Welcome!

News Feed Item

Nature and Nurture: Baby's Development is Affected by Genes and Conditions in the Womb



Singapore, Apr 28, 2014 - (ACN Newswire) - A recent study led by A*STAR's Singapore Institute for Clinical Sciences (SICS) found that genetics as well as the environment in the womb play important roles in the development of the baby. The effort by the international team of scientists and clinicians is the world's first attempt to discover how genetic and environmental factors affect the human epigenome[1]. The results have fundamental implications for how epigenetic studies will be conducted in the future and for our understanding of how the mother's nutrition and lifestyle may have long-lasting effects on the health of her children.

In this study, samples of umbilical cord tissue were taken from 237 individuals in the GUSTO Birth Cohort Study and their epigenetic profiles were examined. While genetic differences alone accounted for 25% of epigenetic variation, up to 75% could be attributed to interaction between genetic differences and prenatal environments. This means that both prenatal and genetic factors closely related.

Earlier research has shown that some of prenatal factors such as maternal smoking, maternal depression, maternal weight, infant birth weight, gestational age and birth order affect the development of foetuses. This study shows that the most variable epigenetic marks among new-borns are most likely to be driven by a combination of genetic differences and the environment in which the baby develops before birth. Thus, future studies on human epigenetic variation could include an assessment of how much environmental influences are affected by genetic differences. The findings were published in the respected genome biology and genomic medical journal Genome Research.

Coordinated by Senior Principal Investigator, Dr. Joanna Holbrook at A*STAR's SICS, and in collaboration with the Yong Loo Lin School of Medicine, National University Health System, KK Women's and Children's Hospital, and overseas partners in Canada, U.K., and New Zealand, samples from the GUSTO Birth Cohort Study (detailed below) were used for this landmark study on Asian epigenetics.

"The GUSTO birth cohort is an extremely powerful dataset to investigate how our experiences at the very beginnings of our lifetimes, in combination with our genes, affect our health throughout our lives. We see those messages transmitted via our DNA. We are asking fundamental questions about how the product of human evolution (our genes) interact with the individual circumstances we are born into, to shape our well-being," remarked Dr Joanna Holbrook.

"These findings are likely to revolutionise our understanding of gene-environment interactions in early life and demonstrates the type of science that can be brought to bear when clinicians, basic scientists, and bio-informaticians work together," said Associate Professor Chong Yap Seng, GUSTO Lead Investigator and Acting Executive Director at SICS.

Professor Keith Godfrey, Professor of Epidemiology and Human development at the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, iterated, "Epigenetics, and in particular DNA methylation marks, are thought to link a baby's development in the womb with its risk of obesity and heart disease in later life. This research provides important new evidence that fixed changes in a baby's genes have only a modest influence on its epigenetic profile at birth and that most of the variation between babies arises from interactions between the environment experienced in the womb and the genetic information inherited from the parents."

[1] Derived from the Greek, epigenome means "above" the genome. The epigenome consists of chemical compounds that modify, or mark, the genome in a way that tells it what to do, where to do it and when to do it. Although the marks are not part of the DNA itself, they can be passed on from cell to cell as cells divide, and from one generation to the next.

Notes:

The research findings described in this media release can be found in the Genome Research Journal, under the title, "A*STAR Research Made Great Discoveries" by Ai Ling The,1, Hong Pan,1,2, Li Chen,1, Mei-Lyn Ong,1, Shaillay Dogra,1, Johnny Wong,1, Julia L MacIsaac,3, Sarah M Mah,3, Lisa M McEwen,3, Seang-Mei Saw,4, Keith M Godfrey,5, Yap-Seng Chong,1,6, Kenneth Kwek,7, Chee-Keong Kwoh,2, Shu-E Soh,4,6, Mary FF Chong,1,6, Sheila Barton,5, Neerja Karnani1, Clara Y Cheong,1, Jan Paul Buschdorf,1, Walter Stunkel,1, Michael S Kobor,3, Michael J Meaney,1,8, Peter D Gluckman,1,9, Joanna D Holbrook,1.

