Welcome!

News Feed Item

Statins May Lower Blood Clot Risk Following Joint Replacement Surgery

When combined with conventional blood clot prevention therapies, statins lowered the occurrence of venous thromboembolic (VTE) events by 48 percent

NEW ORLEANS, March 11, 2014 /PRNewswire-USNewswire/ -- Statins have long been known to lower cholesterol and, more recently, to decrease the risk of deep vein thrombosis (blood clots) in healthy, non-surgical patients. New, first-of-its-kind research presented today at the 2014 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS), found that statins, when used in conjunction with conventional blood clot prevention therapies, significantly reduced the risk for venous thromboembolic (VTE) events following total joint replacement (TJR) surgery.

The number of total hip and total knee replacement surgeries continues to rise each year (more than one million were performed in 2011). And while these procedures are safe and effective, and diminish pain and restore mobility in the vast majority of patients, there is a risk for side effects, including the rare formation of a VTE a blood clot located within a deep vein in the thigh or calf following surgery.

Current, standard VTE prevention techniques include the use of an elastic stocking and/or other external compression device upon admittance to the hospital, patient movement and rehabilitation beginning the first day after surgery and continuing for several months, and anticoagulant therapy (blood thinning medications) starting the night before surgery and continuing after the patient is discharged.

In this new study, researchers reviewed the outcomes of 546 total hip and knee replacement patients with a minimum of 11 months post-operative follow up. All patients received the standard VTE post-operative therapy, based on AAOS guidelines. Patients who received a revision joint replacement surgery, a TJR following a fracture, patients with a history of blood clots, or patients taking hormone replacement therapy were excluded from the study. The average patient age was 65.5 years old, and 61 percent of patients were obese with a Body Mass Index (BMI) of 33 kg/m². Patients were divided into two groups: 196 patients who took statins before, during and after surgery (perioperatively); and 221 patients who did not take statins.

The statin group had a significantly lower amount of VTE events (15 patients or 7.7 percent) compared to the non-statin group (32 patients or 14.5 percent).

"Our study found that statins, in addition to conventional venous thromboembolic pharmacologic therapy, significantly reduced the event of VTE in the post-operative period for patients undergoing elective total hip and knee replacements," said Philadelphia-based orthopaedic surgeon and lead study author Katharine T. Criner, MD. "The relative risk of VTE with use of statins was reduced by 48 percent. Statins not only have lipid-lowering effects, but anti-inflammatory effects that may account for their ability to decrease the development of VTE."

Study abstract

View disclosure statement for Dr. Criner.

About AAOS 

Follow us on Facebook.com/AAOS1 and Twitter.com/AAOS1

Orthopaedic surgeons restore mobility, reduce pain and provide value; they help people get back to work and to independent, productive lives. Visit ANationInMotion.org to read successful orthopaedic stories.

For more information on bone and joint health, visit Orthoinfo.org.

SOURCE American Academy of Orthopaedic Surgeons

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
SoftLayer operates a global cloud infrastructure platform built for Internet scale. With a global footprint of data centers and network points of presence, SoftLayer provides infrastructure as a service to leading-edge customers ranging from Web startups to global enterprises. SoftLayer's modular architecture, full-featured API, and sophisticated automation provide unparalleled performance and control. Its flexible unified platform seamlessly spans physical and virtual devices linked via a world...
SYS-CON Events announced today TechTarget has been named “Media Sponsor” of SYS-CON's 18th International Cloud Expo, which will take place on June 7–9, 2016, at the Javits Center in New York City, NY, and the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. TechTarget is the Web’s leading destination for serious technology buyers researching and making enterprise technology decisions. Its extensive global networ...
SYS-CON Events announced today that Commvault, a global leader in enterprise data protection and information management, has been named “Bronze Sponsor” of SYS-CON's 18th International Cloud Expo, which will take place on June 7–9, 2016, at the Javits Center in New York City, NY, and the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Commvault is a leading provider of data protection and information management...
SYS-CON Events announced today that BMC Software has been named "Siver Sponsor" of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2015 at the Javits Center in New York, New York. BMC is a global leader in innovative software solutions that help businesses transform into digital enterprises for the ultimate competitive advantage. BMC Digital Enterprise Management is a set of innovative IT solutions designed to make digital business fast, seamless, and optimized from mainframe to mo...
SYS-CON Events announced today that Tintri Inc., a leading producer of VM-aware storage (VAS) for virtualization and cloud environments, will exhibit at the 18th International CloudExpo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, New York, and the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
SYS-CON Events announced today BZ Media LLC has been named “Media Sponsor” of SYS-CON's 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. BZ Media LLC is a high-tech media company that produces technical conferences and expositions, and publishes a magazine, newsletters and websites in the software development, SharePoint, mobile development and Commercial Drone markets.
Enterprise networks are complex. Moreover, they were designed and deployed to meet a specific set of business requirements at a specific point in time. But, the adoption of cloud services, new business applications and intensifying security policies, among other factors, require IT organizations to continuously deploy configuration changes. Therefore, enterprises are looking for better ways to automate the management of their networks while still leveraging existing capabilities, optimizing perf...
SYS-CON Events announced today that MangoApps will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. MangoApps provides modern company intranets and team collaboration software, allowing workers to stay connected and productive from anywhere in the world and from any device. For more information, please visit https://www.mangoapps.com/.
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, wh...
The IoT is changing the way enterprises conduct business. In his session at @ThingsExpo, Eric Hoffman, Vice President at EastBanc Technologies, discuss how businesses can gain an edge over competitors by empowering consumers to take control through IoT. We'll cite examples such as a Washington, D.C.-based sports club that leveraged IoT and the cloud to develop a comprehensive booking system. He'll also highlight how IoT can revitalize and restore outdated business models, making them profitable...
Many banks and financial institutions are experimenting with containers in development environments, but when will they move into production? Containers are seen as the key to achieving the ultimate in information technology flexibility and agility. Containers work on both public and private clouds, and make it easy to build and deploy applications. The challenge for regulated industries is the cost and complexity of container security compliance. VM security compliance is already challenging, ...
SYS-CON Events announced today that ContentMX, the marketing technology and services company with a singular mission to increase engagement and drive more conversations for enterprise, channel and SMB technology marketers, has been named “Sponsor & Exhibitor Lounge Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York City, New York. “CloudExpo is a great opportunity to start a conversation with new prospects, but what happens after the...
The pace of innovation, vendor lock-in, production sustainability, cost-effectiveness, and managing risk… In his session at 18th Cloud Expo, Dan Choquette, Founder of RackN, will discuss how CIOs are challenged finding the balance of finding the right tools, technology and operational model that serves the business the best. He will discuss how clouds, open source software and infrastructure solutions have benefits but also drawbacks and how workload and operational portability between vendors...
The essence of data analysis involves setting up data pipelines that consist of several operations that are chained together – starting from data collection, data quality checks, data integration, data analysis and data visualization (including the setting up of interaction paths in that visualization). In our opinion, the challenges stem from the technology diversity at each stage of the data pipeline as well as the lack of process around the analysis.
As machines are increasingly connected to the internet, it’s becoming easier to discover the numerous ways Industrial IoT (IIoT) is helping to shape the business world. This is exactly why we have decided to take a closer look at this pervasive movement and to examine the desire to connect more things! Now if you need a refresher on IIoT and how it is changing the world, take a moment and listen to Greg Gorbach with ARC Advisory Group. Gorbach believes, "IIoT will significantly change the worl...