Welcome!

News Feed Item

Kava May Help Prevent Lung Cancer in Smokers Say University Researchers

Preliminary study in mice suggests possible lung cancer preventative effect of South Pacific herb

AUSTIN, Texas, Jan. 8, 2014 /PRNewswire-USNewswire/ -- Researchers at the University of Minnesota (UM) and Texas Tech University recently studied the effects of a special preparation of the kava root (Piper methysticum) on lung cancer in mice, and have concluded that the chemically defined extract may have the potential to reduce the risk of lung cancer in humans, according to a press release (appended below) issued today by UM.

(Logo: http://photos.prnewswire.com/prnh/20100430/DC95601LOGO)

"This is highly interesting research and suggests a potential new use for certain preparations made from kava root and rhizome," said Mark Blumenthal, founder and executive director of the nonprofit American Botanical Council (ABC). "Of course," he added, "the preliminary results must be confirmed in human clinical trials.

Blumenthal noted that ABC policy on reporting of scientific and clinical research on herbs and their preparations designates that "ABC does not usually cover animal research in its scientific reporting, preferring human clinical trials. However, in this case ABC believes that the potential implications for human health and the herb kava are significant enough, as suggested by this particular animal research, to warrant attention by ABC."

According to Stefan Gafner, Chief Science Officer of ABC, "The fact that the researchers were able to find evidence of the ability of a kava fraction to prevent the formation of tumors in mice, in support of epidemiological data showing a lower incidence of lung cancer in people living on the South Pacific Islands where kava is traditionally used, makes this study very compelling. If confirmed in human clinical studies, the results could have a big impact on human health and may lead to a greater emphasis on prevention rather than cure."

Prof. Bill Gurley, PhD, professor of pharmaceutical sciences at the College of Pharmacy of the University of Arkansas for Medical Sciences in Little Rock, reviewed the study and commented to ABC, "…the findings are both compelling and certainly merit further research in order to translate them into the clinic. The findings are a breath of fresh air for kava, in particular, and botanical supplements, in general. Recently supplements have suffered quite a bit of negative publicity — some of it deserved, some not — but the kava study from the University of Minnesota emphasizes what good science coupled with quality botanicals can produce."

According to Rick Kingston, PharmD, a clinical professor of pharmacy at the University of Minnesota and president of Regulatory and Scientific Affairs at SafetyCall International in Minneapolis, "This research is truly unprecedented in its potential impact. A 99% cancer prevention efficacy is unheard of with this very sensitive research model and paves the way for future clinical trials to assess human applications. Another fascinating aspect relates to identifying kava components likely responsible for rare cases of liver toxicity associated with kava dietary supplements. Fortunately, the risk of kava liver complications is low, but this will allow development of supplement preparations devoid of [compounds that may cause] adverse liver effects that can be used for both anti-anxiety and wellness applications in the supplement arena."

The University of Minnesota Press release is appended immediately below:

University of Minnesota research finds kava plant may prevent cigarette smoke-induced lung cancer

MINNEAPOLIS/ ST. PAUL (EMBARGOED UNTIL 11:05 PM CST JANUARY 7, 2014) – New research from the University of Minnesota College of Pharmacy and Masonic Cancer Center has found that consumption of the root of Piper methysticum, or kava, a plant native to the South Pacific Islands, may prevent the development of tobacco smoke-induced lung cancer.

In addition, the research team has identified the naturally occurring components of kava that appear responsible for all the cancer-preventative benefits. By using a patent-pending blend of these active kava ingredients, the research team was also able to avoid liver damage, a rare side effect previously associated with various commercially available kava-containing dietary supplements.

The findings are published ahead-of-print today in the journal Cancer Prevention Research.

In the latest study, the University of Minnesota research team found daily consumption of a kava-derived dietary supplement prevented the formation of 99 percent of tumors in a mouse lung tumorigenesis model that is routinely used in predicting lung cancer behavior in humans. The unprecedented level of tumor prevention was coupled with the finding that some mice developed no tumors at all. DNA damage resulting from tobacco carcinogens was also significantly reduced by way of prevention, providing a clue to what is potentially behind kava's effectiveness.

The findings open up the future possibility of health care professionals recommending or prescribing kava-derived products in the form of dietary supplements or drugs for current tobacco smokers to reduce their risk of developing lung cancer. According to the Centers for Disease Control and Prevention, smoking increases the risk of developing lung cancer 13-fold for women and 23-fold for men.

