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Stem Cell Therapeutics Provides Corporate Update

TORONTO, ONTARIO -- (Marketwired) -- 01/13/14 -- Stem Cell Therapeutics Corp. (TSX VENTURE: SSS)(OTCQX: SCTPF), an immuno-oncology company developing cancer stem cell-related therapeutics, today provided the following six-month corporate update:


--  Pilot non-human primate tolerability studies have been completed using
    SIRPaFc, Stem Cell Therapeutics' proprietary CD47 antagonist. Three
    separate human SIRPaFc proteins, possessing different Fc regions with
    varying levels of effector function, were evaluated in a repeat-dose
    regimen in cynomolgus macaques. Safe dosing levels, substantially above
    the anticipated human therapeutic dose, were established for each drug
    candidate. Greater tolerability was observed to correlate with
    decreasing effector function. Anemia and thrombocytopenia were the
    primary adverse events observed, which in most cases were asymptomatic
    and reversible. These studies, while preliminary in nature, provided
    firm support for moving the SIRPaFc program forward into the next
    development phase. In parallel with conducting the manufacturing
    activities and toxicology studies typically associated with the IND-
    enabling phase of drug development, the company will significantly
    amplify its preclinical efficacy studies. This will be critical in order
    to uncover the full potential of this promising immune checkpoint
    inhibitor and to expand its use in the treatment of both solid and
    liquid tumors.

--  Preclinical SIRPaFc efficacy data in an acute myeloid leukemia xenograft
    model was recently reported at the 55th Annual Meeting of the American
    Society of Hematology (ASH). SIRPaFc was shown to promote potent anti-
    leukemic responses at low doses. When combined with the non-human
    primate tolerability data, this indicates a wide therapeutic window. For
    details on the ASH presentation please consult our website at
    www.stemcellthera.com.

--  On December 13, 2013, the company completed a $33 million private
    placement, principally with participation from experienced U.S.
    healthcare institutional investors.Importantly, this substantial
    financing, one of the largest by a Canadianbiopharmaceutical company
    last year, was primarily driven by the strength and promise of the
    SIRPaFc technology. Its proceeds will allow the company to execute an
    optimal development program over the next three years, which will
    include manufacturing, formal toxicology testing, as well as clinical
    studies in cancer patients.

--  Dosing in the investigator-driven Phase I multicenter dose-escalation
    study (50mg- 350mg) with tigecycline in patients with relapsed or
    refractory acute myeloid leukemia (AML) is nearing completion. Dosing
    has advanced to the 350mg cohort, a dose level that greatly exceeds the
    100mg dose approved for anti-infective use and is well within the range
    of doses that have demonstrated anti-cancer activity in published
    preclinical studies. Patient recruitment has been slowed by the
    submission of a protocol amendment. The cost of this study has been
    covered by the academic sponsor. As the exclusive licensee of this
    technology, the company continues to monitor the progress of the trial
    and anticipates its completion in 2014. Following a thorough evaluation
    of the clinical data and the program's commercial potential the company
    will decide on an appropriate path forward.

About Stem Cell Therapeutics:

Stem Cell Therapeutics Corp. (SCT) is an immuno-oncology company advancing cancer stem cell discoveries into novel and innovative cancer therapies. Building on over half a century of leading and groundbreaking Canadian stem cell research, the company is supported by established links to a group of prominent Toronto academic research institutes and cancer treatment centers, representing one of the world's most acclaimed cancer research hubs. The Company has two premier preclinical programs, SIRPaFc and a CD200 monoclonal antibody (mAb), which target two key immunoregulatory pathways that tumor cells exploit to evade the host immune system. SIRPaFc is an antibody-like fusion protein that blocks the activity of CD47, a molecule that is upregulated on cancer stem cells in AML and several other tumors. The CD200 mAb is a fully human monoclonal antibody that blocks the activity of CD200, an immunosuppressive molecule that is overexpressed by many hematopoietic and solid tumors. SCT's clinical stage programs include the recently in-licensed program focused on the structure of tigecycline, which is currently being evaluated in a multi-centre Phase I study in patients with acute myeloid leukemia (AML), as well as TTI-1612, a non- cancer stem cell asset that recently completed a 28-patient Phase I trial in interstitial cystitis ("IC") patients. For more information, visit: www.stemcellthera.com

Caution Regarding Forward-Looking Information:

This press release may contain forward-looking statements, which reflect SCT's current expectation regarding future events. These forward-looking statements involve risks and uncertainties that may cause actual results, events or developments to be materially different from any future results, events or developments expressed or implied by such forward-looking statements. Such factors include changing market conditions; the successful and timely completion of pre-clinical and clinical studies; the establishment of corporate alliances; the impact of competitive products and pricing; new product development risks; uncertainties related to the regulatory approval process or the ability to obtain drug product in sufficient quantity or at standards acceptable to health regulatory authorities to complete clinical trials or to meet commercial demand; and other risks detailed from time to time in SCT's ongoing quarterly and annual reporting. Except as required by applicable securities laws, SCT undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Contacts:
Stem Cell Therapeutics Corp.
James Parsons
Chief Financial Officer
+1 416 595 0627
[email protected]
www.stemcellthera.com

ProActive Capital
Jeff Ramson
Investor Contact
+1 646-863-6519
[email protected]

ProActive Capital
Kirin Smith
Investor Contact
+1 646-863-6519
[email protected]

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