|By PR Newswire||
|April 17, 2013 03:01 AM EDT||
Throat cancers on the rise due to epidemic of HPV infection
TORONTO, April 17, 2013 /CNW/ - Researchers in London, Ontario, are conducting a first-ever clinical trial to determine which treatment option gives patients with throat cancers the best quality of life. These cancers are dramatically on the rise due to the epidemic of HPV (human papilloma virus) infection.
Surgeon Dr Anthony Nichols and radiation oncologist Dr David Palma at the Lawson Research Centre have received a $223,000 Quality of Life Grant from the Canadian Cancer Society to conduct the study. Dr Nichols is an assistant professor in head and neck surgery at Western University. Dr Palma is a clinician-scientist with the Ontario Institute for Cancer Research.
The current standard treatment for throat cancers is radiation and chemotherapy, which results in good control of the disease but can leave patients with a variety of life-changing side effects, such as problems with speaking, swallowing, tasting and hearing and even feeding tube dependence.
A minimally invasive robotic surgery has emerged as a promising alternative treatment that appears to have fewer side effects.
"Patients with HPV-related throat cancers tend to be younger and healthier and have a good chance of being cured. As they will have to live with the side effects of treatment for decades, post-treatment quality of life is of paramount importance," says Dr Nichols.
"Before we can adopt a new treatment, we have to prove that the rates of cure are as good as they are with the standard treatment, which is chemotherapy with radiation," says Dr. Palma. "Sometimes new technologies are introduced with a lot of hype but don't prove to be helpful in the end. Transoral robotic surgery has shown tremendous promise as a treatment option, and we are the only ones in the world doing this type of study right now."
For the 3-year study, patients with early stage cancer of the oropharynx (which includes the tongue, soft palate, side and back walls of the throat, and tonsils) are invited to participate in a randomized phase II clinical trial. Patients will be assigned to receive either the current standard treatment (radiation, plus or minus chemotherapy) or the robotic surgery. One year after treatment, patient quality of life will be assessed for side effects.
This will be the first clinical trial to directly compare the 2 treatment methods and has the potential to have an international impact on the treatment of patients with throat cancers. In the United States, the robotic surgery is already being used for these types of cancers despite the lack of high-level evidence to support it.
To do the surgery, doctors use tiny robotically controlled surgical implements to remove tumours of the tongue, tonsils, palate or throat. The robot has a viewfinder and 3-D camera that can see around corners, and the tiny robotic arms can get into tight spaces where the surgeon's hands cannot fit. While the surgeon watches what's happening on a screen, the robotic arms precisely mimic the movements of the surgeon's hands and can even filter out the surgeon's hand tremor.
"The Canadian Cancer Society knows how important a patient's quality of life is during and after cancer treatment," says Dr Siân Bevan, Director of Research at the Canadian Cancer Society. "This exciting new surgical method shows great promise to vastly improve quality of life, and we are happy to be able to fund this important study, with the generous support of our donors."
About HPV and cancer
According to Dr. Nichols, HPV is the most common sexually transmitted infection. "The incidence of throat cancers has increased dramatically in recent years due in large part to widespread infection with HPV. The increase is thought to be because of changes in sexual practices that began in the 1960s."
These cancers typically take more than 20 years to develop. Some strains of the HPV virus cause cervical cancer as well as ano-genital cancers. More recently, HPV infections have been found to cause cancers of the oropharynx.
It is estimated that 75% of sexually-active Canadians will have at least one HPV infection in their lifetime. The body's immune system usually gets rid of an HPV infection on its own. Most HPV infections (about 70%) go away without any treatment within 1-2 years. Persistent infection with high-risk HPV types over many years can cause precancerous changes and cancer.
HPV infection is associated with about:
- 25%-35% of oropharyngeal cancers
- 40% of vaginal and vulvar cancers
- 40%-50% of penile cancers
- 80%-90% of anal cancers
Dr. Nichols says that throat cancer patients whose disease was caused by an HPV infection tend to be diagnosed in their 40s and 50s, as opposed to patients whose throat cancer was caused by smoking and alcohol (these patients tend to be diagnosed at 60 or older).
A vaccine is available in Canada to prevent HPV infection. It protects against the types of HPV that cause 70% of HPV-related cancers. For more information, visit cancer.ca.
Other Quality of Life Grants
Dr Kim Edelstein, Toronto, $299,754 - Since cancer in young adults occurs during crucial formative years, it can have a particularly devastating effect, leaving survivors with a variety of long-term side-effects as a result of the disease and treatment. In her study, Dr Edelstein is exploring the impact of chemotherapy on thinking abilities during the first year after being diagnosed with cancer and whether these changes impact psychosocial development, with the findings to be used to develop strategies to help prevent or decrease these problems.
