Welcome!

News Feed Item

Clinical trial: robotic surgery may reduce side effects of throat cancer treatment

Throat cancers on the rise due to epidemic of HPV infection

TORONTO, April 17, 2013 /CNW/ - Researchers in London, Ontario, are conducting a first-ever clinical trial to determine which treatment option gives patients with throat cancers the best quality of life. These cancers are dramatically on the rise due to the epidemic of HPV (human papilloma virus) infection.

Surgeon Dr Anthony Nichols and radiation oncologist Dr David Palma at the Lawson Research Centre have received a $223,000 Quality of Life Grant from the Canadian Cancer Society to conduct the study. Dr Nichols is an assistant professor in head and neck surgery at Western University. Dr Palma is a clinician-scientist with the Ontario Institute for Cancer Research.

The current standard treatment for throat cancers is radiation and chemotherapy, which results in good control of the disease but can leave patients with a variety of life-changing side effects, such as problems with speaking, swallowing, tasting and hearing and even feeding tube dependence.

A minimally invasive robotic surgery has emerged as a promising alternative treatment that appears to have fewer side effects.

"Patients with HPV-related throat cancers tend to be younger and healthier and have a good chance of being cured. As they will have to live with the side effects of treatment for decades, post-treatment quality of life is of paramount importance," says Dr Nichols.

"Before we can adopt a new treatment, we have to prove that the rates of cure are as good as they are with the standard treatment, which is chemotherapy with radiation," says Dr. Palma. "Sometimes new technologies are introduced with a lot of hype but don't prove to be helpful in the end. Transoral robotic surgery has shown tremendous promise as a treatment option, and we are the only ones in the world doing this type of study right now."

For the 3-year study, patients with early stage cancer of the oropharynx (which includes the tongue, soft palate, side and back walls of the throat, and tonsils) are invited to participate in a randomized phase II clinical trial. Patients will be assigned to receive either the current standard treatment (radiation, plus or minus chemotherapy) or the robotic surgery. One year after treatment, patient quality of life will be assessed for side effects.

This will be the first clinical trial to directly compare the 2 treatment methods and has the potential to have an international impact on the treatment of patients with throat cancers. In the United States, the robotic surgery is already being used for these types of cancers despite the lack of high-level evidence to support it.

To do the surgery, doctors use tiny robotically controlled surgical implements to remove tumours of the tongue, tonsils, palate or throat. The robot has a viewfinder and 3-D camera that can see around corners, and the tiny robotic arms can get into tight spaces where the surgeon's hands cannot fit. While the surgeon watches what's happening on a screen, the robotic arms precisely mimic the movements of the surgeon's hands and can even filter out the surgeon's hand tremor.

"The Canadian Cancer Society knows how important a patient's quality of life is during and after cancer treatment," says Dr Siân Bevan, Director of Research at the Canadian Cancer Society. "This exciting new surgical method shows great promise to vastly improve quality of life, and we are happy to be able to fund this important study, with the generous support of our donors."

About HPV and cancer

According to Dr. Nichols, HPV is the most common sexually transmitted infection. "The incidence of throat cancers has increased dramatically in recent years due in large part to widespread infection with HPV. The increase is thought to be because of changes in sexual practices that began in the 1960s."

These cancers typically take more than 20 years to develop. Some strains of the HPV virus cause cervical cancer as well as ano-genital cancers. More recently, HPV infections have been found to cause cancers of the oropharynx.

It is estimated that 75% of sexually-active Canadians will have at least one HPV infection in their lifetime. The body's immune system usually gets rid of an HPV infection on its own. Most HPV infections (about 70%) go away without any treatment within 1-2 years. Persistent infection with high-risk HPV types over many years can cause precancerous changes and cancer.

HPV infection is associated with about:

  • 25%-35% of oropharyngeal cancers
  • 40% of vaginal and vulvar cancers
  • 40%-50% of penile cancers
  • 80%-90% of anal cancers

Dr. Nichols says that throat cancer patients whose disease was caused by an HPV infection tend to be diagnosed in their 40s and 50s, as opposed to patients whose throat cancer was caused by smoking and alcohol (these patients tend to be diagnosed at 60 or older).

A vaccine is available in Canada to prevent HPV infection. It protects against the types of HPV that cause 70% of HPV-related cancers. For more information, visit cancer.ca.

