Welcome!

News Feed Item

Five New Human Studies Completed by Greenleaf Medical AB Since 2013 NutrAward Win for Best New Ingredient

Global Leader in Nutraceutical Research and Development Announces Results of Five Human Studies and Two Animal Trials

STOCKHOLM, SWEDEN -- (Marketwired) -- 03/08/14 -- Since winning NutrAward's 'Best New Ingredient' at Nutracon in March 2013, Greenleaf Medical's Appethyl ™ has been the subject of five new successful clinical trials. These five human studies and two animal trials have affirmed both the appetite suppression and weight loss effects found in the original pilot trials.

Appethyl™ is the tradename for the clinically-tested appetite suppression product from spinach that is being brought to the marketplace by Greenleaf Medical (GLM), a Swedish company that has licensed the patented technology from Lund University in Sweden.

In the clinical trials completed in 2013, Appethyl has been shown to provide the following key benefits:

1. Significantly reducing appetite four to six hours after ingesting the product with a meal. In addition, post hoc analysis showed that there was no difference between 3.7g and 7.4g dose as both doses were equally effective in reducing both hunger and thinking about food at four hours.(1)

2. Significantly reducing cravings for sweets after the first dose of 5 g, but even more significantly after 90 days and throughout the entire day.(2)

3. Significant weight loss and fat loss as well as significant loss in waist circumference compared to placebo in a very well-controlled (DBPC), 12 week independent clinical trial utilizing 2.5g given twice daily.(3)

Post-market analysis has also provided additional insights including a common experience being an increase in appetite suppression over three to four days. This effect is interesting since there is published clinical data supporting a significant reduction in appetite after just one dose which is now further supported by another yet to be published clinical trial. In addition, there are many reports of individuals feeling better when they take the product, which may be explained by one of those 100 or so proteins found in the active thylakoids found within Appethyl and one in particular, rubisco.

Two animal trials were also completed in 2013, which helped expand the physiological effects of this proprietary spinach extract. The first trial investigated the effects of Appethyl on the gut flora in rats while the second investigated the effects of Appethyl on CCK and blood glucose and insulin in pigs fed only glucose. The results are summarized below:

1. Rats fed Appethyl™ for just 10 days resulted in a significant prebiotic effect increasing the growth of Lactobacillus reuteri, a beneficial probiotic, as well as producing a completely different fecal flora from that of the control group. In addition, the product was found to significantly reduce food intake as well as a 60% lower plasma insulin levels two hours after ingesting an oral glucose tolerance test (OGTT).(4) The novel prebiotic finding is the basis for a new patent application.

2. Pigs fed Appethyl along with receiving OGTT resulted in significantly lower blood glucose levels within the first hour, greater CCK within just 30 min and an even more significant drop in ghrelin between 2 and 4 hours post-ingestion.(5)

Since the 2013 NutraAward win, Greenleaf Medical celebrated their first product launch of Appethyl in Sweden. Sales numbers surpassed projections, as Appethyl was the number one selling nutraceutical in the largest health food store chain in Sweden within weeks of its introduction to the market. Appethyl sold out in the first few days of its Swedish launch resulting in sales of $1.2 million in the first week in Sweden alone, where the population is only 9.5 million, less than a twentieth of the United States population.

For more information on Appethyl ™ or Greenleaf Medical, please visit http://www.gl-medical.com or contact Maria Soderberg at +46 70 869 27 06, (GMT +1) email: ms(at)gl-medical(dot)com.

About Greenleaf Medical AB
Greenleaf Medical is a Swedish research and development company, active in the global nutraceutical market, which sells and develops natural ingredients with well-documented, beneficial health effects. Greenleaf Medical works together with universities and international science and regulatory groups. Their products are used in both Functional Food and Dietary Supplements.

Greenleaf Medical believes the secret of health and beauty is based on finding the best ingredients through scientific validation. Dedicated to creating natural products with published mechanism-of-action and efficacy studies, the Greenleaf Medical team believes in the unique composition of natural, active ingredients and innovative formula of their supplements.

