Welcome!

News Feed Item

New Hope for Organ Transplant Patients

CHERTSEY, England, March 24, 2014 /PRNewswire/ --



A recent study supported by an Astellas European Foundation Grant has identified potential therapeutic targets for transplantation treatment research. The study, carried out by Dr Nuria Lloberas, examined whether changing specific proteins in the body leads to a reduction in the immuno-inflammatory response thus lowering the risk of organ rejection.  

Dr Lloberas, from Hospital Universitario de Bellvitge, Barcelona, received the Astellas European Foundation Transplantation Grant in 2007 to support her research culminating in her findings, 'Dendritic cells (DC) phenotype fitting under hypoxia or LPS. ABC transporters far beyond an efflux pump' appeared in Clinical  and  Experimental  Immunology  Journal.[1] The study focused on ABC transporters to see whether they are essential in the development of maturing immune cells in an oxygen-deprived microenvironment. The modulation of these maturing cells through ABC transporters could be a potential target to reduce immuno-inflammatory responses in organ transplantation.

Dr Lloberas said, "As DC are the most potent Antigen-Presenting Cells (APC) of the immune system, it is crucial to know the underlying mechanisms in their activation. Furthermore, their ability to change their phenotype and function depending on their stage of maturation is an interesting target in immune system modulation towards tolerance in solid organs transplant. The first goal of our work was to study the contribution of ABC molecules in       DC maturation and, in a second step, we are studying whether ABC transporter proteins under different immunosuppressive therapies are able to modify DC maturation states and potentially ABC pro-inflammatory substrates. Our study will provide more information on DC migration and maturation requirements, considering that ABC molecules transporters have a potential target in DC-based immunosuppressive therapies."

Over 30,000 transplants are performed per year in Europe.[2]   Success in transplantation has occurred through innovations in surgical and patient care and the development of immunosuppressive therapies. There is a need to increase the specificity of immunosuppression in order to improve efficacy and tolerability profiles. Identifying novel targets for the immune system is an important step in the development of such specific immunotherapies.

Dr Ayad Abdulahad, Astellas European Foundation Trustee and Senior Vice President Medical Affairs and Health Economics for Astellas Pharma Europe Ltd. stated: "I am delighted to see the progress made by the 2007 Grant winners. The team was selected because its work was seen to have the potential to identify new routes that researchers can target. Dr Lloberas and the team's work highlights ABC-transporters as potential targets in immunosuppressive therapies."

The Astellas European Foundation Transplantation Grant for 2014 will be awarded in September.  A grant of US$150,000 will be awarded to the successful research unit or institution. The Grant will be offered for extensive and meaningful research in the area of transplantation. "We receive many entries from across Europe for the Astellas European Foundation Grants. We look forward to receiving many more entries again for this coming year," said Dr Abdulahad.

Application forms will be available in May of 2014. Please contact [email protected] or call +44(0)203-379-8039.

References

  1. Lloberas, N.  Dendritic cells (DC) phenotype fitting under hypoxia or LPS. ABC transporters far beyond an efflux pump. Clinical  and  Experimental  Immunology  Journal  2013 Jun;172(3):444-54
  2. Matesanz, R. International  Figures  on  Donation  and  Transplantation  2012, Council of Europe, European Committee, Vol. 18, No. 1, September 2013

Notes  to  Editors 

About The Astellas European Foundation

The Astellas European Foundation is a registered charity, formed in 2005, with the long-term goal of providing support for programmes and activities that contribute to the advancement of an increasingly healthy society. In line with this aim, the Foundation made substantial donations to global charities. The Astellas European Foundation also supports Astellas employees in their private fundraising efforts for charitable causes. The Astellas European Foundation is registered with the Charity Commission for England and Wales, number 1036344.

The Astellas European Foundation was established by funding from Astellas Pharma Inc, but operates independently of it.

