Welcome!

News Feed Item

Understanding and Tackling Prostate and Colorectal Cancer Through Unlocking the Cancer's DNA Code

LEIDEN, The Netherlands, February 27, 2014 /PRNewswire/ --

With a large contribution of the Center for Translational Molecular Medicine (CTMM), a new Dutch consortium will study the relationship between DNA aberrations and the development of both prostate and colorectal tumours. The project application has been filed by the Erasmus Medical Center, ServiceXS B.V. and the VU University Medical Center and will be coordinated by professor Guido Jenster (Erasmus MC). They have received funding of 1 million euros for this project called "NGS-ProToCol".

Cancer and DNA

Cancer is a disease of the DNA, caused by changes in the genome of normal cells, resulting in cancer cells with the ability to continuously grow and to respond variably on anticancer treatments. In order to understand why normal cells become cancer cells and how we can identify and destroy them, the researchers in this project want to uncover all the DNA changes in a large set of individual tumors. Particularly for common tumor types such as prostate and colorectal cancers the researchers hope to make a serious impact and improve diagnosis, prognosis and treatment.

Recent developments in the area of genome sequencing (also called next-generation sequencing) make it possible to discover all mutations in a tumour in a single experiment. By analyzing the genome and transcriptome of multiple prostate and colorectal tumours, the researchers expect to discover and validate markers useful for finding tumors in an early stage and for predicting the aggressiveness of the disease. In addition, the genomic information will result in the identification of novel cancer proteins for which new therapeutic drugs can be designed.

Website: http://www.ctmm.nl/en/projecten/translational-research-it-trait/ngs-protocol


Background information NGS ProToCol

The study project has been named NGS-ProToCol and aligns well with the expertise and the ambitions of the Erasmus MC and VUmc in the field of cancer research and that of ServiceXS in the area of genome and transcriptome analyses. The researchers at the Erasmus MC will study in prostate tumours how DNA mutations will influence the nature of the tumour, whereas VUmc will perform similar analyses in colorectal tumours. Being a pioneer in the area of genome sequencing, ServiceXS will perform the DNA and RNA sequencing experiments. The researchers expect to be able to come with results within 2 years.

NGS-ProToCol extends the genomic work initiated by two other CTMM projects: Prostate Cancer Molecular Medicine (PCMM; coordinated by Prof. dr. Chris Bangma, Erasmus MC) and Decrease Colorectal cancer Death (DeCoDe; coordinated by Prof. dr. Gerrit Meijer, VUmc). Within these consortia, DNA and RNA analyses already identified candidate biomarkers that with next-generation sequencing technologies will be validated in NGS-ProToCol. In addition, the challenging and complex workflows for NGS data management and data processing will be captured and made publicly available through a third CTMM project, TRAnslational research IT (TraIT; coordinated by Prof. dr. Gerrit Meijer, VUmc).    

About CTMM

The CTMM (Center for Translational Molecular Medicine) is a Netherlands-based public-private partnership. It is dedicated to the development of technologies in molecular medicine that enable early diagnosis and personalized treatment for main areas of disease causing mortality and diminished quality of life in the western world. Focus lies on oncology, cardiovascular, neurodegenerative and infectious/auto-immune disease. CTMM operates by inviting, assessing and funding multidisciplinary projects that involve active participation by Netherlands-based academia and industry. All CTMM projects are judged by an independent International Advisory Board and approved by a Supervisory Board based on their significant potential to translate research knowledge into clinical practice. The CTMM is funded by the Dutch government (50%), academia (25%) and industry (25%). Additional funding is provided by supporting foundations on behalf of patients.

Key figures CTMM: 122 partners, M€ 302.7 allocated budget until the end of 2015, 25 projects/consortia

http://www.ctmm.nl

About Erasmus MC and VUmc

As centres of medical innovation, the Erasmus Medical Center (Erasmus MC) and VU University Medical Center (VUmc) play an (inter)nationally recognized leading role in cancer research. The core tasks of the both centers are research, education, patient care and training. Both hospitals are part of the Dutch Federation of University Medical Centers (NFU). The NFU is a cooperation of the eight University Medical Centers in the Netherlands.

http://www.erasmusmc.nl

http://www.vumc.nl

About ServiceXS B.V.

ServiceXS is a service company in the area of molecular genetics and is based in Leiden, The Netherlands. In 2006 ServiceXS was the first company in Europe to offer next-generation sequencing services. Recently, ServiceXS was the first service provider world-wide to acquire Ion-Proton equipment, which offers new possibilities for whole-genome genetic analysis and will be used for this first Dutch large-scale cancer genetics project.

