|By Marketwired .||
|March 11, 2014 10:09 AM EDT||
OTTAWA, ONTARIO -- (Marketwired) -- 03/11/14 -- Researchers from the Ottawa Heart Institute have found a new heart failure-protective protein. In findings published this week in Nature Communications, the researchers detail the protective role of a new protein called HACE1. They had found it to be present at increased levels in the blood of patients with heart failure, prompting them to look further at its function in the heart. This research is made possible thanks to funding from the Canadian Institutes of Health Research (CIHR).
Protecting the heart from injury so that it does not fail is the "holy grail" to prevent heart failure, said Peter Liu, MD, Scientific Director of the University of Ottawa Heart Institute. Very few new approaches have emerged recently to ameliorate heart failure, but now Dr. Liu and his colleagues have uncovered an exciting new possibility, that also has broader implications for other chronic diseases.
What makes these findings particularly interesting is that Dr. Liu and his colleagues had previously found that HACE1 is important in protecting against tumour growth and metastasis in many forms of cancer (published in Nature Medicine, 2007). This previous link to multiple cancers suggests that HACE1 may be an important player in cleaning up damage caused by many forms of chronic diseases.
Using human cells and mouse models, the investigators found that HACE1 is critical in regulating the removal of damaged proteins from cardiac cells after injury. Without this housekeeping function, heart tissue rapidly accumulates damaged proteins which, in time, interfere with normal function.
"People with high blood pressure, diabetes or chronic valve leakage can have heart failure, too. So why, when the muscle is intact, is the heart failing and not working properly? The likelihood is that when stress is placed on the heart, the proteins get damaged and accumulate. And if you don't have a mechanism to turn over these proteins and get good proteins back, the heart gradually lose its sophisticated coordination and function," said Dr. Liu.
When having a stressor that causes damage to the proteins, which accumulate in cells and make the situation worse, the damaged proteins trigger the appearance of HACE1 to remove the offending proteins to improve cell function. HACE1 appears to be one of a new class of protein quality control "police" that only appears in times of cellular stress.
The researchers are now looking for ways to facilitate or enhance HACE1 action and searching for other proteins that may play a similar role. "The intriguing possibility is that, if you could augment this system, you could help to protect the heart from failing as we age," said Dr. Liu. "And it could help to ameliorate other chronic diseases, too."
Heart failure is a weakness in the pumping function of the heart muscle, leading to shortness of breath and fluid buildup in the patient, and visits to the emergency room. One in 5 North Americans will succumb to heart failure, and it is one of the most costly and deadly chronic conditions. Heart failure is usually the result of damage to the heart muscle caused by a heart attack, high blood pressure, diabetes, or a virus.
Senior Manager, Public Affairs
University of Ottawa Heart Institute
The Quantified Economy represents the total global addressable market (TAM) for IoT that, according to a recent IDC report, will grow to an unprecedented $1.3 trillion by 2019. With this the third wave of the Internet-global proliferation of connected devices, appliances and sensors is poised to take off in 2016. In his session at @ThingsExpo, David McLauchlan, CEO and co-founder of Buddy Platform, will discuss how the ability to access and analyze the massive volume of streaming data from mil...
Feb. 12, 2016 09:00 AM EST
WebSocket is effectively a persistent and fat pipe that is compatible with a standard web infrastructure; a "TCP for the Web." If you think of WebSocket in this light, there are other more hugely interesting applications of WebSocket than just simply sending data to a browser. In his session at 18th Cloud Expo, Frank Greco, Director of Technology for Kaazing Corporation, will compare other modern web connectivity methods such as HTTP/2, HTTP Streaming, Server-Sent Events and new W3C event APIs ...
Feb. 12, 2016 09:00 AM EST
Advances in technology and ubiquitous connectivity have made the utilization of a dispersed workforce more common. Whether that remote team is located across the street or country, management styles/ approaches will have to be adjusted to accommodate this new dynamic. In his session at 17th Cloud Expo, Sagi Brody, Chief Technology Officer at Webair Internet Development Inc., focused on the challenges of managing remote teams, providing real-world examples that demonstrate what works and what do...
Feb. 12, 2016 08:00 AM EST Reads: 319
The cloud competition for database hosts is fierce. How do you evaluate a cloud provider for your database platform? In his session at 18th Cloud Expo, Chris Presley, a Solutions Architect at Pythian, will give users a checklist of considerations when choosing a provider. Chris Presley is a Solutions Architect at Pythian. He loves order – making him a premier Microsoft SQL Server expert. Not only has he programmed and administered SQL Server, but he has also shared his expertise and passion w...
Feb. 12, 2016 08:00 AM EST
SYS-CON Events announced today that Men & Mice, the leading global provider of DNS, DHCP and IP address management overlay solutions, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. The Men & Mice Suite overlay solution is already known for its powerful application in heterogeneous operating environments, enabling enterprises to scale without fuss. Building on a solid range of diverse platform support,...
