Welcome!

News Feed Item

Prostate Cancer: Reducing the Negative Side Effects of Hormone Therapy

Study Finds Benefits in Halving the Duration of Hormone Therapy in Conjunction With Radiation for Prostate Cancer, Says Robotic Surgeon, David Samadi, MD

NEW YORK, NY -- (Marketwired) -- 04/02/14 -- Patients underdoing adjuvant radiation therapy for localized prostate cancer may benefit from a significantly reduced course of androgen deprivation therapy (ADT). In comparing the outcomes of 18-month and 36-month ADT courses, Canadian researchers found comparable disease-free survival rates and reduced side effects. The findings suggest that halving the traditional 36-month dosing could reduce costs and improve patients' quality of life without jeopardizing treatment benefits.

To more aggressively target cancer cells, androgen blockade therapy is commonly added to standard pelvic radiotherapy in patients with high-risk, node-negative prostate cancer. Based on a study of 630 men, researchers report that halving the ADT course to 18 months safely and comparably addresses node and bone metastases. New York robotic prostate surgeon, David B. Samadi, MD, is encouraged by these findings.

"Long-term use of androgen blockades can lead to low testosterone and impotence," said Dr. Samadi, Chairman of Urology and Chief of Robotic Surgery at Lenox Hill Hospital. "Prostate cancer treatment side effects and their duration are of top concern when patients evaluate prostate cancer treatments such as robotic prostatectomy, radiation therapy and hormone therapy."

The study was conducted across 10 Canadian centers from October 2000 through January 2008. Radiation patients were randomly assigned to 18 months and 36 months of simultaneous androgen blockade therapy. In a multivariate analysis, all participants had similar PSA levels, Gleason scores and disease stages. At five- and 10-year follow-ups, the differences in mortality and biochemical failure rates between the 18-month and 36-month groups were not statistically significant. Pelvic node metastases and bone metastases were also comparable.

Researchers are hopeful that the 18-month mark may represent a threshold beyond which no additional ADT benefit is realized. If so, patients could face a shorter duration of side effects such as erectile dysfunction (ED). Findings were presented at the 2013 Genitourinary Cancers Symposium, http://meetinglibrary.asco.org/content/107219-134

The quality of life data from the study are under continued review and likely will be published in a follow-up report later this year.

Radiation therapy and hormone therapy for prostate cancer are disease management modalities. Whereas robotic surgery removes the cancer from the body, radiation and hormone therapy treat it in place. Side effects of hormone therapy may include bone weakening and cancer treatment-induced bone loss, acute kidney injury, erectile dysfunction, fatigue and depression.

Image Available: http://www2.marketwire.com/mw/frame_mw?attachid=2558091

Add to Digg Bookmark with del.icio.us Add to Newsvine

David B. Samadi, M.D.
Chairman of Urology
Chief of Robotic Surgery at Lenox Hill Hospital

Tel: 1-212-365-5000
Fax: 1-646-692-6744

Address:
485 Madison Avenue
21st floor
New York, NY 10022

http://www.roboticoncology.com/contact/

Twitter: @drdavidsamadi
https://twitter.com/drdavidsamadi

Google+: +DavidSamadi
https://plus.google.com/+DavidSamadi

Facebook: facebook.com/drdavidsamadi
https://www.facebook.com/drdavidsamadi

More Stories By Marketwired .

Copyright © 2009 Marketwired. All rights reserved. All the news releases provided by Marketwired are copyrighted. Any forms of copying other than an individual user's personal reference without express written permission is prohibited. Further distribution of these materials is strictly forbidden, including but not limited to, posting, emailing, faxing, archiving in a public database, redistributing via a computer network or in a printed form.

