|By Marketwired .||
|January 7, 2014 02:28 PM EST||
NEW YORK, NY -- (Marketwired) -- 01/07/14 -- In the news release, "Classic Textbook on Critical Care, the ICU book by Paul Marino, M.D., PhD., Recommends Direct Measurement of Blood Volume in Evaluating Critically Ill Patients," issued earlier today by Daxor Corporation (NYSE MKT: DXR), we are advised by the company that the last sentence of the second paragraph should read "8% death rate vs. a 24% death rate" rather than "8% survival rate vs. a 20% death rate" as originally issued. Complete corrected text follows.
Classic Textbook on Critical Care, the ICU book by Paul Marino, M.D., PhD., Recommends Direct Measurement of Blood Volume in Evaluating Critically Ill Patients
NEW YORK, NY -- January 7, 2014 -- Daxor Corporation (NYSE MKT: DXR)
The most widely read textbook in critical care medicine is the ICU book (intensive care unit) by Paul Marino, M.D. The fourth edition of this book has just been published by Lippincott Williams & Wilkins, and has important information about blood volume measurement. Dr. Marino, who is on the staff of Cornell Medical School, is an internationally recognized authority on critical care medicine.
The previous third edition was published in 2007. The fourth edition has important new information about the use of blood volume measurement. In a chapter on hypovolemia (low blood volume) Dr. Marino writes "Blood volume measurements have traditionally required too much time to perform to be clinically useful in an ICU setting, but this has changed with the introduction of a semi-automated blood volume analyzer (Daxor Corporation, New York, NY) that provides blood volume measurements in less than an hour. Blinded measurements of blood, red cell, and plasma volumes were performed in patients with circulatory shock who were managed with pulmonary artery catheters, and the results show that blood and plasma volumes were considerably higher than normal. When blood volume measurements were made available for patient care, 53% of the measurements led to a change in fluid management, and this was associated with a significant decrease in mortality rate (from 24% to 8%). These results will require corroboration, but they highlight the limitations of the clinical assessment of blood volume, and the potential for improved outcomes when blood volume measurements are utilized for fluid management." Dr. Marino's book cited a study by Dr. Mihae Yu and included a graph of her research which was published in Shock (A Prospective Randomized Trial Using Blood Volume Analysis in Addition to Pulmonary Artery Catheter, Compared with Pulmonary Artery Catheter Alone, to Guide Shock Resuscitation in Critically Ill Surgical Patients; Shock, Vo. 35, No. 3, pp 220-228, 2011). This landmark study by Dr. Yu studied 100 critically ill patients in the ICU. 50 of them were treated on the basis of a blood volume measurement plus PAC, and 50 were treated on the basis of PAC without knowledge of the blood volume measurement. The patients who were treated on the basis of a blood volume measurement had an 8% death rate vs. a 24% death rate in the patients who were treated without knowledge of the blood volume measurement.
The most common laboratory tests to evaluate a patient's blood volume are the hematocrit and hemoglobin tests. These tests only measure the concentration of red blood cells, not the volume of the patient's blood. Dr. Marino's book contains the following statement "The use of the hematocrit (and hemoglobin concentration) to evaluate the presence and severity of acute blood loss is both common and inappropriate. Changes in hematocrit show a poor correlation with blood volume deficits and erythrocyte deficits in acute hemorrhage. Acute blood loss involves the loss of whole blood, which results in proportional decreases in the volume of plasma and erythrocytes. As a result, acute blood loss results in a decrease in blood volume but not a decrease in hematocrit. (There is a small dilutional effect from transcapillary refill in acute blood loss, but this is usually not enough to cause a significant decrease in hematocrit.) In the absence of volume resuscitation, the hematocrit will eventually decrease because hypovolemia activates the rennin-angiotensin-aldosterone system, and the renal retention of sodium and water that follows will have a dilutional effect on the hematocrit. This process begins 8 to 12 hours after acute blood loss, and can take a few days to become fully established." That statement is based on original research by Drs. S. Oohashi and H. Endoh, who examined physicians' assessments of patients' blood volumes with actual blood volume measurements and found them to be extremely disparate. Previously, studies from Columbia Presbyterian Medical Center also demonstrated that physicians treating heart failure patients were only correct 51% of the time using the usual clinical parameters and laboratory tests in evaluating the blood volume status of a patient.