http://www.servicexs.com

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
The IoT is changing the way enterprises conduct business. In his session at @ThingsExpo, Eric Hoffman, Vice President at EastBanc Technologies, discussed how businesses can gain an edge over competitors by empowering consumers to take control through IoT. He cited examples such as a Washington, D.C.-based sports club that leveraged IoT and the cloud to develop a comprehensive booking system. He also highlighted how IoT can revitalize and restore outdated business models, making them profitable ...
StackIQ has announced the release of Stacki 3.2. Stacki is an easy-to-use Linux server provisioning tool. Stacki 3.2 delivers new capabilities that simplify the automation and integration of site-specific requirements. StackIQ is the commercial entity behind this open source bare metal provisioning tool. Since the release of Stacki in June of 2015, the Stacki core team has been focused on making the Community Edition meet the needs of members of the community, adding features and value, while ...
The cloud competition for database hosts is fierce. How do you evaluate a cloud provider for your database platform? In his session at 18th Cloud Expo, Chris Presley, a Solutions Architect at Pythian, gave users a checklist of considerations when choosing a provider. Chris Presley is a Solutions Architect at Pythian. He loves order – making him a premier Microsoft SQL Server expert. Not only has he programmed and administered SQL Server, but he has also shared his expertise and passion with b...
With 15% of enterprises adopting a hybrid IT strategy, you need to set a plan to integrate hybrid cloud throughout your infrastructure. In his session at 18th Cloud Expo, Steven Dreher, Director of Solutions Architecture at Green House Data, discussed how to plan for shifting resource requirements, overcome challenges, and implement hybrid IT alongside your existing data center assets. Highlights included anticipating workload, cost and resource calculations, integrating services on both sides...
Big Data engines are powering a lot of service businesses right now. Data is collected from users from wearable technologies, web behaviors, purchase behavior as well as several arbitrary data points we’d never think of. The demand for faster and bigger engines to crunch and serve up the data to services is growing exponentially. You see a LOT of correlation between “Cloud” and “Big Data” but on Big Data and “Hybrid,” where hybrid hosting is the sanest approach to the Big Data Infrastructure pro...
In his session at @DevOpsSummit at 19th Cloud Expo, Yoseph Reuveni, Director of Software Engineering at Jet.com, will discuss Jet.com's journey into containerizing Microsoft-based technologies like C# and F# into Docker. He will talk about lessons learned and challenges faced, the Mono framework tryout and how they deployed everything into Azure cloud. Yoseph Reuveni is a technology leader with unique experience developing and running high throughput (over 1M tps) distributed systems with extre...
"We are a well-established player in the application life cycle management market and we also have a very strong version control product," stated Flint Brenton, CEO of CollabNet,, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
We all know the latest numbers: Gartner, Inc. forecasts that 6.4 billion connected things will be in use worldwide in 2016, up 30 percent from last year, and will reach 20.8 billion by 2020. We're rapidly approaching a data production of 40 zettabytes a day – more than we can every physically store, and exabytes and yottabytes are just around the corner. For many that’s a good sign, as data has been proven to equal money – IF it’s ingested, integrated, and analyzed fast enough. Without real-ti...
In his session at 18th Cloud Expo, Sagi Brody, Chief Technology Officer at Webair Internet Development Inc., and Logan Best, Infrastructure & Network Engineer at Webair, focused on real world deployments of DDoS mitigation strategies in every layer of the network. He gave an overview of methods to prevent these attacks and best practices on how to provide protection in complex cloud platforms. He also outlined what we have found in our experience managing and running thousands of Linux and Unix ...
"Operations is sort of the maturation of cloud utilization and the move to the cloud," explained Steve Anderson, Product Manager for BMC’s Cloud Lifecycle Management, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
I wanted to gather all of my Internet of Things (IOT) blogs into a single blog (that I could later use with my University of San Francisco (USF) Big Data “MBA” course). However as I started to pull these blogs together, I realized that my IOT discussion lacked a vision; it lacked an end point towards which an organization could drive their IOT envisioning, proof of value, app dev, data engineering and data science efforts. And I think that the IOT end point is really quite simple…
A critical component of any IoT project is what to do with all the data being generated. This data needs to be captured, processed, structured, and stored in a way to facilitate different kinds of queries. Traditional data warehouse and analytical systems are mature technologies that can be used to handle certain kinds of queries, but they are not always well suited to many problems, particularly when there is a need for real-time insights.
UpGuard has become a member of the Center for Internet Security (CIS), and will continue to help businesses expand visibility into their cyber risk by providing hardening benchmarks to all customers. By incorporating these benchmarks, UpGuard's CSTAR solution builds on its lead in providing the most complete assessment of both internal and external cyber risk. CIS benchmarks are a widely accepted set of hardening guidelines that have been publicly available for years. Numerous solutions exist t...
Unless your company can spend a lot of money on new technology, re-engineering your environment and hiring a comprehensive cybersecurity team, you will most likely move to the cloud or seek external service partnerships. In his session at 18th Cloud Expo, Darren Guccione, CEO of Keeper Security, revealed what you need to know when it comes to encryption in the cloud.
We're entering the post-smartphone era, where wearable gadgets from watches and fitness bands to glasses and health aids will power the next technological revolution. With mass adoption of wearable devices comes a new data ecosystem that must be protected. Wearables open new pathways that facilitate the tracking, sharing and storing of consumers’ personal health, location and daily activity data. Consumers have some idea of the data these devices capture, but most don’t realize how revealing and...