Other Quality of Life Grants

Dr Kim Edelstein, Toronto, $299,754 - Since cancer in young adults occurs during crucial formative years, it can have a particularly devastating effect, leaving survivors with a variety of long-term side-effects as a result of the disease and treatment. In her study, Dr Edelstein is exploring the impact of chemotherapy on thinking abilities during the first year after being diagnosed with cancer and whether these changes impact psychosocial development, with the findings to be used to develop strategies to help prevent or decrease these problems.

Dr Stephen Hall, Kingston, $153,029 - Using a series of questionnaires delivered over a 3-year period, Dr Hall will lead the first study of its kind to examine how patients who have had head and neck cancer perceive follow-up appointments to understand their attitudes, needs, fears and expected benefits about the appointments. His goal is to improve the quality of life for survivors by making the follow-up care more effective for individual patients while improving the efficiency of the health care system.

Dr Robert Klaassen, Ottawa, $177,794 - Using a survey developed with the input of patients, caregivers, health care providers and quality of life experts, Dr Klaassen aims to assess the impact of treatments on the quality of life of patients with incurable blood disorders that put them at a high risk of developing cancer. Because of the incurable nature of the conditions - named myelodysplastic syndromes - determining the impact of treatment on quality of life is crucial and this survey may become a critical resource and powerful tool to achieve this.

Dr Andrew Matthew, Toronto, $137,233 - Sexual dysfunction after prostate cancer surgery is one of the most substantial concerns for patients and their partners and has a significant impact on quality of life. To address this important health issue, Dr Matthew is developing a biomedical-psychosocial intervention which incorporates the active participation of the partner and features medical, psychological and social methods, with the eventual goal of introducing a new and effective way to support intimacy and optimal sexual health.

Dr Roanne Thomas, Ottawa, $244,128 - Using a variety of methods, including group discussion, photography, journaling and film, Dr Thomas will document the breast cancer experiences of First Nations, Inuit and Metis women.  Since little is known about the factors which affect the breast cancer experiences of these groups of women, Dr Thomas' study will address gaps in knowledge and care to uncover valuable information for the development of future support programs and education materials for health professionals.

About the Quality of Life Grants

This program has been created to support quality of life cancer research that has the potential to make a significant impact on the burden of disease in patients, survivors and caregivers

About the Canadian Cancer Society

For 75 years the Canadian Cancer Society has been with Canadians in the fight for life. We have been relentless in our commitment to prevent cancer, fund research and support Canadians touched by cancer. From this foundation, we will work with Canadians to change cancer forever so fewer Canadians are diagnosed with the disease and more survive.

Visit cancer.ca or call us at 1-888-939-3333 (TTY 1-866-786-3934).

SOURCE Canadian Cancer Society (National Office)

Image with caption: "With a Quality of Life grant from the Canadian Cancer Society, Dr. Anthony Nichols (right) and Dr. David Palma will lead a first-ever clinical trial to determine if robotic surgery to treat throat cancer reduces side effects. (CNW Group/Canadian Cancer Society (National Office))". Image available at: http://photos.newswire.ca/images/download/20130417_C5793_PHOTO_EN_25578.jpg

Image with caption: "Dr. Anthony Nichols performs robotic surgery on a throat cancer patient. With a Quality of Life grant from the Canadian Cancer Society, he will study if this non-invasive approach reduces side effects. (CNW Group/Canadian Cancer Society (National Office))". Image available at: http://photos.newswire.ca/images/download/20130417_C5793_PHOTO_EN_25576.jpg

