Welcome!

News Feed Item

Daily Humidification of the Mouth and Throat Region During Radiation Therapy for Head and Neck Cancer Reduces Mucositis and Hospitalization

SCOTTSDALE, AZ--(Marketwired - February 20, 2014) - Patients who received daily humidification of the mouth and throat region beginning from day one of radiation therapy treatment spent nearly 50 percent fewer days in the hospital to manage their side effects, according to research presented today at the 2014 Multidisciplinary Head and Neck Cancer Symposium.

The study was conducted by the Trans Tasman Radiation Oncology Group and evaluated 210 head and neck cancer patients in New Zealand and Australia from June 2007 through June 2011. Patients in this Phase III trial were randomized to institutional standard of care (control arm) or humidification (HUM) using the Fisher & Paykel Healthcare MR880 humidifier. The humidified air is delivered through the nose via a plastic interface (mask-type apparatus) that can be worn by patients while sleeping or while sitting during the day.

Patients began HUM on day one of radiation therapy and continued until the ulceration their mouth and throat had resolved. On average, HUM patients spent 57 percent as many days in the hospital to manage side effects (control = 4.1 days vs. HUM = 2.3 days). The return of eating patterns to close to normal was also significantly higher at three months after radiotherapy in the group using humidifiers. (Nutritional Mode score at 20 weeks, a clinician-reported assessment of nutritional status, control = 4.8 vs. HUM = 5.23.)

Only 43 patients (42 percent of the patients in the HUM arm) met the defined benchmark of HUM compliance and were able to contribute to the per protocol (PP) analysis; the mean average use of humidification for these patients was 3.6 hours per day (range of 0-14 hours/day). In patients who met the HUM compliance benchmark, the area under the curve for CTCAE version 3.0 functional mucositis score (a clinician assessment of mucositis symptom burden for patients) was reduced (control = 8.63 vs. HUM PP = 6.74). The proportion of compliant HUM patients who never required a feeding tube was also increased (control = 0.73 vs. HUM PP = 0.85). There was also a trend for patients to report a reduction in symptom burden when using humidification but only in those patients compliant in using the humidifier.

"Mucositis (inflammation and ulceration of the mouth and throat) is a painful side effect of radiation therapy that can negatively affect patients' quality of life. This study has provided efficacy signals consistent with a role for humidification in reducing symptom burden for patients during radiotherapy for head and neck cancer. Preventing or reducing hospitalizations may also mean it is cost effective. The rationale for using humidification is based on the fact that moisturizing wounds generally helps them heal faster," said Andrew Macann, FRANZCR, lead author of the study and a radiation oncologist at Auckland City Hospital in Auckland, New Zealand. "These results are encouraging, particularly given the signals favouring humidification were seen across clinician-reported outcomes, patient-reported outcomes and independent data such as hospitalizations. Although patients in the study did not use the humidifiers as much as was hoped, we obtained feedback about why some patients did not like using the humidifier. Our next step is to work at increasing the proportion of patients who use the humidifier effectively."

The abstract, "Domiciliary Humidification Reduces Symptom Burden and Hospital Admissions Associated With Mucositis During Radiotherapy For Head And Neck Cancer: Trans Tasman Radiation Oncology Group (TROG) 07.03 RadioHUM Randomised Phase III Trial Results," will be presented in detail in the Plenary session at the 2014 Multidisciplinary Head and Neck Cancer Symposium at 12:30 p.m. Mountain time on Thursday, February 20, 2014. To speak with Dr. Macann, contact Michelle Kirkwood on February 20 - 21, 2014 in the ASTRO Press Office at the JW Marriott Camelback Inn Resort and Spa in Scottsdale, Arizona at 480-596-7085 or email [email protected].

The 2014 Multidisciplinary Head and Neck Cancer Symposium is sponsored by the American Society for Radiation Oncology (ASTRO), the American Society of Clinical Oncology (ASCO) and the American Head & Neck Society (AHNS). The two-and-a-half day meeting includes interactive educational sessions focused on topics such as supportive care, directed therapy, new surgical and radio therapeutic techniques, as well as 12 oral abstract presentations of the current science of relevance to the head and neck cancer community. A total of 189 abstracts will be presented including 177 posters. Keynote speakers include Jennifer Grandis, MD, of the University of Pittsburgh, to present "The Molecular Road to Defining and Targeting High-risk Head and Neck Patients;" and Julia H. Rowland, PhD, of the National Cancer Institute, to present "Cancer Survivorship: Research Opportunities on the Path to Where We Want to Be."

