Welcome!

News Feed Item

New Clinical Trial Uses fMRI to Demonstrate Stress Reduction after Acute Administration of Zembrin®

Study is the First to Test the Activity of Sceletium tortuosum on Brain Activity and the First to Study the Effects of a Dual PDE4 and 5-HT Reuptake Inhibitor in Humans

MORRISTOWN, N.J., March 24, 2014 /PRNewswire/ -- PLT Health Solutions, Inc. and HG&H Pharmaceuticals Pty. Ltd. announced the publication of a clinical trial that used functional Magnetic Resonance Imaging (fMRI) technology to study the effects of acute (short term) supplementation with Zembrin® on the "threat circuitry" of the human brain. The double-blind placebo-controlled crossover trial conducted with 16 healthy university students showed that 25 mg of Zembrin reduced anxiety-related activity of the amygdala and its associated anxiety circuitry within 2 hours of administration. These results provide the first evidence for the areas of brain where Zembrin's anti-anxiety activity acts, and confirmation of the potential for Zembrin to help in the management of stress.

Photo - http://photos.prnewswire.com/prnh/20140324/PH89106-a
Logo - http://photos.prnewswire.com/prnh/20140324/PH89106LOGO-b

Zembrin is the first patented, standardized and clinically studied extract of a unique selection of the South African plant Sceletium tortuosum. It is marketed to nutraceutical and functional food and beverage producers who are interested in incorporating this innovative, evidence-based ingredient in products that experientially support reduced anxiety, enhanced mood, and improved cognitive function. In a related development, PLT Health Solutions announced that HG&H Pharmaceuticals has been awarded U.S. Patent #8,552,051 covering the use of one of Zembrin's key alkaloids – mesembrenone – for its PDE4 and serotonin-reuptake inhibition properties.

According to Barbara Davis, Director, Medical & Scientific Affairs at PLT Health Solutions, the new study gives further depth to the understanding of Zembrin as a dual 5-HT reuptake and PDE4 inhibitor in helping to manage stress. "Anxiety is characterized by hyper-responsivity to mild threats and the amygdala is the part of the brain that manages threat activity. This study is the first of its kind to directly examine the effects of these types of compounds on brain activity. It further supports the science on the mechanisms of action for Zembrin, and has pioneered the use of brain-imaging technology to evaluate and validate the activity of a plant used for centuries by the San people of southern Africa," she said. "We're pleased to be able to offer this type of leading edge science to our customers in support of Zembrin as they look to create innovative consumer products," she added. The study, entitled Acute effects of Sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human amygdala and its connection to the hypothalamus (Terberg, et. al. 2013) was conducted at the Department of Psychology at Utrecht University in the Netherlands and the Department of Psychiatry & Mental Health at the University of Cape Town in South Africa.

HG&H Receives Patent on Use of Sceletium and Components for PDE4 Inhibition

Zembrin is a patented, proprietary extract of the South African traditional medicinal plant Sceletium tortuosum.  It is standardized to total alkaloid content and conforms to a defined alkaloid profile for four main actives: mesembrenone, mesembrenol, mesembranone and mesembrine. According to Seth Flowerman, Director of Business Development, it is the unique 'fingerprint' of Zembrin that is the subject of clinical trials, an extensive safety portfolio and the current patent portfolio. "Zembrin is distinguished by its relatively low level of mesembrine and relatively high level of mesembrenone. The U.S. patent recently awarded to HG&H Pharmaceuticals protects the modulation of 5-HT and PDE4 and the application of mesembrenone as a PDE4 inhibitor," he said. "The issuance of this patent underscores the unique composition and functionality of Zembrin as an ingredient. Combined with the continuing program of scientific support, it helps companies who incorporate Zembrin into their finished products differentiate themselves and build trust with consumers," he added.

For more information on the Zembrin fMRI clinical trial, contact PLT Health Solutions.

Media Contact:
Mark Falconer
Sciencewerks
Voice: 407-412-9705
E-mail

Company Contact:
Bob Berman
PLT Health Solutions, Inc.
Voice: 973-984-0900 x214
E-mail

Read more news from PLT Health Solutions.

SOURCE PLT Health Solutions, Inc.

