Welcome!

News Feed Item

Teflon: Not just for pots and pans as Sentinel Bioactive Paper researchers find

EDMONTON, April 16, 2014 /CNW/ - When a drop of ink hits blotting paper, it "bleeds" much wider than the circumference of the original drop. And quickly, too. Although researchers have developed ways of containing water-based solutions to specific areas of paper, until now, there was no easy way to modify paper to restrict chemicals such as organic solvents, bases and acids or surfactants to particular areas. The beauty of this discovery is that it dramatically expands the range of usable reagents and speeds up their efforts to develop multiple tests on the same sheet.

Under the leadership of Dr. Ratmir Derda at the University of Alberta in Edmonton, Alberta, Canada, Sentinel Bioactive Paper Network researchers Frédérique Deiss (lead author), Wadim L. Matochko, Natasha Govindasamy, Edith Y. Lin and Derda himself introduced a grid of solvent-repelling Teflon barriers inside the paper, which confine liquid to where it is wanted. Why Teflon? It is resistant to a wide range of solvent, non-toxic and non-fluorescent, and researchers can now modify paper and generate arrays with 96 test-zones per sheet. (See video link to view the production of the Teflon-patterned paper http://youtu.be/vMlCg_vZADI ).

"Converting ordinary paper to a synthesis platform is easy," says Deiss. "First, we draw a pattern on the computer and print it on an ordinary printer. Then, we add a sugar solution to an area we do not want modified, soak Teflon into the remaining areas, wash off the sugar, and voilà. We automated the entire process."

The Teflon barriers allow an excess of liquid to be delivered in each zone, generating a dynamic flow through the paper with mere gravity, and improving the mixing of reagents. When used for synthesis, the Teflon-patterned paper improves the yield of chemical reactions compared to synthesis on plain, non-patterned paper. The Derda group demonstrated it with the synthesis of peptides (short chain of amino acids) on paper and used the resulting sheet of 96 peptides to test which peptides will allow breast cancer cells to adhere and grow.

The research has been published on-line April 11, 2014 by a leading Chemistry journal, Angewandte Chemie-International Edition, which has cited it as a Hot Paper. Hot Papers are chosen by the journal's editors for their importance in a rapidly evolving field of high current interest.

But the researchers weren't done. The journal article also provides a "sneak preview" of the next phase of their work—in which plain old gravity is again the star (see video). They stacked up several layers of paper and dripped liquids from one test sheet into the layers below, performing multiple tests or paper-modification simultaneously.

"We no longer have to compromise quality and purity vs. synthesis conditions, cost and speed," confirms Derda. "By taking our minds off chemistry, we can focus on the next steps and use high-quality arrays of compounds to fuel our screen for protein inhibitors, drug leads and materials that can reprogram normal and cancerous cells."

The Alberta Glycomics Centre, www.glycomicscentre.ca, is an Alberta Innovates Centre for Research and Commercialization. The Centre uses glycomics to address complex health issues by exploring novel strategies to lead the development of vaccines, diagnostics and other medical applications. Applications include strategies to combat tuberculosis, pneumonia and other infectious diseases and food-borne pathogens. Glycomics is the study of the role of carbohydrates and carbohydrate-containing biomolecules in biological systems. Glycomics is expected to lead to the development of new drugs, vaccines and diagnostics.

Sentinel Bioactive Paper Network, www.bioactivepaper.ca, brings together 28 academic researchers and more than 50 graduate students and post-doctoral fellows from 11 universities, with industry and government partners. Sentinel operates with $7.5-million in funding over five years (2010-2015) from NSERC, and another $2.5-million and over $2-million (in-kind) from industry partners: SC Johnson, FPInnovations, Stora Enso, Cascades, FUJIFILM Dimatix, and Canadian government partners: NSERC and the National Research Council and the Ontario Centres of Excellence. McMaster University in Hamilton, Ontario leads the Sentinel Bioactive Paper Network and hosts its administrative centre.

