Welcome!

News Feed Item

Gecko Biomedical's Co-Founders Demonstrate a 'Bio-Inspired' Tissue Adhesive That Shows Promise for Minimally Invasive Heart Surgery and Vessel Repair

PARIS, January 9, 2014 /PRNewswire/ --

Innovative adhesive technology published as a cover feature in the high impact journal, Science Translational Medicine

Gecko Biomedical, a French medical device company developing 'bio-inspired' biodegradable surgical glues and patches for wound closure, announces that the Company's co-founders have published data demonstrating the potential of its paradigm-shifting technologies for minimally invasive reconstructive heart surgery.

'Bio-inspired' biodegradable surgical glue repairs defects of the heart and blood vessels

In a paper entitled "A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects", published in the January 8, 2014 issue of Science Translational Medicine (online) (Ref. 1), the authors, including Gecko Biomedical co-founders Robert Langer Sc.D. (Massachusetts Institute of Technology) and Jeffrey Karp Ph.D. (Brigham and Women's Hospital), describe a revolutionary biodegradable and biocompatible surgical glue that was inspired by adhesive mechanisms observed in nature that function in challenging yet comparable (wet and dynamic) environments to those found in the body.

The 'bio-inspired' glue described is non-toxic, binds strongly to tissues offering a leak-proof seal on demand, and works well in the presence of actively contracting tissues and blood flow. The authors demonstrate how the adhesive, alone or in conjunction with a biodegradable patch, can effectively be used to repair defects (ruptures) of the heart and blood vessels during minimally invasive procedures.

Precise control of the wound closure process could shift the surgical paradigm

The glue is based on the combination of safe, naturally occurring compounds to form a biocompatible pre-polymer with tunable adhesive and mechanical properties. The glue is soft and elastic when applied to the wet surfaces of the wounds where it adheres gently to the tissues, permitting fine adjustments or repositioning when used with the patch. The glue is activated (polymerized) upon exposure to ultraviolet (UV) light to form a strong, leak-proof but flexible seal, giving the surgeon full control of the process. The adhesive can be engineered with mechanical characteristics similar to arteries and the digestive system, where initial applications are targeted. The authors also describe how the composition of the pre-polymer can be adjusted for strength or rate of biodegradation to suit the wound being repaired.

Jeffrey Karp, from the Department of Medicine at the Brigham and Women's Hospital, a co-founder of Gecko Biomedical and co-senior author of the study, said: "The tissue adhesive that we developed satisfies a long list of design criteria including biodegradation, biocompatibility, ability to strongly adhere on-demand to tissue with a water-tight seal in the presence of flowing blood, and elastic properties to accommodate cyclical forces such as those exerted by a beating heart or blood vessel. It offers the potential to reduce the invasiveness of surgical procedures, reduce operative times, and improve outcomes for patients."

"This platform of adhesive elastomers is truly versatile to address multiple meaningful applications in the clinic," said Maria N. Pereira, Ph.D., co-first author of the study who was previously in the Department of Medicine at the Brigham and Women's Hospital and is now Head of Adhesive Technologies at Gecko Biomedical.

Christophe Bancel, Chief Executive Officer of Gecko Biomedical, added: "The science and research supporting the development of Gecko's liquid film adhesive and patch technologies is of the highest quality. What has been achieved so far is very exciting and we are focused on undertaking the further necessary steps to get these innovative products into the hands of surgeons within the next few years, for the benefit of patients."

Reference: Lang, N. et al (2014) "A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects," Sci. Transl. Med. 6, 218ra6 (2014)

Notes to Editors

About Gecko Biomedical

Gecko Biomedical is a privately owned medical device company based in Paris, France that is dedicated to the rapid development and the commercialization of revolutionary biodegradable sealants and adhesives for wound closure in the field of surgery, with a key focus on minimally invasive surgery. Gecko Biomedical is developing products that are non-toxic, bind strongly to tissues and deliver 'on-demand' wound closure within the 'wet' and dynamic environments in the body. The Company's technology and products are based on world-class research and intellectual property from the laboratories of Robert Langer (MIT) and Jeff Karp (Brigham and Women's Hospital). Gecko was founded in 2013 and is backed by leading healthcare investors Omnes Capital, CM-CIC and CapDecisif Management.

