Click here to close now.




















Welcome!

News Feed Item

Teflon: Not just for pots and pans as Sentinel Bioactive Paper researchers find

EDMONTON, April 16, 2014 /CNW/ - When a drop of ink hits blotting paper, it "bleeds" much wider than the circumference of the original drop. And quickly, too. Although researchers have developed ways of containing water-based solutions to specific areas of paper, until now, there was no easy way to modify paper to restrict chemicals such as organic solvents, bases and acids or surfactants to particular areas. The beauty of this discovery is that it dramatically expands the range of usable reagents and speeds up their efforts to develop multiple tests on the same sheet.

Under the leadership of Dr. Ratmir Derda at the University of Alberta in Edmonton, Alberta, Canada, Sentinel Bioactive Paper Network researchers Frédérique Deiss (lead author), Wadim L. Matochko, Natasha Govindasamy, Edith Y. Lin and Derda himself introduced a grid of solvent-repelling Teflon barriers inside the paper, which confine liquid to where it is wanted. Why Teflon? It is resistant to a wide range of solvent, non-toxic and non-fluorescent, and researchers can now modify paper and generate arrays with 96 test-zones per sheet. (See video link to view the production of the Teflon-patterned paper http://youtu.be/vMlCg_vZADI ).

"Converting ordinary paper to a synthesis platform is easy," says Deiss. "First, we draw a pattern on the computer and print it on an ordinary printer. Then, we add a sugar solution to an area we do not want modified, soak Teflon into the remaining areas, wash off the sugar, and voilà. We automated the entire process."

The Teflon barriers allow an excess of liquid to be delivered in each zone, generating a dynamic flow through the paper with mere gravity, and improving the mixing of reagents. When used for synthesis, the Teflon-patterned paper improves the yield of chemical reactions compared to synthesis on plain, non-patterned paper. The Derda group demonstrated it with the synthesis of peptides (short chain of amino acids) on paper and used the resulting sheet of 96 peptides to test which peptides will allow breast cancer cells to adhere and grow.

The research has been published on-line April 11, 2014 by a leading Chemistry journal, Angewandte Chemie-International Edition, which has cited it as a Hot Paper. Hot Papers are chosen by the journal's editors for their importance in a rapidly evolving field of high current interest.

But the researchers weren't done. The journal article also provides a "sneak preview" of the next phase of their work—in which plain old gravity is again the star (see video). They stacked up several layers of paper and dripped liquids from one test sheet into the layers below, performing multiple tests or paper-modification simultaneously.

"We no longer have to compromise quality and purity vs. synthesis conditions, cost and speed," confirms Derda. "By taking our minds off chemistry, we can focus on the next steps and use high-quality arrays of compounds to fuel our screen for protein inhibitors, drug leads and materials that can reprogram normal and cancerous cells."

The Alberta Glycomics Centre, www.glycomicscentre.ca, is an Alberta Innovates Centre for Research and Commercialization. The Centre uses glycomics to address complex health issues by exploring novel strategies to lead the development of vaccines, diagnostics and other medical applications. Applications include strategies to combat tuberculosis, pneumonia and other infectious diseases and food-borne pathogens. Glycomics is the study of the role of carbohydrates and carbohydrate-containing biomolecules in biological systems. Glycomics is expected to lead to the development of new drugs, vaccines and diagnostics.

Sentinel Bioactive Paper Network, www.bioactivepaper.ca, brings together 28 academic researchers and more than 50 graduate students and post-doctoral fellows from 11 universities, with industry and government partners. Sentinel operates with $7.5-million in funding over five years (2010-2015) from NSERC, and another $2.5-million and over $2-million (in-kind) from industry partners: SC Johnson, FPInnovations, Stora Enso, Cascades, FUJIFILM Dimatix, and Canadian government partners: NSERC and the National Research Council and the Ontario Centres of Excellence. McMaster University in Hamilton, Ontario leads the Sentinel Bioactive Paper Network and hosts its administrative centre.

