|By PR Newswire||
|January 20, 2014 06:00 AM EST||
BETHANY, Conn., Jan. 20, 1014 /PRNewswire-iReach/ -- AMxTek LLC announced today the USPTO 'Notice of Allowance' regarding claims pertaining to U.S. Patent Publication # US2011/0196502, entitled: Methods of Using Water-Soluble Inorganic Compounds for Implants. The patent provides for the use of inorganic compounds, more specifically bioactive glass, to enhance osteostimulative bone ingrowth and provide broad-spectrum antimicrobial implant prophylaxis. The intellectual property has broad clinical application in the fields of orthopedic trauma, reconstruction and revision surgery, as well as spinal and dental implants. Details regarding the intellectual property can be found on the AMxTek blog at: http://amxtek.com/blog/2014/01/13/uspto-notice-of-allowance/
Aseptic loosening of orthopedic implants has been a primary cause of revision surgery. Additionally, another 14% of such revision surgeries have been attributed to implant infection1. A prosthetic hip infection in the U.S. costs between $60,000 - $70,000 to treat2. Hospital Acquired Infections in the U.S. account for nearly 99,000 annual deaths3; the cost of care of which is estimated to be $35.7 – $45.0B/yr.4 The intellectual property provides for the release of calcium and other osteostimulative ions, upon the dissolution of bioactive glass, which up-regulates osteoblast growth factor gene expression and bone matrix deposition5-7. When such bioactive glass incorporates silver-oxide compounds its dissolution releases ionic silver, which provides broad-spectrum antimicrobial implant prophylaxis. The technology therefore provides for osteoblast stimulated implant fixation and antimicrobial prophylaxis.
"By combining bioactive glass of differing solubilities, particle size and/or silver concentration, one can custom-tailor antimicrobial elution kinetics to correspond with the clinical need", said Jim Walls, AMxTek's President. "The high temperature stability of bioactive glass also accommodates various implant terminal sterilization methods, including autoclave, without adversely affecting or degrading the osteostimulative and/or antimicrobial properties of the implant."
AMxTek will be seeking business development, co-development or other commercial opportunities for the intellectual property. Continuing application filings, based upon the original U.S. Patent Application, are envisioned.
About AMxTek LLC
AMxTek LLC is a combination product, medical device consulting and intellectual property development company. The company assists corporate clients with front-end technology needs, technology due diligence, product development and US FDA regulatory strategy, pathway development and filings, associated with antimicrobial and osteogenic medical devices and implants. AMxTek also develops intellectual property for license when technology can be brought to bear on unmet clinical needs, particularly in the field of Hospital Acquired Infections.
- Kazemzadeh-Narbat M, et al.: Antimicrobial Peptides on Calcium Phosphate-coated Titanium for the Prevention of Implant-Associated Infections; Biomaterials; 2010; 31:9519-9526
- Kienapfel H, Kuhn K-D [Eds]: The Infected Implant; Springer 2009; Chapter 6, pp. 20
- Klevens RM, et al.: Estimating Health Care-Associated Infections and Deaths in U. S. Hospitals, 2002; Public Health Report 2007; 122:160-166
- Scott II RD: The Direct Medical Costs Of Healthcare-Associated Infections in U. S. Hospitals and the Benefit of Prevention; Centers for Disease Control and Prevention; March 2009
- Hench LL: The Story of Bioglass®; J Mater Sci; Mater Med (2006) 17: 967-978
- Barradas A: Molecular analysis of biomaterial-driven osteogenic differentiation of human mesenchymal stem cells; BioInterface 2011
- Qui Z, et al.: Ionic dissolution products of NovaBone promote osteoblastic proliferation via influences on the cell cycle; J of International Medical Research, 2009; 37(3): 737-45
Media Contact: James Walls, AMxTek LLC, 203-393-1387, [email protected]
News distributed by PR Newswire iReach: https://ireach.prnewswire.com
SOURCE AMxTek LLC
You think you know what’s in your data. But do you? Most organizations are now aware of the business intelligence represented by their data. Data science stands to take this to a level you never thought of – literally. The techniques of data science, when used with the capabilities of Big Data technologies, can make connections you had not yet imagined, helping you discover new insights and ask new questions of your data. In his session at @ThingsExpo, Sarbjit Sarkaria, data science team lead ...
May. 2, 2016 11:00 PM EDT Reads: 986
Much of the value of DevOps comes from a (renewed) focus on measurement, sharing, and continuous feedback loops. In increasingly complex DevOps workflows and environments, and especially in larger, regulated, or more crystallized organizations, these core concepts become even more critical. In his session at @DevOpsSummit at 18th Cloud Expo, Andi Mann, Chief Technology Advocate at Splunk, will show how, by focusing on 'metrics that matter,' you can provide objective, transparent, and meaningfu...
May. 2, 2016 08:30 PM EDT Reads: 702
If there is anything we have learned by now, is that every business paves their own unique path for releasing software- every pipeline, implementation and practices are a bit different, and DevOps comes in all shapes and sizes. Software delivery practices are often comprised of set of several complementing (or even competing) methodologies – such as leveraging Agile, DevOps and even a mix of ITIL, to create the combination that’s most suitable for your organization and that maximize your busines...
