Click here to close now.




















Welcome!

News Feed Item

The Leukemia & Lymphoma Society Awards $12.6 Million in Research Grants in Six Critical Areas of Unmet Medical Need

WHITE PLAINS, N.Y., Jan. 6, 2014 /PRNewswire/ -- The Leukemia & Lymphoma Society (LLS) has awarded 21 new grants representing a total investment of $12.6 million to tackle six areas of high unmet medical need in the blood cancers.

In response to requests for proposals (RFPs) from researchers in these six critical areas, LLS has awarded these grants under its Translational Research Program (TRP), an initiative designed to help accelerate the movement of promising discoveries from the lab to the clinic. Each grant is for a three-year duration with a total value of $600,000.

The RFPs mark LLS's proactive approach to addressing the challenge of improving outcomes for cancer patients with particularly urgent needs. The focus of the TRP grants, and the grant recipients are as follows:

  • New immunotherapeutics for patients with acute myelogenous leukemia (AML):

    • David Avigan, M.D., Beth Israel Deaconess Medical Center. Clinical trial evaluating DC/AML fusion vaccine with PD1 blockade
    • Stephen Forman, M.D., Beckman Research Institute of the City of Hope. Adoptive therapy for AML using CAR123-transduced T cells
    • Dean Lee, M.D., Ph.D., University of Texas MD Anderson Cancer Center. Targeting NK cell immunotherapy against AML stem cells.
    • Ulrich Steidl, M.D., Ph.D., Albert Einstein College of Medicine of Yeshiva University. Targeting IL-1 receptor accessory protein in malignant stem cells in AML
    • Chengcheng Zhang, Ph.D., UT Southwestern Medical Center. Blocking immune inhibitory receptor LAIR1 for AML treatment

  • Novel therapeutics for patients with non-cutaneous T-cell malignancies:

    • Thomas Loughran, M.D., The Pennsylvania State University College of Medicine. Targeting JAK/STAT and NF-kB pathways in large granular lymphocytic leukemia
    • David Wiest, Ph.D., Fox Chase Cancer Center, Role of ER stress responses in pathogenesis and treatment of T-cell acute lymphocytic leukemia
    • Javeed Iqbal, Ph.D., Board of Regents of the University of Nebraska Medical Center. Somatic mutations and epimutations in peripheral T-cell lymphoma

  • Introduction of novel agents in the treatment of patients with diffuse large B-cell lymphom(DLBCL) and mantle cell lymphoma(MCL):

    • Robert Baiocchi, M.D., Ph.D., The Ohio State University Research Foundation. Targeting PRMT5 expression in DLBCL and MCL
    • Leandro Cerchietti, M.D., Joan & Sanford I. Weill Cornell Medical College of Cornell University. EIF4E targeted therapy in lymphomas
    • Ari Melnick, M.D., Joan & Sanford I. Weill Cornell Medical College of Cornell University. Rational translational of EZH2 targeted therapy
    • Alessandra Pernis, M.D., The Hospital for Special Surgery. Novel signaling pathways in DLBCL
    • James Rubenstein, M.D., Ph.D., The Regents of the University of California, San Francisco. Molecular targets for high-risk primary CNS lymphoma
    • John Timmerman, M.D., The Regents of the University of California, Los Angeles. PD-1/PD-L1 blockade plus kinase inhibitor therapies for B cell lymphomas

  • Therapies for patients with myelodysplastic syndromes(MDS) who have failed hypomethylating agents:

    • Maria Figueroa, M.D., University of Michigan Health System, Epigenetic markers of sensitivity and resistance to hypomethylating agents

  • Therapies for new targets such as bromodomains, methylation and other epigenetic approaches for patients with high-risk myeloma:

    • Xiu-Bao Chang, Ph.D., Mayo Clinic Arizona. Immunomodulatory drugs target cereblon and its downstream substrates
    • Constantine Mitsiades, M.D., Ph.D., Dana-Farber Cancer Institute. Individualizing myeloma treatment with BET bromodomain inhibitors

  • Research that addresses long-term and late effects of blood cancer therapies:

    • Mukta Arora, M.D., Regents of the University of Minnesota, Twin Cities. Biomarkers of frailty and its impact on geriatric HSCT outcomes
    • Seth Corey, M.D., Northwestern UniversityChicago campus. Development of an oral anti-fibrotic drug for patients with myelofibrosis
    • Patricia Gallagher, Ph.D., Wake Forest University Health Sciences. Prevention of doxorubicin-induced cardiotoxic late effects by Ang-(1-7)
    • Matthew Matasar, M.D., Memorial Sloan-Kettering Cancer Center. Tissue and functional assessment of myocardial injury in HL survivors

LLS also announced the awarding of an additional 20 TRP grants not related to the RFPs, totaling $11.4 million, to scientists working in other areas of blood cancer research.

"The translation of research discoveries in the laboratory to the patient's bedside for the treatment of blood cancer is a central part of the mission of LLS," said Lee Greenberger, Ph.D., LLS chief scientific officer. "By taking a strategic, proactive approach, LLS is directing grant funds with the intent to accelerate the advancement of breakthrough therapies and provide the best quality of life for our patients."

About The Leukemia & Lymphoma Society
The Leukemia & Lymphoma Society ® (LLS) is the world's largest voluntary health agency dedicated to blood cancer. The LLS mission: Cure leukemia, lymphoma, multiple myeloma, and improve the quality of life of patients and their families. LLS funds lifesaving blood cancer research around the world, provides free information and support services, and is the voice for all blood cancer patients seeking access to quality, affordable, coordinated care.  

