Welcome!

News Feed Item

New Data Highlight Considerable Burden of Nocturia

MILAN, March 17, 2013 /PRNewswire/ --

Chronic condition associated with disturbed sleep and notable

loss of productivity and non-work related activity

New data presented today at the European Association of Urology (EAU) congress show that nocturia (waking up one or more times to void at night) is associated with significant reductions in work productivity and leisure activity in line with other common chronic disorders such as asthma, COPD (chronic obstructive pulmonary disease) and GERD (gastro-esophageal reflux disease).[1] Nocturia was found to reduce work productivity by almost 25% in the working population.[1]

Further study results also show that sufferers consider disturbed sleep to be the most burdensome symptom, and around a third of people with nocturia are unable to get back to sleep after urinating, leading to insomnia.[2]

Fragmented sleep is a serious consequence of nocturia and has the potential to negatively affect daytime performance.  An analysis of data collected from two, three-month, randomised, controlled clinical trials (n=646) was carried out as part of an economic evaluation to compare the effect of nocturia on productivity and activity with that of other chronic diseases.  Work productivity was assessed using the Work Productivity and Activity Impairment Questionnaire.[3]

A work productivity loss of 24% was observed with nocturia.  This is higher than that reported for over active bladder (10-12%),[4] and comparable to other non-urological chronic conditions such as GERD (25%),[5] severe asthma (21%),[6] COPD (19%)[7] and constipation (34%).[8]  Furthermore, patients' ability to conduct daytime activities was reduced by 34% with nocturia.[1]

Commenting on the results of the study, Philip Van Kerrebroeck, MD, PhD, University of Maastricht said: "Nocturia is a common problem affecting around a third of adults, but its burden is underestimated and it is often dismissed as being less serious than other chronic conditions in terms of impact on quality of life and societal costs.  These data show that nocturia negatively affects both sleep and day time performance and its impact on work productivity is in line with many other chronic conditions.  Patients with nocturia should seek specific treatment for this debilitating condition."

The second data set presented at EAU was an analysis of subjective, patient-reported data on which nocturia symptoms they find most bothersome.  The multiple negative effects on quality of life associated with nocturia have been reported previously, but no studies to date have asked patients to give their reasons why nocturia is so debilitating.

Men and women in two randomised controlled trials (n=786, women 273, men 513) were asked what bothers them most about having to get up at night to void and answers were recorded verbatim.[2] Sleep disturbance was the most bothersome symptom associated with nocturia (57% of males and 42% of women).  The inability to go back to sleep was ranked as the second most bothersome symptom by 32% of men and 28% of women, and the third ranked symptom was feeling tired the next morning (17% of men and 15% of women).  Self-reported signs and symptoms did not differ significantly with gender.  However, age was important as a small subgroup of older patients specifically mentioned fear of falling, especially due to dizziness and walking through a dark house to go to the toilet, as bothersome.

"I have started considering my sleep pattern as a series of naps", explained one patient in the study.  "I can't ever fall back asleep.  I start watching TV all night and I am miserable the next day", said another.

About Nocturia

Nocturia is a bothersome and highly prevalent condition defined by the International Continence Society as the need to wake one or more times nightly to void with each void preceded and followed by sleep.[9]

Studies of the relationship between QoL and nocturia suggest that the condition becomes clinically significant when 2 or more voids nightly are experienced. Among LUTS, nocturia is consistently reported to be one of the most bothersome symptoms by men as well as women and significantly compromises sleep and overall QoL.[10] Often trivialised and assumed to be an inevitable part of the ageing process, nocturia is a serious condition with far-reaching social, health and economic implications for patients, their families and society.[11]

About Ferring Pharmaceuticals

Headquartered in Switzerland, Ferring Pharmaceuticals is a research-driven, specialty biopharmaceutical group active in global markets. The company identifies, develops and markets innovative products in the areas of reproductive health, urology, gastroenterology and endocrinology. Ferring has its own operating subsidiaries in 50 countries and markets its products in more than 70 countries. To learn more about Ferring or its products please visit http://www.ferring.com.

