Welcome!

News Feed Item

New Data Highlight Considerable Burden of Nocturia

MILAN, March 17, 2013 /PRNewswire/ --

Chronic condition associated with disturbed sleep and notable

loss of productivity and non-work related activity

New data presented today at the European Association of Urology (EAU) congress show that nocturia (waking up one or more times to void at night) is associated with significant reductions in work productivity and leisure activity in line with other common chronic disorders such as asthma, COPD (chronic obstructive pulmonary disease) and GERD (gastro-esophageal reflux disease).[1] Nocturia was found to reduce work productivity by almost 25% in the working population.[1]

Further study results also show that sufferers consider disturbed sleep to be the most burdensome symptom, and around a third of people with nocturia are unable to get back to sleep after urinating, leading to insomnia.[2]

Fragmented sleep is a serious consequence of nocturia and has the potential to negatively affect daytime performance.  An analysis of data collected from two, three-month, randomised, controlled clinical trials (n=646) was carried out as part of an economic evaluation to compare the effect of nocturia on productivity and activity with that of other chronic diseases.  Work productivity was assessed using the Work Productivity and Activity Impairment Questionnaire.[3]

A work productivity loss of 24% was observed with nocturia.  This is higher than that reported for over active bladder (10-12%),[4] and comparable to other non-urological chronic conditions such as GERD (25%),[5] severe asthma (21%),[6] COPD (19%)[7] and constipation (34%).[8]  Furthermore, patients' ability to conduct daytime activities was reduced by 34% with nocturia.[1]

Commenting on the results of the study, Philip Van Kerrebroeck, MD, PhD, University of Maastricht said: "Nocturia is a common problem affecting around a third of adults, but its burden is underestimated and it is often dismissed as being less serious than other chronic conditions in terms of impact on quality of life and societal costs.  These data show that nocturia negatively affects both sleep and day time performance and its impact on work productivity is in line with many other chronic conditions.  Patients with nocturia should seek specific treatment for this debilitating condition."

The second data set presented at EAU was an analysis of subjective, patient-reported data on which nocturia symptoms they find most bothersome.  The multiple negative effects on quality of life associated with nocturia have been reported previously, but no studies to date have asked patients to give their reasons why nocturia is so debilitating.

Men and women in two randomised controlled trials (n=786, women 273, men 513) were asked what bothers them most about having to get up at night to void and answers were recorded verbatim.[2] Sleep disturbance was the most bothersome symptom associated with nocturia (57% of males and 42% of women).  The inability to go back to sleep was ranked as the second most bothersome symptom by 32% of men and 28% of women, and the third ranked symptom was feeling tired the next morning (17% of men and 15% of women).  Self-reported signs and symptoms did not differ significantly with gender.  However, age was important as a small subgroup of older patients specifically mentioned fear of falling, especially due to dizziness and walking through a dark house to go to the toilet, as bothersome.

"I have started considering my sleep pattern as a series of naps", explained one patient in the study.  "I can't ever fall back asleep.  I start watching TV all night and I am miserable the next day", said another.

About Nocturia

Nocturia is a bothersome and highly prevalent condition defined by the International Continence Society as the need to wake one or more times nightly to void with each void preceded and followed by sleep.[9]

Studies of the relationship between QoL and nocturia suggest that the condition becomes clinically significant when 2 or more voids nightly are experienced. Among LUTS, nocturia is consistently reported to be one of the most bothersome symptoms by men as well as women and significantly compromises sleep and overall QoL.[10] Often trivialised and assumed to be an inevitable part of the ageing process, nocturia is a serious condition with far-reaching social, health and economic implications for patients, their families and society.[11]

About Ferring Pharmaceuticals

Headquartered in Switzerland, Ferring Pharmaceuticals is a research-driven, specialty biopharmaceutical group active in global markets. The company identifies, develops and markets innovative products in the areas of reproductive health, urology, gastroenterology and endocrinology. Ferring has its own operating subsidiaries in 50 countries and markets its products in more than 70 countries. To learn more about Ferring or its products please visit http://www.ferring.com.

