Welcome!

News Feed Item

BioLeonhardt to Unveil Stem Cell Pump at Cell Therapy Meeting New York

First implantable pump for timed dosed repeat delivery of stem cells and growth factors

SANTA MONICA, Calif., Jan. 22, 2014 /PRNewswire/ -- BioLeonhardt, a Leonhardt Ventures company based in Los Angeles, will unveil its implantable Stem Cell Pump at the 9th Annual Cell Therapy for Cardiovascular Disease meeting at Columbia University in New York on Thursday, January 23, 2014 at 10:30 am.

BioLeonhardt – Has developed a programmable implantable stem cell infusion pump and electrical stimulator combination for treating advanced heart failure. The stem cell pump is implanted in the patient's abdomen and has a silicone septum which allows re-loading via a micro needle syringe of stem cells, genes, growth factors and nutrient hydrogels.  The pump is attached to a combination coaxial reinforced infusion catheter and electrical conduction lead which has its tip anchored into the patient's damaged heart tissue.  

BioLeonhardt is teamed with Core Manufacturing LLC, an Alfred Mann Companies spin out, that is staffed with members that have a long history developing related devices including the Pacesetter Systems heart pacer sold to Siemens then St. Jude Medical, the MiniMed implantable insulin pump sold to Medtronic and the Advanced Bionics implantable pain relief pumps sold to Boston Scientific - www.core-manufacturing.com

BioLeonhardt intends to bring to market a therapy for heart failure utilizing their own stem cell pump and to offer the pump as well to other researchers with different therapies.

BioLeonhardt's own proposed method to treating heart failure:

1.  Pre-Treat Scar - Micro-RNAs, Nutrient Hydrogel, Growth Factors, Electrical Stimulation, GCSF, endothelial progenitor cells and adipose derived cells.

2.  Treat Scar - Muscle derived cardiac progenitor cells in center of scar, cardiac stem cells or iPS cells at rim edge of scar, temporary implantable circulatory assist pump to allow heart to rest (www.cardiobridge.com or www.procyrion.com).

3.  Post Implantation Scar Maintenance - Repeat injections/infusions + electrical stimulation. 

"For the past 14 years all stem cell related studies have been limited to one single half hour session of injections or infusions.  We believe superior results can be obtained by repeat dosing utilizing our programmable implantable pump. BioLeonhardt is designing a controlled study for heart failure with intent to prove this hypothesis," stated Howard J. Leonhardt, Founder, CEO, BioLeonhardt and lead inventor for the new technology. 

BioLeonhardt has granted an exclusive license for myoblast transplantation with their pump to another Leonhardt founded company Bioheart, Inc. that has been in clinical trials utilizing selected immature myoblasts to treat heart failure since early 2001. Over 400 patients have been enrolled in various myoblast trials worldwide. New myoblast related independent trial results will be presented at the conference this week. 

Electrical stimulation technology for these studies will be provided by MyoStim Pacers - www.myostimpacers.com.  Electrical stimulation has demonstrated an ability to recruit stem cells to injury sites and differentiate them into useful tissues while improving blood flow and thus healing scars, in both pre-clinical and clinical studies for various applications.  

Summary of myoblast transplantation data for heart failure clinical studies:

  • 84% of myoblast treated patients have improved in at least one parameter while only 16% have worsened.  In comparison 69% of control or placebo patients in the same studies have worsened.
  • 33% of MyoCell treated patients have improved by two heart failure classes.
  • Bioheart MyoCell treated patients improved 95.7 meters in exercise capacity over placebo patients that declined 4 meters.   No other cell type has bettered 53 meters.  Allogeneic bone marrow derived cells 10 meters.  CRT Pacers 20 meters.
  • Myoblasts are the only cell composition that has demonstrated an ability to grow new contractile muscle in the center of heart scar tissue.

Pre-clinical studies have confirmed that even superior results can be obtained when the cells are modified to over-express SDF-1 and repeat doses are given over time - http://eurheartj.oxfordjournals.org/content/31/8/1013.full.pdf

Cal-X Stars Business Accelerator, Inc. announced Nov. 18th, 2013 a $15 million capital raise under the new JOBS ACT Title II 506c regulations - http://www.prnewswire.com/news-releases/leonhardt-ventures-cal-x-stars-business-accelerator-raising-15-million-232350001.html

The Leonhardt Ventures' Scientific Advisory Board is made up of leading researchers -http://calxstars.com/scientific-advisory-board/.  Jane Reedy, the former VP of Clinical Affairs & Marketing at HeartWare and former Thoratec executive, and Suresh Gurunathan, Director of Engineering at Nanostim (first leadless pacemaker developed sold to St. Jude in October), have recently joined our advisory team. 

About Leonhardt Ventures:  Since 1982 Leonhardt Ventures has a strong history of inventing, developing, backing and bringing to market leadership products for treating heart and cardiovascular disease. Over 200,000 patients have been treated to date with Leonhardt inventions. Founder Howard Leonhardt holds 21 U.S. patents for treating cardiovascular disease - http://patents.justia.com/inventor/howard-j-leonhardt

About Conference on Cell Therapy for Cardiovascular Disease:  For the past 9 years the Cardiovascular Research Foundation (CRF) and Columbia University hosted conference led by Dr. Warren Sherman has been the premier scientific information exchange forum for this important specialty - http://www.crf.org/celltherapy/the-conference/overview

Contact:  Howard Leonhardt, BioLeonhardt, 1531 6th Street, Unit 401, Santa Monica, California, 90401, Office direct 310 310 2534, Email

This press release distribution was issued via PR Syndication.