The research may also help explain the low rate of cancer incidence where kava is traditionally consumed. Rates of cancer in the South Pacific Islands of Vanuatu, Fiji and Western Samoa are dramatically lower than those in countries with no kava consumption. Similarly, despite tobacco smoking rates comparable to those of the United States, the occurrence of lung cancer in Fiji is just 5 to 10 percent of the U.S. lung cancer occurrence rate.

However, not all commercially available kava products on the market today are equal and many may carry the risk of liver injury.

In Europe, where kava had been routinely used to treat anxiety, kava products were temporarily pulled from the market after being linked to liver problems. Many factors have been hypothesized to contribute to the rare problems, and although a definitive cause has not been identified, current products in the market typically carry a liver injury warning. Prior to liver toxicity concerns, Hawaii served as one of the largest sources of commercially available kava.

"I wouldn't recommend using kava supplements on the market today with the hopes of receiving cancer prevention benefits," said Chengguo Xing, Ph.D., an associate professor of medicinal chemistry at the University of Minnesota College of Pharmacy and a member of Masonic Cancer Center. "Although occasional use of currently available kava supplements is likely to have a low risk of liver injury, they may not safely provide the intended chemopreventative benefits."

Preliminary data from University of Minnesota has identified the potential compound behind kava-related liver problems and human clinical trials for the new, patent-pending kava supplement enriched with cancer-preventative benefits alone are planned. The University of Minnesota research team is also pursuing development of kava-derived drugs that may aid in both the prevention and treatment of other types of cancers.

Scientists collaborating in this research include lead authors Pablo Leitzman and Sreekanth Narayanapillai in the U of M College of Pharmacy (Chengguo Xing Group), and their peers in the U of M Masonic Cancer Center (Stephen Hecht Group), U of M College of Veterinary Medicine (M. Gerry O'Sullivan) and Texas Tech University Health Sciences Center (Junxuan Lu). Funding for this research was provided by National Institutes of Health grant no. R01 CA142649.

About the University of Minnesota College of Pharmacy
The University of Minnesota College of Pharmacy, the only school of pharmacy in Minnesota, offers its program on the Twin Cities and Duluth campuses. Founded in 1892, the College of Pharmacy educates pharmacists and scientists and engages in research and practice to improve the health of the people of Minnesota and society. The college is part of the Academic Health Center, which is home to the University of Minnesota's six health professional schools and colleges as well as several health-related centers and institutes. Learn more at www.pharmacy.umn.edu.

About the Masonic Cancer Center, University of Minnesota
The Masonic Cancer Center at the University of Minnesota is part of the University's Academic Health Center and is designated a Comprehensive Cancer Center by the National Cancer Institute for cancer research, treatment, and education. For more information about the Masonic Cancer Center, visit www.cancer.umn.edu or call 612-624-2620.

About the American Botanical Council
Founded in 1988, the American Botanical Council is a leading international nonprofit organization that addresses research and educational issues regarding botanicals, teas, medicinal plants, essential oils, and other beneficial plant-derived materials. ABC's members include individuals, companies, and organizations in the herb, dietary supplement, and cosmetic industries; journalists; consumers; and others in more than 80 countries. The organization occupies a historic 2.5-acre site in Austin, Texas, where it publishes the peer-reviewed quarterly journal HerbalGram, the monthly e-publication HerbalEGram, the weekly e-newsletter Herbal News & Events, HerbClips (summaries of scientific and clinical publications), reference books, and other educational materials. ABC also hosts HerbMedPro, a powerful herbal database, covering scientific and clinical publications on more than 250 herbs. ABC also co-produces the "Herbal Insights" segment for Healing Quest, a television series on PBS.

ABC is tax-exempt under section 501(c)(3) of the IRS Code. Information: Contact ABC at P.O. Box 144345, Austin, TX 78714-4345, Phone: 512-926-4900. Website: www.herbalgram.org. Contact: Public Relations.

