dec. 26, 2012 /PRNewswire-USNewswire/ -- MS research continued to advance on many fronts in 2012. This year saw:

(Logo: http://photos.prnewswire.com/prnh/20090302/DC77093LOGO)

  • The approval of a second oral therapy for relapsing forms of MS and other emerging treatments progressing through the development pipeline;
  • The launch of the International Progressive MS Collaborative, the largest effort to date to speed research to stop progressive forms of MS;
  • The discovery of what could be a target of the immune attack in people with MS may lead to new understanding of the disease and new treatment strategies;
  • The completion of the first human trial of an experimental therapy targeting myelin repair;
  • Progress in restoring functions using innovative rehabilitation techniques, including memory enhancement using a technique involving stories and imagery to solidify learning, and improving balance and mobility with specific exercises;and
  • Advances in uncovering MS triggering factors, bringing us closer to finding ways to prevent the disease; and many other advances pushing us closer to a world free of MS.

The National MS Society continues to propel research forward with a comprehensive strategy aimed at stopping MS, restoring function and ending MS forever (http://www.nationalmssociety.org/research/index.aspx):

In the world's largest meeting dedicated to MS research, over 7,000 scientists convened in Lyon, France to present findings at ECTRIMS (European Committee for Treatment and Research in MS). Over 1250 studies covering virtually every aspect of research were presented:

View videos on specific ECTRIMS topics http://www.youtube.com/playlist?list=PLnPWMdCPZiBbT4OEEunsWbzFTkWNoguQD&feature=addto

PROGRESS TOWARD STOPPING MS

The Society continued to invest in research to stop MS, including:

  • Funding of clinical trials:
    • Testing whether vitamin D, or the sex hormone estriol, or the probiotic approach of a sports drink containing parasite eggs, can reduce MS immune attacks
    • Determining if treatments available for other disorders, such as riluzole (a treatment for ALS or Lou Gehrig's disease) or phenytoin (a treatment for epilepsy), or the antioxidants lipoic acid or green tea extract, can protect the nervous system from damage.
    • Supporting a syndicate formed in the United Kingdom to conduct innovative clinical trials of neuroprotective drugs in secondary-progressive MS.
  • New projects focusing on discovering "biomarkers" to aid better diagnosis and treatment decisions;
  • Collaboration in a cross-disease drug screening initiative aimed at discovering the potential of compounds to stop nerve degeneration and protect the brain from harm;
  • In partnership with Merck Serono, Fast Forward provided funding for lab research to discover small molecules that can deliver therapies to areas of nervous system damage and protect against that damage in MS.

Other important 2012 results toward stopping MS include:

Treatment Pipeline

FDA Approves Oral Aubagio® (Teriflunomide, Genzyme, a Sanofi company) The once-daily pill was approved as a disease-modifying therapy for relapsing forms of MS. Aubagio is the second oral disease-modifying therapy approved for the treatment of MS, and it became available for prescription in October 2012 in the U.S. http://www.nationalmssociety.org/news/news-detail/index.aspx?nid=6864

Two potential therapies are before FDA

Tysabri® label updated to include lab test to enhance treatment decisions –  The test detects antibodies to the JC virus and can help determine a person's risk of developing PML, a severe brain infection that has emerged in some people who have taken Tysabri (natalizumab, Biogen Idec and Elan). The test should enhance the ability of people with MS to weigh risks and benefits of this therapy. http://www.nationalmssociety.org/news/news-detail/index.aspx?nid=5887

Clinical trials discussed at ECTRIMS 2012 – Positive results from trials of statins (cholesterol-reducing medication) and Tysabri in progressive forms of MS, a new approach called AIN457 for treating relapsing MS, and results from phase II and III clinical trials of therapies were among results presented at ECTRIMS focusing on stopping MS. http://www.nationalmssociety.org/news/news-detail/index.aspx?nid=7052

Phase II results of ocrelizumab in relapsing MS – Experimental ocrelizumab (Genentech), given intravenously, significantly reduced disease activity on MRI scans in a study of 218 people with relapsing-remitting MS. One person died due to brain edema; the relation of this death to the medication is unclear. Additional research, now going on in primary-progressive MS and relapsing-remitting MS, is needed to further determine this therapy's safety and benefits. http://www.nationalmssociety.org/research/research-news/news-detail/index.aspx?nid=5659

