Welcome!

News Feed Item

Guardant Health Releases Breakthrough Blood Test to Improve Cancer Treatment

GUARDANT360 provides oncologists with real-time genetic information to improve therapies for cancer patients; announces partnership with Sequoia

REDWOOD CITY, Calif., Feb. 12, 2014 /PRNewswire/ -- Guardant Health TM today announced the commercial availability of GUARDANT360TM, the first pan-cancer blood test that helps oncologists prescribe the right treatments at the right time based on the changing genetics of a patient's cancer. Guardant also announced that last year it partnered with Sequoia Capital and raised $10 million to accelerate development of the technology behind the test.

(Logo: http://photos.prnewswire.com/prnh/20140212/SF64352LOGO)

"The introduction of GUARDANT360 opens a new front in the war on cancer," said Helmy Eltoukhy, Ph.D., Guardant Health's co-founder and chief executive officer. "Patients and their oncologists can now non-invasively track cancer genetically before, during and after treatment. This is particularly helpful because until now we have been blind to the way cancer evolves in response to treatment. The ability to see these changes can lead to significantly more effective treatments."

Current treatment often requires surgery to retrieve biopsies for genetic analysis. Biopsies are risky, costly and do not capture genetic changes that may emerge over time or in response to several cycles of therapy. In contrast, GUARDANT360's non-invasive blood test makes it much easier for physicians to more frequently obtain genetic information crucial to treating successfully a patient's cancer. The test is now available to select cancer centers across the United States.

GUARDANT360 works by reconstructing the relevant portions of a patient's cancer genome using trace fragments of tumor DNA that are shed into the bloodstream ("cell-free DNA"). Unfortunately, these fragments are typically found at exceedingly low concentrations (around one part in 200), and current DNA sequencing technologies can only reliably detect at one part in 20. Guardant's breakthrough "Digital Sequencing," technology enables high-fidelity, single-molecule DNA sequencing and improves detection sensitivity well over 100-fold.

"GUARDANT360 is built on a unique technology platform that is able to comprehensively detect all major classes of tumor genetic alterations with unprecedented sensitivity," said AmirAli Talasaz, co-founder and president at Guardant Health. "This technology is the first of its kind and empowers oncologists to discover many novel genetic aspects of why cancer treatments fail, and to combat these failures through existing drugs that are often overlooked."

Recent clinical studies with GUARDANT360 have shown excellent performance in the top five cancers (breast, lung, colorectal, skin and prostate), which, combined, account for over half of all cancer cases.  Today at the Molecular Medicine Tri-Conference in San Francisco, Dr. Dave Hoon, Chief of Scientific Intelligence and Director, Molecular Oncology at the John Wayne Cancer Institute ("JWCI"), will present findings that show that the test can detect cancer-specific genetic alterations in nearly 90% of patients across various disease types and stages. Dr. Hoon is known as a pioneer in the area of using cell-free DNA for oncology applications, and Guardant Health has been working with Dr. Hoon and JWCI since the company's early days.

"We have long known about the potential to monitor patients for emergent tumor mutations through blood analysis and how critical this could be to improving outcomes for cancer patients," said Dr Hoon.  "I'm very excited that the power of non-invasive tumor sequencing will soon be widely available through GUARDANT360."

"Helmy and AmirAli are archetypal Sequoia founders: maniacally driven, technical, and targeting a critical unmet need," said Warren Hogarth, Sequoia partner and Guardant board member. "We're thrilled to be partners with a company that is so uniquely positioned to improve treatment outcomes and ultimately, the quality of life of cancer patients."

To learn more, visit www.guardanthealth.com.

About Guardant Health
Guardant Health is focused on developing breakthrough diagnostic technologies that can transform cancer from a silent killer into a manageable disease.  Guardant was founded in 2012 by a team of serial entrepreneurs with expertise in next-generation sequencing, single-cell genomics and cancer diagnostics.  To date, the Company has raised over $10M in funds from Sequoia Capital and various angel investors, including a few well-known Silicon Valley tech executives.

About Sequoia Capital
Sequoia Capital helps founders turn imaginative ideas into enduring companies. As the "Entrepreneurs Behind the Entrepreneurs," the Sequoia team has worked closely with legendary founders such as Steve Jobs of Apple, Larry Ellison of Oracle, Len Bosack and Sandy Lerner of Cisco, David Filo and Jerry Yang of Yahoo!, Max Levchin, Elon Musk and Peter Thiel of PayPal, Sergey Brin and Larry Page of Google, Steve Chen and Chad Hurley of YouTube, and Reid Hoffman and Jeff Weiner of LinkedIn. Sequoia is now helping the next generation of innovators build the lasting companies of tomorrow. 

