Welcome!

News Feed Item

Frost & Sullivan Applauds Asymptote's Efforts toward the Development of a Liquid Nitrogen-free, End-to-End Cold Chain Solution

Asymptote's liquid nitrogen-free cryogenic solutions are aligned with most of the cutting-edge technologies in the fields of regenerative medicine, stem cells, tissue transplantation and biobanking

LONDON, March 25, 2014 /PRNewswire/ -- Based on its recent analysis of the cryopreservation industry, Frost & Sullivan recognizes Asymptote Limited (Asymptote) with the 2014 European Frost & Sullivan Award for Technology Innovation Leadership. Asymptote's commitment to providing novel, effective and environmental-friendly cryopreservation solutions is evident from its efforts to produce a liquid nitrogen-free, good manufacturing practices (cGMP)-compliant cold chain comprising end-to-end cryopreservation, shipping, and thawing of materials.

"Asymptote's portable, self-charging, cryogenic solutions aim to improve the storage of live vaccines in developing nations. It has excelled in developing ultra-low-temperature storage equipment that helps to prevent the discarding of vaccines due to thermal stabilisation problems," said Frost & Sullivan Senior Research Analyst Cecilia Van Cauwenberghe. "The company, which is innovatively using electrically powered Stirling cryocoolers in cryopreservation equipment, expects to significantly improve the distribution of live vaccines in territories where liquid nitrogen is not readily available and the supply of electricity is unreliable."

Asymptote's current low-volume liquid nitrogen-free cryocooler, the EF600-controlled rate freezer, consists of a low-cost, ultra-portable cryocooler, specifically designed for the cryopreservation of stem cells, embryos, and spermatozoa. It demonstrates a high level of cooling rate control accuracy, while simultaneously being simple and easy to handle. It supports numerous sample formats and enables the lab technician to work with linear as well as non-linear cooling profiles.

As EF600s do not require liquid nitrogen, the running costs are estimated to be one per cent of that of liquid nitrogen-controlled rate freezing. By not using liquid nitrogen and its detrimental effects on sterility, particulate generation, and oxygen depletion, the solution is ideal for use in Grade B clean rooms and can be adapted for use in operating rooms for the optimised cryopreservation of source material for autologous treatments.

The new VIA Freeze™ range of controlled rate freezers are designed to be very easy to use with a touch screen interface and remote access (with 21 CRF 11 compliance) can be used with the SBS plate standards from 1-4 plates. This allows users to easily program and upload cooling profiles for further validation and report generation. Furthermore designed to minimise temperature gradients, the VIA Freeze™ achieves precision control of the cooling rate and the temperature. The systems can also be adapted to be used with bespoke systems and automation if required.  Since Asymptote's cryogenic solutions (controlled rate freezers and long term storage solutions) do not use liquid nitrogen they do not require the liquid nitrogen infrastructure and the associated health and safety systems required by other systems or the ongoing liquid nitrogen running costs and possibilities of contamination from liquid nitrogen.

The VIA Freeze™ enables the cryopreservation of cells in different formats such as cryovials, cryobags and cassettes. With a capacity of 250 cryovials, the VIA Freeze™ represents the best option for the creation of seed cell banks (SCBs) and master cell banks (MCBs), which require validated, reproducible, and safe methods of freezing cells during their creation.

Asymptote has also developed a novel active nucleation biocompatible material named 'IceStart™' that helps to reduce the damage caused by supercooling during the cryopreservation process. Compared to other products in the market, IceStart™ induces ice nucleation closer to the freezing point of the solution. This results in an important reduction in the number of samples that are subjected to extreme undercooling. Consequently the viability of the cells is substantially increased.

Asymptote's research in cryopreservation is based on five principal projects - the development of a GMP cryogenic cold chain for the clinical delivery of regenerative medicine therapeutics; the development of coatings that induce ice nucleation; an improved method of freeze drying; the development of a portable, self-charging cryogenic vessel for the shipment and short-term storage of cryopreserved material; and the development and testing of technology for the cryopreservation of hepatocytes in microtiter plates for subsequent screening applications. These projects are carried out in collaboration with its customers, in order to continuously improve their results and ensure that their needs are met.

