Welcome!

News Feed Item

Microscopic Revelations Make it Big Time: A*STAR Scientists' Prize-Winning Image to Light up Times Square, New York



First win for Singapore in annual GE Healthcare Life Sciences cell imaging competition

Singapore, 3/18 - Mouse spermatocyte[1] stained for two proteins - KASH-5 (red) and SCP3 (green) - and DNA (blue) illuminates understanding on fertility
Singapore, Mar 18, 2014 - (ACN Newswire) - Drs Graham Wright and Henning Horn from A*STAR's Institute of Medical Biology (IMB) are the Asia-Pacific winners in the microscopy category at the 2013 GE Cell imaging competition. With over 23,000 votes cast by scientists and the public, the winners can now look forward to seeing their prize-winning images illuminate Times Square, New York between 25 and 27 April 2014.

For seven years, GE Healthcare - a leader in providing transformational medical technologies and services for more affordable healthcare around the world - has organised an annual competition showcasing the beauty of cells and the inspiring research of cellular biologists from around the world. This year's competition attracted over 100 entries from scientists all over the world who are using either high-content analysis or high- and super resolution microscopy to investigate at the cellular level a wide variety of diseases such as cancer, muscle disease and the effects of parasitic infections.

A panel of six scientific experts shortlisted 30 finalists, after which voting was open to the public. A*STAR's scientists are one of three winners in the competition this year (see Annex A for details of winners). Their winning image showcases a developing mouse sperm cell that has been stained for two proteins - KASH5 and SCP3. The teams under Dr Colin Stewart and Dr Brian Burke at IMB have determined that the nuclear envelope protein KASH5 is important for chromosome movement during meiosis[2]. "This chromosome movement is essential for the maturation of sperm and eggs, and without it, individuals are sterile. Besides understanding the role of KASH5, this finding also helps to gain greater insight into the process of meiosis, which may have potential implications for our understanding of infertility," said Dr Horn.

"We are thrilled that our scientists have won this award. This image is truly pioneering; to see biology at this level of detail is mind-opening and awe-inspiring in its beauty. Research at A*STAR's IMB is driven by our desire to understand disease and improve wellbeing, and many new discoveries are first seen as microscopy images, so images like this also represent important scientific progress," said Prof Birgit Lane, Executive Director of IMB, A*STAR.

With the increased resolution of this image, the team was able to definitively identify the pairing of chromosomes. Paired chromosomes (paired red lines in the image) are not resolved by conventional light microscopy techniques, and being able to determine whether chromosomes are paired or not is critical for understanding the function of KASH5 in meiosis.

Dr Wright said, "This image was particularly striking when we captured it - the orientation of the proteins we were studying and the two sperm cells stained in blue on both sides made it beautiful. We spent a good session consistently producing high quality images, but this one stood out due to the way the chromosomes were organised. It is a great honour to have our image screened at Times Square, New York."

While the research carried out at IMB varies in its subject matter, microscopy is usually used to visualise and analyse the way proteins, cells and tissues are organised and how they behave. The use of fluorescent dyes enables the imaging of the proteins to determine what they do over time. This provides insight into the function of a protein, and how this function goes wrong in diseases studied at IMB.

Leading the Microscopy Unit at IMB, Dr Wright is involved in the teaching and training of researchers in how to apply advanced microscopy techniques to their research. "Personally, my aim is to ensure the most appropriate microscopy techniques are applied to the best of their ability by the researchers in our institute - we're lucky to have a fantastic infrastructure of cutting-edge imaging equipment here so we want to make the most of it," said Dr Wright.

Image caption: Mouse spermatocyte[1] stained for two proteins - KASH-5 (red) and SCP3 (green) - and DNA (blue) illuminates understanding on fertility

[1] A male sperm cell in its developmental stage, during which meiosis occurs
[2] A type of cell division necessary for sexual reproduction to occur in animals, plants and fungi

Please see the full press release, with Annexes, at http://bit.ly/1qNvLtD.

About the Institute of Medical Biology (IMB)

IMB is one of the Biomedical Sciences Institutes of the Agency for Science, Technology and Research (A*STAR). It was formed in 2007, with a mission to study mechanisms of human disease in order to discover new and effective therapeutic strategies for improved quality of life.

IMB has 20 research teams working in three primary focus areas - skin biology, genetic disease and stem cells. The teams work closely with clinical collaborators as well as industry partners, to target the challenging interface between basic science and clinical medicine. IMB's strategic research topics are targeted at translational research to understand the mechanisms of human disease so as to identify new strategies for disease amelioration, cure and eradication and to improve health and wellbeing. Since 2011, IMB has also hosted the inter-research institute Skin Biology Cluster platform, and leads major strategic funding programs in rare genetic diseases and in skin biology. In 2013 IMB became a founding institute of the Skin Research Institute of Singapore. For more information on IMB, please visit www.imb.a-star.edu.sg.

About A*STAR

The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector agency that fosters world-class scientific research and talent to drive economic growth and transform Singapore into a vibrant knowledge-based and innovation driven economy.

In line with its mission-oriented mandate, A*STAR spearheads research and development in fields that are essential to growing Singapore's manufacturing sector and catalysing new growth industries. A*STAR supports these economic clusters by providing intellectual, human and industrial capital to its partners in industry.

A*STAR oversees 18 biomedical sciences and physical sciences and engineering research entities, located in Biopolis and Fusionopolis, as well as their vicinity. These two R&D hubs house a bustling and diverse community of local and international research scientists and engineers from A*STAR's research entities as well as a growing number of corporate laboratories. For more information on A*STAR, please visit www.a-star.edu.sg.

