|By PR Newswire||
|February 12, 2014 04:31 PM EST||
REDWOOD CITY, Calif., Feb. 12, 2014 /PRNewswire/ -- Guardant Health TM today announced the commercial availability of GUARDANT360TM, the first pan-cancer blood test that helps oncologists prescribe the right treatments at the right time based on the changing genetics of a patient's cancer. Guardant also announced that last year it partnered with Sequoia Capital and raised $10 million to accelerate development of the technology behind the test.
"The introduction of GUARDANT360 opens a new front in the war on cancer," said Helmy Eltoukhy, Ph.D., Guardant Health's co-founder and chief executive officer. "Patients and their oncologists can now non-invasively track cancer genetically before, during and after treatment. This is particularly helpful because until now we have been blind to the way cancer evolves in response to treatment. The ability to see these changes can lead to significantly more effective treatments."
Current treatment often requires surgery to retrieve biopsies for genetic analysis. Biopsies are risky, costly and do not capture genetic changes that may emerge over time or in response to several cycles of therapy. In contrast, GUARDANT360's non-invasive blood test makes it much easier for physicians to more frequently obtain genetic information crucial to treating successfully a patient's cancer. The test is now available to select cancer centers across the United States.
GUARDANT360 works by reconstructing the relevant portions of a patient's cancer genome using trace fragments of tumor DNA that are shed into the bloodstream ("cell-free DNA"). Unfortunately, these fragments are typically found at exceedingly low concentrations (around one part in 200), and current DNA sequencing technologies can only reliably detect at one part in 20. Guardant's breakthrough "Digital Sequencing," technology enables high-fidelity, single-molecule DNA sequencing and improves detection sensitivity well over 100-fold.
"GUARDANT360 is built on a unique technology platform that is able to comprehensively detect all major classes of tumor genetic alterations with unprecedented sensitivity," said AmirAli Talasaz, co-founder and president at Guardant Health. "This technology is the first of its kind and empowers oncologists to discover many novel genetic aspects of why cancer treatments fail, and to combat these failures through existing drugs that are often overlooked."
Recent clinical studies with GUARDANT360 have shown excellent performance in the top five cancers (breast, lung, colorectal, skin and prostate), which, combined, account for over half of all cancer cases. Today at the Molecular Medicine Tri-Conference in San Francisco, Dr. Dave Hoon, Chief of Scientific Intelligence and Director, Molecular Oncology at the John Wayne Cancer Institute ("JWCI"), will present findings that show that the test can detect cancer-specific genetic alterations in nearly 90% of patients across various disease types and stages. Dr. Hoon is known as a pioneer in the area of using cell-free DNA for oncology applications, and Guardant Health has been working with Dr. Hoon and JWCI since the company's early days.
"We have long known about the potential to monitor patients for emergent tumor mutations through blood analysis and how critical this could be to improving outcomes for cancer patients," said Dr Hoon. "I'm very excited that the power of non-invasive tumor sequencing will soon be widely available through GUARDANT360."
"Helmy and AmirAli are archetypal Sequoia founders: maniacally driven, technical, and targeting a critical unmet need," said Warren Hogarth, Sequoia partner and Guardant board member. "We're thrilled to be partners with a company that is so uniquely positioned to improve treatment outcomes and ultimately, the quality of life of cancer patients."
To learn more, visit www.guardanthealth.com.
About Guardant Health
Guardant Health is focused on developing breakthrough diagnostic technologies that can transform cancer from a silent killer into a manageable disease. Guardant was founded in 2012 by a team of serial entrepreneurs with expertise in next-generation sequencing, single-cell genomics and cancer diagnostics. To date, the Company has raised over $10M in funds from Sequoia Capital and various angel investors, including a few well-known Silicon Valley tech executives.
About Sequoia Capital
Sequoia Capital helps founders turn imaginative ideas into enduring companies. As the "Entrepreneurs Behind the Entrepreneurs," the Sequoia team has worked closely with legendary founders such as Steve Jobs of Apple, Larry Ellison of Oracle, Len Bosack and Sandy Lerner of Cisco, David Filo and Jerry Yang of Yahoo!, Max Levchin, Elon Musk and Peter Thiel of PayPal, Sergey Brin and Larry Page of Google, Steve Chen and Chad Hurley of YouTube, and Reid Hoffman and Jeff Weiner of LinkedIn. Sequoia is now helping the next generation of innovators build the lasting companies of tomorrow.
SOURCE Guardant Health
Without a clear strategy for cost control and an architecture designed with cloud services in mind, costs and operational performance can quickly get out of control. To avoid multiple architectural redesigns requires extensive thought and planning. Boundary (now part of BMC) launched a new public-facing multi-tenant high resolution monitoring service on Amazon AWS two years ago, facing challenges and learning best practices in the early days of the new service. In his session at 19th Cloud Exp...
Dec. 2, 2016 05:15 PM EST Reads: 303
The cloud promises new levels of agility and cost-savings for Big Data, data warehousing and analytics. But it’s challenging to understand all the options – from IaaS and PaaS to newer services like HaaS (Hadoop as a Service) and BDaaS (Big Data as a Service). In her session at @BigDataExpo at @ThingsExpo, Hannah Smalltree, a director at Cazena, provided an educational overview of emerging “as-a-service” options for Big Data in the cloud. This is critical background for IT and data professionals...