May. 2, 2016 07:45 PM EDT Reads: 1,884
In his session at @ThingsExpo, Chris Klein, CEO and Co-founder of Rachio, will discuss next generation communities that are using IoT to create more sustainable, intelligent communities. One example is Sterling Ranch, a 10,000 home development that – with the help of Siemens – will integrate IoT technology into the community to provide residents with energy and water savings as well as intelligent security. Everything from stop lights to sprinkler systems to building infrastructures will run ef...
May. 2, 2016 07:00 PM EDT Reads: 1,046
SYS-CON Events announced today that Peak 10, Inc., a national IT infrastructure and cloud services provider, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Peak 10 provides reliable, tailored data center and network services, cloud and managed services. Its solutions are designed to scale and adapt to customers’ changing business needs, enabling them to lower costs, improve performance and focus inter...
May. 2, 2016 06:30 PM EDT Reads: 1,301
In the world of DevOps there are ‘known good practices’ – aka ‘patterns’ – and ‘known bad practices’ – aka ‘anti-patterns.' Many of these patterns and anti-patterns have been developed from real world experience, especially by the early adopters of DevOps theory; but many are more feasible in theory than in practice, especially for more recent entrants to the DevOps scene. In this power panel at @DevOpsSummit at 18th Cloud Expo, moderated by DevOps Conference Chair Andi Mann, panelists will dis...
May. 2, 2016 06:00 PM EDT Reads: 715
Up until last year, enterprises that were looking into cloud services usually undertook a long-term pilot with one of the large cloud providers, running test and dev workloads in the cloud. With cloud’s transition to mainstream adoption in 2015, and with enterprises migrating more and more workloads into the cloud and in between public and private environments, the single-provider approach must be revisited. In his session at 18th Cloud Expo, Yoav Mor, multi-cloud solution evangelist at Cloudy...
May. 2, 2016 05:30 PM EDT Reads: 1,562
Artificial Intelligence has the potential to massively disrupt IoT. In his session at 18th Cloud Expo, AJ Abdallat, CEO of Beyond AI, will discuss what the five main drivers are in Artificial Intelligence that could shape the future of the Internet of Things. AJ Abdallat is CEO of Beyond AI. He has over 20 years of management experience in the fields of artificial intelligence, sensors, instruments, devices and software for telecommunications, life sciences, environmental monitoring, process...
May. 2, 2016 05:15 PM EDT Reads: 996
Increasing IoT connectivity is forcing enterprises to find elegant solutions to organize and visualize all incoming data from these connected devices with re-configurable dashboard widgets to effectively allow rapid decision-making for everything from immediate actions in tactical situations to strategic analysis and reporting. In his session at 18th Cloud Expo, Shikhir Singh, Senior Developer Relations Manager at Sencha, will discuss how to create HTML5 dashboards that interact with IoT devic...
May. 2, 2016 05:00 PM EDT Reads: 1,097
See storage differently! Storage performance problems have only gotten worse and harder to solve as applications have become largely virtualized and moved to a cloud-based infrastructure. Storage performance in a virtualized environment is not just about IOPS, it is about how well that potential performance is guaranteed to individual VMs for these apps as the number of VMs keep going up real time. In his session at 18th Cloud Expo, Dhiraj Sehgal, in product and marketing at Tintri, will discu...
May. 2, 2016 04:00 PM EDT Reads: 907
So, you bought into the current machine learning craze and went on to collect millions/billions of records from this promising new data source. Now, what do you do with them? Too often, the abundance of data quickly turns into an abundance of problems. How do you extract that "magic essence" from your data without falling into the common pitfalls? In her session at @ThingsExpo, Natalia Ponomareva, Software Engineer at Google, will provide tips on how to be successful in large scale machine lear...
May. 2, 2016 03:45 PM EDT Reads: 1,350
SYS-CON Events announced today that SoftLayer, an IBM Company, has been named “Gold Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. SoftLayer, an IBM Company, provides cloud infrastructure as a service from a growing number of data centers and network points of presence around the world. SoftLayer’s customers range from Web startups to global enterprises.
May. 2, 2016 03:30 PM EDT Reads: 1,069
The IoTs will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform. In his session at @ThingsExpo, Craig Sproule, CEO of Metavine, will demonstrate how to move beyond today's coding paradigm and share the must-have mindsets for removing complexity from the development proc...
May. 2, 2016 03:00 PM EDT Reads: 373
SYS-CON Events announced today that Ericsson has been named “Gold Sponsor” of SYS-CON's @ThingsExpo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. Ericsson is a world leader in the rapidly changing environment of communications technology – providing equipment, software and services to enable transformation through mobility. Some 40 percent of global mobile traffic runs through networks we have supplied. More than 1 billion subscribers around the world re...
May. 2, 2016 02:45 PM EDT Reads: 1,095