Dr. Marino's chapter focused particularly on the detection of hypovolemia (low blood volume). He cited studies which used invasive procedures such as pulmonary artery catheterization (PAC) and central venous pressure to assess a patient's blood volume. Previous studies have demonstrated, in situations where blood volume measurements were actually made, that such assessments are frequently wrong.
Dr. Feldschuh, the president of Daxor, a board certified cardiologist, noted that it is truly tragic that the overwhelming majority of patients treated in intensive care units are not treated based on actual blood volume measurements. Instead, they are treated on the basis of inaccurate tests such as hematocrits and hemoglobins, and invasive procedures such as pulmonary artery catheterization, which multiple studies have shown to be inaccurate for evaluating a patient's blood volume.
Dr. Feldschuh stated that it is unfortunate that thousands of patients die every year because they are not treated correctly due to inaccurate assessments of blood volume. These tests only measure the concentration of red blood cells in a patient, they do not measure a patient's total blood volume. The BVA-100 can measure blood volume to an accuracy of 98%.
Dr. Marino closed this particular chapter with the following comments: "The clinical evaluation of intravascular volume, including the use of central venous pressure (CVP) measurements, is so flawed it has been called a 'comedy of errors'" and "Direct measurements of blood volume are clinically feasible, but are underutilized."
The past week extensive publicity was given to the case of a 13 year old girl in California who had a tonsillectomy and was said to have bled extensively. Unfortunately her blood loss was not properly replaced and she was pronounced brain dead. This is the type of case that occurs by the thousands every year. In addition to patients who die from inadequate treatment, thousands more suffer heart attacks and strokes. Many patients with lack of brain oxygen ultimately develop dementia. Lack of oxygen to the brain is well known to destroy and irreversibly damage brain cells. The knowledge of how to perform accurate blood volume measurement has been known for more than 70 years. An automated blood volume measurement instrument has been available for more than 10 years. The excuse for not performing blood volume measurement has always been that the test is too difficult to perform accurately and takes 4 to 8 hours. The BVA-100 has automated most of the procedure and enables the blood volume measurement to be done in under an hour. Inability to obtain rapid blood volume measurements should no longer be an excuse for treating critically ill patients with blood volume derangements on the basis of tests which are known to be inaccurate and may result in irreversible damage and even death to patients.
Dr. Feldschuh will be attending the annual meeting of Critical Care Medicine in San Francisco January 8 - 13, 2014. This is the main annual meeting of physicians specializing in intensive care unit medicine.
Video experiences should be unique and exciting! But that doesn’t mean you need to patch all the pieces yourself. Users demand rich and engaging experiences and new ways to connect with you. But creating robust video applications at scale can be complicated, time-consuming and expensive. In his session at @ThingsExpo, Zohar Babin, Vice President of Platform, Ecosystem and Community at Kaltura, will discuss how VPaaS enables you to move fast, creating scalable video experiences that reach your...
Sep. 29, 2016 02:00 PM EDT Reads: 1,134
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, wh...
Sep. 29, 2016 02:00 PM EDT Reads: 3,931
In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, provided an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life sett...
Sep. 29, 2016 02:00 PM EDT Reads: 3,588
Cloud computing is being adopted in one form or another by 94% of enterprises today. Tens of billions of new devices are being connected to The Internet of Things. And Big Data is driving this bus. An exponential increase is expected in the amount of information being processed, managed, analyzed, and acted upon by enterprise IT. This amazing is not part of some distant future - it is happening today. One report shows a 650% increase in enterprise data by 2020. Other estimates are even higher....
Sep. 29, 2016 02:00 PM EDT Reads: 4,167
SYS-CON Events announced today that SoftLayer, an IBM Company, has been named “Gold Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. SoftLayer, an IBM Company, provides cloud infrastructure as a service from a growing number of data centers and network points of presence around the world. SoftLayer’s customers range from Web startups to global enterprises.
