Welcome!

News Feed Item

Prostate Cancer: Reducing the Negative Side Effects of Hormone Therapy

Study Finds Benefits in Halving the Duration of Hormone Therapy in Conjunction With Radiation for Prostate Cancer, Says Robotic Surgeon, David Samadi, MD

NEW YORK, NY -- (Marketwired) -- 04/02/14 -- Patients underdoing adjuvant radiation therapy for localized prostate cancer may benefit from a significantly reduced course of androgen deprivation therapy (ADT). In comparing the outcomes of 18-month and 36-month ADT courses, Canadian researchers found comparable disease-free survival rates and reduced side effects. The findings suggest that halving the traditional 36-month dosing could reduce costs and improve patients' quality of life without jeopardizing treatment benefits.

To more aggressively target cancer cells, androgen blockade therapy is commonly added to standard pelvic radiotherapy in patients with high-risk, node-negative prostate cancer. Based on a study of 630 men, researchers report that halving the ADT course to 18 months safely and comparably addresses node and bone metastases. New York robotic prostate surgeon, David B. Samadi, MD, is encouraged by these findings.

"Long-term use of androgen blockades can lead to low testosterone and impotence," said Dr. Samadi, Chairman of Urology and Chief of Robotic Surgery at Lenox Hill Hospital. "Prostate cancer treatment side effects and their duration are of top concern when patients evaluate prostate cancer treatments such as robotic prostatectomy, radiation therapy and hormone therapy."

The study was conducted across 10 Canadian centers from October 2000 through January 2008. Radiation patients were randomly assigned to 18 months and 36 months of simultaneous androgen blockade therapy. In a multivariate analysis, all participants had similar PSA levels, Gleason scores and disease stages. At five- and 10-year follow-ups, the differences in mortality and biochemical failure rates between the 18-month and 36-month groups were not statistically significant. Pelvic node metastases and bone metastases were also comparable.

Researchers are hopeful that the 18-month mark may represent a threshold beyond which no additional ADT benefit is realized. If so, patients could face a shorter duration of side effects such as erectile dysfunction (ED). Findings were presented at the 2013 Genitourinary Cancers Symposium, http://meetinglibrary.asco.org/content/107219-134

The quality of life data from the study are under continued review and likely will be published in a follow-up report later this year.

Radiation therapy and hormone therapy for prostate cancer are disease management modalities. Whereas robotic surgery removes the cancer from the body, radiation and hormone therapy treat it in place. Side effects of hormone therapy may include bone weakening and cancer treatment-induced bone loss, acute kidney injury, erectile dysfunction, fatigue and depression.

Image Available: http://www2.marketwire.com/mw/frame_mw?attachid=2558091

Add to Digg Bookmark with del.icio.us Add to Newsvine

David B. Samadi, M.D.
Chairman of Urology
Chief of Robotic Surgery at Lenox Hill Hospital

Tel: 1-212-365-5000
Fax: 1-646-692-6744

Address:
485 Madison Avenue
21st floor
New York, NY 10022

http://www.roboticoncology.com/contact/

Twitter: @drdavidsamadi
https://twitter.com/drdavidsamadi

Google+: +DavidSamadi
https://plus.google.com/+DavidSamadi

Facebook: facebook.com/drdavidsamadi
https://www.facebook.com/drdavidsamadi

More Stories By Marketwired .

Copyright © 2009 Marketwired. All rights reserved. All the news releases provided by Marketwired are copyrighted. Any forms of copying other than an individual user's personal reference without express written permission is prohibited. Further distribution of these materials is strictly forbidden, including but not limited to, posting, emailing, faxing, archiving in a public database, redistributing via a computer network or in a printed form.