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
"Storpool does only block-level storage so we do one thing extremely well. The growth in data is what drives the move to software-defined technologies in general and software-defined storage," explained Boyan Ivanov, CEO and co-founder at StorPool, in this SYS-CON.tv interview at 16th Cloud Expo, held June 9-11, 2015, at the Javits Center in New York City.
You know you need the cloud, but you’re hesitant to simply dump everything at Amazon since you know that not all workloads are suitable for cloud. You know that you want the kind of ease of use and scalability that you get with public cloud, but your applications are architected in a way that makes the public cloud a non-starter. You’re looking at private cloud solutions based on hyperconverged infrastructure, but you’re concerned with the limits inherent in those technologies.
Is advanced scheduling in Kubernetes achievable?Yes, however, how do you properly accommodate every real-life scenario that a Kubernetes user might encounter? How do you leverage advanced scheduling techniques to shape and describe each scenario in easy-to-use rules and configurations? In his session at @DevOpsSummit at 21st Cloud Expo, Oleg Chunikhin, CTO at Kublr, answered these questions and demonstrated techniques for implementing advanced scheduling. For example, using spot instances and co...
As Marc Andreessen says software is eating the world. Everything is rapidly moving toward being software-defined – from our phones and cars through our washing machines to the datacenter. However, there are larger challenges when implementing software defined on a larger scale - when building software defined infrastructure. In his session at 16th Cloud Expo, Boyan Ivanov, CEO of StorPool, provided some practical insights on what, how and why when implementing "software-defined" in the datacent...
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, whic...
The cloud era has reached the stage where it is no longer a question of whether a company should migrate, but when. Enterprises have embraced the outsourcing of where their various applications are stored and who manages them, saving significant investment along the way. Plus, the cloud has become a defining competitive edge. Companies that fail to successfully adapt risk failure. The media, of course, continues to extol the virtues of the cloud, including how easy it is to get there. Migrating...
The use of containers by developers -- and now increasingly IT operators -- has grown from infatuation to deep and abiding love. But as with any long-term affair, the honeymoon soon leads to needing to live well together ... and maybe even getting some relationship help along the way. And so it goes with container orchestration and automation solutions, which are rapidly emerging as the means to maintain the bliss between rapid container adoption and broad container use among multiple cloud host...
Blockchain is a shared, secure record of exchange that establishes trust, accountability and transparency across business networks. Supported by the Linux Foundation's open source, open-standards based Hyperledger Project, Blockchain has the potential to improve regulatory compliance, reduce cost as well as advance trade. Are you curious about how Blockchain is built for business? In her session at 21st Cloud Expo, René Bostic, Technical VP of the IBM Cloud Unit in North America, discussed the b...
Imagine if you will, a retail floor so densely packed with sensors that they can pick up the movements of insects scurrying across a store aisle. Or a component of a piece of factory equipment so well-instrumented that its digital twin provides resolution down to the micrometer.
The need for greater agility and scalability necessitated the digital transformation in the form of following equation: monolithic to microservices to serverless architecture (FaaS). To keep up with the cut-throat competition, the organisations need to update their technology stack to make software development their differentiating factor. Thus microservices architecture emerged as a potential method to provide development teams with greater flexibility and other advantages, such as the abili...
In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, provided an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life settle...
Blockchain. A day doesn’t seem to go by without seeing articles and discussions about the technology. According to PwC executive Seamus Cushley, approximately $1.4B has been invested in blockchain just last year. In Gartner’s recent hype cycle for emerging technologies, blockchain is approaching the peak. It is considered by Gartner as one of the ‘Key platform-enabling technologies to track.’ While there is a lot of ‘hype vs reality’ discussions going on, there is no arguing that blockchain is b...
Product connectivity goes hand and hand these days with increased use of personal data. New IoT devices are becoming more personalized than ever before. In his session at 22nd Cloud Expo | DXWorld Expo, Nicolas Fierro, CEO of MIMIR Blockchain Solutions, will discuss how in order to protect your data and privacy, IoT applications need to embrace Blockchain technology for a new level of product security never before seen - or needed.
ChatOps is an emerging topic that has led to the wide availability of integrations between group chat and various other tools/platforms. Currently, HipChat is an extremely powerful collaboration platform due to the various ChatOps integrations that are available. However, DevOps automation can involve orchestration and complex workflows. In his session at @DevOpsSummit at 20th Cloud Expo, Himanshu Chhetri, CTO at Addteq, will cover practical examples and use cases such as self-provisioning infra...
As DevOps methodologies expand their reach across the enterprise, organizations face the daunting challenge of adapting related cloud strategies to ensure optimal alignment, from managing complexity to ensuring proper governance. How can culture, automation, legacy apps and even budget be reexamined to enable this ongoing shift within the modern software factory? In her Day 2 Keynote at @DevOpsSummit at 21st Cloud Expo, Aruna Ravichandran, VP, DevOps Solutions Marketing, CA Technologies, was jo...