Welcome!

News Feed Item

Five New Human Studies Completed by Greenleaf Medical AB Since 2013 NutrAward Win for Best New Ingredient

Global Leader in Nutraceutical Research and Development Announces Results of Five Human Studies and Two Animal Trials

STOCKHOLM, SWEDEN -- (Marketwired) -- 03/08/14 -- Since winning NutrAward's 'Best New Ingredient' at Nutracon in March 2013, Greenleaf Medical's Appethyl ™ has been the subject of five new successful clinical trials. These five human studies and two animal trials have affirmed both the appetite suppression and weight loss effects found in the original pilot trials.

Appethyl™ is the tradename for the clinically-tested appetite suppression product from spinach that is being brought to the marketplace by Greenleaf Medical (GLM), a Swedish company that has licensed the patented technology from Lund University in Sweden.

In the clinical trials completed in 2013, Appethyl has been shown to provide the following key benefits:

1. Significantly reducing appetite four to six hours after ingesting the product with a meal. In addition, post hoc analysis showed that there was no difference between 3.7g and 7.4g dose as both doses were equally effective in reducing both hunger and thinking about food at four hours.(1)

2. Significantly reducing cravings for sweets after the first dose of 5 g, but even more significantly after 90 days and throughout the entire day.(2)

3. Significant weight loss and fat loss as well as significant loss in waist circumference compared to placebo in a very well-controlled (DBPC), 12 week independent clinical trial utilizing 2.5g given twice daily.(3)

Post-market analysis has also provided additional insights including a common experience being an increase in appetite suppression over three to four days. This effect is interesting since there is published clinical data supporting a significant reduction in appetite after just one dose which is now further supported by another yet to be published clinical trial. In addition, there are many reports of individuals feeling better when they take the product, which may be explained by one of those 100 or so proteins found in the active thylakoids found within Appethyl and one in particular, rubisco.

Two animal trials were also completed in 2013, which helped expand the physiological effects of this proprietary spinach extract. The first trial investigated the effects of Appethyl on the gut flora in rats while the second investigated the effects of Appethyl on CCK and blood glucose and insulin in pigs fed only glucose. The results are summarized below:

1. Rats fed Appethyl™ for just 10 days resulted in a significant prebiotic effect increasing the growth of Lactobacillus reuteri, a beneficial probiotic, as well as producing a completely different fecal flora from that of the control group. In addition, the product was found to significantly reduce food intake as well as a 60% lower plasma insulin levels two hours after ingesting an oral glucose tolerance test (OGTT).(4) The novel prebiotic finding is the basis for a new patent application.

2. Pigs fed Appethyl along with receiving OGTT resulted in significantly lower blood glucose levels within the first hour, greater CCK within just 30 min and an even more significant drop in ghrelin between 2 and 4 hours post-ingestion.(5)

Since the 2013 NutraAward win, Greenleaf Medical celebrated their first product launch of Appethyl in Sweden. Sales numbers surpassed projections, as Appethyl was the number one selling nutraceutical in the largest health food store chain in Sweden within weeks of its introduction to the market. Appethyl sold out in the first few days of its Swedish launch resulting in sales of $1.2 million in the first week in Sweden alone, where the population is only 9.5 million, less than a twentieth of the United States population.

For more information on Appethyl ™ or Greenleaf Medical, please visit http://www.gl-medical.com or contact Maria Soderberg at +46 70 869 27 06, (GMT +1) email: ms(at)gl-medical(dot)com.

About Greenleaf Medical AB
Greenleaf Medical is a Swedish research and development company, active in the global nutraceutical market, which sells and develops natural ingredients with well-documented, beneficial health effects. Greenleaf Medical works together with universities and international science and regulatory groups. Their products are used in both Functional Food and Dietary Supplements.

Greenleaf Medical believes the secret of health and beauty is based on finding the best ingredients through scientific validation. Dedicated to creating natural products with published mechanism-of-action and efficacy studies, the Greenleaf Medical team believes in the unique composition of natural, active ingredients and innovative formula of their supplements.

References:
(1) Stenblom EL, Montelius C, Ostbring K, Hakansson M, Nilsson S, Rehfeld JF, Erlanson-Albertsson C. Supplementation by thylakoids to a high carbohydrate meal decreases feelings of hunger, elevates CCK levels and prevents postprandial hypoglycaemia in overweight women. Appetite 2013;68:118-23.
(2) Erlanson-Albertsson C, Montelius C, Erlandsson D, Vitija E, Egecioglu E, Podgórski K. Suppressed urge for sweet and release of GLP-1 in overweight women through consumption of green plant thylakoids. Presented at 5th Swiss Winter Conference on Ingestive Behavior, March 3, 2014, St Moritz, Swiss.
(3) Unpublished data.
(4) Montelius C, Osman N, Wstrom B, Ahrne S, Molin G, Albertsson P-A, Erlanson-Albertsson C. Feeding of spinach thylakoids to rat modulates the gut microbiota, decreases food intake and affects the insulin response. Journal of Nutritional Science 2013;2:1-9.
(5) Montelius C, Szwiec K, Kardas M, Lozinska L, Erlanson-Albertsson C, Pierzynowski S, Rehfeld JF, Weström B. Dietary thylakoids suppress blood glucose and modulate appetite-regulating hormones in pigs exposed to oral glucose tolerance test. Clinical Nutrition. 2014.

Elizabeth Maxim
Media Contact
Email Contact
Phone: +1 (310) 994-7381

More Stories By Marketwired .

