Click here to close now.




















Welcome!

News Feed Item

BioLeonhardt to Unveil Stem Cell Pump at Cell Therapy Meeting New York

First implantable pump for timed dosed repeat delivery of stem cells and growth factors

SANTA MONICA, Calif., Jan. 22, 2014 /PRNewswire/ -- BioLeonhardt, a Leonhardt Ventures company based in Los Angeles, will unveil its implantable Stem Cell Pump at the 9th Annual Cell Therapy for Cardiovascular Disease meeting at Columbia University in New York on Thursday, January 23, 2014 at 10:30 am.

BioLeonhardt – Has developed a programmable implantable stem cell infusion pump and electrical stimulator combination for treating advanced heart failure. The stem cell pump is implanted in the patient's abdomen and has a silicone septum which allows re-loading via a micro needle syringe of stem cells, genes, growth factors and nutrient hydrogels.  The pump is attached to a combination coaxial reinforced infusion catheter and electrical conduction lead which has its tip anchored into the patient's damaged heart tissue.  

BioLeonhardt is teamed with Core Manufacturing LLC, an Alfred Mann Companies spin out, that is staffed with members that have a long history developing related devices including the Pacesetter Systems heart pacer sold to Siemens then St. Jude Medical, the MiniMed implantable insulin pump sold to Medtronic and the Advanced Bionics implantable pain relief pumps sold to Boston Scientific - www.core-manufacturing.com

BioLeonhardt intends to bring to market a therapy for heart failure utilizing their own stem cell pump and to offer the pump as well to other researchers with different therapies.

BioLeonhardt's own proposed method to treating heart failure:

1.  Pre-Treat Scar - Micro-RNAs, Nutrient Hydrogel, Growth Factors, Electrical Stimulation, GCSF, endothelial progenitor cells and adipose derived cells.

2.  Treat Scar - Muscle derived cardiac progenitor cells in center of scar, cardiac stem cells or iPS cells at rim edge of scar, temporary implantable circulatory assist pump to allow heart to rest (www.cardiobridge.com or www.procyrion.com).

3.  Post Implantation Scar Maintenance - Repeat injections/infusions + electrical stimulation. 

"For the past 14 years all stem cell related studies have been limited to one single half hour session of injections or infusions.  We believe superior results can be obtained by repeat dosing utilizing our programmable implantable pump. BioLeonhardt is designing a controlled study for heart failure with intent to prove this hypothesis," stated Howard J. Leonhardt, Founder, CEO, BioLeonhardt and lead inventor for the new technology. 

BioLeonhardt has granted an exclusive license for myoblast transplantation with their pump to another Leonhardt founded company Bioheart, Inc. that has been in clinical trials utilizing selected immature myoblasts to treat heart failure since early 2001. Over 400 patients have been enrolled in various myoblast trials worldwide. New myoblast related independent trial results will be presented at the conference this week. 

Electrical stimulation technology for these studies will be provided by MyoStim Pacers - www.myostimpacers.com.  Electrical stimulation has demonstrated an ability to recruit stem cells to injury sites and differentiate them into useful tissues while improving blood flow and thus healing scars, in both pre-clinical and clinical studies for various applications.  

Summary of myoblast transplantation data for heart failure clinical studies:

  • 84% of myoblast treated patients have improved in at least one parameter while only 16% have worsened.  In comparison 69% of control or placebo patients in the same studies have worsened.
  • 33% of MyoCell treated patients have improved by two heart failure classes.
  • Bioheart MyoCell treated patients improved 95.7 meters in exercise capacity over placebo patients that declined 4 meters.   No other cell type has bettered 53 meters.  Allogeneic bone marrow derived cells 10 meters.  CRT Pacers 20 meters.
  • Myoblasts are the only cell composition that has demonstrated an ability to grow new contractile muscle in the center of heart scar tissue.

Pre-clinical studies have confirmed that even superior results can be obtained when the cells are modified to over-express SDF-1 and repeat doses are given over time - http://eurheartj.oxfordjournals.org/content/31/8/1013.full.pdf

Cal-X Stars Business Accelerator, Inc. announced Nov. 18th, 2013 a $15 million capital raise under the new JOBS ACT Title II 506c regulations - http://www.prnewswire.com/news-releases/leonhardt-ventures-cal-x-stars-business-accelerator-raising-15-million-232350001.html

The Leonhardt Ventures' Scientific Advisory Board is made up of leading researchers -http://calxstars.com/scientific-advisory-board/.  Jane Reedy, the former VP of Clinical Affairs & Marketing at HeartWare and former Thoratec executive, and Suresh Gurunathan, Director of Engineering at Nanostim (first leadless pacemaker developed sold to St. Jude in October), have recently joined our advisory team. 

About Leonhardt Ventures:  Since 1982 Leonhardt Ventures has a strong history of inventing, developing, backing and bringing to market leadership products for treating heart and cardiovascular disease. Over 200,000 patients have been treated to date with Leonhardt inventions. Founder Howard Leonhardt holds 21 U.S. patents for treating cardiovascular disease - http://patents.justia.com/inventor/howard-j-leonhardt

About Conference on Cell Therapy for Cardiovascular Disease:  For the past 9 years the Cardiovascular Research Foundation (CRF) and Columbia University hosted conference led by Dr. Warren Sherman has been the premier scientific information exchange forum for this important specialty - http://www.crf.org/celltherapy/the-conference/overview

Contact:  Howard Leonhardt, BioLeonhardt, 1531 6th Street, Unit 401, Santa Monica, California, 90401, Office direct 310 310 2534, Email

This press release distribution was issued via PR Syndication.

