Welcome!

News Feed Item

PharmaPoint: Atopic Dermatitis - US Drug Forecast and Market Analysis to 2022

LONDON, April 16, 2014 /PRNewswire/ -- Reportbuyer.com has added a new market research report:

PharmaPoint: Atopic Dermatitis - US Drug Forecast and Market Analysis to 2022

http://www.reportbuyer.com/pharma_healthcare/diseases/pharmapoint_atopic_dermatitis_us_drug_forecast_market_analysis_2022.html

PharmaPoint: Atopic Dermatitis - US Drug Forecast and Market Analysis to 2022

Summary

Although the past decade has seen the atopic dermatitis market remain relatively unchanged and a saturated, highly genericized arena, the coming decade could see the launch of the first biologic, which will set a precedent and pave the way for others to follow suit.

By the mid-to-late term of GlobalData's 2012 to 2022 forecast, Sanofi/Regeneron's dupilumab is expected to reshape the moderate and severe treatment landscape.

Other events that are expected to invoke change to the previously stagnant atopic dermatitis market include the launch of a non-steroidal topical from Anacor, AN2728, generic erosion of branded topicals Protopic and Elidel in the US, and the increasing use of pharmacological treatments in the growing markets of India and China.

However, these classes represent the crowded, saturated, generic portion of the US atopic dermatitis market, with little room for innovative products. That said, the reliance on these agents will lead to an overall steady growth over the 10-year forecast period, with respective CAGRs of 1.2% and 0.5% for corticosteroids and moisturizers/emollients during this timeframe.

Scope

- Overview of Atopic Dermatitis including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on the key drugs in the US including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for the top drugs in the US from 2012-2022.
- Analysis of the impact of key events as well the drivers and restraints affecting the US Atopic Dermatitis market.