For Interviews please contact:

Dr. Frédérique T. Deiss
Post-doctoral Researcher in Derda's Group
University of Alberta
Department of Chemistry & Alberta Glycomics Centre
Edmonton, AB, Canada
Tel: 587-778-0270
[email protected]

Dr. Ratmir Derda
University of Alberta
Assistant Professor Department of Chemistry & Alberta Glycomics Centre
Edmonton, AB, Canada
Tel: 780-492-8370
[email protected]
http://derda.chem.ualberta.ca/

Links:
Journal article  - http://onlinelibrary.wiley.com/doi/10.1002/anie.201402037/abstract


SOURCE Sentinel Bioactive Paper Network

Image with caption: "Flow of solvent through paper; automated deposition onto a 96-zone arrays of solutions with the excess volume confined to each zone; confocal microscopy images of cells in paper after peptide synthesis (left to right). (CNW Group/Sentinel Bioactive Paper Network)". Image available at: http://photos.newswire.ca/images/download/20140416_C9932_PHOTO_EN_39314.jpg

Video with caption: "Flow of reagents through a stack of four Teflon-patterned paper arrays: adding solutions (here, dyes) in excess to the top paper and allow them to flow by simple gravity through the full stack, then adding an excess of solvent to wash them off.". Video available at: http://stream1.newswire.ca/cgi-bin/playback.cgi?file=20140416_C9932_VIDEO_EN_39320.mp4&posterurl=http://photos.newswire.ca/images/20140416_C9932_PHOTO_EN_39320.jpg&clientName=Sentinel%20Bioactive%20Paper%20Network&caption=Flow%20of%20reagents%20through%20a%20stack%20of%20four%20Teflon%2Dpatterned%20paper%20arrays%3A%20adding%20solutions%20%28here%2C%20dyes%29%20in%20excess%20to%20the%20top%20paper%20and%20allow%20them%20to%20flow%20by%20simple%20gravity%20through%20the%20full%20stack%2C%20then%20adding%20an%20excess%20of%20solvent%20to%20wash%20them%20off%2E&title=SENTINEL%20BIOACTIVE%20PAPER%20NETWORK%20%2D%20Teflon%3A%20Not%20just%20for%20pots%20and%20pans%20as%20Sentinel%20Bioactive%20Paper%20researchers%20find&headline=Teflon%3A%20Not%20just%20for%20pots%20and%20pans%20as%20Sentinel%20Bioactive%20Paper%20researchers%20find

Image with caption: "Sentinel Bioactive Paper Network (CNW Group/Sentinel Bioactive Paper Network)". Image available at: http://photos.newswire.ca/images/download/20140416_C9932_PHOTO_EN_39315.jpg