RELATED LINKS

http://bioleonhardt.com 

SOURCE BioLeonhardt

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
The speed of software changes in growing and large scale rapid-paced DevOps environments presents a challenge for continuous testing. Many organizations struggle to get this right. Practices that work for small scale continuous testing may not be sufficient as the requirements grow. In his session at DevOps Summit, Marc Hornbeek, Sr. Solutions Architect of DevOps continuous test solutions at Spirent Communications, explained the best practices of continuous testing at high scale, which is rele...
"We got started as search consultants. On the services side of the business we have help organizations save time and save money when they hit issues that everyone more or less hits when their data grows," noted Otis Gospodnetić, Founder of Sematext, in this SYS-CON.tv interview at @DevOpsSummit, held June 9-11, 2015, at the Javits Center in New York City.
"We have been in business for 21 years and have been building many enterprise solutions, all IT plumbing - server, storage, interconnects," stated Alex Gorbachev, President of Intelligent Systems Services, in this SYS-CON.tv interview at 16th Cloud Expo, held June 9-11, 2015, at the Javits Center in New York City.
In a recent research, analyst firm IDC found that the average cost of a critical application failure is $500,000 to $1 million per hour and the average total cost of unplanned application downtime is $1.25 billion to $2.5 billion per year for Fortune 1000 companies. In addition to the findings on the cost of the downtime, the research also highlighted best practices for development, testing, application support, infrastructure, and operations teams.
"We specialize in testing. DevOps is all about continuous delivery and accelerating the delivery pipeline and there is no continuous delivery without testing," noted Marc Hornbeek, Sr. Solutions Architect at Spirent Communications, in this SYS-CON.tv interview at @DevOpsSummit, held June 9-11, 2015, at the Javits Center in New York City.
How do you securely enable access to your applications in AWS without exposing any attack surfaces? The answer is usually very complicated because application environments morph over time in response to growing requirements from your employee base, your partners and your customers. In his session at @DevOpsSummit, Haseeb Budhani, CEO and Co-founder of Soha, shared five common approaches that DevOps teams follow to secure access to applications deployed in AWS, Azure, etc., and the friction an...
"Alert Logic is a managed security service provider that basically deploys technologies, but we support those technologies with the people and process behind it," stated Stephen Coty, Chief Security Evangelist at Alert Logic, in this SYS-CON.tv interview at 16th Cloud Expo, held June 9-11, 2015, at the Javits Center in New York City.
Digital Transformation is the ultimate goal of cloud computing and related initiatives. The phrase is certainly not a precise one, and as subject to hand-waving and distortion as any high-falutin' terminology in the world of information technology. Yet it is an excellent choice of words to describe what enterprise IT—and by extension, organizations in general—should be working to achieve. Digital Transformation means: handling all the data types being found and created in the organizat...
The essence of cloud computing is that all consumable IT resources are delivered as services. In his session at 15th Cloud Expo, Yung Chou, Technology Evangelist at Microsoft, demonstrated the concepts and implementations of two important cloud computing deliveries: Infrastructure as a Service (IaaS) and Platform as a Service (PaaS). He discussed from business and technical viewpoints what exactly they are, why we care, how they are different and in what ways, and the strategies for IT to tran...
The Internet of Everything (IoE) brings together people, process, data and things to make networked connections more relevant and valuable than ever before – transforming information into knowledge and knowledge into wisdom. IoE creates new capabilities, richer experiences, and unprecedented opportunities to improve business and government operations, decision making and mission support capabilities.
The Software Defined Data Center (SDDC), which enables organizations to seamlessly run in a hybrid cloud model (public + private cloud), is here to stay. IDC estimates that the software-defined networking market will be valued at $3.7 billion by 2016. Security is a key component and benefit of the SDDC, and offers an opportunity to build security 'from the ground up' and weave it into the environment from day one. In his session at 16th Cloud Expo, Reuven Harrison, CTO and Co-Founder of Tufin,...
The Internet of Things is not only adding billions of sensors and billions of terabytes to the Internet. It is also forcing a fundamental change in the way we envision Information Technology. For the first time, more data is being created by devices at the edge of the Internet rather than from centralized systems. What does this mean for today's IT professional? In this Power Panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists addressed this very serious issue of pro...
With SaaS use rampant across organizations, how can IT departments track company data and maintain security? More and more departments are commissioning their own solutions and bypassing IT. A cloud environment is amorphous and powerful, allowing you to set up solutions for all of your user needs: document sharing and collaboration, mobile access, e-mail, even industry-specific applications. In his session at 16th Cloud Expo, Shawn Mills, President and a founder of Green House Data, discussed h...
Container technology is sending shock waves through the world of cloud computing. Heralded as the 'next big thing,' containers provide software owners a consistent way to package their software and dependencies while infrastructure operators benefit from a standard way to deploy and run them. Containers present new challenges for tracking usage due to their dynamic nature. They can also be deployed to bare metal, virtual machines and various cloud platforms. How do software owners track the usag...
"Our biggest growth area has been the security services, the managed services - the things that differentiate us in the market that there is no client that's too small and there's no client that's too big," explained Paul Mazzucco, Chief Security Officer at TierPoint, in this SYS-CON.tv interview at 16th Cloud Expo, held June 9-11, 2015, at the Javits Center in New York City.