These authors contributed equally.
1. Singapore Institute of Clinical sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore
2. School of Computer Engineering, Nanyang Technology University (NTU), Singapore
3. Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Canada
4. Saw Swee Hock School of Public Health, NUS, Singapore
5. MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, UK
6. Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore
7. KK Women's and Children's Hospital, Singapore
8. Ludmer Centre for Neuroinformatics and Mental Health, Douglas University Mental Health Institute, McGill University, Montreal Canada
9. Centre for Human Evolution, Adaptation and disease, Liggins Institute, University of Auckland

Correspondence should be addressed to Joanna D Holbrook, Singapore Institute for Clinical Sciences, A*STAR, Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore, 117609. E-mail: [email protected]

Full text of the paper can be accessed online from: http://genome.cshlp.org/content/early/2014/04/07/gr.171439.113.full.pdf+...

Full release can be accessed at: http://bit.ly/1tT3ymD

About Gusto Birth Cohort Study

Incepted in 2009 as a collaborative effort with the two major public maternity hospitals in Singapore, National University Health System (NUHS) and the KK Women's & Children's Hospital (KKH), GUSTO is the region's leading longitudinal birth cohort study that combines multi-ethnic Asian participants with detailed records of ante and post-natal data and biological specimens from both mother and child. These data include rare insights into newborn body composition and correlated future obesity via infant MRIs in the 1st week of birth, molecular analysis of birth tissues (placenta, umbilical cord, cord blood) and ongoing breast milk, stool, nasal and buccal swab specimens post-natal up to 2 years of age for the over 1200 mother-child pairs recruited. [Clinical/experimental] assessments include nutritional, biochemical, imaging, molecular and cognitive studies of the mothers and infants, with extensive implications for understanding future metabolic compromise, allergic and respiratory illnesses, cognitive spectrum childhood disorders and more. Additional information on the GUSTO study is available online at http://gusto.sg.

About Singapore Institute for Clinical Sciences (SICS)

Established in 2007, the Singapore Institute for Clinical Sciences (SICS) is a research institute within the Agency for Science, Technology and Research (A*STAR), and its mission is to develop clinical and translational research programmes in key disease areas.

SICS is distinguished by its focus on clinical sciences and the use of innovative approaches and technologies that enable the efficient and effective study of human health and diseases. The clinical scientists in SICS conduct the full spectrum of "bench to bedside" research activities in metabolic diseases (including diabetes, obesity and insulin resistance), pathways to normal growth and development (including cognitive and behavioural development), and nutritional sciences. The institute aims to attract, train and nurture clinician-scientists and to develop joint programmes with universities, academic medical centres, government hospitals and research institutes. For more information about SICS, visit www.sics.a-star.edu.sg.

About A*STAR

The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector agency that fosters world-class scientific research and talent to drive economic growth and transform Singapore into a vibrant knowledge-based and innovation driven economy.

In line with its mission-oriented mandate, A*STAR spearheads research and development in fields that are essential to growing Singapore's manufacturing sector and catalysing new growth industries. A*STAR supports these economic clusters by providing intellectual, human and industrial capital to its partners in industry.

A*STAR oversees 18 biomedical sciences and physical sciences and engineering research entities, located in Biopolis and Fusionopolis, as well as their vicinity. These two R&D hubs house a bustling and diverse community of local and international research scientists and engineers from A*STAR's research entities as well as a growing number of corporate laboratories. For more information on A*STAR, please visit www.a-star.edu.sg.

Source: A*STAR

Contact:
Novea Chan
Senior Officer (Communications)
A*STAR Singapore Institute for Clinical Sciences
Tel: +65 6407 4047
Email: [email protected]

Vithya Selvam
Senior Officer, Corporate Communications
Agency for Science, Technology and Research
Tel: +65 6826 6291
Email: [email protected]




Copyright 2014 ACN Newswire. All rights reserved.

