Click here to close now.




















Welcome!

News Feed Item

AIT Announces Phase II Study of NOxCureCF, a Respiratory Treatment for Cystic Fibrosis Patients Using a Nitric Oxide-Base Formulation

Enrollment in the Multicenter Trial Begins in Soroka Medical Center in Israel

REHOVOT, Israel, January 7, 2014 /PRNewswire/ --

Advanced Inhalation Therapies (AIT Ltd.), an Israeli drug development company, announced today that it has begun enrollment in Israel for a multicenter, open label, Phase II clinical trial of NOxCureCF, a respiratory treatment for patients with cystic fibrosis (CF). NOxCureCF is a specialized formulation of inhaled Nitric Oxide (NO) delivered using AIT's patented drug delivery system.

David Greenberg, M.D., AIT's Chief Medical Officer and a professor of pediatrics and infectious diseases at Soroka Medical Center in Beersheva, Israel, said: "This study, in combination with the continuation of our Phase II trial of the use of NO for treatment of infants with RSV/bronchiolitis, will allow us to substantiate and enhance the use of inhaled NO in the treatment of respiratory disease and distress."

Prof. Asher Tal, head of the Pediatrics Department at Soroka University Medical Center, adds: "The NOxCureCF treatment may serve as a major improvement in the quality of life for CF patients, and may significally contribute to their life expectancy." The study  takes place at Soroka's CF Clinic, which is led by Dr. Micha Aviram.

CF is a life-threatening genetic disease that causes the abnormal transport of salts across cells and most critically affects the lungs. CF patients are highly prone to opportunistic bacterial infections that often lead to prolonged, chronic lung infections, reducing life expectancy due to significant destruction of lung tissue. Approximately 70,000 individuals in Europe and North America suffer from CF, making it the most common life-threatening autosomal recessive disease.

The aim of the study is to assess the improvement in lung function after treatment with NOxCureCF in CF patients 10 years old and older. The study will also allow continuous testing of the safety and tolerability of the dosage and delivery system.

Prof Yossef Av Gay, AIT's CSO and a professor of microbiology at the University of British Columbia, Canada, states: "The ongoing studies, an outgrowth of the strategic alliance between Clalit Health Services and AIT, will strengthen the research and development in the critically important area of treatment of acute and chronic respiratory illness treatment with NO solutions."

About Nitric Oxide (NO)

Nitric Oxide (NO) is a small, naturally produced gas that acts as an anti-infection agent, making it very effective for the treatment of a wide range of diseases. AIT uses NO in unique dosages and in specialized delivery modes to enable direct, effective access to the lungs.

About AIT

AIT (http://www.ait-pharm.com) is a drug development company focused on the development and commercialization of NO-based formulations for the treatment of respiratory or infectious diseases such as bronchiolitis, cystic fibrosis, pneumonia and asthma. NOxCureCF is one of a group of inhaled NO based therapeutics developed by AIT, for the treatment of infectious respiratory diseases such as Respiratory Syncytial Virus (RSV)/bronchiolitis, CF, pneumonia and asthma. The company successfully concluded Phase I trials and is currently conducting Phase II trials on RSV/bronchiolitis.

AIT was founded by Mor Research Applications, a subsidiary of Clalit Health Services, Israel's largest health management organization. The company is headquartered in Rehovot, Israel.

About Clalit Health Services

Clalit is the major health organization in Israel, and one of the most progressive public health associations in the world. Through its 14 hospitals and more than 1,400 primary and specialized clinics, Clalit provides comprehensive health insurance and highly advanced medical care to the majority of Israel's population. Clalit maintains a total of 14 general and special-care hospitals, all of which are affiliated with Israel's universities, a countrywide network of pharmacies, dental clinics, radiology facilities, as well as computerized diagnostic equipment at a number of central laboratories.

Clalit has 4 million insured members, a >52% market share, and managed an annual budget of more than $6 billion.

About Soroka University Medical Center

The Pediatric Division of the Soroka University Medical Center is one of the largest Pediatric Medical Center is Israel with 190 admission beds, 35,000 visits at the Pediatric ER, 14,500 admissions and 42,000 ambulatory visits. As the only tertiary medical center, which serves the diverse Negev Population, the medical team copes with unique medical conditions in children.

The medical team of 85 staff physicians and 270 nurses provides medical care to almost 300,000 children of the Negev population.