Source: A*STAR

Contact:
Vithya Selvam (Ms)
Senior Officer, Corporate Communications 
Agency for Science, Technology and Research
Tel: +65 6826 6291
Email: [email protected]




Copyright 2014 ACN Newswire. All rights reserved.

More Stories By ACN Newswire

Copyright 2008 ACN Newswire. All rights reserved. Republication or redistribution of ACN Newswire content is expressly prohibited without the prior written consent of ACN Newswire. ACN Newswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
"This is specifically designed to accommodate some of the needs for high availability and failover in a network managed system for the major Korean corporations," stated Thomas Masters, Managing Director at InfranicsUSA, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Unsecured IoT devices were used to launch crippling DDOS attacks in October 2016, targeting services such as Twitter, Spotify, and GitHub. Subsequent testimony to Congress about potential attacks on office buildings, schools, and hospitals raised the possibility for the IoT to harm and even kill people. What should be done? Does the government need to intervene? This panel at @ThingExpo New York brings together leading IoT and security experts to discuss this very serious topic.
More and more brands have jumped on the IoT bandwagon. We have an excess of wearables – activity trackers, smartwatches, smart glasses and sneakers, and more that track seemingly endless datapoints. However, most consumers have no idea what “IoT” means. Creating more wearables that track data shouldn't be the aim of brands; delivering meaningful, tangible relevance to their users should be. We're in a period in which the IoT pendulum is still swinging. Initially, it swung toward "smart for smar...
CloudJumper, a Workspace as a Service (WaaS) platform innovator for agile business IT, has been recognized with the Customer Value Leadership Award for its nWorkSpace platform by Frost & Sullivan. The company was also featured in a new report(1) by the industry research firm titled, “Desktop-as-a-Service Buyer’s Guide, 2016,” which provides a comprehensive comparison of DaaS providers, including CloudJumper, Amazon, VMware, and Microsoft.
"Dice has been around for the last 20 years. We have been helping tech professionals find new jobs and career opportunities," explained Manish Dixit, VP of Product and Engineering at Dice, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Complete Internet of Things (IoT) embedded device security is not just about the device but involves the entire product’s identity, data and control integrity, and services traversing the cloud. A device can no longer be looked at as an island; it is a part of a system. In fact, given the cross-domain interactions enabled by IoT it could be a part of many systems. Also, depending on where the device is deployed, for example, in the office building versus a factory floor or oil field, security ha...
"At ROHA we develop an app called Catcha. It was developed after we spent a year meeting with, talking to, interacting with senior citizens watching them use their smartphones and talking to them about how they use their smartphones so we could get to know their smartphone behavior," explained Dave Woods, Chief Innovation Officer at ROHA, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
"ReadyTalk is an audio and web video conferencing provider. We've really come to embrace WebRTC as the platform for our future of technology," explained Dan Cunningham, CTO of ReadyTalk, in this SYS-CON.tv interview at WebRTC Summit at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Rapid innovation, changing business landscapes, and new IT demands force businesses to make changes quickly. In the eyes of many, containers are at the brink of becoming a pervasive technology in enterprise IT to accelerate application delivery. In this presentation, attendees learned about the: The transformation of IT to a DevOps, microservices, and container-based architecture What are containers and how DevOps practices can operate in a container-based environment A demonstration of how ...
Cloud Expo, Inc. has announced today that Andi Mann returns to 'DevOps at Cloud Expo 2017' as Conference Chair The @DevOpsSummit at Cloud Expo will take place on June 6-8, 2017, at the Javits Center in New York City, NY. "DevOps is set to be one of the most profound disruptions to hit IT in decades," said Andi Mann. "It is a natural extension of cloud computing, and I have seen both firsthand and in independent research the fantastic results DevOps delivers. So I am excited to help the great t...
Fact: storage performance problems have only gotten more complicated, as applications not only have become largely virtualized, but also have moved to cloud-based infrastructures. Storage performance in virtualized environments isn’t just about IOPS anymore. Instead, you need to guarantee performance for individual VMs, helping applications maintain performance as the number of VMs continues to go up in real time. In his session at Cloud Expo, Dhiraj Sehgal, Product and Marketing at Tintri, sha...
SYS-CON Events announced today that Fusion, a leading provider of cloud services, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Fusion, a leading provider of integrated cloud solutions to small, medium and large businesses, is the industry’s single source for the cloud. Fusion’s advanced, proprietary cloud service platform enables the integration of leading edge solutions in the cloud, including clou...
Without lifecycle traceability and visibility across the tool chain, stakeholders from Planning-to-Ops have limited insight and answers to who, what, when, why and how across the DevOps lifecycle. This impacts the ability to deliver high quality software at the needed velocity to drive positive business outcomes. In his general session at @DevOpsSummit at 19th Cloud Expo, Phil Hombledal, Solution Architect at CollabNet, discussed how customers are able to achieve a level of transparency that e...
WebRTC is the future of browser-to-browser communications, and continues to make inroads into the traditional, difficult, plug-in web communications world. The 6th WebRTC Summit continues our tradition of delivering the latest and greatest presentations within the world of WebRTC. Topics include voice calling, video chat, P2P file sharing, and use cases that have already leveraged the power and convenience of WebRTC.
"Venafi has a platform that allows you to manage, centralize and automate the complete life cycle of keys and certificates within the organization," explained Gina Osmond, Sr. Field Marketing Manager at Venafi, in this SYS-CON.tv interview at DevOps at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.