Welcome!

News Feed Item

Oklahoma State University study reveals better method to test cats for heartworm infections

- The OSU study, supported by Bayer and published in Parasites & Vectors[1], demonstrates heat treatment of feline serum samples prior to testing dramatically improved sensitivity of antigen tests for heartworm infection in cats.

STILLWATER, Okla. and SHAWNEE, Kan., Jan. 13, 2014 /PRNewswire/ -- New data were published today in Parasites & Vectors from a study conducted at Oklahoma State University (OSU) that identified a method of improving the sensitivity of antigen tests for heartworm (Dirofilaria immitis) infection in cats. The study, funded by Bayer HealthCare LLC Animal Health division, makers of parasiticides, found that heat treatment of feline serum samples prior to testing can considerably improve the sensitivity of antigen assays in feline patients and, in turn, result in a more accurate diagnosis of heartworm infection in cats.

"Heartworm is a very serious disease in cats that can result in significant pulmonary damage and can be fatal," said lead study investigator, Susan E. Little, DVM, Ph.D., Regents professor and Krull-Ewing chair in veterinary parasitology, OSU Center for Veterinary Health Sciences. "We believe this study's findings will enhance detection of heartworm infection in cats, improving both patient care and veterinarians' understanding of the true extent of feline heartworm."

Antigen detection a challenge in cats 

According to the study's authors – which included Byron Blagburn, MS, Ph.D., distinguished university professor, Auburn University College of Veterinary Medicine – the diagnosis of heartworm in cats has been complicated in the past by the difficulty associated with reliable detection of the heartworm antigen in feline samples. In fact, heartworm antigen tests have been considered much less reliable in cats than dogs. The lack of antigen detection has been attributed to low circulating antigenemia (presence of antigens in the blood) resulting from the low number of worms often seen in feline infections. Other feline heartworm assays based on antibody detection can be difficult to interpret since they do not distinguish between past or current infections.

Aiming to determine if antigen-antibody complex formation – antigen blocking – interfered with detection of the heartworm antigen in cats using commercial assays, the study evaluated serum samples from six domestic cats confirmed to be infected with a low number of heartworms. Four different commercially available assays were used before and after heat treatment of sera. The study found that the heartworm antigen was detected in zero to only one of six cats (0 to 16.7 percent), without heat treating the sera, using the assays according to manufacturers' directions. However, after heat treatment of the samples prior to testing, as many as five of six cats (83.3 percent) had detectable antigen – a "dramatic increase," the study's authors noted. Thus, new data suggests that adequate antigen is present in samples from cats infected with heartworm to allow diagnosis, but formation of antigen-antibody complexes may prevent its detection on commercial assays.

The authors concluded, "The data in the present study are exciting in that they suggest that once antigen-antibody complexes are disrupted, antigen tests may be of great value in confirming feline infection with D. immitis, particularly the sensitive microtiter well-based assays. Surveys conducted by antigen testing alone may be greatly underestimating the true prevalence of infection in cats."  

"When antigen based assays were first developed for detecting canine heartworm, the serum was pre-treated with heat or acid to destroy immune complexes prior to testing, as they were recognized as inhibiting detection of antigen in some canine samples," said Dr. Little. "This step is no longer included in protocols of antigen tests, including those labeled for use in cats. I think this study's findings could ultimately lead to a revision in the protocol for feline testing."

"Funding well-designed and carefully-executed research is a vital part of Bayer HealthCare's commitment to our mission, 'Science For a Better Life,'" said Joe Hostetler, DVM, veterinary technical services manager, Bayer HealthCare LLC Animal Health division and a study co-author. "Being part of this study was especially gratifying for me because, once the results were in, we realized the data had the potential to improve feline healthcare in an immediate and important way."

About Oklahoma State University

Oklahoma State University is a modern land-grant university. OSU's Center for Veterinary Health Sciences is the only veterinary college in Oklahoma. One of 30 veterinary colleges in the United States, it is fully accredited by the Council on Education of the American Veterinary Medical Association. The center's Boren Veterinary Medical Teaching Hospital is open to the public and provides routine and specialized care for small and large animals. It also offers 24-hour emergency care and is certified by the American Animal Hospital Association. OSU is preparing students for a brighter future and building a brighter world for all. OSU improves the lives of people in Oklahoma, the nation, and the world through integrated, high quality teaching, research and outreach. For more information, visit www.cvhs.okstate.edu or call (405) 744-7000.

About Bayer HealthCare

The Bayer Group is a global enterprise with core competencies in the fields of health care, agriculture and high-tech materials. Bayer HealthCare, a subgroup of Bayer AG with annual sales of EUR 18.6 million (2012), is one of the world's leading, innovative companies in the healthcare and medical products industry and is based in Leverkusen, Germany. The company combines the global activities of the Animal Health, Consumer Care, Medical Care and Pharmaceuticals divisions. Bayer HealthCare's aim is to discover, develop, manufacture and market products that will improve human and animal health worldwide. Bayer HealthCare has a global workforce of 55,300 employees (Dec. 31, 2012) and is represented in more than 100 countries. More information at www.healthcare.bayer.com.