References:

1. Andersson F et al. Nocturia has a strong impact on productivity - a comparison with different chronic diseases.  EAU 2013: presented at poster session 'Nocturia, OAB, metabolic syndrome - towards a new management', abstract number #406.

2. Holm-Larsen T et al. "My sleep pattern is a series of naps." Subjective patient-reported data on what is most bothersome about nocturia.  EAU 2013: presented at poster session 'Nocturia, OAB, metabolic syndrome - towards a new management', abstract number #405.

3. Reilly MC et al. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics 1993;4:353-365. doi: 10.2165/00019053-199304050-00006.

4. Coyne KS et al. The prevalence of lower urinary tract symptoms (LUTS) and overactive bladder (OAB) by racial/ethnic group and age: Results from OAB-POLL. Neurourol Urodyn 2012 Jul 27. doi: 10.1002/nau.22295.

5. Wahlqvist P et al. Validity of a Work Productivity and Activity Impairment questionnaire for patients with symptoms of gastro-esophageal reflux disease (WPAI-GERD) - results from a cross-sectional study. Value Health 2002;5:106-113.

6. Chen E et al. Chronic traffic-related air pollution and stress interact to predict biologic and clinical outcomes in asthma. Environ Health Perspect 2008;116:970-975.

7. Di Bonaventura M et al. The burden of chronic obstructive pulmonary disease among employed adults. Int J Chron Obstruct Pulmon Dis 2012;7:211-219.

8. Sun SX et al. Impact of chronic constipation on health-related quality of life, work productivity, and healthcare resource use: an analysis of the National Health and Wellness Survey. Dig Dis Sci 2011;56:2688-2695.

9. van Kerrebroeck P et al. The standardization of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. Neurol UroL Urodyn 2002;21:179-83.

10. van Dijk MM et al: The role of nocturia in the quality of life of men with lower urinary tract symptoms. BJU Int 2010;105:1141.

11. Asplund R. Nocturia: consequences for sleep and daytime activities and associated risks. European Urology Supplements 2005;3:24-32.

 

For further information, please contact:


    Emma Coughlan               Moira Gitsham               Patrick Gorman
    Tonic Life Communications   Tonic Life Communications   Ferring Pharmaceuticals
    Tel: +44-(0)7896-075431     Tel: +33-5-46-00-08-20      Tel: +41-(0)58-301-00-53
    [email protected]   [email protected]   [email protected]