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Atopic Dermatitis
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of drug performance
- Obtain sales forecast for drugs from 2012-2022 in the US
1 Table of Contents
1 Table of Contents 5
1.1 List of Tables 8
1.2 List of Figures 10
2 Introduction 11
2.1 Catalyst 11
2.2 Related Reports 11
2.3 Upcoming Related Reports 12
3 Disease Overview 13
3.1 Etiology and Pathophysiology 13
3.1.1 Etiology 13
3.1.2 Pathophysiology 14
3.2 Symptoms 18
4 Disease Management 20
4.1 Diagnosis 20
4.2 Treatment Overview 22
4.3 US 28
4.3.1 Diagnosis 28
4.3.2 Clinical Practice 30
5 Competitive Assessment 33
5.1 Overview 33
5.2 Strategic Competitor Assessment 34
5.3 Product Profiles - Major Brands 35
5.3.1 Protopic (tacrolimus) 35
5.3.2 Elidel 42
5.3.3 Cyclosporine (numerous generic names) 47
5.3.4 Other Therapeutic Drug Classes Used in Atopic Dermatitis 50
5.4 Product Profiles - Off-Label Therapies 52
5.4.1 Actimmune (interferon gamma-1b) 52
6 Opportunity and Unmet Need 56
6.1 Overview 56
6.2 Unmet Needs 57
6.2.1 A Systemic Drug for Severe Recalcitrant Patients 57
6.2.2 Tests that Stratify Patients and Allow for a Tailored Treatment Approach 59
6.2.3 A Drug that Effectively Controls Patients' Pruritus 60
6.2.4 Further Research into the Pathophysiology of Atopic Dermatitis 61
6.2.5 A Drug that Induces Disease Remission 62
6.2.6 Improved Quality of Life for Both Patients and their Carers 63
6.3 Unmet Needs Gap Analysis 63
6.4 Opportunities 65
6.4.1 Increase Treatment Armamentarium for Severe Recalcitrant Patients 65
6.4.2 Predictive Tests for Patient Stratification 65
6.4.3 More Therapeutic Options that Address Patients' Pruritus 66
7 Pipeline Assessment 67
7.1 Overview 67
7.2 Promising Drugs in Clinical Development 69
7.2.1 Dupilumab (SAR231893/ REGN668) 70
7.2.2 AN2728 80
7.2.3 Phase II Pipeline Products 88
8 Market Outlook 89
8.1 Global Drivers and Barriers 89
8.1.1 Driver: Anticipated launch of the first biologic for the treatment of moderate to severe disease 89
8.1.2 Driver: The underserved severe refractory patient segment presents an untapped market opportunity 90
8.1.3 Driver: A drug that is able to target two or more atopic diseases would gain a foothold in these markets 90
8.1.4 Driver: Atopic dermatitis presents an attractive patient population for drug developers 90
8.1.5 Driver: Restoring skin barrier function remains a key goal of disease management, meaning a continued need for moisturizers and topical agents 91
8.1.6 Barrier: First to second line of therapy is dominated by cheap, genericized topical drugs which create significant obstacles for novel drugs hoping to penetrate the market 92
8.1.7 Barrier: The largest atopic dermatitis patient segment - mild disease - can be well-controlled on most forms of topical therapy 92
8.1.8 Barrier: Pediatric sufferers are the largest patient group and pose a high bar in terms of safety for new products 92
8.1.9 Barrier: The complexity of the multiple etiologies that lead to atopic dermatitis means that treatment outcomes with existing drugs are not universal across all patient groups 93
8.1.10 Barrier: A significant proportion of patients experience disease remission in their early adolescent years and this may occur without drug therapy 94
8.2 US 94
8.2.1 Forecast 94
8.2.2 Key Events 97
8.2.3 Drivers and Barriers 98
9 Appendix 101
9.1 Bibliography 101
9.2 Abbreviations 107
9.3 Methodology 109
9.4 Forecasting Methodology 109
9.4.1 Diagnosed Atopic Dermatitis Patients 109
9.4.2 Percent Drug-treated Patients 110
9.4.3 Drugs Included in Each Therapeutic Class 110
9.4.4 Launch and Patent Expiry Dates 110
9.4.5 General Pricing Assumptions 111
9.4.6 Individual Drug Assumptions 112
9.4.7 Generic Erosion 114
9.4.8 Pricing of Pipeline Agents 114
9.5 Physicians and Specialists Included in this Study 115
9.6 Primary Research - Prescriber Survey 116
9.7 About the Authors 117
9.7.1 Author 117
9.7.2 Global Head of Healthcare 118
9.8 About GlobalData 119
9.9 Disclaimer 119