2014 Multidisciplinary Head and Neck Cancer Symposium
News Briefing, Thursday, February 20, 2014, 7:00 a.m. Mountain time

Plenary Session: Thursday, February 20, 2014, 12:30 - 2:00 p.m. MT, Arizona Ballroom A-G, JW Marriott Camelback Inn Resort and Spa

2 Domiciliary Humidification Reduces Symptom Burden and Hospital Admissions Associated With Mucositis During Radiotherapy For Head And Neck Cancer: Trans Tasman Radiation Oncology Group (TROG) 07.03 RadioHUM Randomised Phase III Trial Results

A. Macann1, S. Porceddu2, C. Milross3, T. Fua4, M. Penniment5, M. King6, M. Bell6, C. Fraser-Browne1, V. Thomson1, H. Hockey7, 1Auckland City Hospital, Auckland, New Zealand, 2Princess Alexandra Hospital, Brisbane, Australia, 3Royal Prince Alfred Hospital, Sydney, Australia, 4Peter MacCallum Cancer Centre, Melbourne, Australia, 5Royal Adelaide Hospital, Adelaide, Australia, 6Psycho-Oncology Co-Operative Research Group, University of Sydney, Sydney, Australia, 7Biometrics Matters, Ltd., Hamilton, New Zealand

Background: To assess the impact of domiciliary based humidification (HUM) on symptom burden during radiotherapy (RT) for head and neck (H&N) cancer. Using a humidifier combines the principles of moist wound care and respiratory HUM.
Methods and Materials: From June 2007 through June 2011, 210 patients with H&N cancer receiving RT were randomized to either their institutional standard of care (control arm) or HUM using the Fisher & Paykel Healthcare MR880 humidifier. HUM commenced day 1 of RT and continued until Common Terminology Criteria Adverse Events (CTCAE) version 3.0 clinical mucositis (CMuc) less than or equal to 1. Acute toxicities, hospitalisations, and feeding tube events were recorded. The McMaster University H&N Radiotherapy Questionnaire (HNRQ) was used for patient reported evaluation of symptom burden. The primary endpoint was area under the curve (AUC) for CMuc greater than or equal to 2.
Results: There was no significant difference in AUC CMuc greater than or equal to 2 between the two arms [control 8.38 (7.19 - 9.57) HUM 8.25 (7.11 - 9.38); 95% CI; p 0.845]. Mean average HUM hours per day were 3.6 hours (range 0 - 14). Forty-three patients (42%) met a defined benchmark for HUM compliance and contributed to the per protocol (PP) analysis. In compliant HUM patients within the PP population, the AUC for CTCAE functional mucositis score (FMuc) greater than or equal to 2 was reduced [control 8.63 (7.58 - 9.68); HUM 6.74 (5.40 - 8.08); p=0.009]. Weeks with FMuc greater than or equal to 3 was just outside 5 % significance in the intention to treat (ITT) analysis [control 2.42 (1.82 - 3.01); HUM 1.80 (1.23 - 2.36); p 0.06], but was significantly reduced in the PP analysis [control 2.47 (1.83 - 3.10); HUM 1.07 (0.26 - 1.89); p 0.002]. HUM patients had significantly less days in hospital [mean total inpatient days ITT analysis: control 4.1 (2.7 - 6.0); HUM 2.3 (1.5 - 3.5); p=0.017] and the proportion requiring acute hospital admissions was reduced (PP analysis: control 0.55; HUM 0.31; p 0.013). The proportion never requiring a feeding tube was increased (PP analysis: control 0.73; HUM 0.85; p=0.04). Nutritional Mode, a clinician reported assessment of nutritional status, was higher in HUM patients at week 20 [ITT analysis: control 4.8 (4.47 - 5.13); HUM 5.23 (4.92 - 5.55); p 0.018]. HNRQ PP analysis estimates were in the direction favoring HUM with less symptom severity, although most time points did not reach significance.
Conclusions: TROG 07.03 has demonstrated efficacy signals consistent with a role for HUM in reducing symptom burden from mucositis, but the influence of HUM compliance on the results moderates recommendations regarding effectiveness.

Author Disclosure Block: A. Macann: None. S. Porceddu: None. C. Milross: None. T. Fua: None. M. Penniment: None. M. King: None. M. Bell: None. C. Fraser-Browne: None. V. Thomson: None. H. Hockey: None.

The following files are available for download:

More Stories By Marketwired .

Copyright © 2009 Marketwired. All rights reserved. All the news releases provided by Marketwired are copyrighted. Any forms of copying other than an individual user's personal reference without express written permission is prohibited. Further distribution of these materials is strictly forbidden, including but not limited to, posting, emailing, faxing, archiving in a public database, redistributing via a computer network or in a printed form.