Founded in 1949 and headquartered in White Plains, NY, LLS has chapters throughout the United States and Canada. To learn more, visit www.LLS.org. Patients should contact the Information Resource Center at (800) 955-4572, Monday through Friday, 9 a.m. to 6 p.m. ET.

Contact: Andrea Greif
(914) 821-8958
[email protected] 
www.LLS.org

 

SOURCE The Leukemia & Lymphoma Society

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
In a recent research, analyst firm IDC found that the average cost of a critical application failure is $500,000 to $1 million per hour and the average total cost of unplanned application downtime is $1.25 billion to $2.5 billion per year for Fortune 1000 companies. In addition to the findings on the cost of the downtime, the research also highlighted best practices for development, testing, application support, infrastructure, and operations teams.
"We specialize in testing. DevOps is all about continuous delivery and accelerating the delivery pipeline and there is no continuous delivery without testing," noted Marc Hornbeek, Sr. Solutions Architect at Spirent Communications, in this SYS-CON.tv interview at @DevOpsSummit, held June 9-11, 2015, at the Javits Center in New York City.
How do you securely enable access to your applications in AWS without exposing any attack surfaces? The answer is usually very complicated because application environments morph over time in response to growing requirements from your employee base, your partners and your customers. In his session at @DevOpsSummit, Haseeb Budhani, CEO and Co-founder of Soha, shared five common approaches that DevOps teams follow to secure access to applications deployed in AWS, Azure, etc., and the friction an...
"Alert Logic is a managed security service provider that basically deploys technologies, but we support those technologies with the people and process behind it," stated Stephen Coty, Chief Security Evangelist at Alert Logic, in this SYS-CON.tv interview at 16th Cloud Expo, held June 9-11, 2015, at the Javits Center in New York City.
Digital Transformation is the ultimate goal of cloud computing and related initiatives. The phrase is certainly not a precise one, and as subject to hand-waving and distortion as any high-falutin' terminology in the world of information technology. Yet it is an excellent choice of words to describe what enterprise IT—and by extension, organizations in general—should be working to achieve. Digital Transformation means: handling all the data types being found and created in the organizat...
The essence of cloud computing is that all consumable IT resources are delivered as services. In his session at 15th Cloud Expo, Yung Chou, Technology Evangelist at Microsoft, demonstrated the concepts and implementations of two important cloud computing deliveries: Infrastructure as a Service (IaaS) and Platform as a Service (PaaS). He discussed from business and technical viewpoints what exactly they are, why we care, how they are different and in what ways, and the strategies for IT to tran...
The Internet of Everything (IoE) brings together people, process, data and things to make networked connections more relevant and valuable than ever before – transforming information into knowledge and knowledge into wisdom. IoE creates new capabilities, richer experiences, and unprecedented opportunities to improve business and government operations, decision making and mission support capabilities.
The Software Defined Data Center (SDDC), which enables organizations to seamlessly run in a hybrid cloud model (public + private cloud), is here to stay. IDC estimates that the software-defined networking market will be valued at $3.7 billion by 2016. Security is a key component and benefit of the SDDC, and offers an opportunity to build security 'from the ground up' and weave it into the environment from day one. In his session at 16th Cloud Expo, Reuven Harrison, CTO and Co-Founder of Tufin,...
The Internet of Things is not only adding billions of sensors and billions of terabytes to the Internet. It is also forcing a fundamental change in the way we envision Information Technology. For the first time, more data is being created by devices at the edge of the Internet rather than from centralized systems. What does this mean for today's IT professional? In this Power Panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists addressed this very serious issue of pro...
Container technology is sending shock waves through the world of cloud computing. Heralded as the 'next big thing,' containers provide software owners a consistent way to package their software and dependencies while infrastructure operators benefit from a standard way to deploy and run them. Containers present new challenges for tracking usage due to their dynamic nature. They can also be deployed to bare metal, virtual machines and various cloud platforms. How do software owners track the usag...
With SaaS use rampant across organizations, how can IT departments track company data and maintain security? More and more departments are commissioning their own solutions and bypassing IT. A cloud environment is amorphous and powerful, allowing you to set up solutions for all of your user needs: document sharing and collaboration, mobile access, e-mail, even industry-specific applications. In his session at 16th Cloud Expo, Shawn Mills, President and a founder of Green House Data, discussed h...
Discussions about cloud computing are evolving into discussions about enterprise IT in general. As enterprises increasingly migrate toward their own unique clouds, new issues such as the use of containers and microservices emerge to keep things interesting. In this Power Panel at 16th Cloud Expo, moderated by Conference Chair Roger Strukhoff, panelists addressed the state of cloud computing today, and what enterprise IT professionals need to know about how the latest topics and trends affect t...
"Our biggest growth area has been the security services, the managed services - the things that differentiate us in the market that there is no client that's too small and there's no client that's too big," explained Paul Mazzucco, Chief Security Officer at TierPoint, in this SYS-CON.tv interview at 16th Cloud Expo, held June 9-11, 2015, at the Javits Center in New York City.
SYS-CON Events announced today that HPM Networks will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. For 20 years, HPM Networks has been integrating technology solutions that solve complex business challenges. HPM Networks has designed solutions for both SMB and enterprise customers throughout the San Francisco Bay Area.
Containers are changing the security landscape for software development and deployment. As with any security solutions, security approaches that work for developers, operations personnel and security professionals is a requirement. In his session at DevOps Summit, Kevin Gilpin, CTO and Co-Founder of Conjur, will discuss various security considerations for container-based infrastructure and related DevOps workflows.