References:

1. Andersson F et al. Nocturia has a strong impact on productivity - a comparison with different chronic diseases.  EAU 2013: presented at poster session 'Nocturia, OAB, metabolic syndrome - towards a new management', abstract number #406.

2. Holm-Larsen T et al. "My sleep pattern is a series of naps." Subjective patient-reported data on what is most bothersome about nocturia.  EAU 2013: presented at poster session 'Nocturia, OAB, metabolic syndrome - towards a new management', abstract number #405.

3. Reilly MC et al. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics 1993;4:353-365. doi: 10.2165/00019053-199304050-00006.

4. Coyne KS et al. The prevalence of lower urinary tract symptoms (LUTS) and overactive bladder (OAB) by racial/ethnic group and age: Results from OAB-POLL. Neurourol Urodyn 2012 Jul 27. doi: 10.1002/nau.22295.

5. Wahlqvist P et al. Validity of a Work Productivity and Activity Impairment questionnaire for patients with symptoms of gastro-esophageal reflux disease (WPAI-GERD) - results from a cross-sectional study. Value Health 2002;5:106-113.

6. Chen E et al. Chronic traffic-related air pollution and stress interact to predict biologic and clinical outcomes in asthma. Environ Health Perspect 2008;116:970-975.

7. Di Bonaventura M et al. The burden of chronic obstructive pulmonary disease among employed adults. Int J Chron Obstruct Pulmon Dis 2012;7:211-219.

8. Sun SX et al. Impact of chronic constipation on health-related quality of life, work productivity, and healthcare resource use: an analysis of the National Health and Wellness Survey. Dig Dis Sci 2011;56:2688-2695.

9. van Kerrebroeck P et al. The standardization of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. Neurol UroL Urodyn 2002;21:179-83.

10. van Dijk MM et al: The role of nocturia in the quality of life of men with lower urinary tract symptoms. BJU Int 2010;105:1141.

11. Asplund R. Nocturia: consequences for sleep and daytime activities and associated risks. European Urology Supplements 2005;3:24-32.

 

For further information, please contact:


    Emma Coughlan               Moira Gitsham               Patrick Gorman
    Tonic Life Communications   Tonic Life Communications   Ferring Pharmaceuticals
    Tel: +44-(0)7896-075431     Tel: +33-5-46-00-08-20      Tel: +41-(0)58-301-00-53
    [email protected]   [email protected]   [email protected]