References:
(1) Stenblom EL, Montelius C, Ostbring K, Hakansson M, Nilsson S, Rehfeld JF, Erlanson-Albertsson C. Supplementation by thylakoids to a high carbohydrate meal decreases feelings of hunger, elevates CCK levels and prevents postprandial hypoglycaemia in overweight women. Appetite 2013;68:118-23.
(2) Erlanson-Albertsson C, Montelius C, Erlandsson D, Vitija E, Egecioglu E, Podgórski K. Suppressed urge for sweet and release of GLP-1 in overweight women through consumption of green plant thylakoids. Presented at 5th Swiss Winter Conference on Ingestive Behavior, March 3, 2014, St Moritz, Swiss.
(3) Unpublished data.
(4) Montelius C, Osman N, Wstrom B, Ahrne S, Molin G, Albertsson P-A, Erlanson-Albertsson C. Feeding of spinach thylakoids to rat modulates the gut microbiota, decreases food intake and affects the insulin response. Journal of Nutritional Science 2013;2:1-9.
(5) Montelius C, Szwiec K, Kardas M, Lozinska L, Erlanson-Albertsson C, Pierzynowski S, Rehfeld JF, Weström B. Dietary thylakoids suppress blood glucose and modulate appetite-regulating hormones in pigs exposed to oral glucose tolerance test. Clinical Nutrition. 2014.

Elizabeth Maxim
Media Contact
Email Contact
Phone: +1 (310) 994-7381

More Stories By Marketwired .

Copyright © 2009 Marketwired. All rights reserved. All the news releases provided by Marketwired are copyrighted. Any forms of copying other than an individual user's personal reference without express written permission is prohibited. Further distribution of these materials is strictly forbidden, including but not limited to, posting, emailing, faxing, archiving in a public database, redistributing via a computer network or in a printed form.

