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Bina Technologies Introduces Annotation Platform to Bring Scientific Context to NGS Data Sets Quickly
|By Business Wire
|April 29, 2014 12:03 PM EDT
Technologies today announced the early release of the Bina
Annotation Platform, the newest addition to Bina’s highly scalable and
accurate genomic analysis product suite. With this addition, Bina allows
users to perform secondary analysis (alignment, variant calling) as well
as annotation and filtering on their NGS datasets in an integrated,
easy-to-use platform with unprecedented speed and scalability.
The Bina Annotation Platform is the fastest, most scalable annotation
solution available on the market, empowering scientists to access more
than 130 annotation features and search, filter, and annotate their
variant files in a fraction of a second. Users can define and save
custom and multi-level filters using any combination of important
associations and functional databases available on the platform.
Typical NGS whole genome studies yield between 4-5 million variants.
Because of the complexity and sheer amount of data, assigning biological
meaning and extracting the relevant variants remains one of the primary
challenges that biologists and clinical researchers face. Whereas many
current annotation tools can’t process an entire whole human genome, the
Bina Annotation Module can easily and quickly annotate complex whole
genome data sets.
“The Bina Annotation platform provides a great way to comprehensively
annotate sequence variants,” said Dr. Ekta Khurana, Yale University.
“The user-interface is very intuitive and the process is very fast,
allowing more downstream analyses in a fraction of the time required
with other approaches.” Dr. Khurana, a research scientist in the Program
in Computational Biology and Bioinformatics, is the primary author of a
in Science on annotating human gene variants for cancer genomics
Users can upload their NGS data analysis results or push them directly
from Bina’s secondary analysis appliances to the cloud-based Bina
Annotation Platform. The Platform then quickly provides current
information about relevant variants using databases that are in active
use by the scientific community, including HGMD, PGMD, ClinVar, COSMIC,
dbNSFP, TRANSFAC, 1000 Genomes, and more. Once the annotation is
complete, researchers can interact with their data in real-time, through
filtering of all identified variants according to user selected
annotation and data quality criteria. All this takes place in an
intuitive and easy-to-use interface designed specifically for the
“Bina’s Annotation Platform provides comprehensive annotation to NGS
data with the most relevant scientific and clinical content. Its
sub-second query response for WGS and WES (whole genome and whole exome)
is unprecedented, definitely facilitating genome interpretation,” added
Dr. Shashikant Kulkarni, Associate Professor, Pathology and Immunology
and the Head of Clinical Genomics, Genomics and Pathology Services at
Washington University School of Medicine
“Prior to Bina’s Annotation Platform, researchers had to wait days, if
not weeks, to perform partial analysis on a whole human genome,” said
Narges Bani Asadi, CEO of Bina Technologies. “Today, clinical
researchers have the ability to bring meaning to their entire NGS data
sets in under 60 minutes. Faster, smarter annotation takes us one step
closer to our goal of bringing personalized medicine tools to academic
and clinical researchers everywhere.”
The Bina Technologies team will be presenting the Bina Annotation
Platform to the public this week at the Bio-IT World Expo from April
29th - May 1 in Boston, MA. They will be exhibiting at booth #260, and
will present on April 29th at the Vendor Showcase.
To learn more about Bina’s Annotation Platform, please visit: http://binatechnologies.com.
About Bina Technologies
Bina Technologies is defining the standards of high performance genomic
analysis. Bina’s integrated, scalable, and comprehensive analysis
platform empowers clinical and academic researchers to gain insight from
their genomics data sets. Bina’s products dramatically decrease the
complexity, time, and cost of the analysis, accelerating the science of
Bina is an interdisciplinary team of engineers, computer scientists, and
genomics scientists, revolutionizing human health and genomics research.
To learn more, visit: http://binatechnologies.com.
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