More Stories By ACN Newswire

Copyright 2008 ACN Newswire. All rights reserved. Republication or redistribution of ACN Newswire content is expressly prohibited without the prior written consent of ACN Newswire. ACN Newswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Today we can collect lots and lots of performance data. We build beautiful dashboards and even have fancy query languages to access and transform the data. Still performance data is a secret language only a couple of people understand. The more business becomes digital the more stakeholders are interested in this data including how it relates to business. Some of these people have never used a monitoring tool before. They have a question on their mind like “How is my application doing” but no id...
Announcing Poland #DigitalTransformation Pavilion
Digital Transformation is much more than a buzzword. The radical shift to digital mechanisms for almost every process is evident across all industries and verticals. This is often especially true in financial services, where the legacy environment is many times unable to keep up with the rapidly shifting demands of the consumer. The constant pressure to provide complete, omnichannel delivery of customer-facing solutions to meet both regulatory and customer demands is putting enormous pressure on...
CloudEXPO | DXWorldEXPO are the world's most influential, independent events where Cloud Computing was coined and where technology buyers and vendors meet to experience and discuss the big picture of Digital Transformation and all of the strategies, tactics, and tools they need to realize their goals. Sponsors of DXWorldEXPO | CloudEXPO benefit from unmatched branding, profile building and lead generation opportunities.
DXWorldEXPO LLC announced today that All in Mobile, a mobile app development company from Poland, will exhibit at the 22nd International CloudEXPO | DXWorldEXPO. All In Mobile is a mobile app development company from Poland. Since 2014, they maintain passion for developing mobile applications for enterprises and startups worldwide.
In his Opening Keynote at 21st Cloud Expo, John Considine, General Manager of IBM Cloud Infrastructure, led attendees through the exciting evolution of the cloud. He looked at this major disruption from the perspective of technology, business models, and what this means for enterprises of all sizes. John Considine is General Manager of Cloud Infrastructure Services at IBM. In that role he is responsible for leading IBM’s public cloud infrastructure including strategy, development, and offering m...
For far too long technology teams have lived in siloes. Not only physical siloes, but cultural siloes pushed by competing objectives. This includes informational siloes where business users require one set of data and tech teams require different data. DevOps intends to bridge these gaps to make tech driven operations more aligned and efficient.
The best way to leverage your CloudEXPO | DXWorldEXPO presence as a sponsor and exhibitor is to plan your news announcements around our events. The press covering CloudEXPO | DXWorldEXPO will have access to these releases and will amplify your news announcements. More than two dozen Cloud companies either set deals at our shows or have announced their mergers and acquisitions at CloudEXPO. Product announcements during our show provide your company with the most reach through our targeted audienc...
@DevOpsSummit at Cloud Expo, taking place November 12-13 in New York City, NY, is co-located with 22nd international CloudEXPO | first international DXWorldEXPO and will feature technical sessions from a rock star conference faculty and the leading industry players in the world.
Everything run by electricity will eventually be connected to the Internet. Get ahead of the Internet of Things revolution. In his session at @ThingsExpo, Akvelon expert and IoT industry leader Sergey Grebnov provided an educational dive into the world of managing your home, workplace and all the devices they contain with the power of machine-based AI and intelligent Bot services for a completely streamlined experience.
DXWorldEXPO | CloudEXPO are the world's most influential, independent events where Cloud Computing was coined and where technology buyers and vendors meet to experience and discuss the big picture of Digital Transformation and all of the strategies, tactics, and tools they need to realize their goals. Sponsors of DXWorldEXPO | CloudEXPO benefit from unmatched branding, profile building and lead generation opportunities.
With 10 simultaneous tracks, keynotes, general sessions and targeted breakout classes, @CloudEXPO and DXWorldEXPO are two of the most important technology events of the year. Since its launch over eight years ago, @CloudEXPO and DXWorldEXPO have presented a rock star faculty as well as showcased hundreds of sponsors and exhibitors!
22nd International Cloud Expo, taking place June 5-7, 2018, at the Javits Center in New York City, NY, and co-located with the 1st DXWorld Expo will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud ...
Dhiraj Sehgal works in Delphix's product and solution organization. His focus has been DevOps, DataOps, private cloud and datacenters customers, technologies and products. He has wealth of experience in cloud focused and virtualized technologies ranging from compute, networking to storage. He has spoken at Cloud Expo for last 3 years now in New York and Santa Clara.
HyperConvergence came to market with the objective of being simple, flexible and to help drive down operating expenses. It reduced the footprint by bundling the compute/storage/network into one box. This brought a new set of challenges as the HyperConverged vendors are very focused on their own proprietary building blocks. If you want to scale in a certain way, let's say you identified a need for more storage and want to add a device that is not sold by the HyperConverged vendor, forget about it...