Click here to close now.




















Welcome!

News Feed Item

arGEN-X Uses its Simple Antibody™ Platform to Identify Four 'Hotspots' on MET as Targets for its Therapeutic Antibody Program

BREDA, The Netherlands and GHENT, Belgium, April 7, 2014 /PRNewswire/ --

New findings to be presented at the American Association for Cancer Research annual meeting 

arGEN-X, a clinical stage human therapeutic antibody company, will present data on how its SIMPLE Antibody™ platform has identified four 'hotspots' on the MET protein that are suitable for therapeutic antibody targeting. Encoded by the oncogene c-Met, MET signalling is involved in cancer proliferation and metastasis and is activated by hepatocyte growth factor (HGF) in multiple cancers.

The new findings, resulting from a collaboration between arGEN-X scientists and the group of Professor Paolo Michieli at the Institute for Cancer Research and Treatment (Turin, Italy), will be presented by Dr. Anna Hultberg of arGEN-X on Tuesday 8 April in a Late-Breaking Mini-symposium at the American Association for Cancer Research (AACR) annual meeting in San Diego, CA, USA. Further details are given below.

Using its SIMPLE Antibody™ platform, arGEN-X selected 68 distinct antibodies that competed with HGF for MET binding. From this panel, antibodies recognizing four different regions or 'hotspots' for blockade of HGF-induced signalling on the known extracellular domains of MET were identified. These antibodies prevented metastatic spread in a triple-negative breast cancer model following neo-adjuvant therapy, and in a mutated KRAS colon cancer model as adjuvant therapy.

arGEN-X is targeting MET with ARGX-111, a SIMPLE Antibody™ based monoclonal antibody with differentiated product features, currently in a Phase Ib clinical trial.

According to Prof. Hans de Haard, Chief Scientific Officer of arGEN-X: "MET plays an important role in the signal transduction mechanisms responsible for cancer cell spread. Based on our understanding of the importance of certain MET epitopes in these mechanisms, we have created ARGX-111, a unique, MET-specific antibody with several modes of therapeutic action."

Details of the presentation are:

Four individually druggable MET hotspots mediate HGF-driven tumor progression 

  • Authors: Anna Hultberg, Cristina Basilico, Christophe Blanchetot, Natalie De Jonge, Valérie Hanssens, Gitte De Boeck, Alessia Mira, Manuela Cazzanti, Virginia Morello, Torsten Dreier, Michael Saunders, Hans De Haard, and Paolo Michieli 
  • Abstract #LBB-330, Late-Breaking Mini-symposium: Novel Drug Targets, Compounds, and Signatures of Response and Resistance
  • Tuesday, 8 April, 4.35-4.50pm (Pacific time), Room 8, San Diego Conference Center

About ARGX-111 

ARGX-111 is a human monoclonal antibody that blocks the known mechanisms of action of the cancer target MET, the product of the c-Met oncogene. ARGX-111 was discovered using the SIMPLE Antibody™ platform and has been equipped with NHance™ technology to optimize its pharmacokinetic half-life. Moreover, the antibody has been produced as a de-fucosylated antibody using POTELLIGENT® technology to boost Antibody Dependent Cellular Cytotoxicity (ADCC) and potentiate immune system destruction of MET-positive tumor cells. With this combination of unique attributes, ARGX-111 has demonstrated superior therapeutic potential in both solid and hematological MET-positive malignancies when compared to established biologic and small molecule inhibitors of the target.

A first-in-man Phase Ib study (NCT02055066) is recruiting patients with advanced MET over-expressing cancers that harbor circulating tumor cells (CTCs), from which metastases are known to arise.

POTELLIGENT® technology is licensed by BioWa Inc., a wholly-owned subsidiary of Kyowa Hakko Kirin Co. Ltd.

About arGEN-X  

arGEN-X is a clinical stage human therapeutic antibody company that is rapidly developing a product pipeline using its unique suite of antibody technologies. arGEN-X is creating first and best in class antibody therapeutics with highly differentiated target product profiles. Its therapeutic antibody programs, focused on cancer and autoimmune indications, are designed to deliver tangible benefits to patients with these diseases.