Latest Stories
The many IoT deployments around the world are busy integrating smart devices and sensors into their enterprise IT infrastructures. Yet all of this technology – and there are an amazing number of choices – is of no use without the software to gather, communicate, and analyze the new data flows. Without software, there is no IT. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, Dave McCarthy, Director of Products at Bsquare Corporation; Alan Williamson, Principal...
Businesses and business units of all sizes can benefit from cloud computing, but many don't want the cost, performance and security concerns of public cloud nor the complexity of building their own private clouds. Today, some cloud vendors are using artificial intelligence (AI) to simplify cloud deployment and management. In his session at 20th Cloud Expo, Ajay Gulati, Co-founder and CEO of ZeroStack, will discuss how AI can simplify cloud operations. He will cover the following topics: why clou...
Video experiences should be unique and exciting! But that doesn’t mean you need to patch all the pieces yourself. Users demand rich and engaging experiences and new ways to connect with you. But creating robust video applications at scale can be complicated, time-consuming and expensive. In his session at @ThingsExpo, Zohar Babin, Vice President of Platform, Ecosystem and Community at Kaltura, discussed how VPaaS enables you to move fast, creating scalable video experiences that reach your aud...
Cloud Expo, Inc. has announced today that Andi Mann returns to 'DevOps at Cloud Expo 2017' as Conference Chair The @DevOpsSummit at Cloud Expo will take place on June 6-8, 2017, at the Javits Center in New York City, NY. "DevOps is set to be one of the most profound disruptions to hit IT in decades," said Andi Mann. "It is a natural extension of cloud computing, and I have seen both firsthand and in independent research the fantastic results DevOps delivers. So I am excited to help the great t...
Rapid innovation, changing business landscapes, and new IT demands force businesses to make changes quickly. In the eyes of many, containers are at the brink of becoming a pervasive technology in enterprise IT to accelerate application delivery. In this presentation, attendees learned about the: The transformation of IT to a DevOps, microservices, and container-based architecture What are containers and how DevOps practices can operate in a container-based environment A demonstration of how ...
"At ROHA we develop an app called Catcha. It was developed after we spent a year meeting with, talking to, interacting with senior citizens watching them use their smartphones and talking to them about how they use their smartphones so we could get to know their smartphone behavior," explained Dave Woods, Chief Innovation Officer at ROHA, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
In this strange new world where more and more power is drawn from business technology, companies are effectively straddling two paths on the road to innovation and transformation into digital enterprises. The first path is the heritage trail – with “legacy” technology forming the background. Here, extant technologies are transformed by core IT teams to provide more API-driven approaches. Legacy systems can restrict companies that are transitioning into digital enterprises. To truly become a lead...
Without lifecycle traceability and visibility across the tool chain, stakeholders from Planning-to-Ops have limited insight and answers to who, what, when, why and how across the DevOps lifecycle. This impacts the ability to deliver high quality software at the needed velocity to drive positive business outcomes. In his general session at @DevOpsSummit at 19th Cloud Expo, Phil Hombledal, Solution Architect at CollabNet, discussed how customers are able to achieve a level of transparency that e...
WebRTC is the future of browser-to-browser communications, and continues to make inroads into the traditional, difficult, plug-in web communications world. The 6th WebRTC Summit continues our tradition of delivering the latest and greatest presentations within the world of WebRTC. Topics include voice calling, video chat, P2P file sharing, and use cases that have already leveraged the power and convenience of WebRTC.
"Venafi has a platform that allows you to manage, centralize and automate the complete life cycle of keys and certificates within the organization," explained Gina Osmond, Sr. Field Marketing Manager at Venafi, in this SYS-CON.tv interview at DevOps at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, provided an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life sett...
Get deep visibility into the performance of your databases and expert advice for performance optimization and tuning. You can't get application performance without database performance. Give everyone on the team a comprehensive view of how every aspect of the system affects performance across SQL database operations, host server and OS, virtualization resources and storage I/O. Quickly find bottlenecks and troubleshoot complex problems.
Application transformation and DevOps practices are two sides of the same coin. Enterprises that want to capture value faster, need to deliver value faster – time value of money principle. To do that enterprises need to build cloud-native apps as microservices by empowering teams to build, ship, and run in production. In his session at @DevOpsSummit at 19th Cloud Expo, Neil Gehani, senior product manager at HPE, discussed what every business should plan for how to structure their teams to delive...
20th Cloud Expo, taking place June 6-8, 2017, at the Javits Center in New York City, NY, will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy.
"We analyze the video streaming experience. We are gathering the user behavior in real time from the user devices and we analyze how users experience the video streaming," explained Eric Kim, Founder and CEO at Streamlyzer, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.