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
SYS-CON Events announced today that delaPlex will exhibit at SYS-CON's @CloudExpo, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. delaPlex pioneered Software Development as a Service (SDaaS), which provides scalable resources to build, test, and deploy software. It’s a fast and more reliable way to develop a new product or expand your in-house team.
Extreme Computing is the ability to leverage highly performant infrastructure and software to accelerate Big Data, machine learning, HPC, and Enterprise applications. High IOPS Storage, low-latency networks, in-memory databases, GPUs and other parallel accelerators are being used to achieve faster results and help businesses make better decisions. In his session at 18th Cloud Expo, Michael O'Neill, Strategic Business Development at NVIDIA, focused on some of the unique ways extreme computing is...
The explosion of new web/cloud/IoT-based applications and the data they generate are transforming our world right before our eyes. In this rush to adopt these new technologies, organizations are often ignoring fundamental questions concerning who owns the data and failing to ask for permission to conduct invasive surveillance of their customers. Organizations that are not transparent about how their systems gather data telemetry without offering shared data ownership risk product rejection, regu...
SYS-CON Events announced today that CA Technologies has been named "Platinum Sponsor" of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, New York, and 21st International Cloud Expo, which will take place in November in Silicon Valley, California.
WebRTC is about the data channel as much as about video and audio conferencing. However, basically all commercial WebRTC applications have been built with a focus on audio and video. The handling of “data” has been limited to text chat and file download – all other data sharing seems to end with screensharing. What is holding back a more intensive use of peer-to-peer data? In her session at @ThingsExpo, Dr Silvia Pfeiffer, WebRTC Applications Team Lead at National ICT Australia, looked at differ...
"We got started as search consultants. On the services side of the business we have help organizations save time and save money when they hit issues that everyone more or less hits when their data grows," noted Otis Gospodnetić, Founder of Sematext, in this SYS-CON.tv interview at @DevOpsSummit, held June 9-11, 2015, at the Javits Center in New York City.
"Peak 10 is a national cloud data center solutions managed services provider, and part of that is disaster recovery. We see a growing trend in the industry where companies are coming to us looking for assistance in their DR strategy," stated Andrew Cole, Director of Solutions Engineering at Peak 10, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
In his General Session at DevOps Summit, Asaf Yigal, Co-Founder & VP of Product at Logz.io, explored the value of Kibana 4 for log analysis and provided a hands-on tutorial on how to set up Kibana 4 and get the most out of Apache log files. He examined three use cases: IT operations, business intelligence, and security and compliance. Asaf Yigal is co-founder and VP of Product at log analytics software company Logz.io. In the past, he was co-founder of social-trading platform Currensee, which w...
With major technology companies and startups seriously embracing IoT strategies, now is the perfect time to attend @ThingsExpo 2016 in New York. Learn what is going on, contribute to the discussions, and ensure that your enterprise is as "IoT-Ready" as it can be! Internet of @ThingsExpo, taking place June 6-8, 2017, at the Javits Center in New York City, New York, is co-located with 20th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry p...
Cloud Expo, Inc. has announced today that Andi Mann returns to 'DevOps at Cloud Expo 2017' as Conference Chair The @DevOpsSummit at Cloud Expo will take place on June 6-8, 2017, at the Javits Center in New York City, NY. "DevOps is set to be one of the most profound disruptions to hit IT in decades," said Andi Mann. "It is a natural extension of cloud computing, and I have seen both firsthand and in independent research the fantastic results DevOps delivers. So I am excited to help the great t...
In his keynote at @ThingsExpo, Chris Matthieu, Director of IoT Engineering at Citrix and co-founder and CTO of Octoblu, focused on building an IoT platform and company. He provided a behind-the-scenes look at Octoblu’s platform, business, and pivots along the way (including the Citrix acquisition of Octoblu).
The Internet of Things can drive efficiency for airlines and airports. In their session at @ThingsExpo, Shyam Varan Nath, Principal Architect with GE, and Sudip Majumder, senior director of development at Oracle, discussed the technical details of the connected airline baggage and related social media solutions. These IoT applications will enhance travelers' journey experience and drive efficiency for the airlines and the airports.
A look across the tech landscape at the disruptive technologies that are increasing in prominence and speculate as to which will be most impactful for communications – namely, AI and Cloud Computing. In his session at 20th Cloud Expo, Curtis Peterson, VP of Operations at RingCentral, will highlight the current challenges of these transformative technologies and share strategies for preparing your organization for these changes. This “view from the top” will outline the latest trends and developm...
SYS-CON Events announced today that Technologic Systems Inc., an embedded systems solutions company, will exhibit at SYS-CON's @ThingsExpo, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Technologic Systems is an embedded systems company with headquarters in Fountain Hills, Arizona. They have been in business for 32 years, helping more than 8,000 OEM customers and building over a hundred COTS products that have never been discontinued. Technologic Systems’ pr...
In his keynote at @ThingsExpo, Chris Matthieu, Director of IoT Engineering at Citrix and co-founder and CTO of Octoblu, focused on building an IoT platform and company. He provided a behind-the-scenes look at Octoblu’s platform, business, and pivots along the way (including the Citrix acquisition of Octoblu).