Another step toward personalized medicine in MS Harvard researchers discovered that differences in active genes that are detectable in blood samples may be used to group people with MS into categories that predict disease course and response to therapy. Further research is needed, but it represents an early step toward personalized medicine in MS. http://www.nationalmssociety.org/news/news-detail/index.aspx?nid=6941

New approach to stopping MS Researchers at Northwestern University have developed an innovative strategy for selectively inhibiting the immune attack in MS using tiny "nanoparticles" that were able to reduce disease activity in mice. The team is now planning a phase I clinical trial of this new technology. http://www.nationalmssociety.org/news/news-detail/index.aspx?nid=7126

Understanding MS

Possible target of immune attacks in some people with MS identified – An immune response to a protein – called "KIR4.1," which is found on several types of brain cells – was observed in the serum of 47% of people with MS. Further research is needed to confirm and understand these findings, which were the result co-funding by the National MS Society. http://nationalmssociety.org/news/news-detail/index.aspx?nid=6619

MS Societies worldwide collaborate to stop MS progression The newly formed International Progressive MS Collaborative published a paper outlining challenges and identifying key research priorities to propel efforts to stop MS progression. http://www.nationalmssociety.org/news/news-detail/index.aspx?nid=6847

Stress management reduces MS activity A 24-week stress management program reduced disease activity on MRI scans significantly more than in a control group, in a study at Northwestern University involving 121 people with relapsing MS. However, the benefits appeared to disappear after the weekly in-person stress management sessions were completed. Future studies should provide more clarity for optimizing the potential benefits of stress management. http://www.nationalmssociety.org/news/news-detail/index.aspx?nid=6629

Society launches project to change how MS disability and progression are measured This cross-sector collaboration has the goal of developing new or improved tools that will be able to track benefits of therapies more quickly in people so that new therapies to stop MS progression may be tested using better assessment tools that are accepted by drug regulatory agencies. http://nationalmssociety.org/news/news-detail/index.aspx?nid=6777

Researchers co-funded by the National MS Society discover possible mechanism for MS damage to nerve tissue – The University of California, San Francisco researchers found that a blood-clotting protein called fibrinogen may play an early role in triggering inflammation that damages nerve fibers in a mouse model of MS. This points to a role for fibrinogen in stimulating inflammation by cells called microglia. If confirmed, targeting the interaction of fibrinogen and microglia may prove to be a novel strategy for stopping MS damage in its tracks. http://www.nationalmssociety.org/news/news-detail/index.aspx?nid=7157

Save this date January 30, 2013, 2:00 – 3:00 p.m. ET and sign up for the live webcast, "From the Frontlines: New Avenues In MS Research for 2013." Visit the National MS Society website.

About Multiple Sclerosis
Multiple sclerosis, an unpredictable, often disabling disease of the central nervous system, interrupts the flow of information within the brain, and between the brain and body.  Symptoms range from numbness and tingling to blindness and paralysis. The progress, severity and specific symptoms of MS in any one person cannot yet be predicted, but advances in research and treatment are moving us closer to a world free of MS. Most people with MS are diagnosed between the ages of 20 and 50, with at least two to three times more women than men being diagnosed with the disease. MS affects more than 400,000 people in the U.S. and over 2.1 million worldwide.

About the National Multiple Sclerosis Society
The National MS Society addresses the challenges of each person affected by MS. To fulfill this mission, the Society funds cutting-edge research, drives change through advocacy, facilitates professional education, collaborates with MS organizations around the world, and provides programs and services designed to help people with MS and their families move forward with their lives.  In 2011 alone, through its national office and 50-state network of chapters, the Society devoted $164 million to programs and services that assisted more than one million people. To move us closer to a world free of MS, the Society also invested $40 million to support more than 325 new and ongoing research projects around the world. The Society is dedicated to achieving a world free of MS. Join the movement at www.nationalMSsociety.org.

