|By Marketwired .||
|February 20, 2014 10:00 AM EST||
SCOTTSDALE, AZ--(Marketwired - February 20, 2014) - Patients who received daily humidification of the mouth and throat region beginning from day one of radiation therapy treatment spent nearly 50 percent fewer days in the hospital to manage their side effects, according to research presented today at the 2014 Multidisciplinary Head and Neck Cancer Symposium.
The study was conducted by the Trans Tasman Radiation Oncology Group and evaluated 210 head and neck cancer patients in New Zealand and Australia from June 2007 through June 2011. Patients in this Phase III trial were randomized to institutional standard of care (control arm) or humidification (HUM) using the Fisher & Paykel Healthcare MR880 humidifier. The humidified air is delivered through the nose via a plastic interface (mask-type apparatus) that can be worn by patients while sleeping or while sitting during the day.
Patients began HUM on day one of radiation therapy and continued until the ulceration their mouth and throat had resolved. On average, HUM patients spent 57 percent as many days in the hospital to manage side effects (control = 4.1 days vs. HUM = 2.3 days). The return of eating patterns to close to normal was also significantly higher at three months after radiotherapy in the group using humidifiers. (Nutritional Mode score at 20 weeks, a clinician-reported assessment of nutritional status, control = 4.8 vs. HUM = 5.23.)
Only 43 patients (42 percent of the patients in the HUM arm) met the defined benchmark of HUM compliance and were able to contribute to the per protocol (PP) analysis; the mean average use of humidification for these patients was 3.6 hours per day (range of 0-14 hours/day). In patients who met the HUM compliance benchmark, the area under the curve for CTCAE version 3.0 functional mucositis score (a clinician assessment of mucositis symptom burden for patients) was reduced (control = 8.63 vs. HUM PP = 6.74). The proportion of compliant HUM patients who never required a feeding tube was also increased (control = 0.73 vs. HUM PP = 0.85). There was also a trend for patients to report a reduction in symptom burden when using humidification but only in those patients compliant in using the humidifier.
"Mucositis (inflammation and ulceration of the mouth and throat) is a painful side effect of radiation therapy that can negatively affect patients' quality of life. This study has provided efficacy signals consistent with a role for humidification in reducing symptom burden for patients during radiotherapy for head and neck cancer. Preventing or reducing hospitalizations may also mean it is cost effective. The rationale for using humidification is based on the fact that moisturizing wounds generally helps them heal faster," said Andrew Macann, FRANZCR, lead author of the study and a radiation oncologist at Auckland City Hospital in Auckland, New Zealand. "These results are encouraging, particularly given the signals favouring humidification were seen across clinician-reported outcomes, patient-reported outcomes and independent data such as hospitalizations. Although patients in the study did not use the humidifiers as much as was hoped, we obtained feedback about why some patients did not like using the humidifier. Our next step is to work at increasing the proportion of patients who use the humidifier effectively."
The abstract, "Domiciliary Humidification Reduces Symptom Burden and Hospital Admissions Associated With Mucositis During Radiotherapy For Head And Neck Cancer: Trans Tasman Radiation Oncology Group (TROG) 07.03 RadioHUM Randomised Phase III Trial Results," will be presented in detail in the Plenary session at the 2014 Multidisciplinary Head and Neck Cancer Symposium at 12:30 p.m. Mountain time on Thursday, February 20, 2014. To speak with Dr. Macann, contact Michelle Kirkwood on February 20 - 21, 2014 in the ASTRO Press Office at the JW Marriott Camelback Inn Resort and Spa in Scottsdale, Arizona at 480-596-7085 or email [email protected].
The 2014 Multidisciplinary Head and Neck Cancer Symposium is sponsored by the American Society for Radiation Oncology (ASTRO), the American Society of Clinical Oncology (ASCO) and the American Head & Neck Society (AHNS). The two-and-a-half day meeting includes interactive educational sessions focused on topics such as supportive care, directed therapy, new surgical and radio therapeutic techniques, as well as 12 oral abstract presentations of the current science of relevance to the head and neck cancer community. A total of 189 abstracts will be presented including 177 posters. Keynote speakers include Jennifer Grandis, MD, of the University of Pittsburgh, to present "The Molecular Road to Defining and Targeting High-risk Head and Neck Patients;" and Julia H. Rowland, PhD, of the National Cancer Institute, to present "Cancer Survivorship: Research Opportunities on the Path to Where We Want to Be."