1.1 List of Tables

Table 1: Symptoms of Atopic Dermatitis 19
Table 2: Treatment Guidelines for Atopic Dermatitis 25
Table 3: Most Prescribed Drugs for Atopic Dermatitis by Severity in the Global Markets, 2013 27
Table 4: Referral Rates to a US Dermatologist, Split by Severity and Specialist Type, 2013 29
Table 5: Key Metrics Relating to the Diagnosis, Relapse and Remission Rates of Atopic Dermatitis in the US, 2013 30
Table 6: Leading Treatments for Atopic Dermatitis, 2013 35
Table 7: Product Profile - Protopic 37
Table 8: Clinical Response Data of Protopic (0.03% and 0.1%) versus Vehicle Ointment at Week 12 from One Study in Pediatric Patients and Two Combined Studies in Adult Patients 38
Table 9: Protopic SWOT Analysis, 2013 41
Table 10: Product Profile - Elidel 43
Table 11: Combined Clinical Efficacy Results of Elidel versus Vehicle Cream at Week 6 from Two Phase III Studies 44
Table 12: Elidel SWOT Analysis, 2013 46
Table 13: Product Profile - Cyclosporine 48
Table 14: Cyclosporine SWOT Analysis, 2013 50
Table 15: Summary of Other Therapeutic Classes for Atopic Dermatitis, 2013 51
Table 16: Product Profile - Actimmune 53
Table 17: Actimmune SWOT Analysis, 2013 55
Table 18: Overall Unmet Needs in Atopic Dermatitis - Current Level of Attainment 57
Table 19: Clinical Unmet Needs in Atopic Dermatitis - Gap Analysis, 2013 64
Table 20: Late-Stage Atopic Dermatitis Pipeline, 2013 69
Table 21: Comparison of Therapeutic Classes in Development for Atopic Dermatitis, 2013 70
Table 22: Product Profile - Dupilumab 72
Table 23: Ongoing Clinical Trials of Dupilumab in Atopic Dermatitis Patients, as of September 2013 74
Table 24: Dupilumab SWOT Analysis, 2013 79
Table 25: Product Profile - AN2728 81
Table 26: Efficacy Results for AN2728 in Mild to Moderate Adolescent Atopic Dermatitis Patients (Day 29) 82
Table 27: AN2728 SWOT Analysis, 2013 87
Table 28: Phase II and Phase I Atopic Dermatitis Pipeline, 2013 88
Table 29: Global Atopic Dermatitis Market - Drivers and Barriers, 2012-2022 89
Table 30: Sales Forecasts ($m) for Atopic Dermatitis in the US, 2012-2022 96
Table 31: Key Events Impacting Sales for Atopic Dermatitis in the US, 2012-2022 97
Table 32: Atopic Dermatitis Market in the US - Drivers and Barriers, 2012-2022 98
Table 33: Key Launch Dates 110
Table 34: Key Patent Expiries 110
Table 35: Physicians Surveyed, By Country 116

1.2 List of Figures

Figure 1: Immunologic Pathway Involved in Healthy, Acute Atopic Dermatitis, and Chronic Atopic Dermatitis Skin 16
Figure 2: Flow Chart of the Diagnosis and Management of Atopic Dermatitis 23
Figure 3: Competitive Assessment of Late-Stage Pipeline Agents in Atopic Dermatitis, 2012-2022 69
Figure 4: Sales for Atopic Dermatitis in the US by Drug Class, 2012-2022 97


Read the full report:
PharmaPoint: Atopic Dermatitis - US Drug Forecast and Market Analysis to 2022

http://www.reportbuyer.com/pharma_healthcare/diseases/pharmapoint_atopic_dermatitis_us_drug_forecast_market_analysis_2022.html

For more information:
Sarah Smith
Research Advisor at Reportbuyer.com
Email: [email protected]
Tel: +44 208 816 85 48
Website: www.reportbuyer.com

 

 

