|By PR Newswire||
|January 13, 2014 02:39 PM EST||
STILLWATER, Okla. and SHAWNEE, Kan., Jan. 13, 2014 /PRNewswire/ -- New data were published today in Parasites & Vectors from a study conducted at Oklahoma State University (OSU) that identified a method of improving the sensitivity of antigen tests for heartworm (Dirofilaria immitis) infection in cats. The study, funded by Bayer HealthCare LLC Animal Health division, makers of parasiticides, found that heat treatment of feline serum samples prior to testing can considerably improve the sensitivity of antigen assays in feline patients and, in turn, result in a more accurate diagnosis of heartworm infection in cats.
"Heartworm is a very serious disease in cats that can result in significant pulmonary damage and can be fatal," said lead study investigator, Susan E. Little, DVM, Ph.D., Regents professor and Krull-Ewing chair in veterinary parasitology, OSU Center for Veterinary Health Sciences. "We believe this study's findings will enhance detection of heartworm infection in cats, improving both patient care and veterinarians' understanding of the true extent of feline heartworm."
Antigen detection a challenge in cats
According to the study's authors – which included Byron Blagburn, MS, Ph.D., distinguished university professor, Auburn University College of Veterinary Medicine – the diagnosis of heartworm in cats has been complicated in the past by the difficulty associated with reliable detection of the heartworm antigen in feline samples. In fact, heartworm antigen tests have been considered much less reliable in cats than dogs. The lack of antigen detection has been attributed to low circulating antigenemia (presence of antigens in the blood) resulting from the low number of worms often seen in feline infections. Other feline heartworm assays based on antibody detection can be difficult to interpret since they do not distinguish between past or current infections.
Aiming to determine if antigen-antibody complex formation – antigen blocking – interfered with detection of the heartworm antigen in cats using commercial assays, the study evaluated serum samples from six domestic cats confirmed to be infected with a low number of heartworms. Four different commercially available assays were used before and after heat treatment of sera. The study found that the heartworm antigen was detected in zero to only one of six cats (0 to 16.7 percent), without heat treating the sera, using the assays according to manufacturers' directions. However, after heat treatment of the samples prior to testing, as many as five of six cats (83.3 percent) had detectable antigen – a "dramatic increase," the study's authors noted. Thus, new data suggests that adequate antigen is present in samples from cats infected with heartworm to allow diagnosis, but formation of antigen-antibody complexes may prevent its detection on commercial assays.
The authors concluded, "The data in the present study are exciting in that they suggest that once antigen-antibody complexes are disrupted, antigen tests may be of great value in confirming feline infection with D. immitis, particularly the sensitive microtiter well-based assays. Surveys conducted by antigen testing alone may be greatly underestimating the true prevalence of infection in cats."
"When antigen based assays were first developed for detecting canine heartworm, the serum was pre-treated with heat or acid to destroy immune complexes prior to testing, as they were recognized as inhibiting detection of antigen in some canine samples," said Dr. Little. "This step is no longer included in protocols of antigen tests, including those labeled for use in cats. I think this study's findings could ultimately lead to a revision in the protocol for feline testing."
"Funding well-designed and carefully-executed research is a vital part of Bayer HealthCare's commitment to our mission, 'Science For a Better Life,'" said Joe Hostetler, DVM, veterinary technical services manager, Bayer HealthCare LLC Animal Health division and a study co-author. "Being part of this study was especially gratifying for me because, once the results were in, we realized the data had the potential to improve feline healthcare in an immediate and important way."
About Oklahoma State University
Oklahoma State University is a modern land-grant university. OSU's Center for Veterinary Health Sciences is the only veterinary college in Oklahoma. One of 30 veterinary colleges in the United States, it is fully accredited by the Council on Education of the American Veterinary Medical Association. The center's Boren Veterinary Medical Teaching Hospital is open to the public and provides routine and specialized care for small and large animals. It also offers 24-hour emergency care and is certified by the American Animal Hospital Association. OSU is preparing students for a brighter future and building a brighter world for all. OSU improves the lives of people in Oklahoma, the nation, and the world through integrated, high quality teaching, research and outreach. For more information, visit www.cvhs.okstate.edu or call (405) 744-7000.
