Welcome!

News Feed Item

Three New Peer-reviewed Publications Further Validate the Benefits of Hologic 3D Mammography (Tomosynthesis) in Breast Cancer Screening

- Research Supports the Use of Hologic's Lower Dose 3D Mammography Technology and the Continued Use of Two-views Over One in Breast Cancer Screening

BEDFORD, Massachusetts, March 5, 2014 /PRNewswire/ -- Hologic, Inc. (Hologic or the Company) (NASDAQ: HOLX), a leading developer, manufacturer and supplier of premium diagnostic products, medical imaging systems and surgical products, with an emphasis on serving the healthcare needs of women, announced today the publication of three new studies supporting the use of Hologic's award-winning 3D mammography (tomosynthesis) technology in breast cancer screening.

A number of studies have validated the benefits of Hologic's 3D mammography technology in screening:  a simultaneous increase in cancer detection rates, for invasive cancers in particular, and a significant reduction in unnecessary patient recalls. Although the benefits of 3D mammography far outweigh the perceived risks, some potential users have expressed concern about the increased dose of a combined conventional 2D and 3D mammography exam. While the radiation dose from the combined 2D and 3D exposure is within the U.S. guidelines for mammography, Hologic now offers customers the low dose C-View software option which generates the 2D image from the 3D mammography image slices thereby eliminating the need for a separate 2D exposure.

Two studies published this month evaluated Hologic's Digital Breast Tomosynthesis using 2D images generated from the 3D mammography slices in place of conventional 2D images  – a technique that would reduce the radiation dose of 3D mammography studies to the level of conventional 2D screening and shorten the patient exam time while maintaining all the clinical benefits of 3D. A third study evaluated the use of one-view versus two-view tomosynthesis.

Oslo Study. The results of a four-year prospective trial based on 24,901 screening examinations in a large hospital in Norway, "Two-View Digital Breast Tomosynthesis Screening with Synthetically Reconstructed Projection Images: Comparison with Digital Breast Tomosynthesis with Full-Field Digital Mammographic Images," evaluated the use of 2D images generated from the 3D mammography slices in place of conventional 2D images that are required as part of the Digital Breast Tomosynthesis procedure. Per Skaane, MD, PhD, Department of Radiology, Oslo University Hospital Ullevaal, and his colleagues found that the use of Hologic 3D and generated 2D images constituted an average dose reduction of 45% while not resulting in any clinically meaningful differences in diagnostic accuracy compared to 3D mammography and conventional 2D images. The study was published online in advance of print in the January 24, 2014 issue of Radiology, a scientific journal of the Radiological Society of North America (RSNA).

UPMC Study. A reader study, "Comparison of Two-dimensional Synthesized Mammograms versus Original Digital Mammograms Alone in Combination with Tomosynthesis Images," also looked at whether generated 2D images could be used in place of conventional 2D images in a 3D mammography exam. The authors in this retrospective study compared the results of eight expert readers evaluating a set of cases representing the range of lesions and normal confounders identified in clinical practice. Margarita L. Zuley, MD, Department of Radiology, Magee Women's Hospital, University of Pittsburgh Medical Center, and her colleagues concluded that generated 2D images did not result in any clinically meaningful differences in diagnostic accuracy and could be used to eliminate the need for conventional 2D mammography as part of a routine 3D mammography exam. The study was published online in advance of print in the January 21, 2014 issue of Radiology.

Massachusetts General Hospital Study. A multi-reader study, "Diagnostic Accuracy and Recall Rates for Digital Mammography and Digital Mammography Combined with One-view and Two-view Tomosynthesis: Results of an Enriched Reader Study," found that while the addition of Hologic's one-view 3D mammography to conventional digital mammography significantly improved diagnostic accuracy and reduced the recall rate, the addition of Hologic's two-view 3D mammography provided twice the performance gain in diagnostic accuracy while further reducing unnecessary patient recalls. The researchers concluded that "an approach combining two-view 3D mammography with digital mammography should be the model adopted in clinical practice." In addition, the researchers showed that the addition of two-view 3D mammography provided significantly higher diagnostic accuracy for imaging women with dense breast tissue compared to conventional mammography.

Elizabeth A. Rafferty, MD, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, was lead author of this study that was published in the February 2014 issue of the American Journal of Roentgenology (AJR), the scientific journal of the American Roentgen Ray Society.

"Millions of women across the world have already benefited from Hologic's 3D mammography technology," notes David Harding, Group Senior Vice President and General Manager, Women's Health for Hologic. "These three new studies add to the growing body of research supporting the direction we have taken with this game-changing technology."

"We are glad to see support for our lower dose 3D mammography offering," Harding said. "These studies have demonstrated that Hologic's 3D mammography using generated 2D images results in a clinically superior exam with virtually the same radiation dose as a conventional 2D screening exam. And the research by Dr. Rafferty and her colleagues is the latest in a string of studies concluding that the use of two-views in a 3D mammography screening exam should continue to be the model physicians use in clinical practice."

Hologic pioneered the 3D mammography imaging market with the introduction of its Selenia Dimensions 3D system in countries recognizing the CE mark in 2008 and has placed 3D mammography systems in 59 countries. In 2011 Hologic became the first, and still today the only company to have a U.S. Food and Drug Administration approved 3D mammography system.

About Hologic, Inc.:

Hologic, Inc. is a leading developer, manufacturer and supplier of premium diagnostic products, medical imaging systems and surgical products. The Company operates four core business units focused on breast health, diagnostics, GYN surgical, and skeletal health. With a comprehensive suite of technologies and a robust research and development program, Hologic is committed to improving lives. The Company is headquartered in Massachusetts. For more information, visit www.hologic.com.

Hologic, C-View, Dimensions and Selenia are trademarks and/or registered trademarks of Hologic, Inc., and/or its subsidiaries in the United States and/or other countries.