SOURCE ReportBuyer

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Manufacturers are embracing the Industrial Internet the same way consumers are leveraging Fitbits – to improve overall health and wellness. Both can provide consistent measurement, visibility, and suggest performance improvements customized to help reach goals. Fitbit users can view real-time data and make adjustments to increase their activity. In his session at @ThingsExpo, Mark Bernardo Professional Services Leader, Americas, at GE Digital, discussed how leveraging the Industrial Internet and...
"Tintri was started in 2008 with the express purpose of building a storage appliance that is ideal for virtualized environments. We support a lot of different hypervisor platforms from VMware to OpenStack to Hyper-V," explained Dan Florea, Director of Product Management at Tintri, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
There will be new vendors providing applications, middleware, and connected devices to support the thriving IoT ecosystem. This essentially means that electronic device manufacturers will also be in the software business. Many will be new to building embedded software or robust software. This creates an increased importance on software quality, particularly within the Industrial Internet of Things where business-critical applications are becoming dependent on products controlled by software. Qua...
Fact is, enterprises have significant legacy voice infrastructure that’s costly to replace with pure IP solutions. How can we bring this analog infrastructure into our shiny new cloud applications? There are proven methods to bind both legacy voice applications and traditional PSTN audio into cloud-based applications and services at a carrier scale. Some of the most successful implementations leverage WebRTC, WebSockets, SIP and other open source technologies. In his session at @ThingsExpo, Da...
The speed of software changes in growing and large scale rapid-paced DevOps environments presents a challenge for continuous testing. Many organizations struggle to get this right. Practices that work for small scale continuous testing may not be sufficient as the requirements grow. In his session at DevOps Summit, Marc Hornbeek, Sr. Solutions Architect of DevOps continuous test solutions at Spirent Communications, explained the best practices of continuous testing at high scale, which is rele...
A critical component of any IoT project is what to do with all the data being generated. This data needs to be captured, processed, structured, and stored in a way to facilitate different kinds of queries. Traditional data warehouse and analytical systems are mature technologies that can be used to handle certain kinds of queries, but they are not always well suited to many problems, particularly when there is a need for real-time insights.
Containers have changed the mind of IT in DevOps. They enable developers to work with dev, test, stage and production environments identically. Containers provide the right abstraction for microservices and many cloud platforms have integrated them into deployment pipelines. DevOps and Containers together help companies to achieve their business goals faster and more effectively. In his session at DevOps Summit, Ruslan Synytsky, CEO and Co-founder of Jelastic, reviewed the current landscape of D...
In his General Session at 16th Cloud Expo, David Shacochis, host of The Hybrid IT Files podcast and Vice President at CenturyLink, investigated three key trends of the “gigabit economy" though the story of a Fortune 500 communications company in transformation. Narrating how multi-modal hybrid IT, service automation, and agile delivery all intersect, he will cover the role of storytelling and empathy in achieving strategic alignment between the enterprise and its information technology.
IoT is at the core or many Digital Transformation initiatives with the goal of re-inventing a company's business model. We all agree that collecting relevant IoT data will result in massive amounts of data needing to be stored. However, with the rapid development of IoT devices and ongoing business model transformation, we are not able to predict the volume and growth of IoT data. And with the lack of IoT history, traditional methods of IT and infrastructure planning based on the past do not app...
WebRTC is bringing significant change to the communications landscape that will bridge the worlds of web and telephony, making the Internet the new standard for communications. Cloud9 took the road less traveled and used WebRTC to create a downloadable enterprise-grade communications platform that is changing the communication dynamic in the financial sector. In his session at @ThingsExpo, Leo Papadopoulos, CTO of Cloud9, discussed the importance of WebRTC and how it enables companies to focus o...
"We're bringing out a new application monitoring system to the DevOps space. It manages large enterprise applications that are distributed throughout a node in many enterprises and we manage them as one collective," explained Kevin Barnes, President of eCube Systems, in this SYS-CON.tv interview at DevOps at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
The Internet of Things can drive efficiency for airlines and airports. In their session at @ThingsExpo, Shyam Varan Nath, Principal Architect with GE, and Sudip Majumder, senior director of development at Oracle, discussed the technical details of the connected airline baggage and related social media solutions. These IoT applications will enhance travelers' journey experience and drive efficiency for the airlines and the airports.
All organizations that did not originate this moment have a pre-existing culture as well as legacy technology and processes that can be more or less amenable to DevOps implementation. That organizational culture is influenced by the personalities and management styles of Executive Management, the wider culture in which the organization is situated, and the personalities of key team members at all levels of the organization. This culture and entrenched interests usually throw a wrench in the work...
In his General Session at DevOps Summit, Asaf Yigal, Co-Founder & VP of Product at Logz.io, will explore the value of Kibana 4 for log analysis and will give a real live, hands-on tutorial on how to set up Kibana 4 and get the most out of Apache log files. He will examine three use cases: IT operations, business intelligence, and security and compliance. This is a hands-on session that will require participants to bring their own laptops, and we will provide the rest.
With major technology companies and startups seriously embracing IoT strategies, now is the perfect time to attend @ThingsExpo 2016 in New York. Learn what is going on, contribute to the discussions, and ensure that your enterprise is as "IoT-Ready" as it can be! Internet of @ThingsExpo, taking place June 6-8, 2017, at the Javits Center in New York City, New York, is co-located with 20th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry p...