Contact:

Staci Gouveia, Tel. 203.809.9008
Email: [email protected] 

Derinda Blakeney, Tel. 405.744.6740
Email: [email protected]

Find more information about Bayer HealthCare Animal Health at
www.animalhealth.bayerhealthcare.com

Follow us on Twitter: @Bayer4animalsUS 
Follow us on Facebook: http://www.facebook.com/healthcare.bayer  

Forward-Looking Statements

This release may contain forward-looking statements based on current assumptions and forecasts made by Bayer Group or subgroup management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer's public reports which are available on the Bayer website at www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.

[1] Little SE, Raymond MR, Thomas JE, Gruntmeir J, Hostetler JA, Meinkoth JH, Blagburn BL: Heat treatment prior to testing allows detection of antigen of Dirofilaria immitis in feline serum. Parasites & Vectors (13 January 2014).

SOURCE Bayer HealthCare

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Cloud-based disaster recovery is critical to any production environment and is a high priority for many enterprise organizations today. Nearly 40% of organizations have had to execute their BCDR plan due to a service disruption in the past two years. Zerto on IBM Cloud offer VMware and Microsoft customers simple, automated recovery of on-premise VMware and Microsoft workloads to IBM Cloud data centers.
Why Federal cloud? What is in Federal Clouds and integrations? This session will identify the process and the FedRAMP initiative. But is it sufficient? What is the remedy for keeping abreast of cutting-edge technology? In his session at 21st Cloud Expo, Rasananda Behera will examine the proposed solutions: Private or public or hybrid cloud Responsible governing bodies How can we accomplish?
Real IoT production deployments running at scale are collecting sensor data from hundreds / thousands / millions of devices. The goal is to take business-critical actions on the real-time data and find insights from stored datasets. In his session at @ThingsExpo, John Walicki, Watson IoT Developer Advocate at IBM Cloud, will provide a fast-paced developer journey that follows the IoT sensor data from generation, to edge gateway, to edge analytics, to encryption, to the IBM Bluemix cloud, to Wa...
SYS-CON Events announced today that Massive Networks, that helps your business operate seamlessly with fast, reliable, and secure internet and network solutions, has been named "Exhibitor" of SYS-CON's 21st International Cloud Expo ®, which will take place on Oct 31 - Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. As a premier telecommunications provider, Massive Networks is headquartered out of Louisville, Colorado. With years of experience under their belt, their team of...
With the rise of DevOps, containers are at the brink of becoming a pervasive technology in Enterprise IT to accelerate application delivery for the business. When it comes to adopting containers in the enterprise, security is the highest adoption barrier. Is your organization ready to address the security risks with containers for your DevOps environment? In his session at @DevOpsSummit at 21st Cloud Expo, Chris Van Tuin, Chief Technologist, NA West at Red Hat, will discuss: The top security r...
Many companies start their journey to the cloud in the DevOps environment, where software engineers want self-service access to the custom tools and frameworks they need. Machine learning technology can help IT departments keep up with these demands. In his session at 21st Cloud Expo, Ajay Gulati, Co-Founder, CTO and Board Member at ZeroStack, will discuss the use of machine learning for automating provisioning of DevOps resources, taking the burden off IT teams.
SYS-CON Events announced today that Nihon Micron will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Nihon Micron Co., Ltd. strives for technological innovation to establish high-density, high-precision processing technology for providing printed circuit board and metal mount RFID tags used for communication devices. For more inf...
SYS-CON Events announced today that mruby Forum will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. mruby is the lightweight implementation of the Ruby language. We introduce mruby and the mruby IoT framework that enhances development productivity. For more information, visit http://forum.mruby.org/.
In his session at @ThingsExpo, Greg Gorman is the Director, IoT Developer Ecosystem, Watson IoT, will provide a short tutorial on Node-RED, a Node.js-based programming tool for wiring together hardware devices, APIs and online services in new and interesting ways. It provides a browser-based editor that makes it easy to wire together flows using a wide range of nodes in the palette that can be deployed to its runtime in a single-click. There is a large library of contributed nodes that help so...
SYS-CON Events announced today that Ryobi Systems will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Ryobi Systems Co., Ltd., as an information service company, specialized in business support for local governments and medical industry. We are challenging to achive the precision farming with AI. For more information, visit http:...
SYS-CON Events announced today that SIGMA Corporation will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. uLaser flow inspection device from the Japanese top share to Global Standard! Then, make the best use of data to flip to next page. For more information, visit http://www.sigma-k.co.jp/en/.
SYS-CON Events announced today that Daiya Industry will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Daiya Industry specializes in orthotic support systems and assistive devices with pneumatic artificial muscles in order to contribute to an extended healthy life expectancy. For more information, please visit https://www.daiyak...
Today traditional IT approaches leverage well-architected compute/networking domains to control what applications can access what data, and how. DevOps includes rapid application development/deployment leveraging concepts like containerization, third-party sourced applications and databases. Such applications need access to production data for its test and iteration cycles. Data Security? That sounds like a roadblock to DevOps vs. protecting the crown jewels to those in IT.
SYS-CON Events announced today that B2Cloud will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. B2Cloud specializes in IoT devices for preventive and predictive maintenance in any kind of equipment retrieving data like Energy consumption, working time, temperature, humidity, pressure, etc.
Automation is enabling enterprises to design, deploy, and manage more complex, hybrid cloud environments. Yet the people who manage these environments must be trained in and understanding these environments better than ever before. A new era of analytics and cognitive computing is adding intelligence, but also more complexity, to these cloud environments. How smart is your cloud? How smart should it be? In this power panel at 20th Cloud Expo, moderated by Conference Chair Roger Strukhoff, paneli...