Welcome!

News Feed Item

New Study Confirms High Inter-Observer Agreement Using the WATS3D Biopsy for Evaluation of Esophageal Pre-Cancer

Provides Powerful Validation for the Clinical Value of Using the WATS3D Biopsy Procedure as a Complement to Four Quadrant Biopsy; Results Highlighted in an Oral Presentation at Digestive Disease Week

SUFFERN, NY -- (Marketwired) -- 05/04/14 -- CDx Diagnostics today announced results from a study showing high inter-observer agreement rates in the diagnosis of Barrett's esophagus and dysplasia among pathologists analyzing samples from the WATS3D biopsy. The study showed that WATS3D computer-assisted pathology analysis results in significantly better pathologist inter-observer agreement rates compared to standard manual microscopic histopathology assessment of Barrett's esophagus and dysplasia. The results were presented during an oral session at Digestive Disease Week® 2014 (DDW) on May 3, 2014 in Chicago.

"This study has potentially important implications for clinical care because we know that histopathologic diagnosis of Barrett's esophagus-associated dysplasia has traditionally suffered from poor inter-observer agreement, even among experienced GI pathologists," said lead author Prashanth Vennalaganti, MD of the Division of Gastroenterology and Hepatology, University of Kansas Medical Center, Kansas City, MO. "These high kappa values for the WATS3D biopsy provide powerful validation for the clinical value of this procedure. Providing a more accurate, consistent assessment of esophageal pre-cancer will allow gastroenterologists to make more confident decisions about care strategies for their patients."

The WATS3D biopsy collects a wide area, disaggregated tissue specimen of the entire thickness of the suspect epithelium. This unique tissue specimen is then subjected to specialized, computer-assisted 3-dimensional analysis which selects the 200 "highest ranking" cells from each patient for presentation to a pathologist. The high sensitivity of WATS3D is due to the large tissue area sampled, and the proprietary computer imaging system that is based on an algorithm developed as part of the U.S. Strategic Defense Initiative missile defense program.

In standard manual microscopic inspection of a biopsy specimen the first cells evaluated by the pathologist from each slide are selected randomly. An initial impression of the degree of pathology on the case can then be formed based on these randomly selected cells and this can lead to "confirmation bias" against modifying this initial impression during the remainder of the pathologist's analysis.

In contrast, during WATS3D analysis the pathologist's initial impression of the case is not based on evaluation of a few randomly selected cells but on a subset of 200 mathematically pre-selected cells which are rank ordered for potential abnormality, eliminating "confirmation bias" as a source of inter-observer variability.

In the study presented at DDW, 149 WATS3D slides with varying degrees of Barrett's esophagus and dysplasia were randomly selected and distributed to four pathologists trained in the analysis of WATS3D samples. Each slide was evaluated in a blinded fashion and graded as non-dysplastic, low-grade dysplasia (LGD) or high-grade dysplasia/esophageal adenocarcinoma (HGD/EAC). The agreement rates, or kappa values, were graded based on Landis and Koch scale (kappa values: 0.41 to 0.60 indicate moderate agreement, 0.61 to 0.80 indicate substantial agreement, and above 0.80 indicate nearly perfect agreement).

The overall mean kappa value for all three diagnoses for the 4 observers was calculated at 0.86 (95% CI 0.75-0.97). The kappa values (95% CI) for HGD/EAC, IND/LGD and no dysplasia were 0.95 (0.88-0.99), 0.74 (0.61-0.85) and 0.88 (0.81-0.94) respectively. The authors concluded that the diagnosis of Barrett's esophagus and associated dysplasia using WATS3D has very high inter-observer agreement and represents a significant improvement over current histopathological assessment.

"The excellent inter-observer agreement of pathologists utilizing the WATS3D system found in this study could potentially be due to the computer program that flags the most suspicious cells from each patient for consistent presentation to each pathologist," said Prateek Sharma, MD of the University of Kansas Medical Center and the senior author of the study. "This computer-assisted analysis system thus addresses the possibility that the pathologist may be susceptible to confirmation bias in that they may make their diagnosis based on review of randomly selected fields."

In addition to the inter-observer agreement study, an ASGE/AGA Joint Presidential Plenary presentation at DDW will highlight findings from the largest WATS3D clinical study conducted to date.

  • Sunday, May 4th, beginning at 1:30 PM CDT: "Esophageal Brush Biopsy with Computer-Assisted Tissue Analysis Increases Detection of Barrett's Esophagus and Dysplasia in a Multi-site Community-Based Setting."

DDW attendees can visit booth # 2711 to learn more about WATS3D.

About CDx Diagnostics and the WATS3D Biopsy
CDx Diagnostics' mission is to provide doctors with the most powerful diagnostic technology to help prevent cancer before it can start.

CDx Diagnostics' WATS3D biopsy addresses the sampling error inherent in random forceps biopsy testing of the esophagus. In just a few minutes, gastroenterologists can easily obtain a wide area, full-thickness transepithelial tissue sample for computer-assisted 3D laboratory analysis. In clinical trials, adjunctive use of CDx Diagnostics' WATS3D biopsy significantly increased the detection rate of both Barrett's esophagus and esophageal dysplasia. The high sensitivity of WATS3D is due to the large tissue area sampled, and the proprietary 3-Dimensionial computer imaging system that is based on an algorithm developed as part of the U.S. Strategic Defense Initiative missile defense program. To learn more about WATS3D, visit www.cdxdiagnostics.com.

About Digestive Disease Week®
Digestive Disease Week® (DDW®) is the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly sponsored by the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterological Association (AGA) Institute, the American Society for Gastrointestinal Endoscopy (ASGE) and the Society for Surgery of the Alimentary Tract (SSAT), DDW takes place May 3 - 6, 2014, at McCormick Place, Chicago, IL. The meeting showcases more than 5,000 abstracts and hundreds of lectures on the latest advances in GI research, medicine and technology. More information can be found at www.ddw.org.