2014 Multidisciplinary Head and Neck Cancer Symposium
News Briefing, Thursday, February 20, 2014, 7:00 a.m. Mountain time
Plenary Session: Thursday, February 20, 2014, 12:30 - 2:00 p.m. MT, Arizona Ballroom A-G, JW Marriott Camelback Inn Resort and Spa
2 Domiciliary Humidification Reduces Symptom Burden and Hospital Admissions Associated With Mucositis During Radiotherapy For Head And Neck Cancer: Trans Tasman Radiation Oncology Group (TROG) 07.03 RadioHUM Randomised Phase III Trial Results
A. Macann1, S. Porceddu2, C. Milross3, T. Fua4, M. Penniment5, M. King6, M. Bell6, C. Fraser-Browne1, V. Thomson1, H. Hockey7, 1Auckland City Hospital, Auckland, New Zealand, 2Princess Alexandra Hospital, Brisbane, Australia, 3Royal Prince Alfred Hospital, Sydney, Australia, 4Peter MacCallum Cancer Centre, Melbourne, Australia, 5Royal Adelaide Hospital, Adelaide, Australia, 6Psycho-Oncology Co-Operative Research Group, University of Sydney, Sydney, Australia, 7Biometrics Matters, Ltd., Hamilton, New Zealand
Background: To assess the impact of domiciliary based humidification (HUM) on symptom burden during radiotherapy (RT) for head and neck (H&N) cancer. Using a humidifier combines the principles of moist wound care and respiratory HUM.
Methods and Materials: From June 2007 through June 2011, 210 patients with H&N cancer receiving RT were randomized to either their institutional standard of care (control arm) or HUM using the Fisher & Paykel Healthcare MR880 humidifier. HUM commenced day 1 of RT and continued until Common Terminology Criteria Adverse Events (CTCAE) version 3.0 clinical mucositis (CMuc) less than or equal to 1. Acute toxicities, hospitalisations, and feeding tube events were recorded. The McMaster University H&N Radiotherapy Questionnaire (HNRQ) was used for patient reported evaluation of symptom burden. The primary endpoint was area under the curve (AUC) for CMuc greater than or equal to 2.
Results: There was no significant difference in AUC CMuc greater than or equal to 2 between the two arms [control 8.38 (7.19 - 9.57) HUM 8.25 (7.11 - 9.38); 95% CI; p 0.845]. Mean average HUM hours per day were 3.6 hours (range 0 - 14). Forty-three patients (42%) met a defined benchmark for HUM compliance and contributed to the per protocol (PP) analysis. In compliant HUM patients within the PP population, the AUC for CTCAE functional mucositis score (FMuc) greater than or equal to 2 was reduced [control 8.63 (7.58 - 9.68); HUM 6.74 (5.40 - 8.08); p=0.009]. Weeks with FMuc greater than or equal to 3 was just outside 5 % significance in the intention to treat (ITT) analysis [control 2.42 (1.82 - 3.01); HUM 1.80 (1.23 - 2.36); p 0.06], but was significantly reduced in the PP analysis [control 2.47 (1.83 - 3.10); HUM 1.07 (0.26 - 1.89); p 0.002]. HUM patients had significantly less days in hospital [mean total inpatient days ITT analysis: control 4.1 (2.7 - 6.0); HUM 2.3 (1.5 - 3.5); p=0.017] and the proportion requiring acute hospital admissions was reduced (PP analysis: control 0.55; HUM 0.31; p 0.013). The proportion never requiring a feeding tube was increased (PP analysis: control 0.73; HUM 0.85; p=0.04). Nutritional Mode, a clinician reported assessment of nutritional status, was higher in HUM patients at week 20 [ITT analysis: control 4.8 (4.47 - 5.13); HUM 5.23 (4.92 - 5.55); p 0.018]. HNRQ PP analysis estimates were in the direction favoring HUM with less symptom severity, although most time points did not reach significance.
Conclusions: TROG 07.03 has demonstrated efficacy signals consistent with a role for HUM in reducing symptom burden from mucositis, but the influence of HUM compliance on the results moderates recommendations regarding effectiveness.
Author Disclosure Block: A. Macann: None. S. Porceddu: None. C. Milross: None. T. Fua: None. M. Penniment: None. M. King: None. M. Bell: None. C. Fraser-Browne: None. V. Thomson: None. H. Hockey: None.
The following files are available for download:
Press Room Phone:
WebRTC services have already permeated corporate communications in the form of videoconferencing solutions. However, WebRTC has the potential of going beyond and catalyzing a new class of services providing more than calls with capabilities such as mass-scale real-time media broadcasting, enriched and augmented video, person-to-machine and machine-to-machine communications. In his session at @ThingsExpo, Luis Lopez, CEO of Kurento, will introduce the technologies required for implementing thes...
Oct. 10, 2015 01:00 AM EDT Reads: 756
Achim Weiss is Chief Executive Officer and co-founder of ProfitBricks. In 1995, he broke off his studies to co-found the web hosting company "Schlund+Partner." The company "Schlund+Partner" later became the 1&1 web hosting product line. From 1995 to 2008, he was the technical director for several important projects: the largest web hosting platform in the world, the second largest DSL platform, a video on-demand delivery network, the largest eMail backend in Europe, and a universal billing syste...
Oct. 10, 2015 01:00 AM EDT Reads: 238
SYS-CON Events announced today that Spirent Communications, the leader in testing navigation and positioning systems, will exhibit at SYS-CON's @DevOpsSummit Silicon Valley, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Spirent Communications enables innovations in communications technologies that help connect people. Whether it is service provider, data centers, enterprise IT networks, mobile communications, connected vehicles or the Inte...