For Interviews please contact:

Dr. Frédérique T. Deiss
Post-doctoral Researcher in Derda's Group
University of Alberta
Department of Chemistry & Alberta Glycomics Centre
Edmonton, AB, Canada
Tel: 587-778-0270
[email protected]

Dr. Ratmir Derda
University of Alberta
Assistant Professor Department of Chemistry & Alberta Glycomics Centre
Edmonton, AB, Canada
Tel: 780-492-8370
[email protected]
http://derda.chem.ualberta.ca/

Links:
Journal article  - http://onlinelibrary.wiley.com/doi/10.1002/anie.201402037/abstract


SOURCE Sentinel Bioactive Paper Network

Image with caption: "Flow of solvent through paper; automated deposition onto a 96-zone arrays of solutions with the excess volume confined to each zone; confocal microscopy images of cells in paper after peptide synthesis (left to right). (CNW Group/Sentinel Bioactive Paper Network)". Image available at: http://photos.newswire.ca/images/download/20140416_C9932_PHOTO_EN_39314.jpg

Video with caption: "Flow of reagents through a stack of four Teflon-patterned paper arrays: adding solutions (here, dyes) in excess to the top paper and allow them to flow by simple gravity through the full stack, then adding an excess of solvent to wash them off.". Video available at: http://stream1.newswire.ca/cgi-bin/playback.cgi?file=20140416_C9932_VIDEO_EN_39320.mp4&posterurl=http://photos.newswire.ca/images/20140416_C9932_PHOTO_EN_39320.jpg&clientName=Sentinel%20Bioactive%20Paper%20Network&caption=Flow%20of%20reagents%20through%20a%20stack%20of%20four%20Teflon%2Dpatterned%20paper%20arrays%3A%20adding%20solutions%20%28here%2C%20dyes%29%20in%20excess%20to%20the%20top%20paper%20and%20allow%20them%20to%20flow%20by%20simple%20gravity%20through%20the%20full%20stack%2C%20then%20adding%20an%20excess%20of%20solvent%20to%20wash%20them%20off%2E&title=SENTINEL%20BIOACTIVE%20PAPER%20NETWORK%20%2D%20Teflon%3A%20Not%20just%20for%20pots%20and%20pans%20as%20Sentinel%20Bioactive%20Paper%20researchers%20find&headline=Teflon%3A%20Not%20just%20for%20pots%20and%20pans%20as%20Sentinel%20Bioactive%20Paper%20researchers%20find

Image with caption: "Sentinel Bioactive Paper Network (CNW Group/Sentinel Bioactive Paper Network)". Image available at: http://photos.newswire.ca/images/download/20140416_C9932_PHOTO_EN_39315.jpg