More Stories By Marketwired .

Copyright © 2009 Marketwired. All rights reserved. All the news releases provided by Marketwired are copyrighted. Any forms of copying other than an individual user's personal reference without express written permission is prohibited. Further distribution of these materials is strictly forbidden, including but not limited to, posting, emailing, faxing, archiving in a public database, redistributing via a computer network or in a printed form.

Latest Stories
Why do your mobile transformations need to happen today? Mobile is the strategy that enterprise transformation centers on to drive customer engagement. In his general session at @ThingsExpo, Roger Woods, Director, Mobile Product & Strategy – Adobe Marketing Cloud, covered key IoT and mobile trends that are forcing mobile transformation, key components of a solid mobile strategy and explored how brands are effectively driving mobile change throughout the enterprise.
SYS-CON Events announced today that Adobe has been named “Bronze Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. Adobe is changing the world though digital experiences. Adobe helps customers develop and deliver high-impact experiences that differentiate brands, build loyalty, and drive revenue across every screen, including smartphones, computers, tablets and TVs. Adobe content solutions are used daily by millions of co...
Almost two-thirds of companies either have or soon will have IoT as the backbone of their business in 2016. However, IoT is far more complex than most firms expected. How can you not get trapped in the pitfalls? In his session at @ThingsExpo, Tony Shan, a renowned visionary and thought leader, will introduce a holistic method of IoTification, which is the process of IoTifying the existing technology and business models to adopt and leverage IoT. He will drill down to the components in this fra...
As the world moves toward more DevOps and Microservices, application deployment to the cloud ought to become a lot simpler. The Microservices architecture, which is the basis of many new age distributed systems such as OpenStack, NetFlix and so on, is at the heart of Cloud Foundry - a complete developer-oriented Platform as a Service (PaaS) that is IaaS agnostic and supports vCloud, OpenStack and AWS. Serverless computing is revolutionizing computing. In his session at 19th Cloud Expo, Raghav...
SYS-CON Events announced today that eCube Systems, a leading provider of middleware modernization, integration, and management solutions, will exhibit at @DevOpsSummit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. eCube Systems offers a family of middleware evolution products and services that maximize return on technology investment by leveraging existing technical equity to meet evolving business needs. ...
Data is an unusual currency; it is not restricted by the same transactional limitations as money or people. In fact, the more that you leverage your data across multiple business use cases, the more valuable it becomes to the organization. And the same can be said about the organization’s analytics. In his session at 19th Cloud Expo, Bill Schmarzo, CTO for the Big Data Practice at EMC, will introduce a methodology for capturing, enriching and sharing data (and analytics) across the organizati...
Enterprises have forever faced challenges surrounding the sharing of their intellectual property. Emerging cloud adoption has made it more compelling for enterprises to digitize their content, making them available over a wide variety of devices across the Internet. In his session at 19th Cloud Expo, Santosh Ahuja, Director of Architecture at Impiger Technologies, will introduce various mechanisms provided by cloud service providers today to manage and share digital content in a secure manner....
SYS-CON Events announced today that Isomorphic Software will exhibit at DevOps Summit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Isomorphic Software provides the SmartClient HTML5/AJAX platform, the most advanced technology for building rich, cutting-edge enterprise web applications for desktop and mobile. SmartClient combines the productivity and performance of traditional desktop software with the simp...
With so much going on in this space you could be forgiven for thinking you were always working with yesterday’s technologies. So much change, so quickly. What do you do if you have to build a solution from the ground up that is expected to live in the field for at least 5-10 years? This is the challenge we faced when we looked to refresh our existing 10-year-old custom hardware stack to measure the fullness of trash cans and compactors.
The emerging Internet of Everything creates tremendous new opportunities for customer engagement and business model innovation. However, enterprises must overcome a number of critical challenges to bring these new solutions to market. In his session at @ThingsExpo, Michael Martin, CTO/CIO at nfrastructure, outlined these key challenges and recommended approaches for overcoming them to achieve speed and agility in the design, development and implementation of Internet of Everything solutions wi...
Cloud computing is being adopted in one form or another by 94% of enterprises today. Tens of billions of new devices are being connected to The Internet of Things. And Big Data is driving this bus. An exponential increase is expected in the amount of information being processed, managed, analyzed, and acted upon by enterprise IT. This amazing is not part of some distant future - it is happening today. One report shows a 650% increase in enterprise data by 2020. Other estimates are even higher....
With over 720 million Internet users and 40–50% CAGR, the Chinese Cloud Computing market has been booming. When talking about cloud computing, what are the Chinese users of cloud thinking about? What is the most powerful force that can push them to make the buying decision? How to tap into them? In his session at 18th Cloud Expo, Yu Hao, CEO and co-founder of SpeedyCloud, answered these questions and discussed the results of SpeedyCloud’s survey.
Today we can collect lots and lots of performance data. We build beautiful dashboards and even have fancy query languages to access and transform the data. Still performance data is a secret language only a couple of people understand. The more business becomes digital the more stakeholders are interested in this data including how it relates to business. Some of these people have never used a monitoring tool before. They have a question on their mind like “How is my application doing” but no id...
Smart Cities are here to stay, but for their promise to be delivered, the data they produce must not be put in new siloes. In his session at @ThingsExpo, Mathias Herberts, Co-founder and CTO of Cityzen Data, will deep dive into best practices that will ensure a successful smart city journey.
DevOps at Cloud Expo, taking place Nov 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 19th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is no time to wait for long dev...