Welcome!

News Feed Item

Greater Reduction in Pain Intensity and a Greater Patient Responder Rate are the Top Two Areas of Unmet Need in the Treatment of Painful Diabetic Neuropathy

Several Emerging Therapies are Poised to Provide Improvements in Safety and Tolerability and/or Delivery, According to Findings from Decision Resources Group

BURLINGTON, Mass., Feb. 6, 2014 /PRNewswire/ -- Decision Resources Group finds that greater reduction in pain intensity and a greater patient responder rate (measured by the percentage of patients reporting at least 30 percent or at least 50 percent reduction in pain intensity from baseline) are the top two areas of unmet need in painful diabetic neuropathy (PDN) treatment. Additionally, because PDN is a chronic pain condition that requires prolonged treatment, maintenance of pain relief over the long-term is critical but often difficult to achieve with current treatments. Novel pain therapies able to address these needs would be well-positioned for both favorable formulary inclusion and physician uptake.

(Logo:  http://photos.prnewswire.com/prnh/20130103/MM36768LOGO)

Other key findings from the DecisionBase report entitled Painful Diabetic Neuropathy: In an Increasingly Generic Market, Replete with Well-Established Oral Therapies, What Drug Development Opportunities Remain?:

  • Several emerging therapies poised to enter the PDN market have the potential to provide improvements in safety and tolerability and/or delivery. Most notably, Acorda Therapeutics' capsaicin topical solution offers a reduced risk for systemic side effects such as dizziness and nausea that plague oral therapies and has competitive advantages in delivery, if pivotal Phase III data support that the agent's five-minute application time provides three-month analgesic efficacy.
  • Surveyed U.S. managed care organization pharmacy directors are receptive to new PDN therapies that offer substantial improvements over current therapies with regard to the percentage of patients responding to treatment and the percentage of patients reporting global improvement. However, the level of expected clinical improvement is unlikely to be met by late-stage emerging therapies in development for PDN.
  • Surveyed U.S. neurologists expect to prescribe Pfizer's Lyrica CR (pregabalin controlled-release) to 20 percent of their PDN patients. Additionally, Decision Resources Group's analysis for PDN indicates a high prescribing likelihood among surveyed U.S. neurologists for a target product profile similar to that of Lyrica CR.

Comments from Decision Resources Group Analyst Andrea Buurma:

  • "Broadly speaking, current neuropathic pain therapies are, at best, able to achieve 50 percent pain relief in 50 percent of patients. And since no one therapy can completely alleviate the pain associated with PDN, greater analgesic efficacy continues to be a key area of unmet need and is a focus for product differentiation in PDN as well as the broader neuropathic pain market."
  • "Unfortunately, clinical trial data and the opinions of interviewed experts suggest that no near-term emerging therapies are expected to offer greater analgesic efficacy than current first-line treatments. Instead, drug-development efforts to date have been targeted towards improvements in tolerability and/or delivery."

About Decision Resources Group
Decision Resources Group is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources Group at www.DecisionResourcesGroup.com.

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.

For more information, contact:

Decision Resources Group
Christopher Comfort
781-993-2597
[email protected]

