Welcome!

News Feed Item

Guardant Health Releases Breakthrough Blood Test to Improve Cancer Treatment

GUARDANT360 provides oncologists with real-time genetic information to improve therapies for cancer patients; announces partnership with Sequoia

REDWOOD CITY, Calif., Feb. 12, 2014 /PRNewswire/ -- Guardant Health TM today announced the commercial availability of GUARDANT360TM, the first pan-cancer blood test that helps oncologists prescribe the right treatments at the right time based on the changing genetics of a patient's cancer. Guardant also announced that last year it partnered with Sequoia Capital and raised $10 million to accelerate development of the technology behind the test.

(Logo: http://photos.prnewswire.com/prnh/20140212/SF64352LOGO)

"The introduction of GUARDANT360 opens a new front in the war on cancer," said Helmy Eltoukhy, Ph.D., Guardant Health's co-founder and chief executive officer. "Patients and their oncologists can now non-invasively track cancer genetically before, during and after treatment. This is particularly helpful because until now we have been blind to the way cancer evolves in response to treatment. The ability to see these changes can lead to significantly more effective treatments."

Current treatment often requires surgery to retrieve biopsies for genetic analysis. Biopsies are risky, costly and do not capture genetic changes that may emerge over time or in response to several cycles of therapy. In contrast, GUARDANT360's non-invasive blood test makes it much easier for physicians to more frequently obtain genetic information crucial to treating successfully a patient's cancer. The test is now available to select cancer centers across the United States.

GUARDANT360 works by reconstructing the relevant portions of a patient's cancer genome using trace fragments of tumor DNA that are shed into the bloodstream ("cell-free DNA"). Unfortunately, these fragments are typically found at exceedingly low concentrations (around one part in 200), and current DNA sequencing technologies can only reliably detect at one part in 20. Guardant's breakthrough "Digital Sequencing," technology enables high-fidelity, single-molecule DNA sequencing and improves detection sensitivity well over 100-fold.

"GUARDANT360 is built on a unique technology platform that is able to comprehensively detect all major classes of tumor genetic alterations with unprecedented sensitivity," said AmirAli Talasaz, co-founder and president at Guardant Health. "This technology is the first of its kind and empowers oncologists to discover many novel genetic aspects of why cancer treatments fail, and to combat these failures through existing drugs that are often overlooked."

Recent clinical studies with GUARDANT360 have shown excellent performance in the top five cancers (breast, lung, colorectal, skin and prostate), which, combined, account for over half of all cancer cases.  Today at the Molecular Medicine Tri-Conference in San Francisco, Dr. Dave Hoon, Chief of Scientific Intelligence and Director, Molecular Oncology at the John Wayne Cancer Institute ("JWCI"), will present findings that show that the test can detect cancer-specific genetic alterations in nearly 90% of patients across various disease types and stages. Dr. Hoon is known as a pioneer in the area of using cell-free DNA for oncology applications, and Guardant Health has been working with Dr. Hoon and JWCI since the company's early days.

"We have long known about the potential to monitor patients for emergent tumor mutations through blood analysis and how critical this could be to improving outcomes for cancer patients," said Dr Hoon.  "I'm very excited that the power of non-invasive tumor sequencing will soon be widely available through GUARDANT360."

"Helmy and AmirAli are archetypal Sequoia founders: maniacally driven, technical, and targeting a critical unmet need," said Warren Hogarth, Sequoia partner and Guardant board member. "We're thrilled to be partners with a company that is so uniquely positioned to improve treatment outcomes and ultimately, the quality of life of cancer patients."

To learn more, visit www.guardanthealth.com.

About Guardant Health
Guardant Health is focused on developing breakthrough diagnostic technologies that can transform cancer from a silent killer into a manageable disease.  Guardant was founded in 2012 by a team of serial entrepreneurs with expertise in next-generation sequencing, single-cell genomics and cancer diagnostics.  To date, the Company has raised over $10M in funds from Sequoia Capital and various angel investors, including a few well-known Silicon Valley tech executives.

About Sequoia Capital
Sequoia Capital helps founders turn imaginative ideas into enduring companies. As the "Entrepreneurs Behind the Entrepreneurs," the Sequoia team has worked closely with legendary founders such as Steve Jobs of Apple, Larry Ellison of Oracle, Len Bosack and Sandy Lerner of Cisco, David Filo and Jerry Yang of Yahoo!, Max Levchin, Elon Musk and Peter Thiel of PayPal, Sergey Brin and Larry Page of Google, Steve Chen and Chad Hurley of YouTube, and Reid Hoffman and Jeff Weiner of LinkedIn. Sequoia is now helping the next generation of innovators build the lasting companies of tomorrow. 