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Too often with compelling new technologies market participants become overly enamored with that attractiveness of the technology and neglect underlying business drivers. This tendency, what some call the “newest shiny object syndrome,” is understandable given that virtually all of us are heavily engaged in technology. But it is also mistaken. Without concrete business cases driving its deployment, IoT, like many other technologies before it, will fade into obscurity.
Organizations from small to large are increasingly adopting cloud solutions to deliver essential business services at a much lower cost. According to cyber security experts, the frequency and severity of cyber-attacks are on the rise, causing alarm to businesses and customers across a variety of industries. To defend against exploits like these, a company must adopt a comprehensive security defense strategy that is designed for their business. In 2015, organizations such as United Airlines, Sony...
The Internet of Things is in the early stages of mainstream deployment but it promises to unlock value and rapidly transform how organizations manage, operationalize, and monetize their assets. IoT is a complex structure of hardware, sensors, applications, analytics and devices that need to be able to communicate geographically and across all functions. Once the data is collected from numerous endpoints, the challenge then becomes converting it into actionable insight.
Puppet Labs has announced the next major update to its flagship product: Puppet Enterprise 2015.2. This release includes new features providing DevOps teams with clarity, simplicity and additional management capabilities, including an all-new user interface, an interactive graph for visualizing infrastructure code, a new unified agent and broader infrastructure support.
Consumer IoT applications provide data about the user that just doesn’t exist in traditional PC or mobile web applications. This rich data, or “context,” enables the highly personalized consumer experiences that characterize many consumer IoT apps. This same data is also providing brands with unprecedented insight into how their connected products are being used, while, at the same time, powering highly targeted engagement and marketing opportunities. In his session at @ThingsExpo, Nathan Trel...
Amazon and Google have built software-defined data centers (SDDCs) that deliver massively scalable services with great efficiency. Yet, building SDDCs has proven to be a near impossibility for ‘normal’ companies without hyper-scale resources. In his session at 17th Cloud Expo, David Cauthron, founder and chief executive officer of Nimboxx, will discuss the evolution of virtualization (hardware, application, memory, storage) and how commodity / open source hyper converged infrastructure (HCI) so...
In their Live Hack” presentation at 17th Cloud Expo, Stephen Coty and Paul Fletcher, Chief Security Evangelists at Alert Logic, will provide the audience with a chance to see a live demonstration of the common tools cyber attackers use to attack cloud and traditional IT systems. This “Live Hack” uses open source attack tools that are free and available for download by anybody. Attendees will learn where to find and how to operate these tools for the purpose of testing their own IT infrastructu...
The web app is agile. The REST API is agile. The testing and planning are agile. But alas, data infrastructures certainly are not. Once an application matures, changing the shape or indexing scheme of data often forces at best a top down planning exercise and at worst includes schema changes that force downtime. The time has come for a new approach that fundamentally advances the agility of distributed data infrastructures. Come learn about a new solution to the problems faced by software organ...
With the Apple Watch making its way onto wrists all over the world, it’s only a matter of time before it becomes a staple in the workplace. In fact, Forrester reported that 68 percent of technology and business decision-makers characterize wearables as a top priority for 2015. Recognizing their business value early on, FinancialForce.com was the first to bring ERP to wearables, helping streamline communication across front and back office functions. In his session at @ThingsExpo, Kevin Roberts...
IBM’s Blue Box Cloud, powered by OpenStack, is now available in any of IBM’s globally integrated cloud data centers running SoftLayer infrastructure. Less than 90 days after its acquisition of Blue Box, IBM has integrated its Blue Box Cloud Dedicated private-cloud-as-a-service into its broader portfolio of OpenStack® based solutions. The announcement, made today at the OpenStack Silicon Valley event, further highlights IBM’s continued support to deliver OpenStack solutions across all cloud depl...
Red Hat is investing in Tesora, the number one contributor to OpenStack Trove Database as a Service (DBaaS) also ranked among the top 20 companies contributing to OpenStack overall. Tesora, the company bringing OpenStack Trove Database as a Service (DBaaS) to the enterprise, has announced that Red Hat and others have invested in the company as a part of Tesora's latest funding round. The funding agreement expands on the ongoing collaboration between Tesora and Red Hat, which dates back to Febr...
With the proliferation of connected devices underpinning new Internet of Things systems, Brandon Schulz, Director of Luxoft IoT – Retail, will be looking at the transformation of the retail customer experience in brick and mortar stores in his session at @ThingsExpo. Questions he will address include: Will beacons drop to the wayside like QR codes, or be a proximity-based profit driver? How will the customer experience change in stores of all types when everything can be instrumented and a...
The Internet of Things (IoT) is about the digitization of physical assets including sensors, devices, machines, gateways, and the network. It creates possibilities for significant value creation and new revenue generating business models via data democratization and ubiquitous analytics across IoT networks. The explosion of data in all forms in IoT requires a more robust and broader lens in order to enable smarter timely actions and better outcomes. Business operations become the key driver of I...
While many app developers are comfortable building apps for the smartphone, there is a whole new world out there. In his session at @ThingsExpo, Narayan Sainaney, Co-founder and CTO of Mojio, will discuss how the business case for connected car apps is growing and, with open platform companies having already done the heavy lifting, there really is no barrier to entry.
WSM International, the pioneer and leader in server migration services, has announced an agreement with WHOA.com, a leader in providing secure public, private and hybrid cloud computing services. Under terms of the agreement, WSM will provide migration services to WHOA.com customers to relocate some or all of their applications, digital assets, and other computing workloads to WHOA.com enterprise-class, secure cloud infrastructure. The migration services include detailed evaluation and planning...