More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
All clouds are not equal. To succeed in a DevOps context, organizations should plan to develop/deploy apps across a choice of on-premise and public clouds simultaneously depending on the business needs. This is where the concept of the Lean Cloud comes in - resting on the idea that you often need to relocate your app modules over their life cycles for both innovation and operational efficiency in the cloud. In his session at @DevOpsSummit at19th Cloud Expo, Valentin (Val) Bercovici, CTO of Soli...
Enterprise IT has been in the era of Hybrid Cloud for some time now. But it seems most conversations about Hybrid are focused on integrating AWS, Microsoft Azure, or Google ECM into existing on-premises systems. Where is all the Private Cloud? What do technology providers need to do to make their offerings more compelling? How should enterprise IT executives and buyers define their focus, needs, and roadmap, and communicate that clearly to the providers?
SYS-CON Events announced today that Dataloop.IO, an innovator in cloud IT-monitoring whose products help organizations save time and money, has been named “Bronze Sponsor” of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Dataloop.IO is an emerging software company on the cutting edge of major IT-infrastructure trends including cloud computing and microservices. The company, founded in the UK but now based in San Fran...
Join Impiger for their featured webinar: ‘Cloud Computing: A Roadmap to Modern Software Delivery’ on November 10, 2016, at 12:00 pm CST. Very few companies have not experienced some impact to their IT delivery due to the evolution of cloud computing. This webinar is not about deciding whether you should entertain moving some or all of your IT to the cloud, but rather, a detailed look under the hood to help IT professionals understand how cloud adoption has evolved and what trends will impact th...
In his session at 19th Cloud Expo, Claude Remillard, Principal Program Manager in Developer Division at Microsoft, contrasted how his team used config as code and immutable patterns for continuous delivery of microservices and apps to the cloud. He showed how the immutable patterns helps developers do away with most of the complexity of config as code-enabling scenarios such as rollback, zero downtime upgrades with far greater simplicity. He also demoed building immutable pipelines in the cloud ...
"We are the public cloud providers. We are currently providing 50% of the resources they need for doing e-commerce business in China and we are hosting about 60% of mobile gaming in China," explained Yi Zheng, CPO and VP of Engineering at CDS Global Cloud, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Businesses and business units of all sizes can benefit from cloud computing, but many don't want the cost, performance and security concerns of public cloud nor the complexity of building their own private clouds. Today, some cloud vendors are using artificial intelligence (AI) to simplify cloud deployment and management. In his session at 20th Cloud Expo, Ajay Gulati, Co-founder and CEO of ZeroStack, will discuss how AI can simplify cloud operations. He will cover the following topics: why clou...
"We are a custom software development, engineering firm. We specialize in cloud applications from helping customers that have on-premise applications migrating to the cloud, to helping customers design brand new apps in the cloud. And we specialize in mobile apps," explained Peter Di Stefano, Vice President of Marketing at Impiger Technologies, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
IoT solutions exploit operational data generated by Internet-connected smart “things” for the purpose of gaining operational insight and producing “better outcomes” (for example, create new business models, eliminate unscheduled maintenance, etc.). The explosive proliferation of IoT solutions will result in an exponential growth in the volume of IoT data, precipitating significant Information Governance issues: who owns the IoT data, what are the rights/duties of IoT solutions adopters towards t...
As data explodes in quantity, importance and from new sources, the need for managing and protecting data residing across physical, virtual, and cloud environments grow with it. Managing data includes protecting it, indexing and classifying it for true, long-term management, compliance and E-Discovery. Commvault can ensure this with a single pane of glass solution – whether in a private cloud, a Service Provider delivered public cloud or a hybrid cloud environment – across the heterogeneous enter...
@DevOpsSummit taking place June 6-8, 2017 at Javits Center, New York City, is co-located with the 20th International Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. @DevOpsSummit at Cloud Expo New York Call for Papers is now open.
Everyone knows that truly innovative companies learn as they go along, pushing boundaries in response to market changes and demands. What's more of a mystery is how to balance innovation on a fresh platform built from scratch with the legacy tech stack, product suite and customers that continue to serve as the business' foundation. In his General Session at 19th Cloud Expo, Michael Chambliss, Head of Engineering at ReadyTalk, discussed why and how ReadyTalk diverted from healthy revenue and mor...
The many IoT deployments around the world are busy integrating smart devices and sensors into their enterprise IT infrastructures. Yet all of this technology – and there are an amazing number of choices – is of no use without the software to gather, communicate, and analyze the new data flows. Without software, there is no IT. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, Dave McCarthy, Director of Products at Bsquare Corporation; Alan Williamson, Principal...
"Qosmos has launched L7Viewer, a network traffic analysis tool, so it analyzes all the traffic between the virtual machine and the data center and the virtual machine and the external world," stated Sebastien Synold, Product Line Manager at Qosmos, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
President Obama recently announced the launch of a new national awareness campaign to "encourage more Americans to move beyond passwords – adding an extra layer of security like a fingerprint or codes sent to your cellphone." The shift from single passwords to multi-factor authentication couldn’t be timelier or more strategic. This session will focus on why passwords alone are no longer effective, and why the time to act is now. In his session at 19th Cloud Expo, Chris Webber, security strateg...