Dec. 2, 2016 05:00 PM EST Reads: 4,057
Today we can collect lots and lots of performance data. We build beautiful dashboards and even have fancy query languages to access and transform the data. Still performance data is a secret language only a couple of people understand. The more business becomes digital the more stakeholders are interested in this data including how it relates to business. Some of these people have never used a monitoring tool before. They have a question on their mind like “How is my application doing” but no id...
Dec. 2, 2016 04:45 PM EST Reads: 2,088
@GonzalezCarmen has been ranked the Number One Influencer and @ThingsExpo has been named the Number One Brand in the “M2M 2016: Top 100 Influencers and Brands” by Onalytica. Onalytica analyzed tweets over the last 6 months mentioning the keywords M2M OR “Machine to Machine.” They then identified the top 100 most influential brands and individuals leading the discussion on Twitter.
Dec. 2, 2016 04:45 PM EST Reads: 1,954
What happens when the different parts of a vehicle become smarter than the vehicle itself? As we move toward the era of smart everything, hundreds of entities in a vehicle that communicate with each other, the vehicle and external systems create a need for identity orchestration so that all entities work as a conglomerate. Much like an orchestra without a conductor, without the ability to secure, control, and connect the link between a vehicle’s head unit, devices, and systems and to manage the ...
Dec. 2, 2016 04:15 PM EST Reads: 313
More and more brands have jumped on the IoT bandwagon. We have an excess of wearables – activity trackers, smartwatches, smart glasses and sneakers, and more that track seemingly endless datapoints. However, most consumers have no idea what “IoT” means. Creating more wearables that track data shouldn't be the aim of brands; delivering meaningful, tangible relevance to their users should be. We're in a period in which the IoT pendulum is still swinging. Initially, it swung toward "smart for smar...
Dec. 2, 2016 04:15 PM EST Reads: 281
"We are an all-flash array storage provider but our focus has been on VM-aware storage specifically for virtualized applications," stated Dhiraj Sehgal of Tintri in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Dec. 2, 2016 04:01 PM EST Reads: 218
In an era of historic innovation fueled by unprecedented access to data and technology, the low cost and risk of entering new markets has leveled the playing field for business. Today, any ambitious innovator can easily introduce a new application or product that can reinvent business models and transform the client experience. In their Day 2 Keynote at 19th Cloud Expo, Mercer Rowe, IBM Vice President of Strategic Alliances, and Raejeanne Skillern, Intel Vice President of Data Center Group and G...
Dec. 2, 2016 04:00 PM EST Reads: 1,854
"We are a modern development application platform and we have a suite of products that allow you to application release automation, we do version control, and we do application life cycle management," explained Flint Brenton, CEO of CollabNet, in this SYS-CON.tv interview at DevOps at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Dec. 2, 2016 03:45 PM EST Reads: 626
Information technology is an industry that has always experienced change, and the dramatic change sweeping across the industry today could not be truthfully described as the first time we've seen such widespread change impacting customer investments. However, the rate of the change, and the potential outcomes from today's digital transformation has the distinct potential to separate the industry into two camps: Organizations that see the change coming, embrace it, and successful leverage it; and...
Dec. 2, 2016 03:30 PM EST Reads: 3,182
In IT, we sometimes coin terms for things before we know exactly what they are and how they’ll be used. The resulting terms may capture a common set of aspirations and goals – as “cloud” did broadly for on-demand, self-service, and flexible computing. But such a term can also lump together diverse and even competing practices, technologies, and priorities to the point where important distinctions are glossed over and lost.
Dec. 2, 2016 03:15 PM EST Reads: 1,440
All clouds are not equal. To succeed in a DevOps context, organizations should plan to develop/deploy apps across a choice of on-premise and public clouds simultaneously depending on the business needs. This is where the concept of the Lean Cloud comes in - resting on the idea that you often need to relocate your app modules over their life cycles for both innovation and operational efficiency in the cloud. In his session at @DevOpsSummit at19th Cloud Expo, Valentin (Val) Bercovici, CTO of Soli...
Dec. 2, 2016 02:15 PM EST Reads: 1,510
Predictive analytics tools monitor, report, and troubleshoot in order to make proactive decisions about the health, performance, and utilization of storage. Most enterprises combine cloud and on-premise storage, resulting in blended environments of physical, virtual, cloud, and other platforms, which justifies more sophisticated storage analytics. In his session at 18th Cloud Expo, Peter McCallum, Vice President of Datacenter Solutions at FalconStor, discussed using predictive analytics to mon...
Dec. 2, 2016 02:00 PM EST Reads: 4,818
Keeping pace with advancements in software delivery processes and tooling is taxing even for the most proficient organizations. Point tools, platforms, open source and the increasing adoption of private and public cloud services requires strong engineering rigor – all in the face of developer demands to use the tools of choice. As Agile has settled in as a mainstream practice, now DevOps has emerged as the next wave to improve software delivery speed and output. To make DevOps work, organization...
Dec. 2, 2016 01:30 PM EST Reads: 5,690
With major technology companies and startups seriously embracing IoT strategies, now is the perfect time to attend @ThingsExpo 2016 in New York. Learn what is going on, contribute to the discussions, and ensure that your enterprise is as "IoT-Ready" as it can be! Internet of @ThingsExpo, taking place June 6-8, 2017, at the Javits Center in New York City, New York, is co-located with 20th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry p...
Dec. 2, 2016 01:30 PM EST Reads: 1,805