Welcome!

News Feed Item

The Top 10 Discoveries of the Year according to Québec Science - 80,000 New Anonymous Proteins

SHERBROOKE, QC, Jan. 6, 2014 /CNW Telbec/ - The investigations of a team in the Faculty of Medicine and Health Sciences of the Université de Sherbrooke and the CHUS's Centre de Recherche Clinique Étienne-Le Bel rank among the top 10 discoveries in 2013 published in the January edition of Québec Science. The discovery of more than 80,000 proteins - referred to as alternative proteins - is shaking up medicine and biology by putting into question knowledge about proteins.

In August 2013, the team of Xavier Roucou, professor in the Department of Biochemistry, published the discovery of these proteins - until then unknown - in PLoS ONE. Two examples of alternative proteins identified in the laboratory had previously been published in FASEB Journal and Journal of Biological Chemistry. The identification of these proteins opens a new doorway to understanding certain neurodegenerative diseases.

Tenet of One Protein per messenger RNA Undone

DNA contains all of the information essential to the proper operation of the body's cells. Genetic material is safely packed in the nuclei of our cells. This material is required to produce proteins (molecules) to accomplish most cell functions. Consequently, genes must first be transcribed into messenger RNA (mRNA), which is then processed into mature mRNA. Mature mRNA is decoded by "mobile plants" called ribosomes, which are translated into proteins. In short, the ribosome decodes mature mRNA and manufactures the protein corresponding to the origin gene.

mRNA No Longer translated into one Protein only

Cells use mRNA as an intermediate support in producing the proteins they need. One tenet still persists about this mechanism: ribosomes produce a single protein for each mature mRNA, referred to as the reference protein, which plays a very specific role in the cell. Professor Roucou's team discovered that there is not just one way to decode a mature mRNA.

"We can now affirm that the tenet is inexact," explained Roucou. Ribosomes can decode the information transmitted to them by mRNA in a variety of ways, leading to the production of many completely different alternative proteins." In short, from a single mature mRNA, cells produce not one, but many distinct proteins, which necessarily involves many functions.

A Perplexing Discovery for the Scientific Community

The community is perplexed since the discovery puts into question what has long been considered basic knowledge in biology. The observation is so disturbing that Roucou's team had a hard time getting its work published in the most prestigious journals. "Our findings are provocative," explained Roucou. "We have realized that in analyzing the comments made by reviewers and editors. We had to provide more demonstrations to support our findings."

About the Research Team

Xavier Roucou is a professor in the Faculty of Medicine and Health Sciences and investigator at the Centre de Recherche Clinique Étienne-Le Bel at the Centre hospitalier universitaire de Sherbrooke. The members of his laboratory who worked on the discovery of alternative proteins are students Benoît Vanderperre, Danny Bergeron, Cyntia Bissonnette, Catherine Lapointe, and Solène Vanderperre and research professionals Guillaume Tremblay and Julie Motard.

