Welcome!

News Feed Item

Study Finds Pycnogenol® In Combination With Oral Contraceptives Effective In Resolving Endometriosis-Related Pain

Research shows patented pine bark extract plays a key role in reducing inflammation associated with endometriosis and menstruation, which affects more than 5 million U.S. women

HOBOKEN, N.J., Feb. 26, 2014 /PRNewswire/ -- An observational  study published in the December 2013 issue of the International Journal of Women's Health found that the natural supplement Pycnogenol® (pic-noj-en-all), an antioxidant plant extract from the bark of the French maritime pine tree, significantly minimizes pain and inflammation associated with endometriosis and may help eliminate dysmenorrhea – when paired with oral contraceptives. More than five million women in the United States suffer from endometriosis, a chronic inflammatory condition often associated with severe menstrual pain and infertility.

"Endometriosis is a common health issue affecting millions of women. Unfortunately many women suffer without knowing that their extreme menstrual pain doesn't have to be a normal part of their lives – there are potential natural solutions," said physician and nutritional medicine expert Dr. Fred Pescatore. "This new research builds on several studies that have found Pycnogenol® to be a safe and effective natural alternative to reduce inflammation and decrease symptoms such as abdominal pain and cramping during menstruation."

In the study, conducted in collaboration by the Brazilian Instituto da Mulher and Itaigara Memorial Day Hospital, researchers treated and monitored 45 patients of reproductive age (22 – 37 years old) who were diagnosed with varying degrees of endometriosis. Patients were randomly selected to one of four treatment groups and evaluated prior to beginning their regimen and after three months of treatment. Two different types of oral contraceptives were evaluated on their own and in combination with Pycnogenol®.  Pain was evaluated with a visual analog pain scale graded from 0-10.

Patients in Group 1 were treated with only an oral contraceptive containing 0.75 mg gestodene and 0.03 mg ethinylestradiol; Group 2  received the same oral contraceptive containing .75 mg gestodene and 0.03 mg ethinylestradiol in addition to 100 mg Pycnogenol®. Patients in Group 3 received only a contraceptive containing 3 mg drospirenone and 0.03 mg ethinylestradiol (approximately similar to Yaz® in the U.S.); participants in Group 4 received the same oral contraceptive  containing 3 mg drospirenone and 0.03 mg ethinylestradiol in addition to 100 mg Pycnogenol®. Pycnogenol® was administered at 50 mg every 12 hours. In all cases, oral contraceptives were used in a continuous regimen.

Over the course of three months, researchers found:

  • The use of oral contraceptives alone resulted in a decrease of menstrual-related pain
  • Pycnogenol®  significantly reinforced  pain reduction when combined with oral contraceptives in patients suffering from endometriosis
  • Pycnogenol® increased significantly the efficacy of oral contraceptives for the treatment of endometriosis-related pain
  • Most (56%) participants taking Pycnogenol® and an oral contraceptive reported a complete resolution of pain; none of the participants taking an oral contraceptive alone reported full pain resolution

"Pycnogenol® is a natural nuclear factor-kappa B inhibitor, meaning that it reduces inflammation at the on-set, and as a result, may significantly reduce pain and help those who suffer from endometriosis without complication or side effects," said Dr. Peter Rohdewald, Head of Research and Development at Horphag Research. "This research shows that Pycnogenol® is an effective natural alternative to improve the efficacy of oral contraceptives to relieve endometriosis-related pain."

This study confirms previous findings from the catalog of research on women's health and Pycnogenol®, including a 2007 study of 58 women that found Pycnogenol® alone to significantly reduce the symptoms of endometriosis by 33 percent without disruption to the menstrual cycle, allowing women to become pregnant. To review the clinical research and additional information on Pycnogenol® visit www.Pycnogenol.com.

About Pycnogenol®
Pycnogenol® is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and organic acids, which offer extensive natural health benefits.  The extract has been widely studied for the past 40 years and has more than 340 published studies and review articles ensuring safety and efficacy as an ingredient.Today, Pycnogenol® is available in more than 700 dietary supplements, multi-vitamins and health products worldwide.  For more information, visit www.pycnogenol.com.

About Horphag Research (USA) Inc.
Horphag Research (USA) Inc., based in Hoboken, New Jersey, is the North American distributor for Pycnogenol® (pic-noj-en-all) brand French maritime pine bark extract on behalf of Horphag Research. Pycnogenol® is a registered trademark of Horphag Research Ltd. For its patented ingredient, Pycnogenol®, Horphag Research has been awarded the Frost & Sullivan Excellence in Research Award, Nutraceutical Business & Technology Safety & Quality Award, SupplySide West Scientific Excellence Award and The American Botanical Council's Tyler Research Award.  Horphag Research (USA) has the exclusive rights to market and sell Pycnogenol® in North America and benefits from more than 40 years of scientific research assuring the safety and efficacy of Pycnogenol® as a dietary supplement.  For more information about Pycnogenol® visit www.pycnogenol.com.