Oct. 10, 2015 01:00 AM EDT Reads: 200
Containers are revolutionizing the way we deploy and maintain our infrastructures, but monitoring and troubleshooting in a containerized environment can still be painful and impractical. Understanding even basic resource usage is difficult - let alone tracking network connections or malicious activity. In his session at DevOps Summit, Gianluca Borello, Sr. Software Engineer at Sysdig, will cover the current state of the art for container monitoring and visibility, including pros / cons and li...
Oct. 10, 2015 12:00 AM EDT Reads: 265
Too often with compelling new technologies market participants become overly enamored with that attractiveness of the technology and neglect underlying business drivers. This tendency, what some call the “newest shiny object syndrome,” is understandable given that virtually all of us are heavily engaged in technology. But it is also mistaken. Without concrete business cases driving its deployment, IoT, like many other technologies before it, will fade into obscurity.
Oct. 10, 2015 12:00 AM EDT Reads: 174
Containers have changed the mind of IT in DevOps. They enable developers to work with dev, test, stage and production environments identically. Containers provide the right abstraction for microservices and many cloud platforms have integrated them into deployment pipelines. DevOps and Containers together help companies to achieve their business goals faster and more effectively.
Oct. 10, 2015 12:00 AM EDT Reads: 219
As a CIO, are your direct reports IT managers or are they IT leaders? The hard truth is that many IT managers have risen through the ranks based on their technical skills, not their leadership ability. Many are unable to effectively engage and inspire, creating forward momentum in the direction of desired change. Renowned for its approach to leadership and emphasis on their people, organizations increasingly look to our military for insight into these challenges.
Oct. 9, 2015 11:15 PM EDT Reads: 206
SYS-CON Events announced today that Dyn, the worldwide leader in Internet Performance, will exhibit at SYS-CON's 17th International Cloud Expo®, which will take place on November 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Dyn is a cloud-based Internet Performance company. Dyn helps companies monitor, control, and optimize online infrastructure for an exceptional end-user experience. Through a world-class network and unrivaled, objective intelligence into Internet condit...
Oct. 9, 2015 11:00 PM EDT Reads: 650
Today air travel is a minefield of delays, hassles and customer disappointment. Airlines struggle to revitalize the experience. GE and M2Mi will demonstrate practical examples of how IoT solutions are helping airlines bring back personalization, reduce trip time and improve reliability. In their session at @ThingsExpo, Shyam Varan Nath, Principal Architect with GE, and Dr. Sarah Cooper, M2Mi's VP Business Development and Engineering, will explore the IoT cloud-based platform technologies driv...
Oct. 9, 2015 10:15 PM EDT Reads: 144
The IoT market is on track to hit $7.1 trillion in 2020. The reality is that only a handful of companies are ready for this massive demand. There are a lot of barriers, paint points, traps, and hidden roadblocks. How can we deal with these issues and challenges? The paradigm has changed. Old-style ad-hoc trial-and-error ways will certainly lead you to the dead end. What is mandatory is an overarching and adaptive approach to effectively handle the rapid changes and exponential growth.
Oct. 9, 2015 10:00 PM EDT Reads: 245
Who are you? How do you introduce yourself? Do you use a name, or do you greet a friend by the last four digits of his social security number? Assuming you don’t, why are we content to associate our identity with 10 random digits assigned by our phone company? Identity is an issue that affects everyone, but as individuals we don’t spend a lot of time thinking about it. In his session at @ThingsExpo, Ben Klang, Founder & President of Mojo Lingo, will discuss the impact of technology on identity....
Oct. 9, 2015 10:00 PM EDT Reads: 453
There are many considerations when moving applications from on-premise to cloud. It is critical to understand the benefits and also challenges of this migration. A successful migration will result in lower Total Cost of Ownership, yet offer the same or higher level of robustness. Migration to cloud shifts computing resources from your data center, which can yield significant advantages provided that the cloud vendor an offer enterprise-grade quality for your application.
Oct. 9, 2015 09:30 PM EDT Reads: 318
DevOps is gaining traction in the federal government – and for good reasons. Heightened user expectations are pushing IT organizations to accelerate application development and support more innovation. At the same time, budgetary constraints require that agencies find ways to decrease the cost of developing, maintaining, and running applications. IT now faces a daunting task: do more and react faster than ever before – all with fewer resources.
Oct. 9, 2015 09:00 PM EDT Reads: 416
The web app is agile. The REST API is agile. The testing and planning are agile. But alas, data infrastructures certainly are not. Once an application matures, changing the shape or indexing scheme of data often forces at best a top down planning exercise and at worst includes schema changes that force downtime. The time has come for a new approach that fundamentally advances the agility of distributed data infrastructures. Come learn about a new solution to the problems faced by software organ...
Oct. 9, 2015 08:00 PM EDT Reads: 937
The buzz continues for cloud, data analytics and the Internet of Things (IoT) and their collective impact across all industries. But a new conversation is emerging - how do companies use industry disruption and technology enablers to lead in markets undergoing change, uncertainty and ambiguity? Organizations of all sizes need to evolve and transform, often under massive pressure, as industry lines blur and merge and traditional business models are assaulted and turned upside down. In this new da...
Oct. 9, 2015 08:00 PM EDT Reads: 320