|By ACN Newswire||
|February 12, 2014 10:42 PM EST||
The collaboration with Sanofi Pasteur aims to study the loss of immunity and consequent reduced responsiveness to vaccination in elderly.
Singapore, Feb 13, 2014 - (ACN Newswire) - A*STAR's Singapore Immunology Network (SIgN) signed a three-year partnership with the National University of Singapore (NUS), National University Hospital (NUH) and Sanofi Pasteur to embark on a Phase IV clinical trial to understand age-related loss of immunity, known as immunosenescence, in elderly.
Declining birth rates coupled with higher life expectancies have raised the percentage of elderly citizens in Singapore significantly over the last 10 years and the number is expected to increase to 900,000 by 2030. The country's apparent ageing population means greater demand for healthcare facilities to keep elderly healthy. The study therefore aims to meet the growing need by finding new strategies and improving existing ones to sustain elderly's immunity, in the long run.
The research team led by Dr Anis Larbi, Principal Investigator at SIgN, will employ cutting-edge techniques to examine the compromised immunity associated with ageing and identify predictive markers of the condition. A key collaborator for the study is Associate Professor Ng Tze Pin, who heads the Gerontological Research Programme by the Department of Psychological Medicine at the NUS Yong Loo Lin School of Medicine. Both NUS and NUH will provide the essential clinical expertise and know-how on aging cohorts in Singapore. The trial will utilise a vaccine by Sanofi Pasteur and results are expected to be generated over the next two years.
The collaborative study will improve the understanding of impaired immune responsiveness by identifying the immune challenges in individuals, and more specifically, highlight the defective immune functions in Asian elderly. The immune senescence expert, Dr Anis Larbi, said, "Infections account for most mortalities of elderly above the age of seventy, yet there is still no efficient way to sustain immunity in them. The outcome of the study will give us clues on the approaches we can take to reduce or restore dysregulated immunity in elderly to ensure healthier longevity."
Professor Laurent Renia, Acting Executive Director of SIgN, said, "SIgN has harnessed many partnerships since its inauguration in 2008. This collaboration signifies a crucial milestone for SIgN as we will be mobilizing most of our expertise in translational research, analytical immunology and complex data analysis for this purposeful project."
Associate Professor Yeoh Khay Guan, Dean of NUS Yong Loo Lin School of Medicine, said, "NUS and NUH are happy to collaborate with A*STAR and industry partners on clinical trials to help understand changes in immunity in the elderly. It is especially important, in this ageing population that we embark on such projects to protect the elderly from influenza and its complications, so that they remain healthy and active in the community."
Professor Paul Anantharajah Tambyah, Senior Consultant, Division of Infectious Diseases, NUH, said, "This is a very important study which taps on the strengths of collaborating partners. NUH and NUS have strong clinical research traditions and partnerships with the community. Together with A*STAR's and Sanofi's research capabilities, we hope to find an answer to why elderly do not respond well to vaccines and through it, find solutions to help them respond better."
 According to the Department of Statistics Singapore, the percentage of elderly citizens in Singapore has increased from 7.4% in 2002, to 10.5% in 2013.
About the Singapore Immunology Network (SIgN)
The Singapore Immunology Network (SIgN), officially inaugurated on 15 January 2008, is a research consortium under the Agency for Science, Technology and Research (A*STAR)'s Biomedical Research Council. The mandate of SIgN is to advance human immunology research and participate in international efforts to combat major health problems. Since its launch, SIgN has grown rapidly and currently includes 250 scientists from 26 different countries around the world working under 28 renowned principal investigators. At SIgN, researchers investigate immunity during infection and various inflammatory conditions including cancer and are supported by cutting edge technological research platforms and core services.
Through this, SIgN aims to build a strong platform in basic human immunology research for better translation of research findings into clinical applications. SIgN also sets out to establish productive links with local and international institutions, and encourage the exchange of ideas and expertise between academic, industrial and clinical partners and thus contribute to a vibrant research environment in Singapore. For more information about SIgN, please visit www.sign.a-star.edu.sg.
About NUS Yong Loo Lin School of Medicine (YLLSoM)
Established in 1905, the NUS Yong Loo Lin School of Medicine was the first institution of higher learning in Singapore and the genesis of what would become the National University of Singapore. The School offers one of the finest undergraduate medical programs in the Asia Pacific region and commands international recognition and respect. The latest university rankings from Quacqarelli Symonds (QS) have again rated the School as Asia's best for the third consecutive year. Globally, it is now ranked 20th, up one spot from its 2012 ranking.
