|By PR Newswire||
|March 26, 2014 02:00 PM EDT||
WASHINGTON, March 26, 2014 /PRNewswire-USNewswire/ -- Research published online today in Blood, the journal of the American Society of Hematology, presents an unprecedented look at five unique blood cells in the human body, pinpointing the location of key genetic regulators in these cells and providing a new tool that may help scientists to identify how blood cells form and shed light on the etiology of blood diseases.
Work published today in Blood* is a subset of a much larger catalog of genetic information about nearly 1,000 human cells and tissues unveiled today from the international research consortium "Functional Annotation of the Mamaliam Genome" (FANTOM, with this latest installment referred to as FANTOM5). Two flagship manuscripts describing pivotal observations from the expansive genome mapping project were also published online today in Nature; companion work is also being published today in BMC Genomics.
Blood comprises three main types of cells, erythrocytes (red blood cells), leukocytes (white blood cells), and thrombocytes (platelets), all of which arise from blood stem cells. While the origin of these cells is known, the gene expression changes that take place in the stem cell to dictate whether it becomes red cell, white cell, or platelet – or even develops a genetic mutation – are not yet fully understood.
To provide insight into this process, investigators analyzed more than 30 different specialized subtypes of white blood cells (including mast cells, T cells, monocytes, granulocytes, and B cells) and pinpointed the locations of key regions known as enhancers and promoters that determine if a particular gene will be active or silent in a cell. By identifying and mapping the locations of these regulators, investigators were able to correlate them with activity in specific genes.
"Until this point researchers could only recognize the unique signatures of enhancers and promoters; however, their exact location, as well as the association of specific enhancers to specific blood cells, remained unclear," said FANTOM5 Principal Investigator Alistair Forrest, PhD, of the RIKEN Centre for Life Science Technology in Yokohama, Japan. "This new, publicly available resource changes that, providing hematologists with a baseline reference for most blood cell types that allows them to trace the development of these cells and determine what may have occurred along the way to lead them to their final state."
With this new understanding of the location of enhancers and promoters used in each blood cell, investigators will now be better equipped to design experiments to determine how genes become activated, which could potentially lead to the development of strategies for turning off the gene to prevent or treat malignancies.
"The specific genetic alterations that are responsible for a normal cell turning into a cancer cell show up in the levels of messenger RNA in the cell, and these differences are often very subtle," said Dr. Forrest. "Now that we have these incredibly detailed pictures of each of these cell types, we can now work backwards to compare cancer cells to the cells they came from originally to better understand what may have triggered the cells to malfunction, so we will be better equipped to develop new and more effective therapies."
*Studies referenced in this release include:
- Rönnerblad M, Andersson R, Olofsson T, et al. Analysis of the DNA methylome and transcriptome in granulopoiesis reveals timed changes and dynamic enhancer methylation [published online ahead of print March 26, 2014]. Blood. doi:10.1182/blood-2013-02-482893.
- Prasad P, Rönnerblad M, Arner E, et al. High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis [published online ahead of print March 26, 2014]. Blood. doi:10.1182/blood-2013-02-483537.
- Motakis E, Guhl S, Ishizu Y, et al. Redefinition of the human mast cell transcriptome by deep-CAGE sequencing [published online ahead of print March 26, 2014]. Blood. doi:10.1182/blood-2013-02-483792.
- Schmidl C, Renner K, Peter K, et al. Transcription and enhancer profiling in human monocyte subsets [published online ahead of print March 26, 2014]. Blood. doi:10.1182/blood-2013-02-484188.
- Schmidl C, Hansmann L, Lassmann T, et al. The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations [published online ahead of print March 26, 2014]. Blood. doi:10.1182/blood-2013-02-486944.
Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world's largest professional society concerned with the causes and treatment of blood disorders.
ASH's mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.
blood® is a registered trademark of the American Society of Hematology.
SOURCE American Society of Hematology
SYS-CON Events announced today that MobiDev will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. MobiDev is a software company that develops and delivers turn-key mobile apps, websites, web services, and complex software systems for startups and enterprises. Since 2009 it has grown from a small group of passionate engineers and business managers to a full-scale mobile software company with over 200 develope...
May. 28, 2016 07:15 AM EDT Reads: 2,593
SoftLayer operates a global cloud infrastructure platform built for Internet scale. With a global footprint of data centers and network points of presence, SoftLayer provides infrastructure as a service to leading-edge customers ranging from Web startups to global enterprises. SoftLayer's modular architecture, full-featured API, and sophisticated automation provide unparalleled performance and control. Its flexible unified platform seamlessly spans physical and virtual devices linked via a world...