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
"MobiDev is a Ukraine-based software development company. We do mobile development, and we're specialists in that. But we do full stack software development for entrepreneurs, for emerging companies, and for enterprise ventures," explained Alan Winters, U.S. Head of Business Development at MobiDev, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
A look across the tech landscape at the disruptive technologies that are increasing in prominence and speculate as to which will be most impactful for communications – namely, AI and Cloud Computing. In his session at 20th Cloud Expo, Curtis Peterson, VP of Operations at RingCentral, highlighted the current challenges of these transformative technologies and shared strategies for preparing your organization for these changes. This “view from the top” outlined the latest trends and developments i...
Automation is enabling enterprises to design, deploy, and manage more complex, hybrid cloud environments. Yet the people who manage these environments must be trained in and understanding these environments better than ever before. A new era of analytics and cognitive computing is adding intelligence, but also more complexity, to these cloud environments. How smart is your cloud? How smart should it be? In this power panel at 20th Cloud Expo, moderated by Conference Chair Roger Strukhoff, paneli...
You know you need the cloud, but you’re hesitant to simply dump everything at Amazon since you know that not all workloads are suitable for cloud. You know that you want the kind of ease of use and scalability that you get with public cloud, but your applications are architected in a way that makes the public cloud a non-starter. You’re looking at private cloud solutions based on hyperconverged infrastructure, but you’re concerned with the limits inherent in those technologies.
For organizations that have amassed large sums of software complexity, taking a microservices approach is the first step toward DevOps and continuous improvement / development. Integrating system-level analysis with microservices makes it easier to change and add functionality to applications at any time without the increase of risk. Before you start big transformation projects or a cloud migration, make sure these changes won’t take down your entire organization.
The current age of digital transformation means that IT organizations must adapt their toolset to cover all digital experiences, beyond just the end users’. Today’s businesses can no longer focus solely on the digital interactions they manage with employees or customers; they must now contend with non-traditional factors. Whether it's the power of brand to make or break a company, the need to monitor across all locations 24/7, or the ability to proactively resolve issues, companies must adapt to...
SYS-CON Events announced today that TMC has been named “Media Sponsor” of SYS-CON's 21st International Cloud Expo and Big Data at Cloud Expo, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Global buyers rely on TMC’s content-driven marketplaces to make purchase decisions and navigate markets. Learn how we can help you reach your marketing goals.
Managing mission-critical SAP systems and landscapes has never been easy. Add public cloud with its myriad of powerful cloud native services and this may not change any time soon. Public cloud offers exciting new possibilities for enterprise workloads. But to make use of these possibilities and capabilities, IT teams need to re-think everything they have done before. Otherwise, they will just end up using public cloud as a hosting platform for their workloads, aka known as “lift and shift.”
Cloud promises the agility required by today’s digital businesses. As organizations adopt cloud based infrastructures and services, their IT resources become increasingly dynamic and hybrid in nature. Managing these require modern IT operations and tools. In his session at 20th Cloud Expo, Raj Sundaram, Senior Principal Product Manager at CA Technologies, will discuss how to modernize your IT operations in order to proactively manage your hybrid cloud and IT environments. He will be sharing bes...
Cloud applications are seeing a deluge of requests to support the exploding advanced analytics market. “Open analytics” is the emerging strategy to deliver that data through an open data access layer, in the cloud, to be directly consumed by external analytics tools and popular programming languages. An increasing number of data engineers and data scientists use a variety of platforms and advanced analytics languages such as SAS, R, Python and Java, as well as frameworks such as Hadoop and Spark...
SYS-CON Events announced today that TechTarget has been named “Media Sponsor” of SYS-CON's 21st International Cloud Expo, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. TechTarget storage websites are the best online information resource for news, tips and expert advice for the storage, backup and disaster recovery markets.
SYS-CON Events announced today that Telecom Reseller has been named “Media Sponsor” of SYS-CON's 21st International Cloud Expo, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Telecom Reseller reports on Unified Communications, UCaaS, BPaaS for enterprise and SMBs. They report extensively on both customer premises based solutions such as IP-PBX as well as cloud based and hosted platforms.
SYS-CON Events announced today that Ayehu will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place on October 31 - November 2, 2017 at the Santa Clara Convention Center in Santa Clara California. Ayehu provides IT Process Automation & Orchestration solutions for IT and Security professionals to identify and resolve critical incidents and enable rapid containment, eradication, and recovery from cyber security breaches. Ayehu provides customers greater control over IT infras...
SYS-CON Events announced today that Silicon India has been named “Media Sponsor” of SYS-CON's 21st International Cloud Expo, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Published in Silicon Valley, Silicon India magazine is the premiere platform for CIOs to discuss their innovative enterprise solutions and allows IT vendors to learn about new solutions that can help grow their business.
Artificial intelligence, machine learning, neural networks. We’re in the midst of a wave of excitement around AI such as hasn’t been seen for a few decades. But those previous periods of inflated expectations led to troughs of disappointment. Will this time be different? Most likely. Applications of AI such as predictive analytics are already decreasing costs and improving reliability of industrial machinery. Furthermore, the funding and research going into AI now comes from a wide range of com...