Welcome!

News Feed Item

AMxTek Announces USPTO 'Notice of Allowance': Methods of Using Water-Soluble Inorganic Compounds for Implants

BETHANY, Conn., Jan. 20, 1014 /PRNewswire-iReach/ -- AMxTek LLC announced today the USPTO 'Notice of Allowance' regarding claims pertaining to U.S. Patent Publication # US2011/0196502, entitled: Methods of Using Water-Soluble Inorganic Compounds for Implants. The patent provides for the use of inorganic compounds, more specifically bioactive glass, to enhance osteostimulative bone ingrowth and provide broad-spectrum antimicrobial implant prophylaxis. The intellectual property has broad clinical application in the fields of orthopedic trauma, reconstruction and revision surgery, as well as spinal and dental implants. Details regarding the intellectual property can be found on the AMxTek blog at: http://amxtek.com/blog/2014/01/13/uspto-notice-of-allowance/

(Photo: http://photos.prnewswire.com/prnh/20140120/MN47144)

Aseptic loosening of orthopedic implants has been a primary cause of revision surgery. Additionally, another 14% of such revision surgeries have been attributed to implant infection1. A prosthetic hip infection in the U.S. costs between $60,000 - $70,000 to treat2. Hospital Acquired Infections in the U.S. account for nearly 99,000 annual deaths3; the cost of care of which is estimated to be $35.7$45.0B/yr.4 The intellectual property provides for the release of calcium and other osteostimulative ions, upon the dissolution of bioactive glass, which up-regulates osteoblast growth factor gene expression and bone matrix deposition5-7. When such bioactive glass incorporates silver-oxide compounds its dissolution releases ionic silver, which provides broad-spectrum antimicrobial implant prophylaxis. The technology therefore provides for osteoblast stimulated implant fixation and antimicrobial prophylaxis.

"By combining bioactive glass of differing solubilities, particle size and/or silver concentration, one can custom-tailor antimicrobial elution kinetics to correspond with the clinical need", said Jim Walls, AMxTek's President. "The high temperature stability of bioactive glass also accommodates various implant terminal sterilization methods, including autoclave, without adversely affecting or degrading the osteostimulative and/or antimicrobial properties of the implant."

AMxTek will be seeking business development, co-development or other commercial opportunities for the intellectual property. Continuing application filings, based upon the original U.S. Patent Application, are envisioned.

About AMxTek LLC

AMxTek LLC is a combination product, medical device consulting and intellectual property development company. The company assists corporate clients with front-end technology needs, technology due diligence, product development and US FDA regulatory strategy, pathway development and filings, associated with antimicrobial and osteogenic medical devices and implants. AMxTek also develops intellectual property for license when technology can be brought to bear on unmet clinical needs, particularly in the field of Hospital Acquired Infections.

References:

    1. Kazemzadeh-Narbat M, et al.: Antimicrobial Peptides on Calcium Phosphate-coated Titanium for the Prevention of Implant-Associated Infections; Biomaterials; 2010; 31:9519-9526
    2. Kienapfel H, Kuhn K-D [Eds]: The Infected Implant; Springer 2009; Chapter 6, pp. 20
    3. Klevens RM, et al.: Estimating Health Care-Associated Infections and Deaths in U. S. Hospitals, 2002; Public Health Report 2007; 122:160-166
    4. Scott II RD: The Direct Medical Costs Of Healthcare-Associated Infections in U. S. Hospitals and the Benefit of Prevention; Centers for Disease Control and Prevention; March 2009
    5.  Hench LL: The Story of Bioglass®; J Mater Sci; Mater Med (2006) 17: 967-978
    6.  Barradas A: Molecular analysis of biomaterial-driven osteogenic differentiation of human mesenchymal stem cells; BioInterface 2011
    7. Qui Z, et al.: Ionic dissolution products of NovaBone promote osteoblastic proliferation via influences on the cell cycle; J of International Medical Research, 2009; 37(3): 737-45

Media Contact: James Walls, AMxTek LLC, 203-393-1387, [email protected]