SOURCE Guardant Health

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
In his opening keynote at 20th Cloud Expo, Michael Maximilien, Research Scientist, Architect, and Engineer at IBM, discussed the full potential of the cloud and social data requires artificial intelligence. By mixing Cloud Foundry and the rich set of Watson services, IBM's Bluemix is the best cloud operating system for enterprises today, providing rapid development and deployment of applications that can take advantage of the rich catalog of Watson services to help drive insights from the vast t...
Docker containers have brought great opportunities to shorten the deployment process through continuous integration and the delivery of applications and microservices. This applies equally to enterprise data centers as well as the cloud. In his session at 20th Cloud Expo, Jari Kolehmainen, founder and CTO of Kontena, discussed solutions and benefits of a deeply integrated deployment pipeline using technologies such as container management platforms, Docker containers, and the drone.io Cl tool. H...
SYS-CON Events announced today that CA Technologies has been named "Platinum Sponsor" of SYS-CON's 21st International Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. CA Technologies helps customers succeed in a future where every business - from apparel to energy - is being rewritten by software. From planning to development to management to security, CA creates software that fuels transformation for companies in the applic...
There is only one world-class Cloud event on earth, and that is Cloud Expo – which returns to Silicon Valley for the 21st Cloud Expo at the Santa Clara Convention Center, October 31 - November 2, 2017. Every Global 2000 enterprise in the world is now integrating cloud computing in some form into its IT development and operations. Midsize and small businesses are also migrating to the cloud in increasing numbers. Companies are each developing their unique mix of cloud technologies and service...
Cloud adoption is often driven by a desire to increase efficiency, boost agility and save money. All too often, however, the reality involves unpredictable cost spikes and lack of oversight due to resource limitations. In his session at 20th Cloud Expo, Joe Kinsella, CTO and Founder of CloudHealth Technologies, tackled the question: “How do you build a fully optimized cloud?” He will examine: Why TCO is critical to achieving cloud success – and why attendees should be thinking holistically ab...
WebRTC is great technology to build your own communication tools. It will be even more exciting experience it with advanced devices, such as a 360 Camera, 360 microphone, and a depth sensor camera. In his session at @ThingsExpo, Masashi Ganeko, a manager at INFOCOM Corporation, will introduce two experimental projects from his team and what they learned from them. "Shotoku Tamago" uses the robot audition software HARK to track speakers in 360 video of a remote party. "Virtual Teleport" uses a...
Recently, IoT seems emerging as a solution vehicle for data analytics on real-world scenarios from setting a room temperature setting to predicting a component failure of an aircraft. Compared with developing an application or deploying a cloud service, is an IoT solution unique? If so, how? How does a typical IoT solution architecture consist? And what are the essential components and how are they relevant to each other? How does the security play out? What are the best practices in formulating...
Internet of @ThingsExpo, taking place October 31 - November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 21st Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The Internet of Things (IoT) is the most profound change in personal and enterprise IT since the creation of the Worldwide Web more than 20 years ago. All major researchers estimate there will be tens of billions devic...
In his session at @ThingsExpo, Arvind Radhakrishnen discussed how IoT offers new business models in banking and financial services organizations with the capability to revolutionize products, payments, channels, business processes and asset management built on strong architectural foundation. The following topics were covered: How IoT stands to impact various business parameters including customer experience, cost and risk management within BFS organizations.
An increasing number of companies are creating products that combine data with analytical capabilities. Running interactive queries on Big Data requires complex architectures to store and query data effectively, typically involving data streams, an choosing efficient file format/database and multiple independent systems that are tied together through custom-engineered pipelines. In his session at @BigDataExpo at @ThingsExpo, Tomer Levi, a senior software engineer at Intel’s Advanced Analytics ...
SYS-CON Events announced today that Elastifile will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 - Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Elastifile Cloud File System (ECFS) is software-defined data infrastructure designed for seamless and efficient management of dynamic workloads across heterogeneous environments. Elastifile provides the architecture needed to optimize your hybrid cloud environment, by facilitating efficient...
As DevOps methodologies expand their reach across the enterprise, organizations face the daunting challenge of adapting related cloud strategies to ensure optimal alignment, from managing complexity to ensuring proper governance. How can culture, automation, legacy apps and even budget be reexamined to enable this ongoing shift within the modern software factory?
While some vendors scramble to create and sell you a fancy solution for monitoring your spanking new Amazon Lambdas, hear how you can do it on the cheap using just built-in Java APIs yourself. By exploiting a little-known fact that Lambdas aren’t exactly single-threaded, you can effectively identify hot spots in your serverless code. In his session at @DevOpsSummit at 21st Cloud Expo, Dave Martin, Product owner at CA Technologies, will give a live demonstration and code walkthrough, showing how ...
SYS-CON Events announced today that Golden Gate University will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Since 1901, non-profit Golden Gate University (GGU) has been helping adults achieve their professional goals by providing high quality, practice-based undergraduate and graduate educational programs in law, taxation, business and related professions. Many of its courses are taug...
@DevOpsSummit at Cloud Expo taking place Oct 31 - Nov 2, 2017, at the Santa Clara Convention Center, Santa Clara, CA, is co-located with the 21st International Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is ...