The School admits 300 students to its medical undergraduate degree programme annually. It strives to fulfill its tripartite mission of providing excellent clinical care, training the next generation of healthcare professionals, and fostering research that will transform the practice of medicine. It plays a pivotal role in producing future leaders in healthcare delivery, discovery and public service as well as in Singapore's Biomedical Sciences Initiative and Singapore Medicine, an initiative to further develop as a regional medical center.
The School's 16 departments in the basic sciences and clinical specialties work closely with the Alice Lee Centre for Nursing Studies and the Centre for Biomedical Ethics to ensure that teaching and research are aligned and relevant to Singapore's healthcare needs. For more information about the Yong Loo Lin School of Medicine, please visit http://medicine.nus.edu.sg/corporate/.
About the National University Hospital (NUH)
The NUH is a tertiary hospital and major referral centre for a comprehensive range of medical, surgical and dental specialties including Cardiology, Gastroenterology and Hepatology, Obstetrics and Gynaecology, Oncology, Ophthalmology, Paediatrics, Orthopaedic Surgery and Hand and Reconstructive Microsurgery. The Hospital also provides organ transplant programmes for adults (in kidney, liver and pancreas) and is the only public hospital in Singapore to offer paediatric kidney and liver transplant programme.
Staffed by a team of healthcare professionals who rank among the best in the field, the NUH offers quality patient care by embracing innovations and advances in medical treatment.
In 2004, the NUH became the first Singapore hospital to receive the Joint Commission International (JCI) accreditation, an international stamp for excellent clinical practices in patient care and safety. Today, patient safety and good clinical outcomes remain the focus of the hospital as it continues to play a key role in the training of doctors, nurses and allied health professionals, and in translational research which paves the way for new cures and treatment, offering patients hope and a new lease of life.
A member of the National University Health System, it is the principal teaching hospital of the NUS Yong Loo Lin School of Medicine and the NUS Faculty of Dentistry. For more information, please visit www.nuh.com.sg.
The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector agency that fosters world-class scientific research and talent to drive economic growth and transform Singapore into a vibrant knowledge-based and innovation driven economy.
In line with its mission-oriented mandate, A*STAR spearheads research and development in fields that are essential to growing Singapore's manufacturing sector and catalysing new growth industries. A*STAR supports these economic clusters by providing intellectual, human and industrial capital to its partners in industry.
A*STAR oversees 18 biomedical sciences and physical sciences and engineering research entities, located in Biopolis and Fusionopolis, as well as their vicinity. These two R&D hubs house a bustling and diverse community of local and international research scientists and engineers from A*STAR's research entities as well as a growing number of corporate laboratories. Please visit www.a-star.edu.sg.
Tan Yun Yun (Ms) Senior Officer, Corporate Communications Agency for Science, Technology and Research Tel: +65 6826 6273 Email: [email protected] Crystal MK (Ms) Senior Assistant Manager, Communications National University Health System (NUHS) Tel: +65 6772 3986 Email: [email protected]
Copyright 2014 ACN Newswire. All rights reserved.
In his general session at 18th Cloud Expo, Lee Atchison, Principal Cloud Architect and Advocate at New Relic, discussed cloud as a ‘better data center’ and how it adds new capacity (faster) and improves application availability (redundancy). The cloud is a ‘Dynamic Tool for Dynamic Apps’ and resource allocation is an integral part of your application architecture, so use only the resources you need and allocate /de-allocate resources on the fly.
Sep. 27, 2016 09:30 AM EDT Reads: 2,649
Creating replica copies to tolerate a certain number of failures is easy, but very expensive at cloud-scale. Conventional RAID has lower overhead, but it is limited in the number of failures it can tolerate. And the management is like herding cats (overseeing capacity, rebuilds, migrations, and degraded performance). Download Slide Deck: ▸ Here In his general session at 18th Cloud Expo, Scott Cleland, Senior Director of Product Marketing for the HGST Cloud Infrastructure Business Unit, discusse...
Sep. 27, 2016 09:15 AM EDT Reads: 2,293
Much of the value of DevOps comes from a (renewed) focus on measurement, sharing, and continuous feedback loops. In increasingly complex DevOps workflows and environments, and especially in larger, regulated, or more crystallized organizations, these core concepts become even more critical. In his session at @DevOpsSummit at 18th Cloud Expo, Andi Mann, Chief Technology Advocate at Splunk, showed how, by focusing on 'metrics that matter,' you can provide objective, transparent, and meaningful f...
Sep. 27, 2016 09:00 AM EDT Reads: 2,655
SYS-CON Events announced today that Interface Masters Technologies, a leader in Network Visibility and Uptime Solutions, will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Interface Masters Technologies is a leading vendor in the network monitoring and high speed networking markets. Based in the heart of Silicon Valley, Interface Masters' expertise lies in Gigabit, 10 Gigabit and 40 Gigabit Eth...
