Welcome!

News Feed Item

New Findings For Bee Colony Collapse Disorder (CCD) To Be Presented at World Vaccine Congress in Washington March 24-26

Increase in Concentration of Newly Identified Replikin Beetoxingene Preceded Current CCD Outbreaks; Beetoxingene Sequences are CCD Blocker and Vaccine Candidates

LONDON, March 21, 2014 /PRNewswire/ -- Bee Colony Collapse Disorder (CCD) is increasing with unknown cause(s).  There is no effective treatment or prevention of CCD.  Increasing loss of bee colonies since 2005 is resulting in the loss of bee pollination which poses a threat to food production worldwide.              

(Photo: http://photos.prnewswire.com/prnh/20140321/PH88466 )

Bioradar UK Ltd. announced today that the principal organisms associated to date with Colony Collapse Disorder (CCD) in bees, all have increased concentrations of a structure in their genes, which the Replikins scientists have named Beetoxingene.  These CCD genes are related to the specific Replikin gene sequence structures previously described in which relate to infectivity and lethality (1-8).

In the present study, Bioradar software was used to analyze annually all the gene sequence data available on PubMed data bases,  independently for Replikins in each organism for which there is evidence of involvement in CCD in all pre-outbreak years available and in the years of the current CCD outbreaks 2005-2013. The genes of organisms such as Varroa Destructor mite, Nosema Cerenae fungus, and bee viruses including Sackbrood, Israeli, and Kashmir strains, were each independently found to have increased Replikin Counts, Beetoxingene Counts, at p<0.001 at the same times as the lethal CCD pandemic was occuring.  The highest Counts, up to over 10, were found in the genes of the bees themselves. 

Most important, the increases in the bees and in each of the associated organisms was found to occur at the same times.  Annual mean Beetoxingene Counts (number per 100 amino acids) pre-outbreak, before CCD, in each of the organisms and in the bees were usually approximately 2.  Increases and peaks of Counts were observed during the CCD pandemic years both preceding and at the height of CCD attacks (see Figure).  The results in the Figure also show a correlation in time between  two cycles of independent peak Counts in the two organisms, Varroa Destructor and Sackbrood virus as well as in the bee gene.

The Beetoxingenes may increase independently in each organism and in the bees, and the associated organisms of the CCD simply may be multiple independent hosts and carriers of lethal Beetoxingenes. Alternately, the Beetoxingenes may be transferred from the individual organisms to the genes of the bee. The Beetoxingene Counts in individual organisms  may not be sufficient to kill the individual organism, permitting each to function as a carrier to the ultimate host, the bee, where the cumulative Counts reach double or triple that of each individual organism (see Figure), and where the cumulative doses kill the bee.

Increase in Replikin and Beetoxingene Counts has been found to be related to lethality, and Replikins blockers and vaccines have been shown to act effectively against Replikins disorders. However, all of Koch's Postulates for causality have not yet been fulfilled, and increased Beetoxingene Counts do not alone exclude other as yet unidentified CCD pathogens which carry Replikins in their genes.

These findings are the basis of specific solid phase synthetic Anti-Beetoxingene Blockers and Vaccines against CCD in bees like those found effective against H5N1 influenza virus in chickens and against Taura Syndrome Virus in shrimp.

The findings will be presented at the World Vaccine Congress at the Marriot Wardman Park Hotel Washington D.C. March 24th to 26th 2014.

Contact: Anne Borsanyi 
Email, 646-320-8772

References: 
1. Bogoch S and Bogoch ES.Genome Replikin Count Predicts Increased Infectivity/Lethality of Viruses  doi:10.1038/npre.2012.7144.1 
2. Bogoch S and Bogoch ES.  Genome Replikin Count Predicts Increased Lethality of Cancer. doi:10.1038/npre.2012.7143.1 
3. Bogoch S and Bogoch ES. Genomic Replikin Count Predicts Increased Lethality of Malaria doi:10.1038/npre.2012.7142.1 
4. Bogoch S and Bogoch ES Genome Replikin Count Predicts Increased Lethality of Resistant Tuberculosis  doi:10.1038/npre.2012.7141.1 
5. Bogoch S and Bogoch ES Genomic Replikin Counts of Infectious Salmon Anemia Virus (ISAV) in Canada Exceed the Counts in Lethal Outbreaks in Norway, Chile, and Scotland. Real-Time Tracking of the Evolution of the ISAV Genome and the Resultant Replikins Solid Phase ISAV Vaccine Make ISAV Pandemic Prevention Possible. doi:10.1038/npre.2012.6991.1 6. Bogoch S and Bogoch ES Bogoch Replikins Pandemic Prevention: Increase of Strain-Specific Influenza Genomic Replikin Counts, Having Predicted Outbreaks and their Location Seven Times Consecutively, Up to Two Years in Advance, Provides Time for Prevention of Pandemics doi:10.1038/npre.2012.6952.1 
7. Bogoch S and Bogoch ES Marked Rise in Replikin Counts in H5N1 Influenza Virus Localized to Lethality Gene p B1. doi:10.1038/npre.2011.6420.1  
8. Bogoch S and Bogoch ES Prediction of specific virus outbreaks made from the increased concentration of a new class of virus genomic peptides, replikins. doi:10.1038/npre.2011.6279.1

Read more news from Bioradar UK Ltd.