Contact Information
Racheli Vizman, COO, AIT
2 Derech Meir Weisgal
Rehovot 9632605, Israel
E-mail: [email protected]
Direct: +972-8-684-3313

SOURCE Advanced Inhalation Therapies (AIT)

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Consumer IoT applications provide data about the user that just doesn’t exist in traditional PC or mobile web applications. This rich data, or “context,” enables the highly personalized consumer experiences that characterize many consumer IoT apps. This same data is also providing brands with unprecedented insight into how their connected products are being used, while, at the same time, powering highly targeted engagement and marketing opportunities. In his session at @ThingsExpo, Nathan Trel...
Puppet Labs is pleased to share the findings from our 2015 State of DevOps Survey. We have deepened our understanding of how DevOps enables IT performance and organizational performance, based on responses from more than 20,000 technical professionals we’ve surveyed over the past four years. The 2015 State of DevOps Report reveals high-performing IT organizations deploy 30x more frequently with 200x shorter lead times. They have 60x fewer failures and recover 168x faster
Through WebRTC, audio and video communications are being embedded more easily than ever into applications, helping carriers, enterprises and independent software vendors deliver greater functionality to their end users. With today’s business world increasingly focused on outcomes, users’ growing calls for ease of use, and businesses craving smarter, tighter integration, what’s the next step in delivering a richer, more immersive experience? That richer, more fully integrated experience comes ab...
WebRTC has had a real tough three or four years, and so have those working with it. Only a few short years ago, the development world were excited about WebRTC and proclaiming how awesome it was. You might have played with the technology a couple of years ago, only to find the extra infrastructure requirements were painful to implement and poorly documented. This probably left a bitter taste in your mouth, especially when things went wrong.
WebRTC services have already permeated corporate communications in the form of videoconferencing solutions. However, WebRTC has the potential of going beyond and catalyzing a new class of services providing more than calls with capabilities such as mass-scale real-time media broadcasting, enriched and augmented video, person-to-machine and machine-to-machine communications. In his session at @ThingsExpo, Luis Lopez, CEO of Kurento, will introduce the technologies required for implementing thes...
The 5th International DevOps Summit, co-located with 17th International Cloud Expo – being held November 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA – announces that its Call for Papers is open. Born out of proven success in agile development, cloud computing, and process automation, DevOps is a macro trend you cannot afford to miss. From showcase success stories from early adopters and web-scale businesses, DevOps is expanding to organizations of all sizes, including the ...
The 17th International Cloud Expo has announced that its Call for Papers is open. 17th International Cloud Expo, to be held November 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, APM, APIs, Microservices, Security, Big Data, Internet of Things, DevOps and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding bu...
ElasticBox, the agile application delivery manager, announced freely available public boxes for the DevOps community. ElasticBox works with enterprises to help them deploy any application to any cloud. Public boxes are curated reference boxes that represent some of the most popular applications and tools for orchestrating deployments at scale. Boxes are an adaptive way to represent reusable infrastructure as components of code. Boxes contain scripts, variables, and metadata to automate proces...
In his session at @ThingsExpo, Lee Williams, a producer of the first smartphones and tablets, will talk about how he is now applying his experience in mobile technology to the design and development of the next generation of Environmental and Sustainability Services at ETwater. He will explain how M2M controllers work through wirelessly connected remote controls; and specifically delve into a retrofit option that reverse-engineers control codes of existing conventional controller systems so the...
To support developers and operations professionals in their push to implement DevOps principles for their infrastructure environments, ProfitBricks, a provider of cloud infrastructure, is adding support for DevOps tools Ansible and Chef. Ansible is a platform for configuring and managing data center infrastructure that combines multi-node software deployment, ad hoc task execution, and configuration management, and is used by DevOps professionals as they use its playbooks functionality to autom...
The 3rd International WebRTC Summit, to be held Nov. 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA, announces that its Call for Papers is now open. Topics include all aspects of improving IT delivery by eliminating waste through automated business models leveraging cloud technologies. WebRTC Summit is co-located with 15th International Cloud Expo, 6th International Big Data Expo, 3rd International DevOps Summit and 2nd Internet of @ThingsExpo. WebRTC (Web-based Real-Time Com...
It’s been proven time and time again that in tech, diversity drives greater innovation, better team productivity and greater profits and market share. So what can we do in our DevOps teams to embrace diversity and help transform the culture of development and operations into a true “DevOps” team? In her session at DevOps Summit, Stefana Muller, Director, Product Management – Continuous Delivery at CA Technologies, answered that question citing examples, showing how to create opportunities for ...
Puppet Labs has announced the next major update to its flagship product: Puppet Enterprise 2015.2. This release includes new features providing DevOps teams with clarity, simplicity and additional management capabilities, including an all-new user interface, an interactive graph for visualizing infrastructure code, a new unified agent and broader infrastructure support.
SYS-CON Events announced today that Pythian, a global IT services company specializing in helping companies leverage disruptive technologies to optimize revenue-generating systems, has been named “Bronze Sponsor” of SYS-CON's 17th Cloud Expo, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Founded in 1997, Pythian is a global IT services company that helps companies compete by adopting disruptive technologies such as cloud, Big Data, advance...
Skeuomorphism usually means retaining existing design cues in something new that doesn’t actually need them. However, the concept of skeuomorphism can be thought of as relating more broadly to applying existing patterns to new technologies that, in fact, cry out for new approaches. In his session at DevOps Summit, Gordon Haff, Senior Cloud Strategy Marketing and Evangelism Manager at Red Hat, discussed why containers should be paired with new architectural practices such as microservices rathe...