Feb. 12, 2016 06:00 AM EST Reads: 247
Eighty percent of a data scientist’s time is spent gathering and cleaning up data, and 80% of all data is unstructured and almost never analyzed. Cognitive computing, in combination with Big Data, is changing the equation by creating data reservoirs and using natural language processing to enable analysis of unstructured data sources. This is impacting every aspect of the analytics profession from how data is mined (and by whom) to how it is delivered. This is not some futuristic vision: it's ha...
Feb. 12, 2016 05:45 AM EST Reads: 455
Silver Spring Networks, Inc. (NYSE: SSNI) extended its Internet of Things technology platform with performance enhancements to Gen5 – its fifth generation critical infrastructure networking platform. Already delivering nearly 23 million devices on five continents as one of the leading networking providers in the market, Silver Spring announced it is doubling the maximum speed of its Gen5 network to up to 2.4 Mbps, increasing computational performance by 10x, supporting simultaneous mesh communic...
Feb. 12, 2016 05:00 AM EST
Predictive analytics tools monitor, report, and troubleshoot in order to make proactive decisions about the health, performance, and utilization of storage. Most enterprises combine cloud and on-premise storage, resulting in blended environments of physical, virtual, cloud, and other platforms, which justifies more sophisticated storage analytics. In his session at 18th Cloud Expo, Peter McCallum, Vice President of Datacenter Solutions at FalconStor, will discuss using predictive analytics to ...
Feb. 12, 2016 04:45 AM EST Reads: 404
Let’s face it, embracing new storage technologies, capabilities and upgrading to new hardware often adds complexity and increases costs. In his session at 18th Cloud Expo, Seth Oxenhorn, Vice President of Business Development & Alliances at FalconStor, will discuss how a truly heterogeneous software-defined storage approach can add value to legacy platforms and heterogeneous environments. The result reduces complexity, significantly lowers cost, and provides IT organizations with improved effi...
Feb. 12, 2016 03:45 AM EST Reads: 264
Sensors and effectors of IoT are solving problems in new ways, but small businesses have been slow to join the quantified world. They’ll need information from IoT using applications as varied as the businesses themselves. In his session at @ThingsExpo, Roger Meike, Distinguished Engineer, Director of Technology Innovation at Intuit, showed how IoT manufacturers can use open standards, public APIs and custom apps to enable the Quantified Small Business. He used a Raspberry Pi to connect sensors...
Feb. 12, 2016 03:45 AM EST Reads: 344
The cloud promises new levels of agility and cost-savings for Big Data, data warehousing and analytics. But it’s challenging to understand all the options – from IaaS and PaaS to newer services like HaaS (Hadoop as a Service) and BDaaS (Big Data as a Service). In her session at @BigDataExpo at @ThingsExpo, Hannah Smalltree, a director at Cazena, will provide an educational overview of emerging “as-a-service” options for Big Data in the cloud. This is critical background for IT and data profes...
Feb. 12, 2016 02:30 AM EST Reads: 224
Father business cycles and digital consumers are forcing enterprises to respond faster to customer needs and competitive demands. Successful integration of DevOps and Agile development will be key for business success in today’s digital economy. In his session at DevOps Summit, Pradeep Prabhu, Co-Founder & CEO of Cloudmunch, covered the critical practices that enterprises should consider to seamlessly integrate Agile and DevOps processes, barriers to implementing this in the enterprise, and pr...
Feb. 12, 2016 02:00 AM EST Reads: 438
The principles behind DevOps are not new - for decades people have been automating system administration and decreasing the time to deploy apps and perform other management tasks. However, only recently did we see the tools and the will necessary to share the benefits and power of automation with a wider circle of people. In his session at DevOps Summit, Bernard Sanders, Chief Technology Officer at CloudBolt Software, explored the latest tools including Puppet, Chef, Docker, and CMPs needed to...
Feb. 12, 2016 01:30 AM EST Reads: 347
With the Apple Watch making its way onto wrists all over the world, it’s only a matter of time before it becomes a staple in the workplace. In fact, Forrester reported that 68 percent of technology and business decision-makers characterize wearables as a top priority for 2015. Recognizing their business value early on, FinancialForce.com was the first to bring ERP to wearables, helping streamline communication across front and back office functions. In his session at @ThingsExpo, Kevin Roberts...
Feb. 12, 2016 12:45 AM EST Reads: 407
Cognitive Computing is becoming the foundation for a new generation of solutions that have the potential to transform business. Unlike traditional approaches to building solutions, a cognitive computing approach allows the data to help determine the way applications are designed. This contrasts with conventional software development that begins with defining logic based on the current way a business operates. In her session at 18th Cloud Expo, Judith S. Hurwitz, President and CEO of Hurwitz & ...
Feb. 12, 2016 12:00 AM EST Reads: 281