|By PR Newswire||
|February 12, 2014 02:00 AM EST||
MARCO ISLAND, Florida and HILDEN, Germany, February 12, 2014 /PRNewswire/ --
- Significant expansion of 'universal' portfolio compatible with any NGS system includes several novel sample preparation products as well as solutions for clinical use
- New bioinformatics solutions, including CLC Cancer Research Workbench and Ingenuity Clinical will accelerate analysis and interpretation of NGS data
QIAGEN N.V. (NASDAQ: QGEN; Frankfurt Prime Standard: QIA) today announced the launch plans of several novel products designed to significantly reduce the challenges of the most significant bottlenecks in next-generation sequencing (NGS): sample preparation and bioinformatics. The solutions will enable NGS users to generate more valuable insights from any sample. The new products add to QIAGEN's rapidly expanding portfolio of 'universal' solutions designed to run with any NGS platform, including QIAGEN's GeneReader™ platform, which is being prepared for launch in 2014. Several of QIAGEN's new NGS products will be introduced to genomics researchers this week at the 15th annual Advances in Genome Biology and Technology (AGBT) meeting in Marco Island, Florida.
A recent survey of more than 900 participants published on ngsperspectives.com points out that access to clinical samples (23 percent) and analysis of complex NGS data (26 percent) are seen as the biggest bottlenecks among NGS users. QIAGEN is targeting exactly these challenges with a product development strategy that builds on the company's recognized leadership in bioinformatics and sample preparation (sample technologies, enrichment and library preparation) and will be available to all NGS users as universal workflow products.
"By solving these user challenges, QIAGEN is building very robust NGS workflows for routine use in clinical applications and clinical research. Universal products support any NGS platform - with capabilities to allow the processing of even the most difficult samples and to seamlessly integrate the analysis and interpretation of sequencing data," said Peer M. Schatz, Chief Executive Officer of QIAGEN. "Our leading capabilities in sample and assay technologies provide new dimensions of quality for sample collection and isolation and for what is known in NGS workflows as sample preparation (enrichment and library preparation). In addition, our newly created leading position in bioinformatics can significantly improve the performance of all major platforms and also tie into QIAGEN's integrated sample-to-insight GeneReader™ NGS workflow, which is progressing in development."
At the AGBT meeting, QIAGEN will present a luncheon seminar on Saturday, February 15, featuring leading scientists discussing their use of QIAGEN NGS sample technologies, GeneRead custom panels, and Ingenuity and CLC bioinformatics products to enhance their workflows.
Improving Sample Access
Gaining access to adequate amounts of high-quality sample material often is a challenge to all NGS applications. As the industry's leader in innovative sample technologies for collection, stabilization, isolation, purification and storage of samples, QIAGEN has created several new products designed specifically to help NGS users deal with difficult-to-handle samples, including:
- GeneRead DNA FFPE Kit provides a streamlined, easy-to-use procedure for efficient purification of DNA from formalin-fixed, paraffin-embedded (FFPE) tissue sections. Formalin treatment and storage introduce cytosine deamination, which leads to DNA sequence changes and potentially wrong data interpretation. An enzymatic step in the procedure eliminates these molecules from further analysis and reduces those effects significantly. QIAGEN has already shown dramatic improvements of data quality in several studies and will be sharing further data. Additionally the new GeneRead kit enables an increase of DNA yield. The GeneRead DNA FFPE Kit is now available.
- REPLI-g®WTA Single Cell Kit and REPLI-g®Cell WGA & WTA Kit enable transcriptomic NGS analysis from single cells and comparative genomic and transcriptomic analysis from the same small sample. Both kits expand the REPLI-g single cell kit portfolio, which can make single cells accessible to NGS analysis by amplifying either DNA or RNA from individual cells. Using QIAGEN´s proprietary MDA with the new SensiPhi polymerase (1,000-fold higher accuracy than Taq polymerase), the amplified nucleic acids show comparable performance to the original molecules, which allows users to perform multiple experiments from a single cell reliably and reproducibly. The REPLI-G WTA Single Cell Kit and the REPLI-g Cell WGA & WTA Kit are now available.
