Welcome!

News Feed Item

Lumiphore advances its site-directed radiopharmaceutical development program with the receipt of an NSF SBIR Phase II Grant

Lumiphore Inc., a pharmaceutical leader in bifunctional chelator design, is developing in vivo radio-diagnostic imaging and site-directed radio-therapeutics, using its proprietary bifunctional radionuclide metal-chelation technology; it has received a Nat

BERKELEY, Calif., April 17, 2014 /PRNewswire-iReach/ -- Lumimphore Inc., a pharmaceutical leader in bifunctional chelator design, is developing in vivo radio-diagnostic imaging and site-directed radio-therapeutics, using its proprietary bifunctional radionuclide metal-chelation technology; it has received a National Science Foundation Small Business Innovation Research (SBIR) Phase II Grant entitled "Novel macrocyclic chelating groups for use in targeted radioisotope diagnostic and companion diagnostic/therapeutic applications." The Phase II grant will permit Lumiphore to continue its developmen work on site-directed (targeted) radioisotope payload delivery systems through synthesis and evaluation of novel macrocyclic chelating groups, termed aromatic macrocyclic bifunctional chelators (AMBFCs). These consist of a site-directing molecule, such as an antibody to a tumor receptor, coupled to an AMBFC to deliver a radionuclide to a specific site. As radioimmunodiagnostics, site-directed radioisotopes are deployed as imaging agents in single-photon emmission computer tomography (SPECT) and positron emission tomography (PET). These can be also used as a companion diagnostic in targeted radioimmunotherapy wherein a radionuclide which emits therapeutic-effective ionizing radiation is similarly localized within a specific biological sites by attachment to an accessory molecule that imparts appropiate bio-distrubution and pharmokinetic properties.

The work under the Phase II grant will continue improving chelation stability of metalic radioisotopes for imaging and therapeutics, a compelling need for improved chelating groups for use in radiopharmaceuticals and to utilize radionuclides that are at presently underdeveloped in the clinic.

The Company's AMBFCs that will be developed under this project will potentially contribute to progress in the way cancer is detected and treated. Because the AMBRCs have the potential to be used in cancer imaging and companion diagnostics the physician could benefit from effective feedback loop on the therapeutic progress, remission, and prognosis to help shorten the time of treatment. The AMBFCs also have the potential to deliver radionuclide payloads to kill tumors and their metastases by localized lethal micro-irradiation.

About Lumiphore, Inc.

Based in Berkeley, California, Lumiphore Inc., a privately held company, is a biotechnology leader in the development of proprietary metal lanthanide/actinide chelation technology for use in high-value in vivo radio-imaging and radio-therapeutics which are commercialized through market-specific alliances with corporate partners. Lumphore's new classs of metal lanthanide and actinide chelators are based on technoloy patented by Professor Kenneth N. Raymond and coworkers at the University of California, Berkeley and modified by Lumiphore, and Lumiphore's own patents. Lumiphore's partnerships include: Algeta/Bayer (www.algeta.com) in radiotherapeutics and companion in vivo diagnostic tests; Thermo Fisher Scientific Diagnostics (www.thermofisher.com) for in vitro diagnostics tests; Cis Bioassays (www.htrf.com) in drug discovery research assays; and Biophor Diagnostics Inc. (www.biophor.com) for in vitro diagnostic tests of drugs of abuse. For more information about Lumiphore, log onto www.lumiphore.com. Lumi4® is a registerd mark of Lumiphore, Inc.

For more informaton contact:

Stephen H. Blose, VMD, PhD, Chief Business Officer
Lumiphore, Inc.
(415) 381-4457 | Direct Telephone
(510) 898-1190 | Main Office/FAX
[email protected]
www.lumiphore.com

Media Contact: Stephen Blose, Lumiphore, Inc., 510-898-1190, [email protected]

News distributed by PR Newswire iReach: https://ireach.prnewswire.com

SOURCE Lumiphore, Inc.