News distributed by PR Newswire iReach: https://ireach.prnewswire.com

SOURCE AMxTek LLC

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
StarNet Communications Corp has announced the addition of three Secure Remote Desktop modules to its flagship X-Win32 PC X server. The new modules enable X-Win32 to safely tunnel the remote desktops from Linux and Unix servers to the user’s PC over encrypted SSH. Traditionally, users of PC X servers deploy the XDMCP protocol to display remote desktop environments such as the Gnome and KDE desktops on Linux servers and the CDE environment on Solaris Unix machines. XDMCP is used primarily on comp...
Smart Cities are here to stay, but for their promise to be delivered, the data they produce must not be put in new siloes. In his session at @ThingsExpo, Mathias Herberts, Co-founder and CTO of Cityzen Data, will deep dive into best practices that will ensure a successful smart city journey.
Using new techniques of information modeling, indexing, and processing, new cloud-based systems can support cloud-based workloads previously not possible for high-throughput insurance, banking, and case-based applications. In his session at 18th Cloud Expo, John Newton, CTO, Founder and Chairman of Alfresco, described how to scale cloud-based content management repositories to store, manage, and retrieve billions of documents and related information with fast and linear scalability. He addres...
SYS-CON Events announced today that StarNet Communications will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. StarNet Communications’ FastX is the industry first cloud-based remote X Windows emulator. Using standard Web browsers (FireFox, Chrome, Safari, etc.) users from around the world gain highly secure access to applications and data hosted on Linux-based servers in a central data center. ...
SYS-CON Events announced today that Venafi, the Immune System for the Internet™ and the leading provider of Next Generation Trust Protection, will exhibit at @DevOpsSummit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Venafi is the Immune System for the Internet™ that protects the foundation of all cybersecurity – cryptographic keys and digital certificates – so they can’t be misused by bad guys in attacks...
Aspose.Total for .NET is the most complete package of all file format APIs for .NET as offered by Aspose. It empowers developers to create, edit, render, print and convert between a wide range of popular document formats within any .NET, C#, ASP.NET and VB.NET applications. Aspose compiles all .NET APIs on a daily basis to ensure that it contains the most up to date versions of each of Aspose .NET APIs. If a new .NET API or a new version of existing APIs is released during the subscription peri...
The 19th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportuni...
DevOps at Cloud Expo – being held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA – announces that its Call for Papers is open. Born out of proven success in agile development, cloud computing, and process automation, DevOps is a macro trend you cannot afford to miss. From showcase success stories from early adopters and web-scale businesses, DevOps is expanding to organizations of all sizes, including the world's largest enterprises – and delivering real results. Am...
To leverage Continuous Delivery, enterprises must consider impacts that span functional silos, as well as applications that touch older, slower moving components. Managing the many dependencies can cause slowdowns. See how to achieve continuous delivery in the enterprise.
SYS-CON Events announced today that eCube Systems, a leading provider of middleware modernization, integration, and management solutions, will exhibit at @DevOpsSummit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. eCube Systems offers a family of middleware evolution products and services that maximize return on technology investment by leveraging existing technical equity to meet evolving business needs. ...
DevOps at Cloud Expo, taking place Nov 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 19th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is no time to wait for long dev...
SYS-CON Events announced today Telecom Reseller has been named “Media Sponsor” of SYS-CON's 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Telecom Reseller reports on Unified Communications, UCaaS, BPaaS for enterprise and SMBs. They report extensively on both customer premises based solutions such as IP-PBX as well as cloud based and hosted platforms.
Ixia (Nasdaq: XXIA) has announced that NoviFlow Inc.has deployed IxNetwork® to validate the company’s designs and accelerate the delivery of its proven, reliable products. Based in Montréal, NoviFlow Inc. supports network carriers, hyperscale data center operators, and enterprises seeking greater network control and flexibility, network scalability, and the capacity to handle extremely large numbers of flows, while maintaining maximum network performance. To meet these requirements, NoviFlow in...
Enterprises have forever faced challenges surrounding the sharing of their intellectual property. Emerging cloud adoption has made it more compelling for enterprises to digitize their content, making them available over a wide variety of devices across the Internet. In his session at 19th Cloud Expo, Santosh Ahuja, Director of Architecture at Impiger Technologies, will introduce various mechanisms provided by cloud service providers today to manage and share digital content in a secure manner....
As the world moves toward more DevOps and Microservices, application deployment to the cloud ought to become a lot simpler. The Microservices architecture, which is the basis of many new age distributed systems such as OpenStack, NetFlix and so on, is at the heart of Cloud Foundry - a complete developer-oriented Platform as a Service (PaaS) that is IaaS agnostic and supports vCloud, OpenStack and AWS. Serverless computing is revolutionizing computing. In his session at 19th Cloud Expo, Raghav...