SOURCE National Multiple Sclerosis Society

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Leading companies, from the Global Fortune 500 to the smallest companies, are adopting hybrid cloud as the path to business advantage. Hybrid cloud depends on cloud services and on-premises infrastructure working in unison. Successful implementations require new levels of data mobility, enabled by an automated and seamless flow across on-premises and cloud resources. In his general session at 21st Cloud Expo, Greg Tevis, an IBM Storage Software Technical Strategist and Customer Solution Architec...
Coca-Cola’s Google powered digital signage system lays the groundwork for a more valuable connection between Coke and its customers. Digital signs pair software with high-resolution displays so that a message can be changed instantly based on what the operator wants to communicate or sell. In their Day 3 Keynote at 21st Cloud Expo, Greg Chambers, Global Group Director, Digital Innovation, Coca-Cola, and Vidya Nagarajan, a Senior Product Manager at Google, discussed how from store operations and ...
Blockchain. A day doesn’t seem to go by without seeing articles and discussions about the technology. According to PwC executive Seamus Cushley, approximately $1.4B has been invested in blockchain just last year. In Gartner’s recent hype cycle for emerging technologies, blockchain is approaching the peak. It is considered by Gartner as one of the ‘Key platform-enabling technologies to track.’ While there is a lot of ‘hype vs reality’ discussions going on, there is no arguing that blockchain is b...
In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, provided an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life settle...
"As we've gone out into the public cloud we've seen that over time we may have lost a few things - we've lost control, we've given up cost to a certain extent, and then security, flexibility," explained Steve Conner, VP of Sales at Cloudistics,in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
Blockchain is a shared, secure record of exchange that establishes trust, accountability and transparency across business networks. Supported by the Linux Foundation's open source, open-standards based Hyperledger Project, Blockchain has the potential to improve regulatory compliance, reduce cost as well as advance trade. Are you curious about how Blockchain is built for business? In her session at 21st Cloud Expo, René Bostic, Technical VP of the IBM Cloud Unit in North America, discussed the b...
The use of containers by developers -- and now increasingly IT operators -- has grown from infatuation to deep and abiding love. But as with any long-term affair, the honeymoon soon leads to needing to live well together ... and maybe even getting some relationship help along the way. And so it goes with container orchestration and automation solutions, which are rapidly emerging as the means to maintain the bliss between rapid container adoption and broad container use among multiple cloud host...
In his session at 21st Cloud Expo, Michael Burley, a Senior Business Development Executive in IT Services at NetApp, described how NetApp designed a three-year program of work to migrate 25PB of a major telco's enterprise data to a new STaaS platform, and then secured a long-term contract to manage and operate the platform. This significant program blended the best of NetApp’s solutions and services capabilities to enable this telco’s successful adoption of private cloud storage and launching ...
You know you need the cloud, but you’re hesitant to simply dump everything at Amazon since you know that not all workloads are suitable for cloud. You know that you want the kind of ease of use and scalability that you get with public cloud, but your applications are architected in a way that makes the public cloud a non-starter. You’re looking at private cloud solutions based on hyperconverged infrastructure, but you’re concerned with the limits inherent in those technologies.
Imagine if you will, a retail floor so densely packed with sensors that they can pick up the movements of insects scurrying across a store aisle. Or a component of a piece of factory equipment so well-instrumented that its digital twin provides resolution down to the micrometer.
"Since we launched LinuxONE we learned a lot from our customers. More than anything what they responded to were some very unique security capabilities that we have," explained Mark Figley, Director of LinuxONE Offerings at IBM, in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
Is advanced scheduling in Kubernetes achievable?Yes, however, how do you properly accommodate every real-life scenario that a Kubernetes user might encounter? How do you leverage advanced scheduling techniques to shape and describe each scenario in easy-to-use rules and configurations? In his session at @DevOpsSummit at 21st Cloud Expo, Oleg Chunikhin, CTO at Kublr, answered these questions and demonstrated techniques for implementing advanced scheduling. For example, using spot instances and co...
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, whic...
Sanjeev Sharma Joins June 5-7, 2018 @DevOpsSummit at @Cloud Expo New York Faculty. Sanjeev Sharma is an internationally known DevOps and Cloud Transformation thought leader, technology executive, and author. Sanjeev's industry experience includes tenures as CTO, Technical Sales leader, and Cloud Architect leader. As an IBM Distinguished Engineer, Sanjeev is recognized at the highest levels of IBM's core of technical leaders.
The need for greater agility and scalability necessitated the digital transformation in the form of following equation: monolithic to microservices to serverless architecture (FaaS). To keep up with the cut-throat competition, the organisations need to update their technology stack to make software development their differentiating factor. Thus microservices architecture emerged as a potential method to provide development teams with greater flexibility and other advantages, such as the abili...