Latest Stories
In his session at @ThingsExpo, Eric Lachapelle, CEO of the Professional Evaluation and Certification Board (PECB), provided an overview of various initiatives to certify the security of connected devices and future trends in ensuring public trust of IoT. Eric Lachapelle is the Chief Executive Officer of the Professional Evaluation and Certification Board (PECB), an international certification body. His role is to help companies and individuals to achieve professional, accredited and worldwide re...
Both SaaS vendors and SaaS buyers are going “all-in” to hyperscale IaaS platforms such as AWS, which is disrupting the SaaS value proposition. Why should the enterprise SaaS consumer pay for the SaaS service if their data is resident in adjacent AWS S3 buckets? If both SaaS sellers and buyers are using the same cloud tools, automation and pay-per-transaction model offered by IaaS platforms, then why not host the “shrink-wrapped” software in the customers’ cloud? Further, serverless computing, cl...
You know you need the cloud, but you’re hesitant to simply dump everything at Amazon since you know that not all workloads are suitable for cloud. You know that you want the kind of ease of use and scalability that you get with public cloud, but your applications are architected in a way that makes the public cloud a non-starter. You’re looking at private cloud solutions based on hyperconverged infrastructure, but you’re concerned with the limits inherent in those technologies.
Today we can collect lots and lots of performance data. We build beautiful dashboards and even have fancy query languages to access and transform the data. Still performance data is a secret language only a couple of people understand. The more business becomes digital the more stakeholders are interested in this data including how it relates to business. Some of these people have never used a monitoring tool before. They have a question on their mind like “How is my application doing” but no id...
Join us at Cloud Expo June 6-8 to find out how to securely connect your cloud app to any cloud or on-premises data source – without complex firewall changes. More users are demanding access to on-premises data from their cloud applications. It’s no longer a “nice-to-have” but an important differentiator that drives competitive advantages. It’s the new “must have” in the hybrid era. Users want capabilities that give them a unified view of the data to get closer to customers and grow business. The...
The current age of digital transformation means that IT organizations must adapt their toolset to cover all digital experiences, beyond just the end users’. Today’s businesses can no longer focus solely on the digital interactions they manage with employees or customers; they must now contend with non-traditional factors. Whether it's the power of brand to make or break a company, the need to monitor across all locations 24/7, or the ability to proactively resolve issues, companies must adapt to...
It is ironic, but perhaps not unexpected, that many organizations who want the benefits of using an Agile approach to deliver software use a waterfall approach to adopting Agile practices: they form plans, they set milestones, and they measure progress by how many teams they have engaged. Old habits die hard, but like most waterfall software projects, most waterfall-style Agile adoption efforts fail to produce the results desired. The problem is that to get the results they want, they have to ch...
IoT solutions exploit operational data generated by Internet-connected smart “things” for the purpose of gaining operational insight and producing “better outcomes” (for example, create new business models, eliminate unscheduled maintenance, etc.). The explosive proliferation of IoT solutions will result in an exponential growth in the volume of IoT data, precipitating significant Information Governance issues: who owns the IoT data, what are the rights/duties of IoT solutions adopters towards t...
Wooed by the promise of faster innovation, lower TCO, and greater agility, businesses of every shape and size have embraced the cloud at every layer of the IT stack – from apps to file sharing to infrastructure. The typical organization currently uses more than a dozen sanctioned cloud apps and will shift more than half of all workloads to the cloud by 2018. Such cloud investments have delivered measurable benefits. But they’ve also resulted in some unintended side-effects: complexity and risk. ...
With the introduction of IoT and Smart Living in every aspect of our lives, one question has become relevant: What are the security implications? To answer this, first we have to look and explore the security models of the technologies that IoT is founded upon. In his session at @ThingsExpo, Nevi Kaja, a Research Engineer at Ford Motor Company, discussed some of the security challenges of the IoT infrastructure and related how these aspects impact Smart Living. The material was delivered interac...
The taxi industry never saw Uber coming. Startups are a threat to incumbents like never before, and a major enabler for startups is that they are instantly “cloud ready.” If innovation moves at the pace of IT, then your company is in trouble. Why? Because your data center will not keep up with frenetic pace AWS, Microsoft and Google are rolling out new capabilities. In his session at 20th Cloud Expo, Don Browning, VP of Cloud Architecture at Turner, posited that disruption is inevitable for comp...
In 2014, Amazon announced a new form of compute called Lambda. We didn't know it at the time, but this represented a fundamental shift in what we expect from cloud computing. Now, all of the major cloud computing vendors want to take part in this disruptive technology. In his session at 20th Cloud Expo, Doug Vanderweide, an instructor at Linux Academy, discussed why major players like AWS, Microsoft Azure, IBM Bluemix, and Google Cloud Platform are all trying to sidestep VMs and containers wit...
While DevOps most critically and famously fosters collaboration, communication, and integration through cultural change, culture is more of an output than an input. In order to actively drive cultural evolution, organizations must make substantial organizational and process changes, and adopt new technologies, to encourage a DevOps culture. Moderated by Andi Mann, panelists discussed how to balance these three pillars of DevOps, where to focus attention (and resources), where organizations might...
With major technology companies and startups seriously embracing Cloud strategies, now is the perfect time to attend 21st Cloud Expo October 31 - November 2, 2017, at the Santa Clara Convention Center, CA, and June 12-14, 2018, at the Javits Center in New York City, NY, and learn what is going on, contribute to the discussions, and ensure that your enterprise is on the right path to Digital Transformation.
No hype cycles or predictions of zillions of things here. IoT is big. You get it. You know your business and have great ideas for a business transformation strategy. What comes next? Time to make it happen. In his session at @ThingsExpo, Jay Mason, Associate Partner at M&S Consulting, presented a step-by-step plan to develop your technology implementation strategy. He discussed the evaluation of communication standards and IoT messaging protocols, data analytics considerations, edge-to-cloud tec...