Welcome!

News Feed Item

MD Anderson Announces Collaboration With Johnson & Johnson Innovation On Cancer Immunotherapy

HOUSTON, Jan. 21, 2014 /PRNewswire-USNewswire/ -- The University of Texas MD Anderson Cancer Center  will collaborate with Johnson & Johnson Innovation, LLC, and its affiliate Janssen Biotech, Inc., to develop immunology-based cancer treatments through the MD Anderson Moon Shots Program immunotherapy platform.

"The strengths of both organizations in the rapidly growing field of cancer immunotherapy can exploit opportunities to develop more effective treatments for cancer patients," said Jim Allison, Ph.D., chair of Immunology and executive director of the immunotherapy platform.  "We look forward to collaborating with Johnson & Johnson Innovation."

MD Anderson's Moon Shots Program is an ambitious effort to dramatically reduce cancer deaths, starting with six moon shots that target eight cancers and are backed by several platforms - infrastructure, technology or expertise - that support research efforts.

The 3-year translational research agreement brings together the scientific and clinical capabilities of MD Anderson and Johnson & Johnson Innovation and Janssen Biotech, Inc., to develop rational combination therapies and personalized medicine approaches as well as to identify new treatment opportunities.

The collaboration with Johnson & Johnson Innovation is the second such arrangement made through the moon shots immunotherapy platform. Only a few companies will be selected to become partners to the platform.

"Our new collaborations with pharmaceutical and biotech companies through our immunotherapy platform are different from traditional agreements, because they allow both parties to work on any project they deem appropriate without additional budgets," said Ferran Prat, Ph.D., J.D., MD Anderson's vice president of strategic industry ventures.

"We provide our pharma and biotech collaborators access to state-of-the-art facilities, novel research protocols for clinical trials open to our large and diverse patient population, and an opportunity to work with leaders in the field of immunotherapy," Prat said.

Prat said this collaboration will explore oncology focus areas of interest to Janssen Biotech, Inc.

Allison's basic science research on T cell biology led to an entirely new method of treating cancer called immune checkpoint blockade, which blocks receptors on the surface of T cells that tumors use to turn off immune attack.

Allison created an antibody to one such checkpoint, called CTLA-4, and worked in its development as the drug ipilimumab (Yervoy), the first drug of its kind and also the first to be approved by the U.S. Food and Drug Administration for late-stage melanoma. More than 20 percent of melanoma patients given the drug develop long-lasting remissions for five years and longer.

In December, the journal Science designated cancer immunotherapy as its 2013 Breakthrough of the Year, noting Allison's leadership in the field, The Economist named Allison winner of its 2013 Innovations Award for Biosciences and he received a $3 million Breakthrough Prize in Life Sciences from the foundation of the same name launched last year by internet and social media entrepreneurs. 

MD Anderson's immunotherapy platform has enhanced and increased the institution's capabilities in expertise, technology and techniques since Allison's arrival in November of 2012.

Patrick Hwu, M.D., chair of Melanoma Medical Oncology is co-director of the platform.  Translational physician-scientist Padmanee Sharma M.D., Ph.D., associate professor of Genitourinary Medical Oncology, is scientific director.

MD Anderson has invested $40 million in the platform, including philanthropic funds and a $10 million Established Investigator grant from the Cancer Prevention and Research Institute of Texas to recruit Allison from Memorial Sloan-Kettering Cancer Center in New York. Allison holds MD Anderson's Vivian L. Smith Distinguished Chair in Immunology.

Since approval of ipilimumab in 2011, additional immune checkpoint receptors and drugs to target them have been discovered and are in clinical trials. At MD Anderson, clinical trials of ipilimumab and other agents target melanoma, lymphoma, lung, breast, gastric and prostate cancers, with more planned.

MD Anderson researchers also are working on a variety of ways to enhance T cell attack on cancer cells. For example, one method involves harvesting a patient's own cancer-targeting T cells, expanding their number in the lab, then reinfusing them in the patient.  Another involves customizing a patient's T cells via gene transfer to more efficiently attack tumors and then giving them back to patients.  Both methods are in clinical trials.

Therapeutic vaccine development also is under way for melanoma, lymphoma and breast cancer.

About MD Anderson

The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world's most respected centers focused on cancer patient care, research, education and prevention. MD Anderson is one of only 41 comprehensive cancer centers designated by the National Cancer Institute (NCI). For ten of the past 12 years, including 2013, MD Anderson has ranked No. 1 in cancer care in "Best Hospitals," a survey published annually in U.S. News & World Report. MD Anderson receives a cancer center support grant from the NCI of the National Institutes of Health (P30 CA016672).

Get MD Anderson News Via RSS  Follow MD Anderson News on Twitter

This news release was issued on behalf of Newswise(TM). For more information, visit http://www.newswise.com.