SOURCE Guardant Health

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Sensors and effectors of IoT are solving problems in new ways, but small businesses have been slow to join the quantified world. They’ll need information from IoT using applications as varied as the businesses themselves. In his session at @ThingsExpo, Roger Meike, Distinguished Engineer, Director of Technology Innovation at Intuit, showed how IoT manufacturers can use open standards, public APIs and custom apps to enable the Quantified Small Business. He used a Raspberry Pi to connect sensors...
SYS-CON Events announced today that Catchpoint Systems, Inc., a provider of innovative web and infrastructure monitoring solutions, has been named “Silver Sponsor” of SYS-CON's DevOps Summit at 18th Cloud Expo New York, which will take place June 7-9, 2016, at the Javits Center in New York City, NY. Catchpoint is a leading Digital Performance Analytics company that provides unparalleled insight into customer-critical services to help consistently deliver an amazing customer experience. Designed...
With the proliferation of both SQL and NoSQL databases, organizations can now target specific fit-for-purpose database tools for their different application needs regarding scalability, ease of use, ACID support, etc. Platform as a Service offerings make this even easier now, enabling developers to roll out their own database infrastructure in minutes with minimal management overhead. However, this same amount of flexibility also comes with the challenges of picking the right tool, on the right ...
DevOps is not just last year’s buzzword. Companies with DevOps practices are 2.5x more likely to exceed profitability, market share, and productivity goals. But how do you enable high performance? What can you do right now to start? Find out from DevOps experts including Gene Kim, co-author of "The Phoenix Project," and the Dynatrace Center of Excellence.
SYS-CON Events announced today that Alert Logic, Inc., the leading provider of Security-as-a-Service solutions for the cloud, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Alert Logic, Inc., provides Security-as-a-Service for on-premises, cloud, and hybrid infrastructures, delivering deep security insight and continuous protection for customers at a lower cost than traditional security solutions. Ful...
SYS-CON Events announced today that Interoute, owner-operator of one of Europe's largest networks and a global cloud services platform, has been named “Bronze Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2015 at the Javits Center in New York, New York. Interoute is the owner-operator of one of Europe's largest networks and a global cloud services platform which encompasses 12 data centers, 14 virtual data centers and 31 colocation centers, with connections to 195 ad...
Recognizing the need to identify and validate information security professionals’ competency in securing cloud services, the two leading membership organizations focused on cloud and information security, the Cloud Security Alliance (CSA) and (ISC)^2, joined together to develop an international cloud security credential that reflects the most current and comprehensive best practices for securing and optimizing cloud computing environments.
Companies can harness IoT and predictive analytics to sustain business continuity; predict and manage site performance during emergencies; minimize expensive reactive maintenance; and forecast equipment and maintenance budgets and expenditures. Providing cost-effective, uninterrupted service is challenging, particularly for organizations with geographically dispersed operations.
SYS-CON Events announced today that Avere Systems, a leading provider of enterprise storage for the hybrid cloud, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Avere delivers a more modern architectural approach to storage that doesn’t require the overprovisioning of storage capacity to achieve performance, overspending on expensive storage media for inactive data or the overbuilding of data centers ...
SYS-CON Events announced today that Commvault, a global leader in enterprise data protection and information management, has been named “Bronze Sponsor” of SYS-CON's 18th International Cloud Expo, which will take place on June 7–9, 2016, at the Javits Center in New York City, NY, and the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Commvault is a leading provider of data protection and information management...
SYS-CON Events announced today that VAI, a leading ERP software provider, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. VAI (Vormittag Associates, Inc.) is a leading independent mid-market ERP software developer renowned for its flexible solutions and ability to automate critical business functions for the distribution, manufacturing, specialty retail and service sectors. An IBM Premier Business Part...
With an estimated 50 billion devices connected to the Internet by 2020, several industries will begin to expand their capabilities for retaining end point data at the edge to better utilize the range of data types and sheer volume of M2M data generated by the Internet of Things. In his session at @ThingsExpo, Don DeLoach, CEO and President of Infobright, will discuss the infrastructures businesses will need to implement to handle this explosion of data by providing specific use cases for filte...
In most cases, it is convenient to have some human interaction with a web (micro-)service, no matter how small it is. A traditional approach would be to create an HTTP interface, where user requests will be dispatched and HTML/CSS pages must be served. This approach is indeed very traditional for a web site, but not really convenient for a web service, which is not intended to be good looking, 24x7 up and running and UX-optimized. Instead, talking to a web service in a chat-bot mode would be muc...
It's easy to assume that your app will run on a fast and reliable network. The reality for your app's users, though, is often a slow, unreliable network with spotty coverage. What happens when the network doesn't work, or when the device is in airplane mode? You get unhappy, frustrated users. An offline-first app is an app that works, without error, when there is no network connection.
SYS-CON Events announced today that AppNeta, the leader in performance insight for business-critical web applications, will exhibit and present at SYS-CON's @DevOpsSummit at Cloud Expo New York, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. AppNeta is the only application performance monitoring (APM) company to provide solutions for all applications – applications you develop internally, business-critical SaaS applications you use and the networks that deli...