SOURCE Pycnogenol

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
DXWorldEXPO LLC announced today that All in Mobile, a mobile app development company from Poland, will exhibit at the 22nd International CloudEXPO | DXWorldEXPO. All In Mobile is a mobile app development company from Poland. Since 2014, they maintain passion for developing mobile applications for enterprises and startups worldwide.
@DevOpsSummit at Cloud Expo, taking place November 12-13 in New York City, NY, is co-located with 22nd international CloudEXPO | first international DXWorldEXPO and will feature technical sessions from a rock star conference faculty and the leading industry players in the world.
In his keynote at 19th Cloud Expo, Sheng Liang, co-founder and CEO of Rancher Labs, discussed the technological advances and new business opportunities created by the rapid adoption of containers. With the success of Amazon Web Services (AWS) and various open source technologies used to build private clouds, cloud computing has become an essential component of IT strategy. However, users continue to face challenges in implementing clouds, as older technologies evolve and newer ones like Docker c...
All organizations that did not originate this moment have a pre-existing culture as well as legacy technology and processes that can be more or less amenable to DevOps implementation. That organizational culture is influenced by the personalities and management styles of Executive Management, the wider culture in which the organization is situated, and the personalities of key team members at all levels of the organization. This culture and entrenched interests usually throw a wrench in the work...
We all know that end users experience the internet primarily with mobile devices. From an app development perspective, we know that successfully responding to the needs of mobile customers depends on rapid DevOps – failing fast, in short, until the right solution evolves in your customers' relationship to your business. Whether you’re decomposing an SOA monolith, or developing a new application cloud natively, it’s not a question of using microservices - not doing so will be a path to eventual ...
The next XaaS is CICDaaS. Why? Because CICD saves developers a huge amount of time. CD is an especially great option for projects that require multiple and frequent contributions to be integrated. But… securing CICD best practices is an emerging, essential, yet little understood practice for DevOps teams and their Cloud Service Providers. The only way to get CICD to work in a highly secure environment takes collaboration, patience and persistence. Building CICD in the cloud requires rigorous ar...
DXWorldEXPO LLC announced today that ICC-USA, a computer systems integrator and server manufacturing company focused on developing products and product appliances, will exhibit at the 22nd International CloudEXPO | DXWorldEXPO. DXWordEXPO New York 2018, colocated with CloudEXPO New York 2018 will be held November 11-13, 2018, in New York City. ICC is a computer systems integrator and server manufacturing company focused on developing products and product appliances to meet a wide range of ...
Sanjeev Sharma Joins November 11-13, 2018 @DevOpsSummit at @CloudEXPO New York Faculty. Sanjeev Sharma is an internationally known DevOps and Cloud Transformation thought leader, technology executive, and author. Sanjeev's industry experience includes tenures as CTO, Technical Sales leader, and Cloud Architect leader. As an IBM Distinguished Engineer, Sanjeev is recognized at the highest levels of IBM's core of technical leaders.
Coca-Cola’s Google powered digital signage system lays the groundwork for a more valuable connection between Coke and its customers. Digital signs pair software with high-resolution displays so that a message can be changed instantly based on what the operator wants to communicate or sell. In their Day 3 Keynote at 21st Cloud Expo, Greg Chambers, Global Group Director, Digital Innovation, Coca-Cola, and Vidya Nagarajan, a Senior Product Manager at Google, discussed how from store operations and ...
We are seeing a major migration of enterprises applications to the cloud. As cloud and business use of real time applications accelerate, legacy networks are no longer able to architecturally support cloud adoption and deliver the performance and security required by highly distributed enterprises. These outdated solutions have become more costly and complicated to implement, install, manage, and maintain.SD-WAN offers unlimited capabilities for accessing the benefits of the cloud and Internet. ...
As Cybric's Chief Technology Officer, Mike D. Kail is responsible for the strategic vision and technical direction of the platform. Prior to founding Cybric, Mike was Yahoo's CIO and SVP of Infrastructure, where he led the IT and Data Center functions for the company. He has more than 24 years of IT Operations experience with a focus on highly-scalable architectures.
Without lifecycle traceability and visibility across the tool chain, stakeholders from Planning-to-Ops have limited insight and answers to who, what, when, why and how across the DevOps lifecycle. This impacts the ability to deliver high quality software at the needed velocity to drive positive business outcomes. In his general session at @DevOpsSummit at 19th Cloud Expo, Eric Robertson, General Manager at CollabNet, will discuss how customers are able to achieve a level of transparency that e...
Headquartered in Plainsboro, NJ, Synametrics Technologies has provided IT professionals and computer systems developers since 1997. Based on the success of their initial product offerings (WinSQL and DeltaCopy), the company continues to create and hone innovative products that help its customers get more from their computer applications, databases and infrastructure. To date, over one million users around the world have chosen Synametrics solutions to help power their accelerated business or per...
Founded in 2000, Chetu Inc. is a global provider of customized software development solutions and IT staff augmentation services for software technology providers. By providing clients with unparalleled niche technology expertise and industry experience, Chetu has become the premiere long-term, back-end software development partner for start-ups, SMBs, and Fortune 500 companies. Chetu is headquartered in Plantation, Florida, with thirteen offices throughout the U.S. and abroad.
Dion Hinchcliffe is an internationally recognized digital expert, bestselling book author, frequent keynote speaker, analyst, futurist, and transformation expert based in Washington, DC. He is currently Chief Strategy Officer at the industry-leading digital strategy and online community solutions firm, 7Summits.