Further information: http://www.geckobiomedical.com or @geckobiomedical or http://www.linkedlinkedin.com/company/gecko-biomedical

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
SYS-CON Events announced today that MangoApps will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. MangoApps provides modern company intranets and team collaboration software, allowing workers to stay connected and productive from anywhere in the world and from any device. For more information, please visit https://www.mangoapps.com/.
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, wh...
Enterprise networks are complex. Moreover, they were designed and deployed to meet a specific set of business requirements at a specific point in time. But, the adoption of cloud services, new business applications and intensifying security policies, among other factors, require IT organizations to continuously deploy configuration changes. Therefore, enterprises are looking for better ways to automate the management of their networks while still leveraging existing capabilities, optimizing perf...
The IoT is changing the way enterprises conduct business. In his session at @ThingsExpo, Eric Hoffman, Vice President at EastBanc Technologies, discuss how businesses can gain an edge over competitors by empowering consumers to take control through IoT. We'll cite examples such as a Washington, D.C.-based sports club that leveraged IoT and the cloud to develop a comprehensive booking system. He'll also highlight how IoT can revitalize and restore outdated business models, making them profitable...
SYS-CON Events announced today that ContentMX, the marketing technology and services company with a singular mission to increase engagement and drive more conversations for enterprise, channel and SMB technology marketers, has been named “Sponsor & Exhibitor Lounge Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York City, New York. “CloudExpo is a great opportunity to start a conversation with new prospects, but what happens after the...
Many banks and financial institutions are experimenting with containers in development environments, but when will they move into production? Containers are seen as the key to achieving the ultimate in information technology flexibility and agility. Containers work on both public and private clouds, and make it easy to build and deploy applications. The challenge for regulated industries is the cost and complexity of container security compliance. VM security compliance is already challenging, ...
The pace of innovation, vendor lock-in, production sustainability, cost-effectiveness, and managing risk… In his session at 18th Cloud Expo, Dan Choquette, Founder of RackN, will discuss how CIOs are challenged finding the balance of finding the right tools, technology and operational model that serves the business the best. He will discuss how clouds, open source software and infrastructure solutions have benefits but also drawbacks and how workload and operational portability between vendors...
The essence of data analysis involves setting up data pipelines that consist of several operations that are chained together – starting from data collection, data quality checks, data integration, data analysis and data visualization (including the setting up of interaction paths in that visualization). In our opinion, the challenges stem from the technology diversity at each stage of the data pipeline as well as the lack of process around the analysis.
As machines are increasingly connected to the internet, it’s becoming easier to discover the numerous ways Industrial IoT (IIoT) is helping to shape the business world. This is exactly why we have decided to take a closer look at this pervasive movement and to examine the desire to connect more things! Now if you need a refresher on IIoT and how it is changing the world, take a moment and listen to Greg Gorbach with ARC Advisory Group. Gorbach believes, "IIoT will significantly change the worl...
The 19th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Containers, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportunity. Submit y...
Internet of @ThingsExpo, taking place November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with the 19th International Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world and ThingsExpo New York Call for Papers is now open.
Designing IoT applications is complex, but deploying them in a scalable fashion is even more complex. A scalable, API first IaaS cloud is a good start, but in order to understand the various components specific to deploying IoT applications, one needs to understand the architecture of these applications and figure out how to scale these components independently. In his session at @ThingsExpo, Nara Rajagopalan is CEO of Accelerite, will discuss the fundamental architecture of IoT applications, ...
In his session at 18th Cloud Expo, Bruce Swann, Senior Product Marketing Manager at Adobe, will discuss how the Adobe Marketing Cloud can help marketers embrace opportunities for personalized, relevant and real-time customer engagement across offline (direct mail, point of sale, call center) and digital (email, website, SMS, mobile apps, social networks, connected objects). Bruce Swann has more than 15 years of experience working with digital marketing disciplines like web analytics, social med...
SYS-CON Events announced today that Enzu, a leading provider of cloud hosting solutions, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Enzu’s mission is to be the leading provider of enterprise cloud solutions worldwide. Enzu enables online businesses to use its IT infrastructure to their competitive advantage. By offering a suite of proven hosting and management services, Enzu wants companies to foc...
Customer experience has become a competitive differentiator for companies, and it’s imperative that brands seamlessly connect the customer journey across all platforms. With the continued explosion of IoT, join us for a look at how to build a winning digital foundation in the connected era – today and in the future. In his session at @ThingsExpo, Chris Nguyen, Group Product Marketing Manager at Adobe, will discuss how to successfully leverage mobile, rapidly deploy content, capture real-time d...