Click here to close now.




















Welcome!

News Feed Item

AbbVie Announces Availability of New Advanced Parkinson's Treatment in Canada

DUODOPA improves quality of life for those with advanced stages of disease

MONTREAL, April 10, 2014 /CNW/ - AbbVie today announced that a new treatment called DUODOPA® (levodopa/carbidopa intestinal gel) is now available to Canadians with advanced Parkinson's disease. Currently, more than 100,000 Canadians live with Parkinson's – a progressive, incurable neurological disorder that can significantly affect the quality of life of patients, their families and caregivers.

DUODOPA is approved in Canada for the management of advanced Parkinson's disease in adults with severe, disabling motor fluctuations and hyper-/dyskinesia (involuntary movements) not satisfactorily controlled by combinations of available oral medicinal products for Parkinson's disease.

"A major problem that emerges over time in people with Parkinson's disease is fluctuations in their ability to move due to unreliable absorption of oral medications. This leads to inconsistent delivery of the chemical dopamine which controls movement to the brain resulting in unpredictable motor function," said Dr. Anthony Lang of the Movement Disorder Centre at Toronto Western Hospital, University Health Network, which is one of four centers of excellence in Canada to treat advanced Parkinson's patients with this new treatment. "DUODOPA is a treatment option that enables patients to regain control over their movements and balance which in turn drastically improves their quality of life."

Parkinson's disease, which involves significant loss of limb and balance control, is most commonly diagnosed at 50-60 years of age – although diagnosis can occur at a much younger age. The standard treatment for Parkinson's disease begins with oral therapies, including levodopa, which usually work well during the first years. As the disease progresses, oral therapies no longer provide satisfactory control over severe motor fluctuations and dyskinesia. Now with DUODOPA there is a new option.

"I am a writer and I could not write. I would have very painful tremors in my right hand and rigidity on my entire left side," said Doug Curtis, a playwright who has been living with Parkinson's disease for 10 years. He is one of the first Parkinson's patients in North America to receive DUODOPA.  "Parkinson's took away my ability to express myself. But now I can write again. The tempo of my life has returned.  I now have the confidence to take on Parkinson's head on."

"My husband was progressively getting worse as he moved into the advanced stages of the disease. Simple daily tasks became a challenge and he became dependent on me," said Heather Moore, Doug's wife and caregiver. "Today, I see Doug's condition improving and because of this progress my family has regained a sense of normalcy in our lives."

About Parkinson's Disease (PD)
PD is a progressive neurological disease that affects approximately 6.3 million people, making it the second most common degenerative neurological disorder worldwide1,2.

The severity of PD and how it impacts an individual varies from person to person. The symptoms are predominantly characterized by problems with body movements, called motor symptoms3. These symptoms include tremor, or shaking (often in the hand, arm or leg); rigidity, or stiffness in muscles; slowness of movement, and poor balance and instability3,4. As the disease progresses, these symptoms can worsen to the point where a person becomes dependent on others to perform even basic activities, such as help getting out of a chair and turning over in bed3,5.

Currently there is no cure for PD and symptoms may gradually continue to worsen in the years following diagnosis6. The goal of treatment for PD is to manage motor symptoms, which reduces tremor, rigidity and slowness of movement1.

About DUODOPA

  • DUODOPA® is indicated for treatment of advanced levodopa-responsive PD with severe motor fluctuations and hyper-/dyskinesia when available combinations of PD medicinal products have not given satisfactory results7.
  • DUODOPA® provides an effective treatment for people with PD enabling more "ON" time in comparison to oral levodopa7.
  • DUODOPA® was approved in recognition of a high unmet need for effective therapies and no satisfactory alternatives8.
  • DUODOPA® is contraindicated in patients with narrow-angle glaucoma, severe liver and renal insufficiency, severe heart failure, severe cardiac arrhythmia, suspicious, undiagnosed skin lesions or a history of melanoma, acute stroke and in patients taking non-selective MAO inhibitors and selective MAO type A inhibitors7.

About AbbVie
AbbVie is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. AbbVie employs approximately 25,000 people worldwide and markets medicines in more than 170 countries. For further information on the company and its people, portfolio and commitments, please visit www.abbvie.com and www.abbvie.ca. Follow @abbvie on Twitter or view careers on our Facebook or LinkedIn page.

________________________________________
1
Mobin A. A comparative analysis of how Michael J. Fox and Muhammad Ali changed the world's views on Parkinson's disease. J Parkinsonism Restless Legs Syndrome 2011;1:1–4.
2 de Lau LM, Breteler MM. Epidemiology of Parkinson's disease. Lancet Neurol 2006;5:525–35.
3 Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 2008;79:368–376.
4 Clarke CE. Parkinson's disease. BMJ 2007;335:441–445.
5 ICD9 Data.com. Parkinson's disease 332. Available at: http://www.icd9data.com/2013/Volume1/320-389/330-337/332/default.htm (Last accessed December 2013).
6 Denyer R, Douglas MR. Gene therapy for Parkinson's disease. Parkinsons Dis 2012;2012:757305.
7 AbbVie Limited. Summary of product characteristics: Duodopa intestinal gel, October 2013. Available at: http://www.medicines.org.uk/emc/medicine/20786/SPC/Duodopa+intestinal+gel/ (Last accessed December 2013).
8 European Medicines Agency. Public summary of opinion on orphan designation: levodopa/carbidopa (gastroenteral use) for the treatment of advanced idiopathic Parkinson's disease with severe motor fluctuations and not responding to oral treatment. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Orphan_designation/2009/10/WC500006499.pdf (Last accessed December 2013).