Dr Stephen Hall, Kingston, $153,029 - Using a series of questionnaires delivered over a 3-year period, Dr Hall will lead the first study of its kind to examine how patients who have had head and neck cancer perceive follow-up appointments to understand their attitudes, needs, fears and expected benefits about the appointments. His goal is to improve the quality of life for survivors by making the follow-up care more effective for individual patients while improving the efficiency of the health care system.
Dr Robert Klaassen, Ottawa, $177,794 - Using a survey developed with the input of patients, caregivers, health care providers and quality of life experts, Dr Klaassen aims to assess the impact of treatments on the quality of life of patients with incurable blood disorders that put them at a high risk of developing cancer. Because of the incurable nature of the conditions - named myelodysplastic syndromes - determining the impact of treatment on quality of life is crucial and this survey may become a critical resource and powerful tool to achieve this.
Dr Andrew Matthew, Toronto, $137,233 - Sexual dysfunction after prostate cancer surgery is one of the most substantial concerns for patients and their partners and has a significant impact on quality of life. To address this important health issue, Dr Matthew is developing a biomedical-psychosocial intervention which incorporates the active participation of the partner and features medical, psychological and social methods, with the eventual goal of introducing a new and effective way to support intimacy and optimal sexual health.
Dr Roanne Thomas, Ottawa, $244,128 - Using a variety of methods, including group discussion, photography, journaling and film, Dr Thomas will document the breast cancer experiences of First Nations, Inuit and Metis women. Since little is known about the factors which affect the breast cancer experiences of these groups of women, Dr Thomas' study will address gaps in knowledge and care to uncover valuable information for the development of future support programs and education materials for health professionals.
About the Quality of Life Grants
This program has been created to support quality of life cancer research that has the potential to make a significant impact on the burden of disease in patients, survivors and caregivers
About the Canadian Cancer Society
For 75 years the Canadian Cancer Society has been with Canadians in the fight for life. We have been relentless in our commitment to prevent cancer, fund research and support Canadians touched by cancer. From this foundation, we will work with Canadians to change cancer forever so fewer Canadians are diagnosed with the disease and more survive.
Visit cancer.ca or call us at 1-888-939-3333 (TTY 1-866-786-3934).
SOURCE Canadian Cancer Society (National Office)
Image with caption: "With a Quality of Life grant from the Canadian Cancer Society, Dr. Anthony Nichols (right) and Dr. David Palma will lead a first-ever clinical trial to determine if robotic surgery to treat throat cancer reduces side effects. (CNW Group/Canadian Cancer Society (National Office))". Image available at: http://photos.newswire.ca/images/download/20130417_C5793_PHOTO_EN_25578.jpg
Image with caption: "Dr. Anthony Nichols performs robotic surgery on a throat cancer patient. With a Quality of Life grant from the Canadian Cancer Society, he will study if this non-invasive approach reduces side effects. (CNW Group/Canadian Cancer Society (National Office))". Image available at: http://photos.newswire.ca/images/download/20130417_C5793_PHOTO_EN_25576.jpg
Internet of @ThingsExpo has announced today that Chris Matthieu has been named tech chair of Internet of @ThingsExpo 2017 New York The 7th Internet of @ThingsExpo will take place on June 6-8, 2017, at the Javits Center in New York City, New York. Chris Matthieu is the co-founder and CTO of Octoblu, a revolutionary real-time IoT platform recently acquired by Citrix. Octoblu connects things, systems, people and clouds to a global mesh network allowing users to automate and control design flo...
Dec. 9, 2016 06:00 AM EST Reads: 820
You are moving to the Cloud. The question is not if, it’s when. Now that your competitors are in the cloud and lapping you, your “when” better hurry up and get here. But saying and doing are two different things. In his session at @DevOpsSummit at 18th Cloud Expo, Robert Reeves, CTO of Datical, explained how DevOps can be your onramp to the cloud. By adopting simple, platform independent DevOps strategies, you can accelerate your move to the cloud. Spoiler Alert: He also makes sure you don’t...
Dec. 9, 2016 05:00 AM EST Reads: 3,132
President Obama recently announced the launch of a new national awareness campaign to "encourage more Americans to move beyond passwords – adding an extra layer of security like a fingerprint or codes sent to your cellphone." The shift from single passwords to multi-factor authentication couldn’t be timelier or more strategic. This session will focus on why passwords alone are no longer effective, and why the time to act is now. In his session at 19th Cloud Expo, Chris Webber, security strateg...
Dec. 9, 2016 04:45 AM EST Reads: 491
"We are an all-flash array storage provider but our focus has been on VM-aware storage specifically for virtualized applications," stated Dhiraj Sehgal of Tintri in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Dec. 9, 2016 04:30 AM EST Reads: 1,030
Redis is not only the fastest database, but it has become the most popular among the new wave of applications running in containers. Redis speeds up just about every data interaction between your users or operational systems. In his session at 18th Cloud Expo, Dave Nielsen, Developer Relations at Redis Labs, shared the functions and data structures used to solve everyday use cases that are driving Redis' popularity.