Sep. 29, 2016 01:45 PM EDT Reads: 1,110
Most of us already know that adopting new cloud applications can boost a business’s productivity by enabling organizations to be more agile and ready to change course in our fast-moving and connected digital world. But the rapid adoption of cloud apps and services also brings with it profound security threats, including visibility and control challenges that aren’t present in traditional on-premises environments. At the same time, the cloud – because of its interconnected, flexible and adaptable...
Sep. 29, 2016 01:45 PM EDT Reads: 1,771
19th Cloud Expo, taking place November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy. Meanwhile, 94% of enterpri...
Sep. 29, 2016 01:30 PM EDT Reads: 4,447
Businesses are struggling to manage the information flow and interactions between all of these new devices and things jumping on their network, and the apps and IT systems they control. The data businesses gather is only helpful if they can do something with it. In his session at @ThingsExpo, Chris Witeck, Principal Technology Strategist at Citrix, will discuss how different the impact of IoT will be for large businesses, expanding how IoT will allow large organizations to make their legacy ap...
Sep. 29, 2016 01:15 PM EDT Reads: 314
In his general session at 18th Cloud Expo, Lee Atchison, Principal Cloud Architect and Advocate at New Relic, discussed cloud as a ‘better data center’ and how it adds new capacity (faster) and improves application availability (redundancy). The cloud is a ‘Dynamic Tool for Dynamic Apps’ and resource allocation is an integral part of your application architecture, so use only the resources you need and allocate /de-allocate resources on the fly.
Sep. 29, 2016 01:15 PM EDT Reads: 2,916
SYS-CON Events announced today the Enterprise IoT Bootcamp, being held November 1-2, 2016, in conjunction with 19th Cloud Expo | @ThingsExpo at the Santa Clara Convention Center in Santa Clara, CA. Combined with real-world scenarios and use cases, the Enterprise IoT Bootcamp is not just based on presentations but with hands-on demos and detailed walkthroughs. We will introduce you to a variety of real world use cases prototyped using Arduino, Raspberry Pi, BeagleBone, Spark, and Intel Edison. Y...
Sep. 29, 2016 01:15 PM EDT Reads: 3,016
The vision of a connected smart home is becoming reality with the application of integrated wireless technologies in devices and appliances. The use of standardized and TCP/IP networked wireless technologies in line-powered and battery operated sensors and controls has led to the adoption of radios in the 2.4GHz band, including Wi-Fi, BT/BLE and 802.15.4 applied ZigBee and Thread. This is driving the need for robust wireless coexistence for multiple radios to ensure throughput performance and th...
Sep. 29, 2016 01:00 PM EDT Reads: 1,689
Internet of @ThingsExpo, taking place November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 19th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The Internet of Things (IoT) is the most profound change in personal and enterprise IT since the creation of the Worldwide Web more than 20 years ago. All major researchers estimate there will be tens of billions devices - comp...
Sep. 29, 2016 12:45 PM EDT Reads: 5,134
The many IoT deployments around the world are busy integrating smart devices and sensors into their enterprise IT infrastructures. Yet all of this technology – and there are an amazing number of choices – is of no use without the software to gather, communicate, and analyze the new data flows. Without software, there is no IT. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists will look at the protocols that communicate data and the emerging data analy...
Sep. 29, 2016 12:30 PM EDT Reads: 1,746
According to Forrester Research, every business will become either a digital predator or digital prey by 2020. To avoid demise, organizations must rapidly create new sources of value in their end-to-end customer experiences. True digital predators also must break down information and process silos and extend digital transformation initiatives to empower employees with the digital resources needed to win, serve, and retain customers.
Sep. 29, 2016 12:00 PM EDT Reads: 460
“We're a global managed hosting provider. Our core customer set is a U.S.-based customer that is looking to go global,” explained Adam Rogers, Managing Director at ANEXIA, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Sep. 29, 2016 12:00 PM EDT Reads: 3,149