SOURCE Decision Resources Group

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
You think you know what’s in your data. But do you? Most organizations are now aware of the business intelligence represented by their data. Data science stands to take this to a level you never thought of – literally. The techniques of data science, when used with the capabilities of Big Data technologies, can make connections you had not yet imagined, helping you discover new insights and ask new questions of your data. In his session at @ThingsExpo, Sarbjit Sarkaria, data science team lead ...
The IoT has the potential to create a renaissance of manufacturing in the US and elsewhere. In his session at 18th Cloud Expo, Florent Solt, CTO and chief architect of Netvibes, will discuss how the expected exponential increase in the amount of data that will be processed, transported, stored, and accessed means there will be a huge demand for smart technologies to deliver it. Florent Solt is the CTO and chief architect of Netvibes. Prior to joining Netvibes in 2007, he co-founded Rift Technol...
If there is anything we have learned by now, is that every business paves their own unique path for releasing software- every pipeline, implementation and practices are a bit different, and DevOps comes in all shapes and sizes. Software delivery practices are often comprised of set of several complementing (or even competing) methodologies – such as leveraging Agile, DevOps and even a mix of ITIL, to create the combination that’s most suitable for your organization and that maximize your busines...
Struggling to keep up with increasing application demand? Learn how Platform as a Service (PaaS) can streamline application development processes and make resource management easy.
New Relic, Inc. has announced a set of new features across the New Relic Software Analytics Cloud that offer IT operations teams increased visibility, and the ability to diagnose and resolve performance problems quickly. The new features further IT operations teams’ ability to leverage data and analytics, as well as drive collaboration and a common, shared understanding between teams. Software teams are under pressure to resolve performance issues quickly and improve availability, as the comple...
The proper isolation of resources is essential for multi-tenant environments. The traditional approach to isolate resources is, however, rather heavyweight. In his session at 18th Cloud Expo, Igor Drobiazko, co-founder of elastic.io, will draw upon their own experience with operating a Docker container-based infrastructure on a large scale and present a lightweight solution for resource isolation using microservices. He will also discuss the implementation of microservices in data and applicat...
Join IBM June 8 at 18th Cloud Expo at the Javits Center in New York City, NY, and learn how to innovate like a startup and scale for the enterprise. You need to deliver quality applications faster and cheaper, attract and retain customers with an engaging experience across devices, and seamlessly integrate your enterprise systems. And you can't take 12 months to do it.
See storage differently! Storage performance problems have only gotten worse and harder to solve as applications have become largely virtualized and moved to a cloud-based infrastructure. Storage performance in a virtualized environment is not just about IOPS, it is about how well that potential performance is guaranteed to individual VMs for these apps as the number of VMs keep going up real time. In his session at 18th Cloud Expo, Dhiraj Sehgal, in product and marketing at Tintri, will discu...
Machine Learning helps make complex systems more efficient. By applying advanced Machine Learning techniques such as Cognitive Fingerprinting, wind project operators can utilize these tools to learn from collected data, detect regular patterns, and optimize their own operations. In his session at 18th Cloud Expo, Stuart Gillen, Director of Business Development at SparkCognition, will discuss how research has demonstrated the value of Machine Learning in delivering next generation analytics to im...
This is not a small hotel event. It is also not a big vendor party where politicians and entertainers are more important than real content. This is Cloud Expo, the world's longest-running conference and exhibition focused on Cloud Computing and all that it entails. If you want serious presentations and valuable insight about Cloud Computing for three straight days, then register now for Cloud Expo.
As you respond to increasing requests for new analytics, you need fast and flexible technology in your arsenal so that you can deploy the right workload to the right platform for the need at hand. Do you need self-service and fast time to value? Do you have data and application control and privacy needs, along with strict SLAs to meet? IBM dashDB™ is data warehouse technology powered by in-memory computing and in-database analytics that are designed for fast results, scalability and more.
SYS-CON Events announced today that SoftLayer, an IBM Company, has been named “Gold Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. SoftLayer, an IBM Company, provides cloud infrastructure as a service from a growing number of data centers and network points of presence around the world. SoftLayer’s customers range from Web startups to global enterprises.
So, you bought into the current machine learning craze and went on to collect millions/billions of records from this promising new data source. Now, what do you do with them? Too often, the abundance of data quickly turns into an abundance of problems. How do you extract that "magic essence" from your data without falling into the common pitfalls? In her session at @ThingsExpo, Natalia Ponomareva, Software Engineer at Google, will provide tips on how to be successful in large scale machine lear...
Up until last year, enterprises that were looking into cloud services usually undertook a long-term pilot with one of the large cloud providers, running test and dev workloads in the cloud. With cloud’s transition to mainstream adoption in 2015, and with enterprises migrating more and more workloads into the cloud and in between public and private environments, the single-provider approach must be revisited. In his session at 18th Cloud Expo, Yoav Mor, multi-cloud solution evangelist at Cloudy...
IoT device adoption is growing at staggering rates, and with it comes opportunity for developers to meet consumer demand for an ever more connected world. Wireless communication is the key part of the encompassing components of any IoT device. Wireless connectivity enhances the device utility at the expense of ease of use and deployment challenges. Since connectivity is fundamental for IoT device development, engineers must understand how to overcome the hurdles inherent in incorporating multipl...