- Exosome sample-preparation kits enable processing of nucleic acids from exosomes, tiny messenger packages in a biological communication system that transmits genetic instructions from cell to cell. The kits will combine QIAGEN's proven sample technologies with technology developed by Exosome Diagnostics Inc. that allows non-invasive detection of key gene mutations and gene expressions in blood, urine and cerebrospinal fluid without the need for a risky and burdensome surgical tissue biopsy. The first kits will be launched in the second quarter of 2014.
Enhancing Variant Identification
QIAGEN also announced plans to launch a line of GeneRead DNAseq panels V2.0 in the second quarter of 2014. This second-generation line of products provides an easy-to-use, highly sensitive and specific PCR-based target enrichment approach compatible with any NGS platform. The 14 new gene panels target a broad range of relevant genetic variants for clinical research.
The GeneRead DNAseq panel V2.0 provides the most extensive collection of wet-bench verified catalog gene panels, covering actionable cancer mutations, clinically-relevant tumor mutations, tissue-specific cancers, comprehensive cancer, cancer predisposition, comprehensive carrier testing, and cardiomyopathy. Researchers also can design customized panels to meet their specific needs.
GeneRead DNAseq panels use as little as 10 ng of starting DNA material, generate small amplicons (~150 bp), and enable preparation of NGS libraries ready for sequencing within one day, making these products an ideal approach for sequencing FFPE samples in clinical research with any NGS sequencer. The panels are further supported by launch of the GeneRead DNAseq V2 chemistry, which along with the panels offers enhanced NGS performance metrics in terms of uniformity and specificity.
Demonstrating Bioinformatics Leadership
QIAGEN also announced important new additions to its leading position in the emerging market for bioinformatics solutions for analysis and interpretation of NGS data in clinical research. Building on its acquisitions of Ingenuity and CLC bio in 2013, QIAGEN is helping a broad range of NGS customers achieve valuable insights from their sequencing data. QIAGEN is discussing these new products at the AGBT meeting:
- CLC Cancer Research Workbench is the world's first comprehensive, user-friendly and customizable cancer-focused bioinformatics solution. Expected to launch in April 2014, it offers flexible, cancer-specific, ready-to-use analysis workflows that can be modified or personalized by the user. Advanced resequencing tools, in combination with an intuitive graphical user interface, allow rapid analysis and accurate interpretation of advanced NGS data.
CLC Cancer Research Workbench provides scientists and clinicians with the tools to identify prognostic markers, identify subclonal somatic mutations, detect inherited traits, find biomarkers for drug response, and determine new oncogenes. The software also enables all results to be filtered, visualized, and compared with relevant databases.
- Ingenuity® Clinical is a new web-based solution designed to deliver faster, easier-to-use and high-confidence clinical interpretation and reporting of insights from NGS-based tests. QIAGEN began collaborating with molecular diagnostics laboratories in the development of this exciting new product in November 2013, and announced plans for a 2014 launch of a larger beta program for Ingenuity Clinical. Collaborators providing important input include several commercial and academic testing laboratories: More than 20 clinical testing laboratories are currently participating in the Ingenuity Clinical early access program. Test indications supported have expanded from hereditary/germline to somatic NGS panels including hereditary cancer, somatic cancer, carrier screening, cardiovascular and neurological test indications.
Drawing upon the vast clinical and genomic data in the expert-curated Ingenuity Knowledge Base, Ingenuity Clinical will be the first product specifically designed to address challenges of scale, speed and decision support that healthcare laboratories face in the adoption of NGS. The time required to make accurate clinical assessments - especially as tests move from single-gene to multiple-gene to panels, exomes and whole genomes - is becoming a fundamental bottleneck and is slowing the clinical adoption of NGS. The new solution will provide clinical labs with automated scoring, interpretation and reporting of findings in standardized, HIPAA Safe Harbor-compliant formats.
- Ingenuity® Variant Analysis™ adoption rates continue to accelerate at leading institutions around the world, based on its broad utility and benefit in analyzing and interpreting human sequencing data. Since the AGBT meeting two years ago more than 200,000 samples have been uploaded into Ingenuity Variant Analysis by more than 2,000 users, including more than 600 institutions and drug discovery companies engaged in all stages of basic, translational and clinical research - making Ingenuity Variant Analysis by far the solution of choice for NGS data interpretation.
These NGS products are all part of QIAGEN's portfolio of universal solutions, compatible with any next-generation sequencer and adding value to any NGS workflow.