SOURCE AbbVie

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
It’s been proven time and time again that in tech, diversity drives greater innovation, better team productivity and greater profits and market share. So what can we do in our DevOps teams to embrace diversity and help transform the culture of development and operations into a true “DevOps” team? In her session at DevOps Summit, Stefana Muller, Director, Product Management – Continuous Delivery at CA Technologies, answered that question citing examples, showing how to create opportunities for ...
Any Ops team trying to support a company in today’s cloud-connected world knows that a new way of thinking is required – one just as dramatic than the shift from Ops to DevOps. The diversity of modern operations requires teams to focus their impact on breadth vs. depth. In his session at DevOps Summit, Adam Serediuk, Director of Operations at xMatters, Inc., will discuss the strategic requirements of evolving from Ops to DevOps, and why modern Operations has begun leveraging the “NoOps” approa...
IBM’s Blue Box Cloud, powered by OpenStack, is now available in any of IBM’s globally integrated cloud data centers running SoftLayer infrastructure. Less than 90 days after its acquisition of Blue Box, IBM has integrated its Blue Box Cloud Dedicated private-cloud-as-a-service into its broader portfolio of OpenStack® based solutions. The announcement, made today at the OpenStack Silicon Valley event, further highlights IBM’s continued support to deliver OpenStack solutions across all cloud depl...
In their Live Hack” presentation at 17th Cloud Expo, Stephen Coty and Paul Fletcher, Chief Security Evangelists at Alert Logic, will provide the audience with a chance to see a live demonstration of the common tools cyber attackers use to attack cloud and traditional IT systems. This “Live Hack” uses open source attack tools that are free and available for download by anybody. Attendees will learn where to find and how to operate these tools for the purpose of testing their own IT infrastructu...
Red Hat is investing in Tesora, the number one contributor to OpenStack Trove Database as a Service (DBaaS) also ranked among the top 20 companies contributing to OpenStack overall. Tesora, the company bringing OpenStack Trove Database as a Service (DBaaS) to the enterprise, has announced that Red Hat and others have invested in the company as a part of Tesora's latest funding round. The funding agreement expands on the ongoing collaboration between Tesora and Red Hat, which dates back to Febr...
SYS-CON Events announced today that DataClear Inc. will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. The DataClear ‘BlackBox’ is the only solution that moves your PC, browsing and data out of the United States and away from prying (and spying) eyes. Its solution automatically builds you a clean, on-demand, virus free, new virtual cloud based PC outside of the United States, and wipes it clean...
WSM International, the pioneer and leader in server migration services, has announced an agreement with WHOA.com, a leader in providing secure public, private and hybrid cloud computing services. Under terms of the agreement, WSM will provide migration services to WHOA.com customers to relocate some or all of their applications, digital assets, and other computing workloads to WHOA.com enterprise-class, secure cloud infrastructure. The migration services include detailed evaluation and planning...
Cloud and datacenter migration innovator AppZero has joined the Microsoft Enterprise Cloud Alliance Program. AppZero is a fast, flexible way to move Windows Server applications from any source machine – physical or virtual – to any destination server, in any cloud or datacenter, using its patented container technology. AppZero’s container is also called a Virtual Application Appliance (VAA). To facilitate Microsoft Azure onboarding, AppZero has two purpose-built offerings: AppZero SP for Azure,...
SYS-CON Events announced today that G2G3 will exhibit at SYS-CON's @DevOpsSummit Silicon Valley, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Based on a collective appreciation for user experience, design, and technology, G2G3 is uniquely qualified and motivated to redefine how organizations and people engage in an increasingly digital world.
SYS-CON Events announced today that IceWarp will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. IceWarp, the leader of cloud and on-premise messaging, delivers secured email, chat, documents, conferencing and collaboration to today's mobile workforce, all in one unified interface
In 2014, the market witnessed a massive migration to the cloud as enterprises finally overcame their fears of the cloud’s viability, security, etc. Over the past 18 months, AWS, Google and Microsoft have waged an ongoing battle through a wave of price cuts and new features. For IT executives, sorting through all the noise to make the best cloud investment decisions has become daunting. Enterprises can and are moving away from a "one size fits all" cloud approach. The new competitive field has ...
In his session at @ThingsExpo, Lee Williams, a producer of the first smartphones and tablets, will talk about how he is now applying his experience in mobile technology to the design and development of the next generation of Environmental and Sustainability Services at ETwater. He will explain how M2M controllers work through wirelessly connected remote controls; and specifically delve into a retrofit option that reverse-engineers control codes of existing conventional controller systems so the...
Everyone talks about continuous integration and continuous delivery but those are just two ends of the pipeline. In the middle of DevOps is continuous testing (CT), and many organizations are struggling to implement continuous testing effectively. After all, without continuous testing there is no delivery. And Lab-As-A-Service (LaaS) enhances the CT with dynamic on-demand self-serve test topologies. CT together with LAAS make a powerful combination that perfectly serves complex software developm...
The Internet of Things is in the early stages of mainstream deployment but it promises to unlock value and rapidly transform how organizations manage, operationalize, and monetize their assets. IoT is a complex structure of hardware, sensors, applications, analytics and devices that need to be able to communicate geographically and across all functions. Once the data is collected from numerous endpoints, the challenge then becomes converting it into actionable insight.
With the proliferation of connected devices underpinning new Internet of Things systems, Brandon Schulz, Director of Luxoft IoT – Retail, will be looking at the transformation of the retail customer experience in brick and mortar stores in his session at @ThingsExpo. Questions he will address include: Will beacons drop to the wayside like QR codes, or be a proximity-based profit driver? How will the customer experience change in stores of all types when everything can be instrumented and a...