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Extreme Computing is the ability to leverage highly performant infrastructure and software to accelerate Big Data, machine learning, HPC, and Enterprise applications. High IOPS Storage, low-latency networks, in-memory databases, GPUs and other parallel accelerators are being used to achieve faster results and help businesses make better decisions. In his session at 18th Cloud Expo, Michael O'Neill, Strategic Business Development at NVIDIA, focused on some of the unique ways extreme computing is...
The emerging Internet of Everything creates tremendous new opportunities for customer engagement and business model innovation. However, enterprises must overcome a number of critical challenges to bring these new solutions to market. In his session at @ThingsExpo, Michael Martin, CTO/CIO at nfrastructure, outlined these key challenges and recommended approaches for overcoming them to achieve speed and agility in the design, development and implementation of Internet of Everything solutions wi...
DevOps at Cloud Expo, taking place Nov 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 19th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is no time to wait for long dev...
Cloud computing is being adopted in one form or another by 94% of enterprises today. Tens of billions of new devices are being connected to The Internet of Things. And Big Data is driving this bus. An exponential increase is expected in the amount of information being processed, managed, analyzed, and acted upon by enterprise IT. This amazing is not part of some distant future - it is happening today. One report shows a 650% increase in enterprise data by 2020. Other estimates are even higher....
I wanted to gather all of my Internet of Things (IOT) blogs into a single blog (that I could later use with my University of San Francisco (USF) Big Data “MBA” course). However as I started to pull these blogs together, I realized that my IOT discussion lacked a vision; it lacked an end point towards which an organization could drive their IOT envisioning, proof of value, app dev, data engineering and data science efforts. And I think that the IOT end point is really quite simple…
Aspose.Total for .NET is the most complete package of all file format APIs for .NET as offered by Aspose. It empowers developers to create, edit, render, print and convert between a wide range of popular document formats within any .NET, C#, ASP.NET and VB.NET applications. Aspose compiles all .NET APIs on a daily basis to ensure that it contains the most up to date versions of each of Aspose .NET APIs. If a new .NET API or a new version of existing APIs is released during the subscription peri...
Today we can collect lots and lots of performance data. We build beautiful dashboards and even have fancy query languages to access and transform the data. Still performance data is a secret language only a couple of people understand. The more business becomes digital the more stakeholders are interested in this data including how it relates to business. Some of these people have never used a monitoring tool before. They have a question on their mind like “How is my application doing” but no id...
Identity is in everything and customers are looking to their providers to ensure the security of their identities, transactions and data. With the increased reliance on cloud-based services, service providers must build security and trust into their offerings, adding value to customers and improving the user experience. Making identity, security and privacy easy for customers provides a unique advantage over the competition.
Qosmos has announced new milestones in the detection of encrypted traffic and in protocol signature coverage. Qosmos latest software can accurately classify traffic encrypted with SSL/TLS (e.g., Google, Facebook, WhatsApp), P2P traffic (e.g., BitTorrent, MuTorrent, Vuze), and Skype, while preserving the privacy of communication content. These new classification techniques mean that traffic optimization, policy enforcement, and user experience are largely unaffected by encryption. In respect wit...
Kubernetes, Docker and containers are changing the world, and how companies are deploying their software and running their infrastructure. With the shift in how applications are built and deployed, new challenges must be solved. In his session at @DevOpsSummit at19th Cloud Expo, Sebastian Scheele, co-founder of Loodse, will discuss the implications of containerized applications/infrastructures and their impact on the enterprise. In a real world example based on Kubernetes, he will show how to ...
Using new techniques of information modeling, indexing, and processing, new cloud-based systems can support cloud-based workloads previously not possible for high-throughput insurance, banking, and case-based applications. In his session at 18th Cloud Expo, John Newton, CTO, Founder and Chairman of Alfresco, described how to scale cloud-based content management repositories to store, manage, and retrieve billions of documents and related information with fast and linear scalability. He addres...
Is the ongoing quest for agility in the data center forcing you to evaluate how to be a part of infrastructure automation efforts? As organizations evolve toward bimodal IT operations, they are embracing new service delivery models and leveraging virtualization to increase infrastructure agility. Therefore, the network must evolve in parallel to become equally agile. Read this essential piece of Gartner research for recommendations on achieving greater agility.
SYS-CON Events announced today that Hitrons Solutions will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Hitrons Solutions Inc. is distributor in the North American market for unique products and services of small and medium-size businesses, including cloud services and solutions, SEO marketing platforms, and mobile applications.
Smart Cities are here to stay, but for their promise to be delivered, the data they produce must not be put in new siloes. In his session at @ThingsExpo, Mathias Herberts, Co-founder and CTO of Cityzen Data, will deep dive into best practices that will ensure a successful smart city journey.
Internet of @ThingsExpo, taking place November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 19th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The Internet of Things (IoT) is the most profound change in personal and enterprise IT since the creation of the Worldwide Web more than 20 years ago. All major researchers estimate there will be tens of billions devices - comp...