Forward-Looking Statement Disclaimer:

This News Release may contain forward-looking information that involves risks and uncertainties, including statements about the use of Hologic products. There can be no assurance these products will achieve the benefits described herein and that such benefits will be replicated in any particular manner with respect to an individual patient as the actual effect of the use of the products can only be determined on a case-by-case basis depending on the particular circumstances and patient in question. Hologic expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any such statements presented herein to reflect any change in expectations or any change in events, conditions or circumstances on which any such data or statements are based.

Contacts:

Marianne McMorrow

Jim Culley

Global PR & Advertising Publicist

Senior Director, Corporate Marketing

Hologic, Inc.

Hologic, Inc.

[email protected]

[email protected]

Tel: +1-781-999-7723

Tel: +1-781-999-7583

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Businesses and business units of all sizes can benefit from cloud computing, but many don't want the cost, performance and security concerns of public cloud nor the complexity of building their own private clouds. Today, some cloud vendors are using artificial intelligence (AI) to simplify cloud deployment and management. In his session at 20th Cloud Expo, Ajay Gulati, Co-founder and CEO of ZeroStack, will discuss how AI can simplify cloud operations. He will cover the following topics: why clou...
"We are a custom software development, engineering firm. We specialize in cloud applications from helping customers that have on-premise applications migrating to the cloud, to helping customers design brand new apps in the cloud. And we specialize in mobile apps," explained Peter Di Stefano, Vice President of Marketing at Impiger Technologies, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
IoT solutions exploit operational data generated by Internet-connected smart “things” for the purpose of gaining operational insight and producing “better outcomes” (for example, create new business models, eliminate unscheduled maintenance, etc.). The explosive proliferation of IoT solutions will result in an exponential growth in the volume of IoT data, precipitating significant Information Governance issues: who owns the IoT data, what are the rights/duties of IoT solutions adopters towards t...
As data explodes in quantity, importance and from new sources, the need for managing and protecting data residing across physical, virtual, and cloud environments grow with it. Managing data includes protecting it, indexing and classifying it for true, long-term management, compliance and E-Discovery. Commvault can ensure this with a single pane of glass solution – whether in a private cloud, a Service Provider delivered public cloud or a hybrid cloud environment – across the heterogeneous enter...
@DevOpsSummit taking place June 6-8, 2017 at Javits Center, New York City, is co-located with the 20th International Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. @DevOpsSummit at Cloud Expo New York Call for Papers is now open.
Everyone knows that truly innovative companies learn as they go along, pushing boundaries in response to market changes and demands. What's more of a mystery is how to balance innovation on a fresh platform built from scratch with the legacy tech stack, product suite and customers that continue to serve as the business' foundation. In his General Session at 19th Cloud Expo, Michael Chambliss, Head of Engineering at ReadyTalk, discussed why and how ReadyTalk diverted from healthy revenue and mor...
The many IoT deployments around the world are busy integrating smart devices and sensors into their enterprise IT infrastructures. Yet all of this technology – and there are an amazing number of choices – is of no use without the software to gather, communicate, and analyze the new data flows. Without software, there is no IT. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, Dave McCarthy, Director of Products at Bsquare Corporation; Alan Williamson, Principal...
"Qosmos has launched L7Viewer, a network traffic analysis tool, so it analyzes all the traffic between the virtual machine and the data center and the virtual machine and the external world," stated Sebastien Synold, Product Line Manager at Qosmos, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
President Obama recently announced the launch of a new national awareness campaign to "encourage more Americans to move beyond passwords – adding an extra layer of security like a fingerprint or codes sent to your cellphone." The shift from single passwords to multi-factor authentication couldn’t be timelier or more strategic. This session will focus on why passwords alone are no longer effective, and why the time to act is now. In his session at 19th Cloud Expo, Chris Webber, security strateg...
Effectively SMBs and government programs must address compounded regulatory compliance requirements. The most recent are Controlled Unclassified Information and the EU's GDPR have Board Level implications. Managing sensitive data protection will likely result in acquisition criteria, demonstration requests and new requirements. Developers, as part of the pre-planning process and the associated supply chain, could benefit from updating their code libraries and design by incorporating changes. In...
In his session at Cloud Expo, Robert Cohen, an economist and senior fellow at the Economic Strategy Institute, provideed economic scenarios that describe how the rapid adoption of software-defined everything including cloud services, SDDC and open networking will change GDP, industry growth, productivity and jobs. This session also included a drill down for several industries such as finance, social media, cloud service providers and pharmaceuticals.
The 20th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held June 6-8, 2017, at the Javits Center in New York City, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Containers, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportunity. Submit your speaking proposal ...
You have great SaaS business app ideas. You want to turn your idea quickly into a functional and engaging proof of concept. You need to be able to modify it to meet customers' needs, and you need to deliver a complete and secure SaaS application. How could you achieve all the above and yet avoid unforeseen IT requirements that add unnecessary cost and complexity? You also want your app to be responsive in any device at any time. In his session at 19th Cloud Expo, Mark Allen, General Manager of...
"IoT is going to be a huge industry with a lot of value for end users, for industries, for consumers, for manufacturers. How can we use cloud to effectively manage IoT applications," stated Ian Khan, Innovation & Marketing Manager at Solgeniakhela, in this SYS-CON.tv interview at @ThingsExpo, held November 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA.
Successful digital transformation requires new organizational competencies and capabilities. Research tells us that the biggest impediment to successful transformation is human; consequently, the biggest enabler is a properly skilled and empowered workforce. In the digital age, new individual and collective competencies are required. In his session at 19th Cloud Expo, Bob Newhouse, CEO and founder of Agilitiv, drew together recent research and lessons learned from emerging and established compa...