RELATED LINKS

http://bioleonhardt.com 

SOURCE BioLeonhardt

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
In 2014, Amazon announced a new form of compute called Lambda. We didn't know it at the time, but this represented a fundamental shift in what we expect from cloud computing. Now, all of the major cloud computing vendors want to take part in this disruptive technology. In his session at 20th Cloud Expo, Doug Vanderweide, an instructor at Linux Academy, discussed why major players like AWS, Microsoft Azure, IBM Bluemix, and Google Cloud Platform are all trying to sidestep VMs and containers wit...
The Internet giants are fully embracing AI. All the services they offer to their customers are aimed at drawing a map of the world with the data they get. The AIs from these companies are used to build disruptive approaches that cannot be used by established enterprises, which are threatened by these disruptions. However, most leaders underestimate the effect this will have on their businesses. In his session at 21st Cloud Expo, Rene Buest, Director Market Research & Technology Evangelism at Ara...
When growing capacity and power in the data center, the architectural trade-offs between server scale-up vs. scale-out continue to be debated. Both approaches are valid: scale-out adds multiple, smaller servers running in a distributed computing model, while scale-up adds fewer, more powerful servers that are capable of running larger workloads. It’s worth noting that there are additional, unique advantages that scale-up architectures offer. One big advantage is large memory and compute capacity...
"We are a monitoring company. We work with Salesforce, BBC, and quite a few other big logos. We basically provide monitoring for them, structure for their cloud services and we fit into the DevOps world" explained David Gildeh, Co-founder and CEO of Outlyer, in this SYS-CON.tv interview at DevOps Summit at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
SYS-CON Events announced today that IBM has been named “Diamond Sponsor” of SYS-CON's 21st Cloud Expo, which will take place on October 31 through November 2nd 2017 at the Santa Clara Convention Center in Santa Clara, California.
A look across the tech landscape at the disruptive technologies that are increasing in prominence and speculate as to which will be most impactful for communications – namely, AI and Cloud Computing. In his session at 20th Cloud Expo, Curtis Peterson, VP of Operations at RingCentral, highlighted the current challenges of these transformative technologies and shared strategies for preparing your organization for these changes. This “view from the top” outlined the latest trends and developments i...
"Loom is applying artificial intelligence and machine learning into the entire log analysis process, from start to finish and at the end you will get a human touch,” explained Sabo Taylor Diab, Vice President, Marketing at Loom Systems, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
In his session at @ThingsExpo, Eric Lachapelle, CEO of the Professional Evaluation and Certification Board (PECB), provided an overview of various initiatives to certify the security of connected devices and future trends in ensuring public trust of IoT. Eric Lachapelle is the Chief Executive Officer of the Professional Evaluation and Certification Board (PECB), an international certification body. His role is to help companies and individuals to achieve professional, accredited and worldwide re...
With major technology companies and startups seriously embracing Cloud strategies, now is the perfect time to attend 21st Cloud Expo October 31 - November 2, 2017, at the Santa Clara Convention Center, CA, and June 12-14, 2018, at the Javits Center in New York City, NY, and learn what is going on, contribute to the discussions, and ensure that your enterprise is on the right path to Digital Transformation.
@DevOpsSummit at Cloud Expo taking place Oct 31 - Nov 2, 2017, at the Santa Clara Convention Center, Santa Clara, CA, is co-located with the 21st International Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is ...
New competitors, disruptive technologies, and growing expectations are pushing every business to both adopt and deliver new digital services. This ‘Digital Transformation’ demands rapid delivery and continuous iteration of new competitive services via multiple channels, which in turn demands new service delivery techniques – including DevOps. In this power panel at @DevOpsSummit 20th Cloud Expo, moderated by DevOps Conference Co-Chair Andi Mann, panelists examined how DevOps helps to meet the de...
Automation is enabling enterprises to design, deploy, and manage more complex, hybrid cloud environments. Yet the people who manage these environments must be trained in and understanding these environments better than ever before. A new era of analytics and cognitive computing is adding intelligence, but also more complexity, to these cloud environments. How smart is your cloud? How smart should it be? In this power panel at 20th Cloud Expo, moderated by Conference Chair Roger Strukhoff, pane...
No hype cycles or predictions of zillions of things here. IoT is big. You get it. You know your business and have great ideas for a business transformation strategy. What comes next? Time to make it happen. In his session at @ThingsExpo, Jay Mason, Associate Partner at M&S Consulting, presented a step-by-step plan to develop your technology implementation strategy. He discussed the evaluation of communication standards and IoT messaging protocols, data analytics considerations, edge-to-cloud tec...
What's the role of an IT self-service portal when you get to continuous delivery and Infrastructure as Code? This general session showed how to create the continuous delivery culture and eight accelerators for leading the change. Don Demcsak is a DevOps and Cloud Native Modernization Principal for Dell EMC based out of New Jersey. He is a former, long time, Microsoft Most Valuable Professional, specializing in building and architecting Application Delivery Pipelines for hybrid legacy, and cloud ...
Amazon started as an online bookseller 20 years ago. Since then, it has evolved into a technology juggernaut that has disrupted multiple markets and industries and touches many aspects of our lives. It is a relentless technology and business model innovator driving disruption throughout numerous ecosystems. Amazon’s AWS revenues alone are approaching $16B a year making it one of the largest IT companies in the world. With dominant offerings in Cloud, IoT, eCommerce, Big Data, AI, Digital Assista...