Sep. 27, 2016 08:45 AM EDT Reads: 2,574
Vidyo, Inc., has joined the Alliance for Open Media. The Alliance for Open Media is a non-profit organization working to define and develop media technologies that address the need for an open standard for video compression and delivery over the web. As a member of the Alliance, Vidyo will collaborate with industry leaders in pursuit of an open and royalty-free AOMedia Video codec, AV1. Vidyo’s contributions to the organization will bring to bear its long history of expertise in codec technolo...
Sep. 27, 2016 08:30 AM EDT Reads: 2,638
There is little doubt that Big Data solutions will have an increasing role in the Enterprise IT mainstream over time. Big Data at Cloud Expo - to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA - has announced its Call for Papers is open. Cloud computing is being adopted in one form or another by 94% of enterprises today. Tens of billions of new devices are being connected to The Internet of Things. And Big Data is driving this bus. An exponential increase is...
Sep. 27, 2016 08:15 AM EDT Reads: 2,627
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, wh...
Sep. 27, 2016 08:00 AM EDT Reads: 3,700
SYS-CON Events announced today that Tintri Inc., a leading producer of VM-aware storage (VAS) for virtualization and cloud environments, will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Tintri VM-aware storage is the simplest for virtualized applications and cloud. Organizations including GE, Toyota, United Healthcare, NASA and 6 of the Fortune 15 have said “No to LUNs.” With Tintri they mana...
Sep. 27, 2016 08:00 AM EDT Reads: 2,783
An IoT product’s log files speak volumes about what’s happening with your products in the field, pinpointing current and potential issues, and enabling you to predict failures and save millions of dollars in inventory. But until recently, no one knew how to listen. In his session at @ThingsExpo, Dan Gettens, Chief Research Officer at OnProcess, will discuss recent research by Massachusetts Institute of Technology and OnProcess Technology, where MIT created a new, breakthrough analytics model f...
Sep. 27, 2016 08:00 AM EDT Reads: 1,993
In his session at @DevOpsSummit at 19th Cloud Expo, Robert Doyle, lead architect at eCube Systems, will examine the issues and need for an agile infrastructure and show the advantages of capturing developer knowledge in an exportable file for migration into production. He will introduce the use of NXTmonitor, a next-generation DevOps tool that captures application environments, dependencies and start/stop procedures in a portable configuration file with an easy-to-use GUI. In addition to captu...
Sep. 27, 2016 08:00 AM EDT Reads: 1,095
More and more companies are looking to microservices as an architectural pattern for breaking apart applications into more manageable pieces so that agile teams can deliver new features quicker and more effectively. What this pattern has done more than anything to date is spark organizational transformations, setting the foundation for future application development. In practice, however, there are a number of considerations to make that go beyond simply “build, ship, and run,” which changes ho...
Sep. 27, 2016 08:00 AM EDT Reads: 2,517
"We have several customers now running private clouds. They're not as large as they should be but it's getting there. The adoption challenge has been pretty simple. Look at the world today of virtualization vs cloud," stated Nara Rajagopalan, CEO of Accelerite, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Sep. 27, 2016 08:00 AM EDT Reads: 2,230
The Internet of Things will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform and how we integrate our thinking to solve complicated problems. In his session at 19th Cloud Expo, Craig Sproule, CEO of Metavine, will demonstrate how to move beyond today's coding paradigm ...
Sep. 27, 2016 07:45 AM EDT Reads: 3,288
Ask someone to architect an Internet of Things (IoT) solution and you are guaranteed to see a reference to the cloud. This would lead you to believe that IoT requires the cloud to exist. However, there are many IoT use cases where the cloud is not feasible or desirable. In his session at @ThingsExpo, Dave McCarthy, Director of Products at Bsquare Corporation, will discuss the strategies that exist to extend intelligence directly to IoT devices and sensors, freeing them from the constraints of ...
Sep. 27, 2016 07:45 AM EDT Reads: 2,499
From wearable activity trackers to fantasy e-sports, data and technology are transforming the way athletes train for the game and fans engage with their teams. In his session at @ThingsExpo, will present key data findings from leading sports organizations San Francisco 49ers, Orlando Magic NBA team. By utilizing data analytics these sports orgs have recognized new revenue streams, doubled its fan base and streamlined costs at its stadiums. John Paul is the CEO and Founder of VenueNext. Prior ...
Sep. 27, 2016 07:30 AM EDT Reads: 2,976