Welcome!

News Feed Item

PharmaPoint: Atopic Dermatitis - US Drug Forecast and Market Analysis to 2022

LONDON, April 16, 2014 /PRNewswire/ -- Reportbuyer.com has added a new market research report:

PharmaPoint: Atopic Dermatitis - US Drug Forecast and Market Analysis to 2022

http://www.reportbuyer.com/pharma_healthcare/diseases/pharmapoint_atopic_dermatitis_us_drug_forecast_market_analysis_2022.html

PharmaPoint: Atopic Dermatitis - US Drug Forecast and Market Analysis to 2022

Summary

Although the past decade has seen the atopic dermatitis market remain relatively unchanged and a saturated, highly genericized arena, the coming decade could see the launch of the first biologic, which will set a precedent and pave the way for others to follow suit.

By the mid-to-late term of GlobalData's 2012 to 2022 forecast, Sanofi/Regeneron's dupilumab is expected to reshape the moderate and severe treatment landscape.

Other events that are expected to invoke change to the previously stagnant atopic dermatitis market include the launch of a non-steroidal topical from Anacor, AN2728, generic erosion of branded topicals Protopic and Elidel in the US, and the increasing use of pharmacological treatments in the growing markets of India and China.

However, these classes represent the crowded, saturated, generic portion of the US atopic dermatitis market, with little room for innovative products. That said, the reliance on these agents will lead to an overall steady growth over the 10-year forecast period, with respective CAGRs of 1.2% and 0.5% for corticosteroids and moisturizers/emollients during this timeframe.

Scope

- Overview of Atopic Dermatitis including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on the key drugs in the US including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for the top drugs in the US from 2012-2022.
- Analysis of the impact of key events as well the drivers and restraints affecting the US Atopic Dermatitis market.

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Atopic Dermatitis
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of drug performance
- Obtain sales forecast for drugs from 2012-2022 in the US
1 Table of Contents
1 Table of Contents 5
1.1 List of Tables 8
1.2 List of Figures 10
2 Introduction 11
2.1 Catalyst 11
2.2 Related Reports 11
2.3 Upcoming Related Reports 12
3 Disease Overview 13
3.1 Etiology and Pathophysiology 13
3.1.1 Etiology 13
3.1.2 Pathophysiology 14
3.2 Symptoms 18
4 Disease Management 20
4.1 Diagnosis 20
4.2 Treatment Overview 22
4.3 US 28
4.3.1 Diagnosis 28
4.3.2 Clinical Practice 30
5 Competitive Assessment 33
5.1 Overview 33
5.2 Strategic Competitor Assessment 34
5.3 Product Profiles - Major Brands 35
5.3.1 Protopic (tacrolimus) 35
5.3.2 Elidel 42
5.3.3 Cyclosporine (numerous generic names) 47
5.3.4 Other Therapeutic Drug Classes Used in Atopic Dermatitis 50
5.4 Product Profiles - Off-Label Therapies 52
5.4.1 Actimmune (interferon gamma-1b) 52
6 Opportunity and Unmet Need 56
6.1 Overview 56
6.2 Unmet Needs 57
6.2.1 A Systemic Drug for Severe Recalcitrant Patients 57
6.2.2 Tests that Stratify Patients and Allow for a Tailored Treatment Approach 59
6.2.3 A Drug that Effectively Controls Patients' Pruritus 60
6.2.4 Further Research into the Pathophysiology of Atopic Dermatitis 61
6.2.5 A Drug that Induces Disease Remission 62
6.2.6 Improved Quality of Life for Both Patients and their Carers 63
6.3 Unmet Needs Gap Analysis 63
6.4 Opportunities 65
6.4.1 Increase Treatment Armamentarium for Severe Recalcitrant Patients 65
6.4.2 Predictive Tests for Patient Stratification 65
6.4.3 More Therapeutic Options that Address Patients' Pruritus 66
7 Pipeline Assessment 67
7.1 Overview 67
7.2 Promising Drugs in Clinical Development 69
7.2.1 Dupilumab (SAR231893/ REGN668) 70
7.2.2 AN2728 80
7.2.3 Phase II Pipeline Products 88
8 Market Outlook 89
8.1 Global Drivers and Barriers 89
8.1.1 Driver: Anticipated launch of the first biologic for the treatment of moderate to severe disease 89
8.1.2 Driver: The underserved severe refractory patient segment presents an untapped market opportunity 90
8.1.3 Driver: A drug that is able to target two or more atopic diseases would gain a foothold in these markets 90
8.1.4 Driver: Atopic dermatitis presents an attractive patient population for drug developers 90
8.1.5 Driver: Restoring skin barrier function remains a key goal of disease management, meaning a continued need for moisturizers and topical agents 91
8.1.6 Barrier: First to second line of therapy is dominated by cheap, genericized topical drugs which create significant obstacles for novel drugs hoping to penetrate the market 92
8.1.7 Barrier: The largest atopic dermatitis patient segment - mild disease - can be well-controlled on most forms of topical therapy 92
8.1.8 Barrier: Pediatric sufferers are the largest patient group and pose a high bar in terms of safety for new products 92
8.1.9 Barrier: The complexity of the multiple etiologies that lead to atopic dermatitis means that treatment outcomes with existing drugs are not universal across all patient groups 93
8.1.10 Barrier: A significant proportion of patients experience disease remission in their early adolescent years and this may occur without drug therapy 94
8.2 US 94
8.2.1 Forecast 94
8.2.2 Key Events 97
8.2.3 Drivers and Barriers 98
9 Appendix 101
9.1 Bibliography 101
9.2 Abbreviations 107
9.3 Methodology 109
9.4 Forecasting Methodology 109
9.4.1 Diagnosed Atopic Dermatitis Patients 109
9.4.2 Percent Drug-treated Patients 110
9.4.3 Drugs Included in Each Therapeutic Class 110
9.4.4 Launch and Patent Expiry Dates 110
9.4.5 General Pricing Assumptions 111
9.4.6 Individual Drug Assumptions 112
9.4.7 Generic Erosion 114
9.4.8 Pricing of Pipeline Agents 114
9.5 Physicians and Specialists Included in this Study 115
9.6 Primary Research - Prescriber Survey 116
9.7 About the Authors 117
9.7.1 Author 117
9.7.2 Global Head of Healthcare 118
9.8 About GlobalData 119
9.9 Disclaimer 119