May. 28, 2016 06:00 AM EDT Reads: 2,225
SYS-CON Events announced today TechTarget has been named “Media Sponsor” of SYS-CON's 18th International Cloud Expo, which will take place on June 7–9, 2016, at the Javits Center in New York City, NY, and the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. TechTarget is the Web’s leading destination for serious technology buyers researching and making enterprise technology decisions. Its extensive global networ...
May. 28, 2016 05:00 AM EDT Reads: 3,210
Companies can harness IoT and predictive analytics to sustain business continuity; predict and manage site performance during emergencies; minimize expensive reactive maintenance; and forecast equipment and maintenance budgets and expenditures. Providing cost-effective, uninterrupted service is challenging, particularly for organizations with geographically dispersed operations.
May. 28, 2016 05:00 AM EDT Reads: 2,085
SYS-CON Events announced today that Commvault, a global leader in enterprise data protection and information management, has been named “Bronze Sponsor” of SYS-CON's 18th International Cloud Expo, which will take place on June 7–9, 2016, at the Javits Center in New York City, NY, and the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Commvault is a leading provider of data protection and information management...
May. 28, 2016 04:15 AM EDT Reads: 3,171
SYS-CON Events announced today Object Management Group® has been named “Media Sponsor” of SYS-CON's 18th International Cloud Expo, which will take place on June 7–9, 2016, at the Javits Center in New York City, NY, and the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
May. 28, 2016 03:00 AM EDT Reads: 2,514
As cloud and storage projections continue to rise, the number of organizations moving to the cloud is escalating and it is clear cloud storage is here to stay. However, is it secure? Data is the lifeblood for government entities, countries, cloud service providers and enterprises alike and losing or exposing that data can have disastrous results. There are new concepts for data storage on the horizon that will deliver secure solutions for storing and moving sensitive data around the world. ...
May. 28, 2016 03:00 AM EDT Reads: 1,301
SYS-CON Events announced today that MangoApps will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. MangoApps provides modern company intranets and team collaboration software, allowing workers to stay connected and productive from anywhere in the world and from any device. For more information, please visit https://www.mangoapps.com/.
May. 28, 2016 02:30 AM EDT Reads: 798
The essence of data analysis involves setting up data pipelines that consist of several operations that are chained together – starting from data collection, data quality checks, data integration, data analysis and data visualization (including the setting up of interaction paths in that visualization). In our opinion, the challenges stem from the technology diversity at each stage of the data pipeline as well as the lack of process around the analysis.
May. 28, 2016 01:30 AM EDT Reads: 1,441
Many banks and financial institutions are experimenting with containers in development environments, but when will they move into production? Containers are seen as the key to achieving the ultimate in information technology flexibility and agility. Containers work on both public and private clouds, and make it easy to build and deploy applications. The challenge for regulated industries is the cost and complexity of container security compliance. VM security compliance is already challenging, ...
May. 28, 2016 01:15 AM EDT Reads: 1,273
Designing IoT applications is complex, but deploying them in a scalable fashion is even more complex. A scalable, API first IaaS cloud is a good start, but in order to understand the various components specific to deploying IoT applications, one needs to understand the architecture of these applications and figure out how to scale these components independently. In his session at @ThingsExpo, Nara Rajagopalan is CEO of Accelerite, will discuss the fundamental architecture of IoT applications, ...
May. 28, 2016 01:00 AM EDT Reads: 1,249
The IoTs will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform. In his session at @ThingsExpo, Craig Sproule, CEO of Metavine, will demonstrate how to move beyond today's coding paradigm and share the must-have mindsets for removing complexity from the development proc...
May. 28, 2016 01:00 AM EDT Reads: 1,924
Enterprise networks are complex. Moreover, they were designed and deployed to meet a specific set of business requirements at a specific point in time. But, the adoption of cloud services, new business applications and intensifying security policies, among other factors, require IT organizations to continuously deploy configuration changes. Therefore, enterprises are looking for better ways to automate the management of their networks while still leveraging existing capabilities, optimizing perf...
May. 28, 2016 12:45 AM EDT Reads: 1,322
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, wh...
May. 28, 2016 12:30 AM EDT Reads: 2,013
SYS-CON Events announced today that Tintri Inc., a leading producer of VM-aware storage (VAS) for virtualization and cloud environments, will exhibit at the 18th International CloudExpo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, New York, and the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
May. 28, 2016 12:15 AM EDT Reads: 2,426