SOURCE Université de Sherbrooke

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Wooed by the promise of faster innovation, lower TCO, and greater agility, businesses of every shape and size have embraced the cloud at every layer of the IT stack – from apps to file sharing to infrastructure. The typical organization currently uses more than a dozen sanctioned cloud apps and will shift more than half of all workloads to the cloud by 2018. Such cloud investments have delivered measurable benefits. But they’ve also resulted in some unintended side-effects: complexity and risk. ...
With the introduction of IoT and Smart Living in every aspect of our lives, one question has become relevant: What are the security implications? To answer this, first we have to look and explore the security models of the technologies that IoT is founded upon. In his session at @ThingsExpo, Nevi Kaja, a Research Engineer at Ford Motor Company, discussed some of the security challenges of the IoT infrastructure and related how these aspects impact Smart Living. The material was delivered interac...
The taxi industry never saw Uber coming. Startups are a threat to incumbents like never before, and a major enabler for startups is that they are instantly “cloud ready.” If innovation moves at the pace of IT, then your company is in trouble. Why? Because your data center will not keep up with frenetic pace AWS, Microsoft and Google are rolling out new capabilities. In his session at 20th Cloud Expo, Don Browning, VP of Cloud Architecture at Turner, posited that disruption is inevitable for comp...
It is ironic, but perhaps not unexpected, that many organizations who want the benefits of using an Agile approach to deliver software use a waterfall approach to adopting Agile practices: they form plans, they set milestones, and they measure progress by how many teams they have engaged. Old habits die hard, but like most waterfall software projects, most waterfall-style Agile adoption efforts fail to produce the results desired. The problem is that to get the results they want, they have to ch...
IoT solutions exploit operational data generated by Internet-connected smart “things” for the purpose of gaining operational insight and producing “better outcomes” (for example, create new business models, eliminate unscheduled maintenance, etc.). The explosive proliferation of IoT solutions will result in an exponential growth in the volume of IoT data, precipitating significant Information Governance issues: who owns the IoT data, what are the rights/duties of IoT solutions adopters towards t...
"We are a monitoring company. We work with Salesforce, BBC, and quite a few other big logos. We basically provide monitoring for them, structure for their cloud services and we fit into the DevOps world" explained David Gildeh, Co-founder and CEO of Outlyer, in this SYS-CON.tv interview at DevOps Summit at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
In 2014, Amazon announced a new form of compute called Lambda. We didn't know it at the time, but this represented a fundamental shift in what we expect from cloud computing. Now, all of the major cloud computing vendors want to take part in this disruptive technology. In his session at 20th Cloud Expo, Doug Vanderweide, an instructor at Linux Academy, discussed why major players like AWS, Microsoft Azure, IBM Bluemix, and Google Cloud Platform are all trying to sidestep VMs and containers wit...
While DevOps most critically and famously fosters collaboration, communication, and integration through cultural change, culture is more of an output than an input. In order to actively drive cultural evolution, organizations must make substantial organizational and process changes, and adopt new technologies, to encourage a DevOps culture. Moderated by Andi Mann, panelists discussed how to balance these three pillars of DevOps, where to focus attention (and resources), where organizations might...
"When we talk about cloud without compromise what we're talking about is that when people think about 'I need the flexibility of the cloud' - it's the ability to create applications and run them in a cloud environment that's far more flexible,” explained Matthew Finnie, CTO of Interoute, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
The Internet giants are fully embracing AI. All the services they offer to their customers are aimed at drawing a map of the world with the data they get. The AIs from these companies are used to build disruptive approaches that cannot be used by established enterprises, which are threatened by these disruptions. However, most leaders underestimate the effect this will have on their businesses. In his session at 21st Cloud Expo, Rene Buest, Director Market Research & Technology Evangelism at Ara...
No hype cycles or predictions of zillions of things here. IoT is big. You get it. You know your business and have great ideas for a business transformation strategy. What comes next? Time to make it happen. In his session at @ThingsExpo, Jay Mason, Associate Partner at M&S Consulting, presented a step-by-step plan to develop your technology implementation strategy. He discussed the evaluation of communication standards and IoT messaging protocols, data analytics considerations, edge-to-cloud tec...
New competitors, disruptive technologies, and growing expectations are pushing every business to both adopt and deliver new digital services. This ‘Digital Transformation’ demands rapid delivery and continuous iteration of new competitive services via multiple channels, which in turn demands new service delivery techniques – including DevOps. In this power panel at @DevOpsSummit 20th Cloud Expo, moderated by DevOps Conference Co-Chair Andi Mann, panelists examined how DevOps helps to meet the de...
When growing capacity and power in the data center, the architectural trade-offs between server scale-up vs. scale-out continue to be debated. Both approaches are valid: scale-out adds multiple, smaller servers running in a distributed computing model, while scale-up adds fewer, more powerful servers that are capable of running larger workloads. It’s worth noting that there are additional, unique advantages that scale-up architectures offer. One big advantage is large memory and compute capacity...
In the world of DevOps there are ‘known good practices’ – aka ‘patterns’ – and ‘known bad practices’ – aka ‘anti-patterns.' Many of these patterns and anti-patterns have been developed from real world experience, especially by the early adopters of DevOps theory; but many are more feasible in theory than in practice, especially for more recent entrants to the DevOps scene. In this power panel at @DevOpsSummit at 18th Cloud Expo, moderated by DevOps Conference Chair Andi Mann, panelists discussed...
After more than five years of DevOps, definitions are evolving, boundaries are expanding, ‘unicorns’ are no longer rare, enterprises are on board, and pundits are moving on. Can we now look at an evolution of DevOps? Should we? Is the foundation of DevOps ‘done’, or is there still too much left to do? What is mature, and what is still missing? What does the next 5 years of DevOps look like? In this Power Panel at DevOps Summit, moderated by DevOps Summit Conference Chair Andi Mann, panelists loo...