1.1 List of Tables

Table 1: Symptoms of Atopic Dermatitis 19
Table 2: Treatment Guidelines for Atopic Dermatitis 25
Table 3: Most Prescribed Drugs for Atopic Dermatitis by Severity in the Global Markets, 2013 27
Table 4: Referral Rates to a US Dermatologist, Split by Severity and Specialist Type, 2013 29
Table 5: Key Metrics Relating to the Diagnosis, Relapse and Remission Rates of Atopic Dermatitis in the US, 2013 30
Table 6: Leading Treatments for Atopic Dermatitis, 2013 35
Table 7: Product Profile - Protopic 37
Table 8: Clinical Response Data of Protopic (0.03% and 0.1%) versus Vehicle Ointment at Week 12 from One Study in Pediatric Patients and Two Combined Studies in Adult Patients 38
Table 9: Protopic SWOT Analysis, 2013 41
Table 10: Product Profile - Elidel 43
Table 11: Combined Clinical Efficacy Results of Elidel versus Vehicle Cream at Week 6 from Two Phase III Studies 44
Table 12: Elidel SWOT Analysis, 2013 46
Table 13: Product Profile - Cyclosporine 48
Table 14: Cyclosporine SWOT Analysis, 2013 50
Table 15: Summary of Other Therapeutic Classes for Atopic Dermatitis, 2013 51
Table 16: Product Profile - Actimmune 53
Table 17: Actimmune SWOT Analysis, 2013 55
Table 18: Overall Unmet Needs in Atopic Dermatitis - Current Level of Attainment 57
Table 19: Clinical Unmet Needs in Atopic Dermatitis - Gap Analysis, 2013 64
Table 20: Late-Stage Atopic Dermatitis Pipeline, 2013 69
Table 21: Comparison of Therapeutic Classes in Development for Atopic Dermatitis, 2013 70
Table 22: Product Profile - Dupilumab 72
Table 23: Ongoing Clinical Trials of Dupilumab in Atopic Dermatitis Patients, as of September 2013 74
Table 24: Dupilumab SWOT Analysis, 2013 79
Table 25: Product Profile - AN2728 81
Table 26: Efficacy Results for AN2728 in Mild to Moderate Adolescent Atopic Dermatitis Patients (Day 29) 82
Table 27: AN2728 SWOT Analysis, 2013 87
Table 28: Phase II and Phase I Atopic Dermatitis Pipeline, 2013 88
Table 29: Global Atopic Dermatitis Market - Drivers and Barriers, 2012-2022 89
Table 30: Sales Forecasts ($m) for Atopic Dermatitis in the US, 2012-2022 96
Table 31: Key Events Impacting Sales for Atopic Dermatitis in the US, 2012-2022 97
Table 32: Atopic Dermatitis Market in the US - Drivers and Barriers, 2012-2022 98
Table 33: Key Launch Dates 110
Table 34: Key Patent Expiries 110
Table 35: Physicians Surveyed, By Country 116

1.2 List of Figures

Figure 1: Immunologic Pathway Involved in Healthy, Acute Atopic Dermatitis, and Chronic Atopic Dermatitis Skin 16
Figure 2: Flow Chart of the Diagnosis and Management of Atopic Dermatitis 23
Figure 3: Competitive Assessment of Late-Stage Pipeline Agents in Atopic Dermatitis, 2012-2022 69
Figure 4: Sales for Atopic Dermatitis in the US by Drug Class, 2012-2022 97