QIAGEN also is developing the benchtop GeneReader™ NGS platform for clinical research applications. Combined with QIAGEN's other NGS products, it will provide the first seamless automated workflow from biological sample, through DNA preparation, enrichment, library preparation, sequencing, data analysis and interpretation, to deliver valuable insights into diseases. Commercialization is planned for 2014.
For more information on QIAGEN's NGS products and resources, please visit http://www.qiagen.com/goto/NGS.
QIAGEN N.V., a Netherlands holding company, is the leading global provider of Sample & Assay Technologies that are used to transform biological materials into valuable molecular information. Sample technologies are used to isolate and process DNA, RNA and proteins from biological samples such as blood or tissue. Assay technologies are then used to make these isolated biomolecules visible and ready for interpretation. QIAGEN markets more than 500 products around the world, selling both consumable kits and automation systems to customers through four customer classes: Molecular Diagnostics (human healthcare), Applied Testing (forensics, veterinary testing and food safety), Pharma (pharmaceutical and biotechnology companies) and Academia (life sciences research). As of December 31, 2013, QIAGEN employed approximately 4,000 people in more than 35 locations worldwide. Further information can be found at http://www.QIAGEN.com/.
Certain of the statements contained in this news release may be considered forward-looking statements within the meaning of Section 27A of the U.S. Securities Act of 1933, as amended, and Section 21E of the U.S. Securities Exchange Act of 1934, as amended. To the extent that any of the statements contained herein relating to QIAGEN's products, markets, strategy or operating results, including without limitation its expected operating results, are forward-looking, such statements are based on current expectations and assumptions that involve a number of uncertainties and risks. Such uncertainties and risks include, but are not limited to, risks associated with management of growth and international operations (including the effects of currency fluctuations, regulatory processes and dependence on logistics), variability of operating results and allocations between customer classes, the commercial development of markets for our products inapplied testing, personalized healthcare, clinical research,proteomics, women's health/HPVtesting andnucleic acid-basedmolecular diagnostics; changing relationships with customers, suppliers and strategic partners; competition; rapid or unexpected changes in technologies; fluctuations in demand for QIAGEN's products (including fluctuations due to general economic conditions, the level and timing of customers' funding, budgets and other factors); our ability to obtain regulatory approval of our products; difficulties in successfully adapting QIAGEN's products to integrated solutions and producing such products; the ability of QIAGEN to identify and develop new products and to differentiate and protect our products from competitors' products; market acceptance of QIAGEN's new products, the consummation of acquisitions, and the integration of acquired technologies and businesses. For further information, please refer to the discussions in reports that QIAGEN has filed with, or furnished to, the U.S. Securities and Exchange Commission (SEC).
Data is an unusual currency; it is not restricted by the same transactional limitations as money or people. In fact, the more that you leverage your data across multiple business use cases, the more valuable it becomes to the organization. And the same can be said about the organization’s analytics. In his session at 19th Cloud Expo, Bill Schmarzo, CTO for the Big Data Practice at EMC, will introduce a methodology for capturing, enriching and sharing data (and analytics) across the organizati...
Aug. 30, 2016 09:08 AM EDT
Enterprises have forever faced challenges surrounding the sharing of their intellectual property. Emerging cloud adoption has made it more compelling for enterprises to digitize their content, making them available over a wide variety of devices across the Internet. In his session at 19th Cloud Expo, Santosh Ahuja, Director of Architecture at Impiger Technologies, will introduce various mechanisms provided by cloud service providers today to manage and share digital content in a secure manner....
Aug. 30, 2016 08:45 AM EDT Reads: 900
SYS-CON Events announced today that Isomorphic Software will exhibit at DevOps Summit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Isomorphic Software provides the SmartClient HTML5/AJAX platform, the most advanced technology for building rich, cutting-edge enterprise web applications for desktop and mobile. SmartClient combines the productivity and performance of traditional desktop software with the simp...
Aug. 30, 2016 05:45 AM EDT Reads: 2,459
Why do your mobile transformations need to happen today? Mobile is the strategy that enterprise transformation centers on to drive customer engagement. In his general session at @ThingsExpo, Roger Woods, Director, Mobile Product & Strategy – Adobe Marketing Cloud, covered key IoT and mobile trends that are forcing mobile transformation, key components of a solid mobile strategy and explored how brands are effectively driving mobile change throughout the enterprise.
