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Eisai Announces Launch of Pariet(R) Triple Formulation Combination Packs Rabecure(R) 400 and 800 and Rabefine(R), for Primary and Secondary H.Pyloei Eradication Respectively, in Japan

Tokyo, Feb 13, 2014 - (JCN Newswire) - Eisai Co., Ltd. announced today that it will launch two types of triple formulation combination packs that contain its proton pump inhibitor Pariet(R) (rabeprazole sodium) in Japan on February 14 for use in Helicobacter pylori eradication.

The launch will feature three products: Rabecure(R) Pack 400 and Rabecure Pack 800, which package together individual blister sheets each containing a daily triple formulation dose of Pariet, amoxicillin hydrate and clarithromycin for use in primary H. pylori eradication, and Rabefine(R) Pack, which similarly packages together individual blister sheets containing a daily triple formulation dose of Pariet, amoxicillin hydrate and metronidazole for use in secondary H. pylori eradication. Eisai received approval to manufacture and market both combination types in Japan from the country's Ministry of Health, Labour and Welfare in August 2013, with all three products added to Japan's National Health Insurance drug price list on December 13 of the same year.

In H. pylori eradication triple therapy with Pariet and two antimicrobial agents, successful eradication significantly depends on whether the patient properly adheres to the prescribed treatment regimen. Taking the incorrect dose or missing doses altogether can lead not only to reduced eradication rates but also to bacterial resistance. With daily-dose blister sheets adopted for both the primary and secondary eradication combinations of Eisai's new triple formulation packs, the launch is expected to help ensure that H. pylori eradication therapy is administered more appropriately and with greater certainty, while also improving patient drug compliance and offering increased convenience in a medical setting.

Eisai believes that the launch of its Rabecure and Rabefine combination packs will further promote the appropriate use of therapeutic agents in H. pylori eradication therapy and contribute to a wider range of treatment options available for gastric cancer eradication and other treatments for diseases associated with H. pylori.

Product details at:

About Pariet(R)

Pariet is a proton pump inhibitor discovered and developed by Eisai. First launched in Japan in 1997, the drug is today approved in more than 100 countries and territories worldwide. In Japan, Pariet is indicated for multiple uses, including for the treatment of gastric ulcer, duodenal ulcer, reflux esophagitis, non-erosive gastroesophageal reflux disease, and as an adjunctive therapy in various types of H. pylori eradication, including in patients with gastric ulcer, duodenal ulcer, and H. pylori gastritis, and is available in both 10 mg and 20 mg tablet formulations based on evidence collected in Japanese patients. In addition, in December 2010, Eisai received approval in Japan for additional twice-daily 10 mg and twice-daily 20 mg dosage and administration of Pariet for treatment of patients with reflux esophagitis who are unable to obtain satisfactory relief with conventional proton pump inhibitor treatment.

In November 2013, Eisai submitted an application for Pariet in Japan seeking a further indication expansion for use in the prevention of recurrence of gastric and duodenal ulcers during treatment with low-dose aspirin and the approval of a new 5 mg tablet formulation. Eisai is currently also conducting a Phase III study in Japan of Pariet as a maintenance therapy for patients with reflux esophagitis resistant to once-daily proton pump inhibitor treatment.

About Eisai

Eisai Co., Ltd. (TSE: 4523; ADR: ESALY) is a research-based human health care (hhc) company that discovers, develops and markets products throughout the world. Eisai focuses its efforts in three therapeutic areas: integrative neuroscience, including neurology and psychiatric medicines; integrative oncology, which encompasses oncotherapy and supportive-care treatments; and vascular/immunological reaction. Through a global network of research facilities, manufacturing sites and marketing subsidiaries, Eisai actively participates in all aspects of the worldwide healthcare system. For more information about Eisai Co., Ltd., please visit

Source: Eisai

Public Relations Department,
Eisai Co., Ltd.

Copyright 2014 JCN Newswire. All rights reserved.

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