SOURCE American Botanical Council

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
ChatOps is an emerging topic that has led to the wide availability of integrations between group chat and various other tools/platforms. Currently, HipChat is an extremely powerful collaboration platform due to the various ChatOps integrations that are available. However, DevOps automation can involve orchestration and complex workflows. In his session at @DevOpsSummit at 20th Cloud Expo, Himanshu Chhetri, CTO at Addteq, will cover practical examples and use cases such as self-provisioning infra...
The financial services market is one of the most data-driven industries in the world, yet it’s bogged down by legacy CPU technologies that simply can’t keep up with the task of querying and visualizing billions of records. In his session at 20th Cloud Expo, Jared Parker, Director of Financial Services at Kinetica, will discuss how the advent of advanced in-database analytics on the GPU makes it possible to run sophisticated data science workloads on the same database that is housing the rich inf...
For organizations that have amassed large sums of software complexity, taking a microservices approach is the first step toward DevOps and continuous improvement / development. Integrating system-level analysis with microservices makes it easier to change and add functionality to applications at any time without the increase of risk. Before you start big transformation projects or a cloud migration, make sure these changes won’t take down your entire organization.
My team embarked on building a data lake for our sales and marketing data to better understand customer journeys. This required building a hybrid data pipeline to connect our cloud CRM with the new Hadoop Data Lake. One challenge is that IT was not in a position to provide support until we proved value and marketing did not have the experience, so we embarked on the journey ourselves within the product marketing team for our line of business within Progress. In his session at @BigDataExpo, Sum...
Apache Hadoop is emerging as a distributed platform for handling large and fast incoming streams of data. Predictive maintenance, supply chain optimization, and Internet-of-Things analysis are examples where Hadoop provides the scalable storage, processing, and analytics platform to gain meaningful insights from granular data that is typically only valuable from a large-scale, aggregate view. One architecture useful for capturing and analyzing streaming data is the Lambda Architecture, represent...
Things are changing so quickly in IoT that it would take a wizard to predict which ecosystem will gain the most traction. In order for IoT to reach its potential, smart devices must be able to work together. Today, there are a slew of interoperability standards being promoted by big names to make this happen: HomeKit, Brillo and Alljoyn. In his session at @ThingsExpo, Adam Justice, vice president and general manager of Grid Connect, will review what happens when smart devices don’t work togethe...
SYS-CON Events announced today that Ocean9will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Ocean9 provides cloud services for Backup, Disaster Recovery (DRaaS) and instant Innovation, and redefines enterprise infrastructure with its cloud native subscription offerings for mission critical SAP workloads.
In his session at @ThingsExpo, Eric Lachapelle, CEO of the Professional Evaluation and Certification Board (PECB), will provide an overview of various initiatives to certifiy the security of connected devices and future trends in ensuring public trust of IoT. Eric Lachapelle is the Chief Executive Officer of the Professional Evaluation and Certification Board (PECB), an international certification body. His role is to help companies and individuals to achieve professional, accredited and worldw...
Adding public cloud resources to an existing application can be a daunting process. The tools that you currently use to manage the software and hardware outside the cloud aren’t always the best tools to efficiently grow into the cloud. All of the major configuration management tools have cloud orchestration plugins that can be leveraged, but there are also cloud-native tools that can dramatically improve the efficiency of managing your application lifecycle.
Providing the needed data for application development and testing is a huge headache for most organizations. The problems are often the same across companies - speed, quality, cost, and control. Provisioning data can take days or weeks, every time a refresh is required. Using dummy data leads to quality problems. Creating physical copies of large data sets and sending them to distributed teams of developers eats up expensive storage and bandwidth resources. And, all of these copies proliferating...
DevOps is often described as a combination of technology and culture. Without both, DevOps isn't complete. However, applying the culture to outdated technology is a recipe for disaster; as response times grow and connections between teams are delayed by technology, the culture will die. A Nutanix Enterprise Cloud has many benefits that provide the needed base for a true DevOps paradigm. In his Day 3 Keynote at 20th Cloud Expo, Chris Brown, a Solutions Marketing Manager at Nutanix, will explore t...
SYS-CON Events announced today that Technologic Systems Inc., an embedded systems solutions company, will exhibit at SYS-CON's @ThingsExpo, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Technologic Systems is an embedded systems company with headquarters in Fountain Hills, Arizona. They have been in business for 32 years, helping more than 8,000 OEM customers and building over a hundred COTS products that have never been discontinued. Technologic Systems’ pr...
SYS-CON Events announced today that CA Technologies has been named “Platinum Sponsor” of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY, and the 21st International Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. CA Technologies helps customers succeed in a future where every business – from apparel to energy – is being rewritten by software. From ...
The taxi industry never saw Uber coming. Startups are a threat to incumbents like never before, and a major enabler for startups is that they are instantly “cloud ready.” If innovation moves at the pace of IT, then your company is in trouble. Why? Because your data center will not keep up with frenetic pace AWS, Microsoft and Google are rolling out new capabilities In his session at 20th Cloud Expo, Don Browning, VP of Cloud Architecture at Turner, will posit that disruption is inevitable for c...
SYS-CON Events announced today that Cloudistics, an on-premises cloud computing company, has been named “Bronze Sponsor” of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Cloudistics delivers a complete public cloud experience with composable on-premises infrastructures to medium and large enterprises. Its software-defined technology natively converges network, storage, compute, virtualization, and management into a ...