Copyright © 2009 Marketwired. All rights reserved. All the news releases provided by Marketwired are copyrighted. Any forms of copying other than an individual user's personal reference without express written permission is prohibited. Further distribution of these materials is strictly forbidden, including but not limited to, posting, emailing, faxing, archiving in a public database, redistributing via a computer network or in a printed form.

Latest Stories
SYS-CON Events announced today that HTBase will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. HTBase (Gartner 2016 Cool Vendor) delivers a Composable IT infrastructure solution architected for agility and increased efficiency. It turns compute, storage, and fabric into fluid pools of resources that are easily composed and re-composed to meet each application’s needs. With HTBase, companies can quickly prov...
SYS-CON Events announced today that Infranics will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Since 2000, Infranics has developed SysMaster Suite, which is required for the stable and efficient management of ICT infrastructure. The ICT management solution developed and provided by Infranics continues to add intelligence to the ICT infrastructure through the IMC (Infra Management Cycle) based on mathemat...
SYS-CON Events announced today that Cloudistics, an on-premises cloud computing company, has been named “Bronze Sponsor” of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Cloudistics delivers a complete public cloud experience with composable on-premises infrastructures to medium and large enterprises. Its software-defined technology natively converges network, storage, compute, virtualization, and management into a ...
SYS-CON Events announced today that Interoute, owner-operator of one of Europe's largest networks and a global cloud services platform, has been named “Bronze Sponsor” of SYS-CON's 20th Cloud Expo, which will take place on June 6-8, 2017 at the Javits Center in New York, New York. Interoute is the owner-operator of one of Europe's largest networks and a global cloud services platform which encompasses 12 data centers, 14 virtual data centers and 31 colocation centers, with connections to 195 add...
Building custom add-ons does not need to be limited to the ideas you see on a marketplace. In his session at 20th Cloud Expo, Sukhbir Dhillon, CEO and founder of Addteq, will go over some adventures they faced in developing integrations using Atlassian SDK and other technologies/platforms and how it has enabled development teams to experiment with newer paradigms like Serverless and newer features of Atlassian SDKs. In this presentation, you will be taken on a journey of Add-On and Integration ...
There are 66 million network cameras capturing terabytes of data. How did factories in Japan improve physical security at the facilities and improve employee productivity? Edge Computing reduces possible kilobytes of data collected per second to only a few kilobytes of data transmitted to the public cloud every day. Data is aggregated and analyzed close to sensors so only intelligent results need to be transmitted to the cloud. Non-essential data is recycled to optimize storage.
"I think that everyone recognizes that for IoT to really realize its full potential and value that it is about creating ecosystems and marketplaces and that no single vendor is able to support what is required," explained Esmeralda Swartz, VP, Marketing Enterprise and Cloud at Ericsson, in this SYS-CON.tv interview at @ThingsExpo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Interoute has announced the integration of its Global Cloud Infrastructure platform with Rancher Labs’ container management platform, Rancher. This approach enables enterprises to accelerate their digital transformation and infrastructure investments. Matthew Finnie, Interoute CTO commented “Enterprises developing and building apps in the cloud and those on a path to Digital Transformation need Digital ICT Infrastructure that allows them to build, test and deploy faster than ever before. The int...
Culture is the most important ingredient of DevOps. The challenge for most organizations is defining and communicating a vision of beneficial DevOps culture for their organizations, and then facilitating the changes needed to achieve that. Often this comes down to an ability to provide true leadership. As a CIO, are your direct reports IT managers or are they IT leaders? The hard truth is that many IT managers have risen through the ranks based on their technical skills, not their leadership abi...
The essence of cloud computing is that all consumable IT resources are delivered as services. In his session at 15th Cloud Expo, Yung Chou, Technology Evangelist at Microsoft, demonstrated the concepts and implementations of two important cloud computing deliveries: Infrastructure as a Service (IaaS) and Platform as a Service (PaaS). He discussed from business and technical viewpoints what exactly they are, why we care, how they are different and in what ways, and the strategies for IT to transi...
Without a clear strategy for cost control and an architecture designed with cloud services in mind, costs and operational performance can quickly get out of control. To avoid multiple architectural redesigns requires extensive thought and planning. Boundary (now part of BMC) launched a new public-facing multi-tenant high resolution monitoring service on Amazon AWS two years ago, facing challenges and learning best practices in the early days of the new service.
Niagara Networks exhibited at the 19th International Cloud Expo, which took place at the Santa Clara Convention Center in Santa Clara, CA, in November 2016. Niagara Networks offers the highest port-density systems, and the most complete Next-Generation Network Visibility systems including Network Packet Brokers, Bypass Switches, and Network TAPs.
All organizations that did not originate this moment have a pre-existing culture as well as legacy technology and processes that can be more or less amenable to DevOps implementation. That organizational culture is influenced by the personalities and management styles of Executive Management, the wider culture in which the organization is situated, and the personalities of key team members at all levels of the organization. This culture and entrenched interests usually throw a wrench in the work...
SYS-CON Events announced today that Outlyer, a monitoring service for DevOps and operations teams, has been named “Bronze Sponsor” of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Outlyer is a monitoring service for DevOps and Operations teams running Cloud, SaaS, Microservices and IoT deployments. Designed for today's dynamic environments that need beyond cloud-scale monitoring, we make monitoring effortless so you ...
My team embarked on building a data lake for our sales and marketing data to better understand customer journeys. This required building a hybrid data pipeline to connect our cloud CRM with the new Hadoop Data Lake. One challenge is that IT was not in a position to provide support until we proved value and marketing did not have the experience, so we embarked on the journey ourselves within the product marketing team for our line of business within Progress. In his session at @BigDataExpo, Sum...