Latest Stories
We all know the latest numbers: Gartner, Inc. forecasts that 6.4 billion connected things will be in use worldwide in 2016, up 30 percent from last year, and will reach 20.8 billion by 2020. We're rapidly approaching a data production of 40 zettabytes a day – more than we can every physically store, and exabytes and yottabytes are just around the corner. For many that’s a good sign, as data has been proven to equal money – IF it’s ingested, integrated, and analyzed fast enough. Without real-ti...
"We view the cloud not really as a specific technology but as a way of doing business and that way of doing business is transforming the way software, infrastructure and services are being delivered to business," explained Matthew Rosen, CEO and Director at Fusion, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
"Software-defined storage is a big problem in this industry because so many people have different definitions as they see fit to use it," stated Peter McCallum, VP of Datacenter Solutions at FalconStor Software, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
I wanted to gather all of my Internet of Things (IOT) blogs into a single blog (that I could later use with my University of San Francisco (USF) Big Data “MBA” course). However as I started to pull these blogs together, I realized that my IOT discussion lacked a vision; it lacked an end point towards which an organization could drive their IOT envisioning, proof of value, app dev, data engineering and data science efforts. And I think that the IOT end point is really quite simple…
With 15% of enterprises adopting a hybrid IT strategy, you need to set a plan to integrate hybrid cloud throughout your infrastructure. In his session at 18th Cloud Expo, Steven Dreher, Director of Solutions Architecture at Green House Data, discussed how to plan for shifting resource requirements, overcome challenges, and implement hybrid IT alongside your existing data center assets. Highlights included anticipating workload, cost and resource calculations, integrating services on both sides...
"We provide DevOps solutions. We also partner with some key players in the DevOps space and we use the technology that we partner with to engineer custom solutions for different organizations," stated Himanshu Chhetri, CTO of Addteq, in this SYS-CON.tv interview at DevOps at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
In his session at @DevOpsSummit at 19th Cloud Expo, Yoseph Reuveni, Director of Software Engineering at Jet.com, will discuss Jet.com's journey into containerizing Microsoft-based technologies like C# and F# into Docker. He will talk about lessons learned and challenges faced, the Mono framework tryout and how they deployed everything into Azure cloud. Yoseph Reuveni is a technology leader with unique experience developing and running high throughput (over 1M tps) distributed systems with extre...
"We are a well-established player in the application life cycle management market and we also have a very strong version control product," stated Flint Brenton, CEO of CollabNet,, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Actian Corporation has announced the latest version of the Actian Vector in Hadoop (VectorH) database, generally available at the end of July. VectorH is based on the same query engine that powers Actian Vector, which recently doubled the TPC-H benchmark record for non-clustered systems at the 3000GB scale factor (see tpc.org/3323). The ability to easily ingest information from different data sources and rapidly develop queries to make better business decisions is becoming increasingly importan...
The IoT has the potential to create a renaissance of manufacturing in the US and elsewhere. In his session at 18th Cloud Expo, Florent Solt, CTO and chief architect of Netvibes, discussed how the expected exponential increase in the amount of data that will be processed, transported, stored, and accessed means there will be a huge demand for smart technologies to deliver it. Florent Solt is the CTO and chief architect of Netvibes. Prior to joining Netvibes in 2007, he co-founded Rift Technologi...
"Operations is sort of the maturation of cloud utilization and the move to the cloud," explained Steve Anderson, Product Manager for BMC’s Cloud Lifecycle Management, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Enterprise networks are complex. Moreover, they were designed and deployed to meet a specific set of business requirements at a specific point in time. But, the adoption of cloud services, new business applications and intensifying security policies, among other factors, require IT organizations to continuously deploy configuration changes. Therefore, enterprises are looking for better ways to automate the management of their networks while still leveraging existing capabilities, optimizing perf...
Security, data privacy, reliability and regulatory compliance are critical factors when evaluating whether to move business applications from in-house client hosted environments to a cloud platform. In her session at 18th Cloud Expo, Vandana Viswanathan, Associate Director at Cognizant, In this session, will provide an orientation to the five stages required to implement a cloud hosted solution validation strategy.
The cloud competition for database hosts is fierce. How do you evaluate a cloud provider for your database platform? In his session at 18th Cloud Expo, Chris Presley, a Solutions Architect at Pythian, gave users a checklist of considerations when choosing a provider. Chris Presley is a Solutions Architect at Pythian. He loves order – making him a premier Microsoft SQL Server expert. Not only has he programmed and administered SQL Server, but he has also shared his expertise and passion with b...
We're entering the post-smartphone era, where wearable gadgets from watches and fitness bands to glasses and health aids will power the next technological revolution. With mass adoption of wearable devices comes a new data ecosystem that must be protected. Wearables open new pathways that facilitate the tracking, sharing and storing of consumers’ personal health, location and daily activity data. Consumers have some idea of the data these devices capture, but most don’t realize how revealing and...