"The company is currently proposing the development of the first GMP-compliant cryogenic cold chain for the clinical delivery of regenerative medicine therapeutics. Asymptote is also developing an ice-nucleating coating for the inside of vessels that are used for cryopreservation, which will overcome the problems caused by random ice nucleation and improve cell recovery upon thawing," noted Van Cauwenberghe. "The company expects to determine the real impact of these new developments in the market, as well as their disruptive influence on an existing solution or the creation of new products."

Each year, Frost & Sullivan presents this award to the company that has demonstrated uniqueness in developing and leveraging new technologies, which significantly impacts both the functionality and the customer value of the new products and applications. The award lauds the high R&D spend towards innovation, its relevance to the industry and the positive impact on brand perception.

Frost & Sullivan Best Practices awards recognize companies in a variety of regional and global markets for demonstrating outstanding achievement and superior performance in areas such as leadership, technological innovation, customer service and strategic product development. Industry analysts compare market participants and measure performance through in-depth interviews, analysis and extensive secondary research to identify best practices in the industry.

About Asymptote Limited

Based in Cambridge, UK, Asymptote Limited is excelling in the development of products and process technologies that are adapted to its customers' requirements. Having on board laureate cryopreservation specialists, Asymptote is innovating the cryopreservation market by providing novel, effective, and environment friendly solutions.

About Frost & Sullivan

Frost & Sullivan, the Growth Partnership Company, works in collaboration with clients to leverage visionary innovation that addresses the global challenges and related growth opportunities that will make or break today's market participants.

Our "Growth Partnership" supports clients by addressing these opportunities and incorporating two key elements driving visionary innovation: The Integrated Value Proposition and The Partnership Infrastructure.

  • The Integrated Value Proposition provides support to our clients throughout all phases of their journey to visionary innovation including: research, analysis, strategy, vision, innovation and implementation.
  • The Partnership Infrastructure is entirely unique as it constructs the foundation upon which visionary innovation becomes possible. This includes our 360 degree research, comprehensive industry coverage, career best practices as well as our global footprint of more than 40 offices.

For more than 50 years, we have been developing growth strategies for the global 1000, emerging businesses, the public sector and the investment community. Is your organization prepared for the next profound wave of industry convergence, disruptive technologies, increasing competitive intensity, Mega Trends, breakthrough best practices, changing customer dynamics and emerging economies?

Contact Us:   Start the discussion

Join Us:      Join our community

Subscribe:    Newsletter on "the next big thing"

Register:     Gain access to visionary innovation

Contact:

Melanie Ayliffe
Best Practices, Frost & Sullivan

E: [email protected]
P: +44 (0) 207 915 7867

www.awards.frost.com

SOURCE Frost & Sullivan

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
"We're a cybersecurity firm that specializes in engineering security solutions both at the software and hardware level. Security cannot be an after-the-fact afterthought, which is what it's become," stated Richard Blech, Chief Executive Officer at Secure Channels, in this SYS-CON.tv interview at @ThingsExpo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
In this strange new world where more and more power is drawn from business technology, companies are effectively straddling two paths on the road to innovation and transformation into digital enterprises. The first path is the heritage trail – with “legacy” technology forming the background. Here, extant technologies are transformed by core IT teams to provide more API-driven approaches. Legacy systems can restrict companies that are transitioning into digital enterprises. To truly become a lead...
In IT, we sometimes coin terms for things before we know exactly what they are and how they’ll be used. The resulting terms may capture a common set of aspirations and goals – as “cloud” did broadly for on-demand, self-service, and flexible computing. But such a term can also lump together diverse and even competing practices, technologies, and priorities to the point where important distinctions are glossed over and lost.
Video experiences should be unique and exciting! But that doesn’t mean you need to patch all the pieces yourself. Users demand rich and engaging experiences and new ways to connect with you. But creating robust video applications at scale can be complicated, time-consuming and expensive. In his session at @ThingsExpo, Zohar Babin, Vice President of Platform, Ecosystem and Community at Kaltura, discussed how VPaaS enables you to move fast, creating scalable video experiences that reach your aud...
All clouds are not equal. To succeed in a DevOps context, organizations should plan to develop/deploy apps across a choice of on-premise and public clouds simultaneously depending on the business needs. This is where the concept of the Lean Cloud comes in - resting on the idea that you often need to relocate your app modules over their life cycles for both innovation and operational efficiency in the cloud. In his session at @DevOpsSummit at19th Cloud Expo, Valentin (Val) Bercovici, CTO of Soli...
"Once customers get a year into their IoT deployments, they start to realize that they may have been shortsighted in the ways they built out their deployment and the key thing I see a lot of people looking at is - how can I take equipment data, pull it back in an IoT solution and show it in a dashboard," stated Dave McCarthy, Director of Products at Bsquare Corporation, in this SYS-CON.tv interview at @ThingsExpo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
What happens when the different parts of a vehicle become smarter than the vehicle itself? As we move toward the era of smart everything, hundreds of entities in a vehicle that communicate with each other, the vehicle and external systems create a need for identity orchestration so that all entities work as a conglomerate. Much like an orchestra without a conductor, without the ability to secure, control, and connect the link between a vehicle’s head unit, devices, and systems and to manage the ...
An IoT product’s log files speak volumes about what’s happening with your products in the field, pinpointing current and potential issues, and enabling you to predict failures and save millions of dollars in inventory. But until recently, no one knew how to listen. In his session at @ThingsExpo, Dan Gettens, Chief Research Officer at OnProcess, discussed recent research by Massachusetts Institute of Technology and OnProcess Technology, where MIT created a new, breakthrough analytics model for ...
IoT is rapidly changing the way enterprises are using data to improve business decision-making. In order to derive business value, organizations must unlock insights from the data gathered and then act on these. In their session at @ThingsExpo, Eric Hoffman, Vice President at EastBanc Technologies, and Peter Shashkin, Head of Development Department at EastBanc Technologies, discussed how one organization leveraged IoT, cloud technology and data analysis to improve customer experiences and effici...
Everyone knows that truly innovative companies learn as they go along, pushing boundaries in response to market changes and demands. What's more of a mystery is how to balance innovation on a fresh platform built from scratch with the legacy tech stack, product suite and customers that continue to serve as the business' foundation. In his General Session at 19th Cloud Expo, Michael Chambliss, Head of Engineering at ReadyTalk, discussed why and how ReadyTalk diverted from healthy revenue and mor...
The 20th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held June 6-8, 2017, at the Javits Center in New York City, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Containers, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportunity. Submit your speaking proposal ...
You have great SaaS business app ideas. You want to turn your idea quickly into a functional and engaging proof of concept. You need to be able to modify it to meet customers' needs, and you need to deliver a complete and secure SaaS application. How could you achieve all the above and yet avoid unforeseen IT requirements that add unnecessary cost and complexity? You also want your app to be responsive in any device at any time. In his session at 19th Cloud Expo, Mark Allen, General Manager of...
The Internet of Things (IoT) promises to simplify and streamline our lives by automating routine tasks that distract us from our goals. This promise is based on the ubiquitous deployment of smart, connected devices that link everything from industrial control systems to automobiles to refrigerators. Unfortunately, comparatively few of the devices currently deployed have been developed with an eye toward security, and as the DDoS attacks of late October 2016 have demonstrated, this oversight can ...
"MathFreeOn.com is a line coding platform for engineers and scientists. When they want to solve an engineering problem and they have to use software - they have to pay a lot of money for licenses - but with MathFreeOn you don't have to pay a lot of money. Just go to our site and write the code and you can check the result right away," explained Simon Lee, CMO of MathFreeOn, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Cla...
In his session at 19th Cloud Expo, Claude Remillard, Principal Program Manager in Developer Division at Microsoft, contrasted how his team used config as code and immutable patterns for continuous delivery of microservices and apps to the cloud. He showed how the immutable patterns helps developers do away with most of the complexity of config as code-enabling scenarios such as rollback, zero downtime upgrades with far greater simplicity. He also demoed building immutable pipelines in the cloud ...