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
"Space Monkey by Vivent Smart Home is a product that is a distributed cloud-based edge storage network. Vivent Smart Home, our parent company, is a smart home provider that places a lot of hard drives across homes in North America," explained JT Olds, Director of Engineering, and Brandon Crowfeather, Product Manager, at Vivint Smart Home, in this SYS-CON.tv interview at @ThingsExpo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
"Codigm is based on the cloud and we are here to explore marketing opportunities in America. Our mission is to make an ecosystem of the SW environment that anyone can understand, learn, teach, and develop the SW on the cloud," explained Sung Tae Ryu, CEO of Codigm, in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
"We're developing a software that is based on the cloud environment and we are providing those services to corporations and the general public," explained Seungmin Kim, CEO/CTO of SM Systems Inc., in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
"We're focused on how to get some of the attributes that you would expect from an Amazon, Azure, Google, and doing that on-prem. We believe today that you can actually get those types of things done with certain architectures available in the market today," explained Steve Conner, VP of Sales at Cloudistics, in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
The question before companies today is not whether to become intelligent, it’s a question of how and how fast. The key is to adopt and deploy an intelligent application strategy while simultaneously preparing to scale that intelligence. In her session at 21st Cloud Expo, Sangeeta Chakraborty, Chief Customer Officer at Ayasdi, provided a tactical framework to become a truly intelligent enterprise, including how to identify the right applications for AI, how to build a Center of Excellence to oper...
"IBM is really all in on blockchain. We take a look at sort of the history of blockchain ledger technologies. It started out with bitcoin, Ethereum, and IBM evaluated these particular blockchain technologies and found they were anonymous and permissionless and that many companies were looking for permissioned blockchain," stated René Bostic, Technical VP of the IBM Cloud Unit in North America, in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Conventi...
WebRTC is great technology to build your own communication tools. It will be even more exciting experience it with advanced devices, such as a 360 Camera, 360 microphone, and a depth sensor camera. In his session at @ThingsExpo, Masashi Ganeko, a manager at INFOCOM Corporation, introduced two experimental projects from his team and what they learned from them. "Shotoku Tamago" uses the robot audition software HARK to track speakers in 360 video of a remote party. "Virtual Teleport" uses a multip...
SYS-CON Events announced today that Telecom Reseller has been named “Media Sponsor” of SYS-CON's 22nd International Cloud Expo, which will take place on June 5-7, 2018, at the Javits Center in New York, NY. Telecom Reseller reports on Unified Communications, UCaaS, BPaaS for enterprise and SMBs. They report extensively on both customer premises based solutions such as IP-PBX as well as cloud based and hosted platforms.
"CA has been doing a lot of things in the area of DevOps. Now we have a complete set of tool sets in order to enable customers to go all the way from planning to development to testing down to release into the operations," explained Aruna Ravichandran, Vice President of Global Marketing and Strategy at CA Technologies, in this SYS-CON.tv interview at DevOps Summit at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
DevOps promotes continuous improvement through a culture of collaboration. But in real terms, how do you: Integrate activities across diverse teams and services? Make objective decisions with system-wide visibility? Use feedback loops to enable learning and improvement? With technology insights and real-world examples, in his general session at @DevOpsSummit, at 21st Cloud Expo, Andi Mann, Chief Technology Advocate at Splunk, explored how leading organizations use data-driven DevOps to close th...
Enterprises are moving to the cloud faster than most of us in security expected. CIOs are going from 0 to 100 in cloud adoption and leaving security teams in the dust. Once cloud is part of an enterprise stack, it’s unclear who has responsibility for the protection of applications, services, and data. When cloud breaches occur, whether active compromise or a publicly accessible database, the blame must fall on both service providers and users. In his session at 21st Cloud Expo, Ben Johnson, C...
Coca-Cola’s Google powered digital signage system lays the groundwork for a more valuable connection between Coke and its customers. Digital signs pair software with high-resolution displays so that a message can be changed instantly based on what the operator wants to communicate or sell. In their Day 3 Keynote at 21st Cloud Expo, Greg Chambers, Global Group Director, Digital Innovation, Coca-Cola, and Vidya Nagarajan, a Senior Product Manager at Google, discussed how from store operations and ...
In his session at 21st Cloud Expo, Carl J. Levine, Senior Technical Evangelist for NS1, will objectively discuss how DNS is used to solve Digital Transformation challenges in large SaaS applications, CDNs, AdTech platforms, and other demanding use cases. Carl J. Levine is the Senior Technical Evangelist for NS1. A veteran of the Internet Infrastructure space, he has over a decade of experience with startups, networking protocols and Internet infrastructure, combined with the unique ability to it...
Gemini is Yahoo’s native and search advertising platform. To ensure the quality of a complex distributed system that spans multiple products and components and across various desktop websites and mobile app and web experiences – both Yahoo owned and operated and third-party syndication (supply), with complex interaction with more than a billion users and numerous advertisers globally (demand) – it becomes imperative to automate a set of end-to-end tests 24x7 to detect bugs and regression. In th...
"The reason Tier 1 companies are coming to us is we're able to narrow the gap where custom applications need to be built. They provide a lot of services, like IBM has Watson, and they provide a lot of hardware but how do you bring it all together? Bringing it all together they have to build custom applications and that's the niche that we are able to help them with," explained Peter Jung, Product Leader at Pulzze Systems Inc., in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2,...