SOURCE The University of Texas M. D. Anderson Cancer Center

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
So, you bought into the current machine learning craze and went on to collect millions/billions of records from this promising new data source. Now, what do you do with them? Too often, the abundance of data quickly turns into an abundance of problems. How do you extract that "magic essence" from your data without falling into the common pitfalls? In her session at @ThingsExpo, Natalia Ponomareva, Software Engineer at Google, will provide tips on how to be successful in large scale machine lear...
The IoT has the potential to create a renaissance of manufacturing in the US and elsewhere. In his session at 18th Cloud Expo, Florent Solt, CTO and chief architect of Netvibes, will discuss how the expected exponential increase in the amount of data that will be processed, transported, stored, and accessed means there will be a huge demand for smart technologies to deliver it. Florent Solt is the CTO and chief architect of Netvibes. Prior to joining Netvibes in 2007, he co-founded Rift Technol...
Struggling to keep up with increasing application demand? Learn how Platform as a Service (PaaS) can streamline application development processes and make resource management easy.
If there is anything we have learned by now, is that every business paves their own unique path for releasing software- every pipeline, implementation and practices are a bit different, and DevOps comes in all shapes and sizes. Software delivery practices are often comprised of set of several complementing (or even competing) methodologies – such as leveraging Agile, DevOps and even a mix of ITIL, to create the combination that’s most suitable for your organization and that maximize your busines...
The increasing popularity of the Internet of Things necessitates that our physical and cognitive relationship with wearable technology will change rapidly in the near future. This advent means logging has become a thing of the past. Before, it was on us to track our own data, but now that data is automatically available. What does this mean for mHealth and the "connected" body? In her session at @ThingsExpo, Lisa Calkins, CEO and co-founder of Amadeus Consulting, will discuss the impact of wea...
SYS-CON Events announced today that Peak 10, Inc., a national IT infrastructure and cloud services provider, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Peak 10 provides reliable, tailored data center and network services, cloud and managed services. Its solutions are designed to scale and adapt to customers’ changing business needs, enabling them to lower costs, improve performance and focus inter...
See storage differently! Storage performance problems have only gotten worse and harder to solve as applications have become largely virtualized and moved to a cloud-based infrastructure. Storage performance in a virtualized environment is not just about IOPS, it is about how well that potential performance is guaranteed to individual VMs for these apps as the number of VMs keep going up real time. In his session at 18th Cloud Expo, Dhiraj Sehgal, in product and marketing at Tintri, will discu...
We’ve worked with dozens of early adopters across numerous industries and will debunk common misperceptions, which starts with understanding that many of the connected products we’ll use over the next 5 years are already products, they’re just not yet connected. With an IoT product, time-in-market provides much more essential feedback than ever before. Innovation comes from what you do with the data that the connected product provides in order to enhance the customer experience and optimize busi...
Up until last year, enterprises that were looking into cloud services usually undertook a long-term pilot with one of the large cloud providers, running test and dev workloads in the cloud. With cloud’s transition to mainstream adoption in 2015, and with enterprises migrating more and more workloads into the cloud and in between public and private environments, the single-provider approach must be revisited. In his session at 18th Cloud Expo, Yoav Mor, multi-cloud solution evangelist at Cloudy...
In his session at @ThingsExpo, Chris Klein, CEO and Co-founder of Rachio, will discuss next generation communities that are using IoT to create more sustainable, intelligent communities. One example is Sterling Ranch, a 10,000 home development that – with the help of Siemens – will integrate IoT technology into the community to provide residents with energy and water savings as well as intelligent security. Everything from stop lights to sprinkler systems to building infrastructures will run ef...
SYS-CON Events announced today that Enzu, a leading provider of cloud hosting solutions, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Enzu’s mission is to be the leading provider of enterprise cloud solutions worldwide. Enzu enables online businesses to use its IT infrastructure to their competitive advantage. By offering a suite of proven hosting and management services, Enzu wants companies to foc...
SYS-CON Events announced today that Stratoscale, the software company developing the next generation data center operating system, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Stratoscale is revolutionizing the data center with a zero-to-cloud-in-minutes solution. With Stratoscale’s hardware-agnostic, Software Defined Data Center (SDDC) solution to store everything, run anything and scale everywhere...
Digital payments using wearable devices such as smart watches, fitness trackers, and payment wristbands are an increasing area of focus for industry participants, and consumer acceptance from early trials and deployments has encouraged some of the biggest names in technology and banking to continue their push to drive growth in this nascent market. Wearable payment systems may utilize near field communication (NFC), radio frequency identification (RFID), or quick response (QR) codes and barcodes...
Angular 2 is a complete re-write of the popular framework AngularJS. Programming in Angular 2 is greatly simplified – now it's a component-based well-performing framework. This immersive one-day workshop at 18th Cloud Expo, led by Yakov Fain, a Java Champion and a co-founder of the IT consultancy Farata Systems and the product company SuranceBay, will provide you with everything you wanted to know about Angular 2.
You think you know what’s in your data. But do you? Most organizations are now aware of the business intelligence represented by their data. Data science stands to take this to a level you never thought of – literally. The techniques of data science, when used with the capabilities of Big Data technologies, can make connections you had not yet imagined, helping you discover new insights and ask new questions of your data. In his session at @ThingsExpo, Sarbjit Sarkaria, data science team lead ...