More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
The cloud market growth today is largely in public clouds. While there is a lot of spend in IT departments in virtualization, these aren’t yet translating into a true “cloud” experience within the enterprise. What is stopping the growth of the “private cloud” market? In his general session at 18th Cloud Expo, Nara Rajagopalan, CEO of Accelerite, will explore the challenges in deploying, managing, and getting adoption for a private cloud within an enterprise. What are the key differences betwee...
What a difference a year makes. Organizations aren’t just talking about IoT possibilities, it is now baked into their core business strategy. With IoT, billions of devices generating data from different companies on different networks around the globe need to interact. From efficiency to better customer insights to completely new business models, IoT will turn traditional business models upside down. In the new customer-centric age, the key to success is delivering critical services and apps wit...
SYS-CON Events announced today that ContentMX, the marketing technology and services company with a singular mission to increase engagement and drive more conversations for enterprise, channel and SMB technology marketers, has been named “Sponsor & Exhibitor Lounge Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York City, New York. “CloudExpo is a great opportunity to start a conversation with new prospects, but what happens after the...
Many banks and financial institutions are experimenting with containers in development environments, but when will they move into production? Containers are seen as the key to achieving the ultimate in information technology flexibility and agility. Containers work on both public and private clouds, and make it easy to build and deploy applications. The challenge for regulated industries is the cost and complexity of container security compliance. VM security compliance is already challenging, ...
SYS-CON Events announced today that 24Notion has been named “Bronze Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. 24Notion is full-service global creative digital marketing, technology and lifestyle agency that combines strategic ideas with customized tactical execution. With a broad understand of the art of traditional marketing, new media, communications and social influence, 24Notion uniquely understands how to con...
The essence of data analysis involves setting up data pipelines that consist of several operations that are chained together – starting from data collection, data quality checks, data integration, data analysis and data visualization (including the setting up of interaction paths in that visualization). In our opinion, the challenges stem from the technology diversity at each stage of the data pipeline as well as the lack of process around the analysis.
SYS-CON Events announced today the Docker Meets Kubernetes – Intro into the Kubernetes World, being held June 9, 2016, in conjunction with 18th Cloud Expo | @ThingsExpo, at the Javits Center in New York, NY. Register for 'Docker Meets Kubernetes Workshop' Here! This workshop led by Sebastian Scheele, co-founder of Loodse, introduces participants to Kubernetes (container orchestration). Through a combination of instructor-led presentations, demonstrations, and hands-on labs, participants learn ...
The initial debate is over: Any enterprise with a serious commitment to IT is migrating to the cloud. But things are not so simple. There is a complex mix of on-premises, colocated, and public-cloud deployments. In this power panel at 18th Cloud Expo, moderated by Conference Chair Roger Strukhoff, panelists will look at the present state of cloud from the C-level view, and how great companies and rock star executives can use cloud computing to meet their most ambitious and disruptive business ...
The demand for organizations to expand their infrastructure to multiple IT environments like the cloud, on-premise, mobile, bring your own device (BYOD) and the Internet of Things (IoT) continues to grow. As this hybrid infrastructure increases, the challenge to monitor the security of these systems increases in volume and complexity. In his session at 18th Cloud Expo, Stephen Coty, Chief Security Evangelist at Alert Logic, will show how properly configured and managed security architecture can...
In his session at 18th Cloud Expo, Andrew Cole, Director of Solutions Engineering at Peak 10, will discuss how the newest technology advances are reducing the cost and complexity of traditional business continuity and disaster recovery solutions. Attendees will: Learn why having a full disaster recovery strategy is more important now than ever before Explore the key drivers of a successful disaster recovery solution Achieve measurable operational and business value from a disaster recovery ...
In his session at 18th Cloud Expo, Bruce Swann, Senior Product Marketing Manager at Adobe, will discuss how the Adobe Marketing Cloud can help marketers embrace opportunities for personalized, relevant and real-time customer engagement across offline (direct mail, point of sale, call center) and digital (email, website, SMS, mobile apps, social networks, connected objects). Bruce Swann has more than 15 years of experience working with digital marketing disciplines like web analytics, social med...
When it comes to IoT in the enterprise, namely the commercial building and hospitality markets, a benefit not getting the attention it deserves is energy efficiency, and IoT's direct impact on a cleaner, greener environment when installed in smart buildings. Until now clean technology was offered piecemeal and led with point solutions that require significant systems integration to orchestrate and deploy. There didn't exist a 'top down' approach that can manage and monitor the way a Smart Buildi...
SYS-CON Events announced today that Hanu Software will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Leveraging best-in-class people, processes, and technologies, Hanu provides high-quality, high-value software development and business process outsourcing services to independent software vendors (ISVs) and enterprises.
SYS-CON Events announced today BZ Media LLC has been named “Media Sponsor” of SYS-CON's 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. BZ Media LLC is a high-tech media company that produces technical conferences and expositions, and publishes a magazine, newsletters and websites in the software development, SharePoint, mobile development and Commercial Drone markets.
WebRTC is bringing significant change to the communications landscape that will bridge the worlds of web and telephony, making the Internet the new standard for communications. Cloud9 took the road less traveled and used WebRTC to create a downloadable enterprise-grade communications platform that is changing the communication dynamic in the financial sector. In his session at @ThingsExpo, Leo Papadopoulos, CTO of Cloud9, will discuss the importance of WebRTC and how it enables companies to fo...