 

 

SOURCE Bioradar UK, Ltd.

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
The emerging Internet of Everything creates tremendous new opportunities for customer engagement and business model innovation. However, enterprises must overcome a number of critical challenges to bring these new solutions to market. In his session at @ThingsExpo, Michael Martin, CTO/CIO at nfrastructure, outlined these key challenges and recommended approaches for overcoming them to achieve speed and agility in the design, development and implementation of Internet of Everything solutions wi...
DevOps at Cloud Expo, taking place Nov 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 19th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is no time to wait for long dev...
Cloud computing is being adopted in one form or another by 94% of enterprises today. Tens of billions of new devices are being connected to The Internet of Things. And Big Data is driving this bus. An exponential increase is expected in the amount of information being processed, managed, analyzed, and acted upon by enterprise IT. This amazing is not part of some distant future - it is happening today. One report shows a 650% increase in enterprise data by 2020. Other estimates are even higher....
I wanted to gather all of my Internet of Things (IOT) blogs into a single blog (that I could later use with my University of San Francisco (USF) Big Data “MBA” course). However as I started to pull these blogs together, I realized that my IOT discussion lacked a vision; it lacked an end point towards which an organization could drive their IOT envisioning, proof of value, app dev, data engineering and data science efforts. And I think that the IOT end point is really quite simple…
Aspose.Total for .NET is the most complete package of all file format APIs for .NET as offered by Aspose. It empowers developers to create, edit, render, print and convert between a wide range of popular document formats within any .NET, C#, ASP.NET and VB.NET applications. Aspose compiles all .NET APIs on a daily basis to ensure that it contains the most up to date versions of each of Aspose .NET APIs. If a new .NET API or a new version of existing APIs is released during the subscription peri...
Today we can collect lots and lots of performance data. We build beautiful dashboards and even have fancy query languages to access and transform the data. Still performance data is a secret language only a couple of people understand. The more business becomes digital the more stakeholders are interested in this data including how it relates to business. Some of these people have never used a monitoring tool before. They have a question on their mind like “How is my application doing” but no id...
Identity is in everything and customers are looking to their providers to ensure the security of their identities, transactions and data. With the increased reliance on cloud-based services, service providers must build security and trust into their offerings, adding value to customers and improving the user experience. Making identity, security and privacy easy for customers provides a unique advantage over the competition.
Qosmos has announced new milestones in the detection of encrypted traffic and in protocol signature coverage. Qosmos latest software can accurately classify traffic encrypted with SSL/TLS (e.g., Google, Facebook, WhatsApp), P2P traffic (e.g., BitTorrent, MuTorrent, Vuze), and Skype, while preserving the privacy of communication content. These new classification techniques mean that traffic optimization, policy enforcement, and user experience are largely unaffected by encryption. In respect wit...
Kubernetes, Docker and containers are changing the world, and how companies are deploying their software and running their infrastructure. With the shift in how applications are built and deployed, new challenges must be solved. In his session at @DevOpsSummit at19th Cloud Expo, Sebastian Scheele, co-founder of Loodse, will discuss the implications of containerized applications/infrastructures and their impact on the enterprise. In a real world example based on Kubernetes, he will show how to ...
Using new techniques of information modeling, indexing, and processing, new cloud-based systems can support cloud-based workloads previously not possible for high-throughput insurance, banking, and case-based applications. In his session at 18th Cloud Expo, John Newton, CTO, Founder and Chairman of Alfresco, described how to scale cloud-based content management repositories to store, manage, and retrieve billions of documents and related information with fast and linear scalability. He addres...
Is the ongoing quest for agility in the data center forcing you to evaluate how to be a part of infrastructure automation efforts? As organizations evolve toward bimodal IT operations, they are embracing new service delivery models and leveraging virtualization to increase infrastructure agility. Therefore, the network must evolve in parallel to become equally agile. Read this essential piece of Gartner research for recommendations on achieving greater agility.
SYS-CON Events announced today that Hitrons Solutions will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Hitrons Solutions Inc. is distributor in the North American market for unique products and services of small and medium-size businesses, including cloud services and solutions, SEO marketing platforms, and mobile applications.
Smart Cities are here to stay, but for their promise to be delivered, the data they produce must not be put in new siloes. In his session at @ThingsExpo, Mathias Herberts, Co-founder and CTO of Cityzen Data, will deep dive into best practices that will ensure a successful smart city journey.
Internet of @ThingsExpo, taking place November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 19th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The Internet of Things (IoT) is the most profound change in personal and enterprise IT since the creation of the Worldwide Web more than 20 years ago. All major researchers estimate there will be tens of billions devices - comp...
SYS-CON Events announced today that Venafi, the Immune System for the Internet™ and the leading provider of Next Generation Trust Protection, will exhibit at @DevOpsSummit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Venafi is the Immune System for the Internet™ that protects the foundation of all cybersecurity – cryptographic keys and digital certificates – so they can’t be misused by bad guys in attacks...