Welcome!

News Feed Item

New Study Confirms High Inter-Observer Agreement Using the WATS3D Biopsy for Evaluation of Esophageal Pre-Cancer

Provides Powerful Validation for the Clinical Value of Using the WATS3D Biopsy Procedure as a Complement to Four Quadrant Biopsy; Results Highlighted in an Oral Presentation at Digestive Disease Week

SUFFERN, NY -- (Marketwired) -- 05/04/14 -- CDx Diagnostics today announced results from a study showing high inter-observer agreement rates in the diagnosis of Barrett's esophagus and dysplasia among pathologists analyzing samples from the WATS3D biopsy. The study showed that WATS3D computer-assisted pathology analysis results in significantly better pathologist inter-observer agreement rates compared to standard manual microscopic histopathology assessment of Barrett's esophagus and dysplasia. The results were presented during an oral session at Digestive Disease Week® 2014 (DDW) on May 3, 2014 in Chicago.

"This study has potentially important implications for clinical care because we know that histopathologic diagnosis of Barrett's esophagus-associated dysplasia has traditionally suffered from poor inter-observer agreement, even among experienced GI pathologists," said lead author Prashanth Vennalaganti, MD of the Division of Gastroenterology and Hepatology, University of Kansas Medical Center, Kansas City, MO. "These high kappa values for the WATS3D biopsy provide powerful validation for the clinical value of this procedure. Providing a more accurate, consistent assessment of esophageal pre-cancer will allow gastroenterologists to make more confident decisions about care strategies for their patients."

The WATS3D biopsy collects a wide area, disaggregated tissue specimen of the entire thickness of the suspect epithelium. This unique tissue specimen is then subjected to specialized, computer-assisted 3-dimensional analysis which selects the 200 "highest ranking" cells from each patient for presentation to a pathologist. The high sensitivity of WATS3D is due to the large tissue area sampled, and the proprietary computer imaging system that is based on an algorithm developed as part of the U.S. Strategic Defense Initiative missile defense program.

In standard manual microscopic inspection of a biopsy specimen the first cells evaluated by the pathologist from each slide are selected randomly. An initial impression of the degree of pathology on the case can then be formed based on these randomly selected cells and this can lead to "confirmation bias" against modifying this initial impression during the remainder of the pathologist's analysis.

In contrast, during WATS3D analysis the pathologist's initial impression of the case is not based on evaluation of a few randomly selected cells but on a subset of 200 mathematically pre-selected cells which are rank ordered for potential abnormality, eliminating "confirmation bias" as a source of inter-observer variability.

In the study presented at DDW, 149 WATS3D slides with varying degrees of Barrett's esophagus and dysplasia were randomly selected and distributed to four pathologists trained in the analysis of WATS3D samples. Each slide was evaluated in a blinded fashion and graded as non-dysplastic, low-grade dysplasia (LGD) or high-grade dysplasia/esophageal adenocarcinoma (HGD/EAC). The agreement rates, or kappa values, were graded based on Landis and Koch scale (kappa values: 0.41 to 0.60 indicate moderate agreement, 0.61 to 0.80 indicate substantial agreement, and above 0.80 indicate nearly perfect agreement).

The overall mean kappa value for all three diagnoses for the 4 observers was calculated at 0.86 (95% CI 0.75-0.97). The kappa values (95% CI) for HGD/EAC, IND/LGD and no dysplasia were 0.95 (0.88-0.99), 0.74 (0.61-0.85) and 0.88 (0.81-0.94) respectively. The authors concluded that the diagnosis of Barrett's esophagus and associated dysplasia using WATS3D has very high inter-observer agreement and represents a significant improvement over current histopathological assessment.

"The excellent inter-observer agreement of pathologists utilizing the WATS3D system found in this study could potentially be due to the computer program that flags the most suspicious cells from each patient for consistent presentation to each pathologist," said Prateek Sharma, MD of the University of Kansas Medical Center and the senior author of the study. "This computer-assisted analysis system thus addresses the possibility that the pathologist may be susceptible to confirmation bias in that they may make their diagnosis based on review of randomly selected fields."

