Welcome!

News Feed Item

Greater Reduction in Pain Intensity and a Greater Patient Responder Rate are the Top Two Areas of Unmet Need in the Treatment of Painful Diabetic Neuropathy

Several Emerging Therapies are Poised to Provide Improvements in Safety and Tolerability and/or Delivery, According to Findings from Decision Resources Group

BURLINGTON, Mass., Feb. 6, 2014 /PRNewswire/ -- Decision Resources Group finds that greater reduction in pain intensity and a greater patient responder rate (measured by the percentage of patients reporting at least 30 percent or at least 50 percent reduction in pain intensity from baseline) are the top two areas of unmet need in painful diabetic neuropathy (PDN) treatment. Additionally, because PDN is a chronic pain condition that requires prolonged treatment, maintenance of pain relief over the long-term is critical but often difficult to achieve with current treatments. Novel pain therapies able to address these needs would be well-positioned for both favorable formulary inclusion and physician uptake.

(Logo:  http://photos.prnewswire.com/prnh/20130103/MM36768LOGO)

Other key findings from the DecisionBase report entitled Painful Diabetic Neuropathy: In an Increasingly Generic Market, Replete with Well-Established Oral Therapies, What Drug Development Opportunities Remain?:

  • Several emerging therapies poised to enter the PDN market have the potential to provide improvements in safety and tolerability and/or delivery. Most notably, Acorda Therapeutics' capsaicin topical solution offers a reduced risk for systemic side effects such as dizziness and nausea that plague oral therapies and has competitive advantages in delivery, if pivotal Phase III data support that the agent's five-minute application time provides three-month analgesic efficacy.
  • Surveyed U.S. managed care organization pharmacy directors are receptive to new PDN therapies that offer substantial improvements over current therapies with regard to the percentage of patients responding to treatment and the percentage of patients reporting global improvement. However, the level of expected clinical improvement is unlikely to be met by late-stage emerging therapies in development for PDN.
  • Surveyed U.S. neurologists expect to prescribe Pfizer's Lyrica CR (pregabalin controlled-release) to 20 percent of their PDN patients. Additionally, Decision Resources Group's analysis for PDN indicates a high prescribing likelihood among surveyed U.S. neurologists for a target product profile similar to that of Lyrica CR.

Comments from Decision Resources Group Analyst Andrea Buurma:

  • "Broadly speaking, current neuropathic pain therapies are, at best, able to achieve 50 percent pain relief in 50 percent of patients. And since no one therapy can completely alleviate the pain associated with PDN, greater analgesic efficacy continues to be a key area of unmet need and is a focus for product differentiation in PDN as well as the broader neuropathic pain market."
  • "Unfortunately, clinical trial data and the opinions of interviewed experts suggest that no near-term emerging therapies are expected to offer greater analgesic efficacy than current first-line treatments. Instead, drug-development efforts to date have been targeted towards improvements in tolerability and/or delivery."

About Decision Resources Group
Decision Resources Group is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources Group at www.DecisionResourcesGroup.com.

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.

For more information, contact:

Decision Resources Group
Christopher Comfort
781-993-2597
[email protected]

SOURCE Decision Resources Group

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
“We're a global managed hosting provider. Our core customer set is a U.S.-based customer that is looking to go global,” explained Adam Rogers, Managing Director at ANEXIA, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
"We've discovered that after shows 80% if leads that people get, 80% of the conversations end up on the show floor, meaning people forget about it, people forget who they talk to, people forget that there are actual business opportunities to be had here so we try to help out and keep the conversations going," explained Jeff Mesnik, Founder and President of ContentMX, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
DevOps at Cloud Expo – being held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA – announces that its Call for Papers is open. Born out of proven success in agile development, cloud computing, and process automation, DevOps is a macro trend you cannot afford to miss. From showcase success stories from early adopters and web-scale businesses, DevOps is expanding to organizations of all sizes, including the world's largest enterprises – and delivering real results. Am...
SYS-CON Events announced today that Isomorphic Software will exhibit at DevOps Summit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Isomorphic Software provides the SmartClient HTML5/AJAX platform, the most advanced technology for building rich, cutting-edge enterprise web applications for desktop and mobile. SmartClient combines the productivity and performance of traditional desktop software with the simp...
"When you think about the data center today, there's constant evolution, The evolution of the data center and the needs of the consumer of technology change, and they change constantly," stated Matt Kalmenson, VP of Sales, Service and Cloud Providers at Veeam Software, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
As organizations shift towards IT-as-a-service models, the need for managing and protecting data residing across physical, virtual, and now cloud environments grows with it. Commvault can ensure protection, access and E-Discovery of your data – whether in a private cloud, a Service Provider delivered public cloud, or a hybrid cloud environment – across the heterogeneous enterprise. In his general session at 18th Cloud Expo, Randy De Meno, Chief Technologist - Windows Products and Microsoft Part...
Internet of @ThingsExpo has announced today that Chris Matthieu has been named tech chair of Internet of @ThingsExpo 2016 Silicon Valley. The 6thInternet of @ThingsExpo will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
When people aren’t talking about VMs and containers, they’re talking about serverless architecture. Serverless is about no maintenance. It means you are not worried about low-level infrastructural and operational details. An event-driven serverless platform is a great use case for IoT. In his session at @ThingsExpo, Animesh Singh, an STSM and Lead for IBM Cloud Platform and Infrastructure, will detail how to build a distributed serverless, polyglot, microservices framework using open source tec...
The 19th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportuni...
"We're bringing out a new application monitoring system to the DevOps space. It manages large enterprise applications that are distributed throughout a node in many enterprises and we manage them as one collective," explained Kevin Barnes, President of eCube Systems, in this SYS-CON.tv interview at DevOps at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
“Being the one true cloud-agnostic and storage-agnostic software solution, more and more customers are coming to Commvault and saying ' What do you recommend? What's your best practice for implementing cloud?” explained Randy De Meno, Chief Technologist at Commvault, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Let’s face it, embracing new storage technologies, capabilities and upgrading to new hardware often adds complexity and increases costs. In his session at 18th Cloud Expo, Seth Oxenhorn, Vice President of Business Development & Alliances at FalconStor, discussed how a truly heterogeneous software-defined storage approach can add value to legacy platforms and heterogeneous environments. The result reduces complexity, significantly lowers cost, and provides IT organizations with improved efficienc...
From wearable activity trackers to fantasy e-sports, data and technology are transforming the way athletes train for the game and fans engage with their teams. In his session at @ThingsExpo, will present key data findings from leading sports organizations San Francisco 49ers, Orlando Magic NBA team. By utilizing data analytics these sports orgs have recognized new revenue streams, doubled its fan base and streamlined costs at its stadiums. John Paul is the CEO and Founder of VenueNext. Prior ...
Continuous testing helps bridge the gap between developing quickly and maintaining high quality products. But to implement continuous testing, CTOs must take a strategic approach to building a testing infrastructure and toolset that empowers their team to move fast. Download our guide to laying the groundwork for a scalable continuous testing strategy.
A critical component of any IoT project is what to do with all the data being generated. This data needs to be captured, processed, structured, and stored in a way to facilitate different kinds of queries. Traditional data warehouse and analytical systems are mature technologies that can be used to handle certain kinds of queries, but they are not always well suited to many problems, particularly when there is a need for real-time insights.