About Bayer HealthCare
The Bayer Group is a global enterprise with core competencies in the fields of health care, agriculture and high-tech materials. Bayer HealthCare, a subgroup of Bayer AG with annual sales of EUR 18.6 million (2012), is one of the world's leading, innovative companies in the healthcare and medical products industry and is based in Leverkusen, Germany. The company combines the global activities of the Animal Health, Consumer Care, Medical Care and Pharmaceuticals divisions. Bayer HealthCare's aim is to discover, develop, manufacture and market products that will improve human and animal health worldwide. Bayer HealthCare has a global workforce of 55,300 employees (Dec. 31, 2012) and is represented in more than 100 countries. More information at www.healthcare.bayer.com.
Staci Gouveia, Tel. 203.809.9008
Email: [email protected]
Derinda Blakeney, Tel. 405.744.6740
Email: [email protected]
Find more information about Bayer HealthCare Animal Health at
This release may contain forward-looking statements based on current assumptions and forecasts made by Bayer Group or subgroup management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer's public reports which are available on the Bayer website at www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.
 Little SE, Raymond MR, Thomas JE, Gruntmeir J, Hostetler JA, Meinkoth JH, Blagburn BL: Heat treatment prior to testing allows detection of antigen of Dirofilaria immitis in feline serum. Parasites & Vectors (13 January 2014).
SOURCE Bayer HealthCare
In their session at 17th Cloud Expo, Hal Schwartz, CEO of Secure Infrastructure & Services (SIAS), and Chuck Paolillo, CTO of Secure Infrastructure & Services (SIAS), provide a study of cloud adoption trends and the power and flexibility of IBM Power and Pureflex cloud solutions. In his role as CEO of Secure Infrastructure & Services (SIAS), Hal Schwartz provides leadership and direction for the company.
Jul. 31, 2015 11:45 AM EDT Reads: 114
In a recent research, analyst firm IDC found that the average cost of a critical application failure is $500,000 to $1 million per hour and the average total cost of unplanned application downtime is $1.25 billion to $2.5 billion per year for Fortune 1000 companies. In addition to the findings on the cost of the downtime, the research also highlighted best practices for development, testing, application support, infrastructure, and operations teams.
Jul. 31, 2015 11:45 AM EDT Reads: 112
Mobile, social, Big Data, and cloud have fundamentally changed the way we live. “Anytime, anywhere” access to data and information is no longer a luxury; it’s a requirement, in both our personal and professional lives. For IT organizations, this means pressure has never been greater to deliver meaningful services to the business and customers.
Jul. 31, 2015 10:50 AM EDT
Puppet Labs has announced the next major update to its flagship product: Puppet Enterprise 2015.2. This release includes new features providing DevOps teams with clarity, simplicity and additional management capabilities, including an all-new user interface, an interactive graph for visualizing infrastructure code, a new unified agent and broader infrastructure support.
Jul. 31, 2015 10:00 AM EDT Reads: 140
For IoT to grow as quickly as analyst firms’ project, a lot is going to fall on developers to quickly bring applications to market. But the lack of a standard development platform threatens to slow growth and make application development more time consuming and costly, much like we’ve seen in the mobile space. In his session at @ThingsExpo, Mike Weiner, Product Manager of the Omega DevCloud with KORE Telematics Inc., discussed the evolving requirements for developers as IoT matures and conducte...
Jul. 31, 2015 08:45 AM EDT Reads: 301
Container technology is sending shock waves through the world of cloud computing. Heralded as the 'next big thing,' containers provide software owners a consistent way to package their software and dependencies while infrastructure operators benefit from a standard way to deploy and run them. Containers present new challenges for tracking usage due to their dynamic nature. They can also be deployed to bare metal, virtual machines and various cloud platforms. How do software owners track the usag...