http://www.arGEN-X.com

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
SYS-CON Events announced today that HPM Networks will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. For 20 years, HPM Networks has been integrating technology solutions that solve complex business challenges. HPM Networks has designed solutions for both SMB and enterprise customers throughout the San Francisco Bay Area.
SYS-CON Events announced today that Micron Technology, Inc., a global leader in advanced semiconductor systems, will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Micron’s broad portfolio of high-performance memory technologies – including DRAM, NAND and NOR Flash – is the basis for solid state drives, modules, multichip packages and other system solutions. Backed by more than 35 years of tech...
As more intelligent IoT applications shift into gear, they’re merging into the ever-increasing traffic flow of the Internet. It won’t be long before we experience bottlenecks, as IoT traffic peaks during rush hours. Organizations that are unprepared will find themselves by the side of the road unable to cross back into the fast lane. As billions of new devices begin to communicate and exchange data – will your infrastructure be scalable enough to handle this new interconnected world?
SYS-CON Events announced today the Containers & Microservices Bootcamp, being held November 3-4, 2015, in conjunction with 17th Cloud Expo, @ThingsExpo, and @DevOpsSummit at the Santa Clara Convention Center in Santa Clara, CA. This is your chance to get started with the latest technology in the industry. Combined with real-world scenarios and use cases, the Containers and Microservices Bootcamp, led by Janakiram MSV, a Microsoft Regional Director, will include presentations as well as hands-on...
Through WebRTC, audio and video communications are being embedded more easily than ever into applications, helping carriers, enterprises and independent software vendors deliver greater functionality to their end users. With today’s business world increasingly focused on outcomes, users’ growing calls for ease of use, and businesses craving smarter, tighter integration, what’s the next step in delivering a richer, more immersive experience? That richer, more fully integrated experience comes ab...
Cloud and datacenter migration innovator AppZero has joined the Microsoft Enterprise Cloud Alliance Program. AppZero is a fast, flexible way to move Windows Server applications from any source machine – physical or virtual – to any destination server, in any cloud or datacenter, using its patented container technology. AppZero’s container is also called a Virtual Application Appliance (VAA). To facilitate Microsoft Azure onboarding, AppZero has two purpose-built offerings: AppZero SP for Azure,...
SYS-CON Events announced today that Pythian, a global IT services company specializing in helping companies leverage disruptive technologies to optimize revenue-generating systems, has been named “Bronze Sponsor” of SYS-CON's 17th Cloud Expo, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Founded in 1997, Pythian is a global IT services company that helps companies compete by adopting disruptive technologies such as cloud, Big Data, advance...
eCube Systems has released NXTmonitor, a full featured application orchestration solution. NXTmonitor, which inherited the code base of NXTminder, has been extended to support multi-discipline processes and will act as a DevOps utility in a heterogeneous enterprise environment. Previously, NXTminder was packaged with NXTera middleware to configure and manage Entera and NXTera RPC servers. “Since we are widening the focus of this solution to DevOps, we felt the need to change the name to NXTmon...
In today's digital world, change is the one constant. Disruptive innovations like cloud, mobility, social media, and the Internet of Things have reshaped the market and set new standards in customer expectations. To remain competitive, businesses must tap the potential of emerging technologies and markets through the rapid release of new products and services. However, the rigid and siloed structures of traditional IT platforms and processes are slowing them down – resulting in lengthy delivery ...
Contrary to mainstream media attention, the multiple possibilities of how consumer IoT will transform our everyday lives aren’t the only angle of this headline-gaining trend. There’s a huge opportunity for “industrial IoT” and “Smart Cities” to impact the world in the same capacity – especially during critical situations. For example, a community water dam that needs to release water can leverage embedded critical communications logic to alert the appropriate individuals, on the right device, as...
In his session at @ThingsExpo, Lee Williams, a producer of the first smartphones and tablets, will talk about how he is now applying his experience in mobile technology to the design and development of the next generation of Environmental and Sustainability Services at ETwater. He will explain how M2M controllers work through wirelessly connected remote controls; and specifically delve into a retrofit option that reverse-engineers control codes of existing conventional controller systems so the...
This Enterprise Strategy Group lab validation report of the NEC Express5800/R320 server with Intel® Xeon® processor presents the benefits of 99.999% uptime NEC fault-tolerant servers that lower overall virtualized server total cost of ownership. This report also includes survey data on the significant costs associated with system outages impacting enterprise and web applications. Click Here to Download Report Now!
U.S. companies are desperately trying to recruit and hire skilled software engineers and developers, but there is simply not enough quality talent to go around. Tiempo Development is a nearshore software development company. Our headquarters are in AZ, but we are a pioneer and leader in outsourcing to Mexico, based on our three software development centers there. We have a proven process and we are experts at providing our customers with powerful solutions. We transform ideas into reality.
Skeuomorphism usually means retaining existing design cues in something new that doesn’t actually need them. However, the concept of skeuomorphism can be thought of as relating more broadly to applying existing patterns to new technologies that, in fact, cry out for new approaches. In his session at DevOps Summit, Gordon Haff, Senior Cloud Strategy Marketing and Evangelism Manager at Red Hat, discussed why containers should be paired with new architectural practices such as microservices rathe...
Whether you like it or not, DevOps is on track for a remarkable alliance with security. The SEC didn’t approve the merger. And your boss hasn’t heard anything about it. Yet, this unruly triumvirate will soon dominate and deliver DevSecOps faster, cheaper, better, and on an unprecedented scale. In his session at DevOps Summit, Frank Bunger, VP of Customer Success at ScriptRock, will discuss how this cathartic moment will propel the DevOps movement from such stuff as dreams are made on to a prac...