Dec. 9, 2016 04:15 AM EST Reads: 3,545
The WebRTC Summit New York, to be held June 6-8, 2017, at the Javits Center in New York City, NY, announces that its Call for Papers is now open. Topics include all aspects of improving IT delivery by eliminating waste through automated business models leveraging cloud technologies. WebRTC Summit is co-located with 20th International Cloud Expo and @ThingsExpo. WebRTC is the future of browser-to-browser communications, and continues to make inroads into the traditional, difficult, plug-in web co...
Dec. 9, 2016 04:15 AM EST Reads: 1,452
Enterprise IT has been in the era of Hybrid Cloud for some time now. But it seems most conversations about Hybrid are focused on integrating AWS, Microsoft Azure, or Google ECM into existing on-premises systems. Where is all the Private Cloud? What do technology providers need to do to make their offerings more compelling? How should enterprise IT executives and buyers define their focus, needs, and roadmap, and communicate that clearly to the providers?
Dec. 9, 2016 04:00 AM EST Reads: 581
Amazon has gradually rolled out parts of its IoT offerings, but these are just the tip of the iceberg. In addition to optimizing their backend AWS offerings, Amazon is laying the ground work to be a major force in IoT - especially in the connected home and office. In his session at @ThingsExpo, Chris Kocher, founder and managing director of Grey Heron, explained how Amazon is extending its reach to become a major force in IoT by building on its dominant cloud IoT platform, its Dash Button strat...
Dec. 9, 2016 04:00 AM EST Reads: 6,342
"We are a custom software development, engineering firm. We specialize in cloud applications from helping customers that have on-premise applications migrating to the cloud, to helping customers design brand new apps in the cloud. And we specialize in mobile apps," explained Peter Di Stefano, Vice President of Marketing at Impiger Technologies, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Dec. 9, 2016 03:30 AM EST Reads: 493
Complete Internet of Things (IoT) embedded device security is not just about the device but involves the entire product’s identity, data and control integrity, and services traversing the cloud. A device can no longer be looked at as an island; it is a part of a system. In fact, given the cross-domain interactions enabled by IoT it could be a part of many systems. Also, depending on where the device is deployed, for example, in the office building versus a factory floor or oil field, security ha...
Dec. 9, 2016 03:00 AM EST Reads: 406
In addition to all the benefits, IoT is also bringing new kind of customer experience challenges - cars that unlock themselves, thermostats turning houses into saunas and baby video monitors broadcasting over the internet. This list can only increase because while IoT services should be intuitive and simple to use, the delivery ecosystem is a myriad of potential problems as IoT explodes complexity. So finding a performance issue is like finding the proverbial needle in the haystack.
Dec. 9, 2016 02:15 AM EST Reads: 6,236
The idea of comparing data in motion (at the sensor level) to data at rest (in a Big Data server warehouse) with predictive analytics in the cloud is very appealing to the industrial IoT sector. The problem Big Data vendors have, however, is access to that data in motion at the sensor location. In his session at @ThingsExpo, Scott Allen, CMO of FreeWave, discussed how as IoT is increasingly adopted by industrial markets, there is going to be an increased demand for sensor data from the outermos...
Dec. 9, 2016 02:00 AM EST Reads: 3,062
"Qosmos has launched L7Viewer, a network traffic analysis tool, so it analyzes all the traffic between the virtual machine and the data center and the virtual machine and the external world," stated Sebastien Synold, Product Line Manager at Qosmos, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Dec. 9, 2016 01:45 AM EST Reads: 993
Between 2005 and 2020, data volumes will grow by a factor of 300 – enough data to stack CDs from the earth to the moon 162 times. This has come to be known as the ‘big data’ phenomenon. Unfortunately, traditional approaches to handling, storing and analyzing data aren’t adequate at this scale: they’re too costly, slow and physically cumbersome to keep up. Fortunately, in response a new breed of technology has emerged that is cheaper, faster and more scalable. Yet, in meeting these new needs they...
Dec. 9, 2016 01:45 AM EST Reads: 1,956
When it comes to cloud computing, the ability to turn massive amounts of compute cores on and off on demand sounds attractive to IT staff, who need to manage peaks and valleys in user activity. With cloud bursting, the majority of the data can stay on premises while tapping into compute from public cloud providers, reducing risk and minimizing need to move large files. In his session at 18th Cloud Expo, Scott Jeschonek, Director of Product Management at Avere Systems, discussed the IT and busin...
Dec. 9, 2016 01:15 AM EST Reads: 3,979