Read the full report:
PharmaPoint: Atopic Dermatitis - US Drug Forecast and Market Analysis to 2022

http://www.reportbuyer.com/pharma_healthcare/diseases/pharmapoint_atopic_dermatitis_us_drug_forecast_market_analysis_2022.html

For more information:
Sarah Smith
Research Advisor at Reportbuyer.com
Email: [email protected]
Tel: +44 208 816 85 48
Website: www.reportbuyer.com

 

 

SOURCE ReportBuyer

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
DevOps at Cloud Expo – being held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA – announces that its Call for Papers is open. Born out of proven success in agile development, cloud computing, and process automation, DevOps is a macro trend you cannot afford to miss. From showcase success stories from early adopters and web-scale businesses, DevOps is expanding to organizations of all sizes, including the world's largest enterprises – and delivering real results. Am...
Basho Technologies has announced the latest release of Basho Riak TS, version 1.3. Riak TS is an enterprise-grade NoSQL database optimized for Internet of Things (IoT). The open source version enables developers to download the software for free and use it in production as well as make contributions to the code and develop applications around Riak TS. Enhancements to Riak TS make it quick, easy and cost-effective to spin up an instance to test new ideas and build IoT applications. In addition to...
The 19th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportuni...
"This week we're really focusing on scalability, asset preservation and how do you back up to the cloud and in the cloud with object storage, which is really a new way of attacking dealing with your file, your blocked data, where you put it and how you access it," stated Jeff Greenwald, Senior Director of Market Development at HGST, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
"We've discovered that after shows 80% if leads that people get, 80% of the conversations end up on the show floor, meaning people forget about it, people forget who they talk to, people forget that there are actual business opportunities to be had here so we try to help out and keep the conversations going," explained Jeff Mesnik, Founder and President of ContentMX, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
SYS-CON Events announced today that Isomorphic Software will exhibit at DevOps Summit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Isomorphic Software provides the SmartClient HTML5/AJAX platform, the most advanced technology for building rich, cutting-edge enterprise web applications for desktop and mobile. SmartClient combines the productivity and performance of traditional desktop software with the simp...
"When you think about the data center today, there's constant evolution, The evolution of the data center and the needs of the consumer of technology change, and they change constantly," stated Matt Kalmenson, VP of Sales, Service and Cloud Providers at Veeam Software, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
“Being the one true cloud-agnostic and storage-agnostic software solution, more and more customers are coming to Commvault and saying ' What do you recommend? What's your best practice for implementing cloud?” explained Randy De Meno, Chief Technologist at Commvault, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
"We're bringing out a new application monitoring system to the DevOps space. It manages large enterprise applications that are distributed throughout a node in many enterprises and we manage them as one collective," explained Kevin Barnes, President of eCube Systems, in this SYS-CON.tv interview at DevOps at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
“delaPlex Software provides software outsourcing services. We have a hybrid model where we have onshore developers and project managers that we can place anywhere in the U.S. or in Europe,” explained Manish Sachdeva, CEO at delaPlex Software, in this SYS-CON.tv interview at @ThingsExpo, held June 7-9, 2016, at the Javits Center in New York City, NY.
From wearable activity trackers to fantasy e-sports, data and technology are transforming the way athletes train for the game and fans engage with their teams. In his session at @ThingsExpo, will present key data findings from leading sports organizations San Francisco 49ers, Orlando Magic NBA team. By utilizing data analytics these sports orgs have recognized new revenue streams, doubled its fan base and streamlined costs at its stadiums. John Paul is the CEO and Founder of VenueNext. Prior ...
IoT is rapidly changing the way enterprises are using data to improve business decision-making. In order to derive business value, organizations must unlock insights from the data gathered and then act on these. In their session at @ThingsExpo, Eric Hoffman, Vice President at EastBanc Technologies, and Peter Shashkin, Head of Development Department at EastBanc Technologies, discussed how one organization leveraged IoT, cloud technology and data analysis to improve customer experiences and effi...
Let’s face it, embracing new storage technologies, capabilities and upgrading to new hardware often adds complexity and increases costs. In his session at 18th Cloud Expo, Seth Oxenhorn, Vice President of Business Development & Alliances at FalconStor, discussed how a truly heterogeneous software-defined storage approach can add value to legacy platforms and heterogeneous environments. The result reduces complexity, significantly lowers cost, and provides IT organizations with improved efficienc...
Organizations planning enterprise data center consolidation and modernization projects are faced with a challenging, costly reality. Requirements to deploy modern, cloud-native applications simultaneously with traditional client/server applications are almost impossible to achieve with hardware-centric enterprise infrastructure. Compute and network infrastructure are fast moving down a software-defined path, but storage has been a laggard. Until now.
The Internet of Things will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform and how we integrate our thinking to solve complicated problems. In his session at 19th Cloud Expo, Craig Sproule, CEO of Metavine, will demonstrate how to move beyond today's coding paradigm ...