Latest Stories
Docker containers have brought great opportunities to shorten the deployment process through continuous integration and the delivery of applications and microservices. This applies equally to enterprise data centers as well as the cloud. In his session at 20th Cloud Expo, Jari Kolehmainen, founder and CTO of Kontena, discussed solutions and benefits of a deeply integrated deployment pipeline using technologies such as container management platforms, Docker containers, and the drone.io Cl tool. H...
Cloud adoption is often driven by a desire to increase efficiency, boost agility and save money. All too often, however, the reality involves unpredictable cost spikes and lack of oversight due to resource limitations. In his session at 20th Cloud Expo, Joe Kinsella, CTO and Founder of CloudHealth Technologies, tackled the question: “How do you build a fully optimized cloud?” He will examine: Why TCO is critical to achieving cloud success – and why attendees should be thinking holistically ab...
The question before companies today is not whether to become intelligent, it’s a question of how and how fast. The key is to adopt and deploy an intelligent application strategy while simultaneously preparing to scale that intelligence. In her session at 21st Cloud Expo, Sangeeta Chakraborty, Chief Customer Officer at Ayasdi, will provide a tactical framework to become a truly intelligent enterprise, including how to identify the right applications for AI, how to build a Center of Excellence to...
Blockchain is a shared, secure record of exchange that establishes trust, accountability and transparency across business networks. Supported by the Linux Foundation's open source, open-standards based Hyperledger Project, Blockchain has the potential to improve regulatory compliance, reduce cost as well as advance trade. Are you curious about how Blockchain is built for business? In her session at 21st Cloud Expo, René Bostic, Technical VP of the IBM Cloud Unit in North America, will discuss th...
SYS-CON Events announced today that Datera, that offers a radically new data management architecture, has been named "Exhibitor" of SYS-CON's 21st International Cloud Expo ®, which will take place on Oct 31 - Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Datera is transforming the traditional datacenter model through modern cloud simplicity. The technology industry is at another major inflection point. The rise of mobile, the Internet of Things, data storage and Big...
An increasing number of companies are creating products that combine data with analytical capabilities. Running interactive queries on Big Data requires complex architectures to store and query data effectively, typically involving data streams, an choosing efficient file format/database and multiple independent systems that are tied together through custom-engineered pipelines. In his session at @BigDataExpo at @ThingsExpo, Tomer Levi, a senior software engineer at Intel’s Advanced Analytics ...
SYS-CON Events announced today that Datera will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Datera offers a radically new approach to data management, where innovative software makes data infrastructure invisible, elastic and able to perform at the highest level. It eliminates hardware lock-in and gives IT organizations the choice to source x86 server nodes, with business model option...
"Cloud computing is certainly changing how people consume storage, how they use it, and what they use it for. It's also making people rethink how they architect their environment," stated Brad Winett, Senior Technologist for DDN Storage, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
yperConvergence came to market with the objective of being simple, flexible and to help drive down operating expenses. It reduced the footprint by bundling the compute/storage/network into one box. This brought a new set of challenges as the HyperConverged vendors are very focused on their own proprietary building blocks. If you want to scale in a certain way, let’s say you identified a need for more storage and want to add a device that is not sold by the HyperConverged vendor, forget about it....
With 10 simultaneous tracks, keynotes, general sessions and targeted breakout classes, Cloud Expo and @ThingsExpo are two of the most important technology events of the year. Since its launch over eight years ago, Cloud Expo and @ThingsExpo have presented a rock star faculty as well as showcased hundreds of sponsors and exhibitors! In this blog post, I provide 7 tips on how, as part of our world-class faculty, you can deliver one of the most popular sessions at our events. But before reading the...
“Why didn’t testing catch this” must become “How did this make it to testing?” Traditional quality teams are the crutch and excuse keeping organizations from making the necessary investment in people, process, and technology to accelerate test automation. Just like societies that did not build waterways because the labor to keep carrying the water was so cheap, we have created disincentives to automate. In her session at @DevOpsSummit at 20th Cloud Expo, Anne Hungate, President of Daring System...
SYS-CON Events announced today that CA Technologies has been named "Platinum Sponsor" of SYS-CON's 21st International Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. CA Technologies helps customers succeed in a future where every business - from apparel to energy - is being rewritten by software. From planning to development to management to security, CA creates software that fuels transformation for companies in the applic...
SYS-CON Events announced today that GrapeUp, the leading provider of rapid product development at the speed of business, will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Grape Up is a software company, specialized in cloud native application development and professional services related to Cloud Foundry PaaS. With five expert teams that operate in various sectors of the market acr...
Internet of @ThingsExpo, taking place October 31 - November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 21st Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The Internet of Things (IoT) is the most profound change in personal and enterprise IT since the creation of the Worldwide Web more than 20 years ago. All major researchers estimate there will be tens of billions devic...
In his session at 21st Cloud Expo, Carl J. Levine, Senior Technical Evangelist for NS1, will objectively discuss how DNS is used to solve Digital Transformation challenges in large SaaS applications, CDNs, AdTech platforms, and other demanding use cases. Carl J. Levine is the Senior Technical Evangelist for NS1. A veteran of the Internet Infrastructure space, he has over a decade of experience with startups, networking protocols and Internet infrastructure, combined with the unique ability to it...