Aug. 30, 2016 03:45 AM EDT Reads: 500
With so much going on in this space you could be forgiven for thinking you were always working with yesterday’s technologies. So much change, so quickly. What do you do if you have to build a solution from the ground up that is expected to live in the field for at least 5-10 years? This is the challenge we faced when we looked to refresh our existing 10-year-old custom hardware stack to measure the fullness of trash cans and compactors.
Aug. 30, 2016 02:30 AM EDT Reads: 1,859
The emerging Internet of Everything creates tremendous new opportunities for customer engagement and business model innovation. However, enterprises must overcome a number of critical challenges to bring these new solutions to market. In his session at @ThingsExpo, Michael Martin, CTO/CIO at nfrastructure, outlined these key challenges and recommended approaches for overcoming them to achieve speed and agility in the design, development and implementation of Internet of Everything solutions wi...
Aug. 30, 2016 02:00 AM EDT Reads: 2,244
Cloud computing is being adopted in one form or another by 94% of enterprises today. Tens of billions of new devices are being connected to The Internet of Things. And Big Data is driving this bus. An exponential increase is expected in the amount of information being processed, managed, analyzed, and acted upon by enterprise IT. This amazing is not part of some distant future - it is happening today. One report shows a 650% increase in enterprise data by 2020. Other estimates are even higher....
Aug. 30, 2016 01:30 AM EDT Reads: 3,051
With over 720 million Internet users and 40–50% CAGR, the Chinese Cloud Computing market has been booming. When talking about cloud computing, what are the Chinese users of cloud thinking about? What is the most powerful force that can push them to make the buying decision? How to tap into them? In his session at 18th Cloud Expo, Yu Hao, CEO and co-founder of SpeedyCloud, answered these questions and discussed the results of SpeedyCloud’s survey.
Aug. 30, 2016 01:15 AM EDT Reads: 2,356
Today we can collect lots and lots of performance data. We build beautiful dashboards and even have fancy query languages to access and transform the data. Still performance data is a secret language only a couple of people understand. The more business becomes digital the more stakeholders are interested in this data including how it relates to business. Some of these people have never used a monitoring tool before. They have a question on their mind like “How is my application doing” but no id...
Aug. 30, 2016 01:00 AM EDT Reads: 1,940
Smart Cities are here to stay, but for their promise to be delivered, the data they produce must not be put in new siloes. In his session at @ThingsExpo, Mathias Herberts, Co-founder and CTO of Cityzen Data, will deep dive into best practices that will ensure a successful smart city journey.
Aug. 30, 2016 12:00 AM EDT Reads: 1,674
DevOps at Cloud Expo, taking place Nov 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 19th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is no time to wait for long dev...
Aug. 29, 2016 10:00 PM EDT Reads: 2,494
Identity is in everything and customers are looking to their providers to ensure the security of their identities, transactions and data. With the increased reliance on cloud-based services, service providers must build security and trust into their offerings, adding value to customers and improving the user experience. Making identity, security and privacy easy for customers provides a unique advantage over the competition.
Aug. 29, 2016 08:30 PM EDT Reads: 2,451
Qosmos has announced new milestones in the detection of encrypted traffic and in protocol signature coverage. Qosmos latest software can accurately classify traffic encrypted with SSL/TLS (e.g., Google, Facebook, WhatsApp), P2P traffic (e.g., BitTorrent, MuTorrent, Vuze), and Skype, while preserving the privacy of communication content. These new classification techniques mean that traffic optimization, policy enforcement, and user experience are largely unaffected by encryption. In respect wit...
Aug. 29, 2016 08:15 PM EDT Reads: 1,880
SYS-CON Events announced today that StarNet Communications will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. StarNet Communications’ FastX is the industry first cloud-based remote X Windows emulator. Using standard Web browsers (FireFox, Chrome, Safari, etc.) users from around the world gain highly secure access to applications and data hosted on Linux-based servers in a central data center. ...
Aug. 29, 2016 08:00 PM EDT Reads: 928
SYS-CON Events announced today that 910Telecom will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Housed in the classic Denver Gas & Electric Building, 910 15th St., 910Telecom is a carrier-neutral telecom hotel located in the heart of Denver. Adjacent to CenturyLink, AT&T, and Denver Main, 910Telecom offers connectivity to all major carriers, Internet service providers, Internet backbones and ...
Aug. 29, 2016 07:00 PM EDT Reads: 1,987