Jul. 31, 2015 08:00 AM EDT Reads: 158
Explosive growth in connected devices. Enormous amounts of data for collection and analysis. Critical use of data for split-second decision making and actionable information. All three are factors in making the Internet of Things a reality. Yet, any one factor would have an IT organization pondering its infrastructure strategy. How should your organization enhance its IT framework to enable an Internet of Things implementation? In his session at @ThingsExpo, James Kirkland, Red Hat's Chief Arch...
Jul. 30, 2015 07:30 PM EDT Reads: 1,398
Providing the needed data for application development and testing is a huge headache for most organizations. The problems are often the same across companies - speed, quality, cost, and control. Provisioning data can take days or weeks, every time a refresh is required. Using dummy data leads to quality problems. Creating physical copies of large data sets and sending them to distributed teams of developers eats up expensive storage and bandwidth resources. And, all of these copies proliferating...
Jul. 30, 2015 06:30 PM EDT Reads: 889
Malicious agents are moving faster than the speed of business. Even more worrisome, most companies are relying on legacy approaches to security that are no longer capable of meeting current threats. In the modern cloud, threat diversity is rapidly expanding, necessitating more sophisticated security protocols than those used in the past or in desktop environments. Yet companies are falling for cloud security myths that were truths at one time but have evolved out of existence.
Jul. 30, 2015 06:00 PM EDT Reads: 1,803
Digital Transformation is the ultimate goal of cloud computing and related initiatives. The phrase is certainly not a precise one, and as subject to hand-waving and distortion as any high-falutin' terminology in the world of information technology. Yet it is an excellent choice of words to describe what enterprise IT—and by extension, organizations in general—should be working to achieve. Digital Transformation means: handling all the data types being found and created in the organizat...
Jul. 30, 2015 05:00 PM EDT Reads: 1,089
Public Cloud IaaS started its life in the developer and startup communities and has grown rapidly to a $20B+ industry, but it still pales in comparison to how much is spent worldwide on IT: $3.6 trillion. In fact, there are 8.6 million data centers worldwide, the reality is many small and medium sized business have server closets and colocation footprints filled with servers and storage gear. While on-premise environment virtualization may have peaked at 75%, the Public Cloud has lagged in adop...
Jul. 30, 2015 04:00 PM EDT Reads: 2,204
SYS-CON Events announced today that HPM Networks will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. For 20 years, HPM Networks has been integrating technology solutions that solve complex business challenges. HPM Networks has designed solutions for both SMB and enterprise customers throughout the San Francisco Bay Area.
Jul. 30, 2015 03:45 PM EDT Reads: 450
The time is ripe for high speed resilient software defined storage solutions with unlimited scalability. ISS has been working with the leading open source projects and developed a commercial high performance solution that is able to grow forever without performance limitations. In his session at Cloud Expo, Alex Gorbachev, President of Intelligent Systems Services Inc., shared foundation principles of Ceph architecture, as well as the design to deliver this storage to traditional SAN storage co...
Jul. 30, 2015 03:00 PM EDT Reads: 1,741
The Software Defined Data Center (SDDC), which enables organizations to seamlessly run in a hybrid cloud model (public + private cloud), is here to stay. IDC estimates that the software-defined networking market will be valued at $3.7 billion by 2016. Security is a key component and benefit of the SDDC, and offers an opportunity to build security 'from the ground up' and weave it into the environment from day one. In his session at 16th Cloud Expo, Reuven Harrison, CTO and Co-Founder of Tufin,...
Jul. 30, 2015 03:00 PM EDT Reads: 487
MuleSoft has announced the findings of its 2015 Connectivity Benchmark Report on the adoption and business impact of APIs. The findings suggest traditional businesses are quickly evolving into "composable enterprises" built out of hundreds of connected software services, applications and devices. Most are embracing the Internet of Things (IoT) and microservices technologies like Docker. A majority are integrating wearables, like smart watches, and more than half plan to generate revenue with ...
Jul. 30, 2015 02:30 PM EDT Reads: 101