In addition to the inter-observer agreement study, an ASGE/AGA Joint Presidential Plenary presentation at DDW will highlight findings from the largest WATS3D clinical study conducted to date.

  • Sunday, May 4th, beginning at 1:30 PM CDT: "Esophageal Brush Biopsy with Computer-Assisted Tissue Analysis Increases Detection of Barrett's Esophagus and Dysplasia in a Multi-site Community-Based Setting."

DDW attendees can visit booth # 2711 to learn more about WATS3D.

About CDx Diagnostics and the WATS3D Biopsy
CDx Diagnostics' mission is to provide doctors with the most powerful diagnostic technology to help prevent cancer before it can start.

CDx Diagnostics' WATS3D biopsy addresses the sampling error inherent in random forceps biopsy testing of the esophagus. In just a few minutes, gastroenterologists can easily obtain a wide area, full-thickness transepithelial tissue sample for computer-assisted 3D laboratory analysis. In clinical trials, adjunctive use of CDx Diagnostics' WATS3D biopsy significantly increased the detection rate of both Barrett's esophagus and esophageal dysplasia. The high sensitivity of WATS3D is due to the large tissue area sampled, and the proprietary 3-Dimensionial computer imaging system that is based on an algorithm developed as part of the U.S. Strategic Defense Initiative missile defense program. To learn more about WATS3D, visit www.cdxdiagnostics.com.

About Digestive Disease Week®
Digestive Disease Week® (DDW®) is the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly sponsored by the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterological Association (AGA) Institute, the American Society for Gastrointestinal Endoscopy (ASGE) and the Society for Surgery of the Alimentary Tract (SSAT), DDW takes place May 3 - 6, 2014, at McCormick Place, Chicago, IL. The meeting showcases more than 5,000 abstracts and hundreds of lectures on the latest advances in GI research, medicine and technology. More information can be found at www.ddw.org.

Contact:
Chantal Beaudry or Christopher Frates for CDx Diagnostics
[email protected]
[email protected]
212-867-1762

More Stories By Marketwired .

Copyright © 2009 Marketwired. All rights reserved. All the news releases provided by Marketwired are copyrighted. Any forms of copying other than an individual user's personal reference without express written permission is prohibited. Further distribution of these materials is strictly forbidden, including but not limited to, posting, emailing, faxing, archiving in a public database, redistributing via a computer network or in a printed form.

Latest Stories
In his session at 21st Cloud Expo, Carl J. Levine, Senior Technical Evangelist for NS1, will objectively discuss how DNS is used to solve Digital Transformation challenges in large SaaS applications, CDNs, AdTech platforms, and other demanding use cases. Carl J. Levine is the Senior Technical Evangelist for NS1. A veteran of the Internet Infrastructure space, he has over a decade of experience with startups, networking protocols and Internet infrastructure, combined with the unique ability to it...
"Infoblox does DNS, DHCP and IP address management for not only enterprise networks but cloud networks as well. Customers are looking for a single platform that can extend not only in their private enterprise environment but private cloud, public cloud, tracking all the IP space and everything that is going on in that environment," explained Steve Salo, Principal Systems Engineer at Infoblox, in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Conventio...
Data scientists must access high-performance computing resources across a wide-area network. To achieve cloud-based HPC visualization, researchers must transfer datasets and visualization results efficiently. HPC clusters now compute GPU-accelerated visualization in the cloud cluster. To efficiently display results remotely, a high-performance, low-latency protocol transfers the display from the cluster to a remote desktop. Further, tools to easily mount remote datasets and efficiently transfer...
It is of utmost importance for the future success of WebRTC to ensure that interoperability is operational between web browsers and any WebRTC-compliant client. To be guaranteed as operational and effective, interoperability must be tested extensively by establishing WebRTC data and media connections between different web browsers running on different devices and operating systems. In his session at WebRTC Summit at @ThingsExpo, Dr. Alex Gouaillard, CEO and Founder of CoSMo Software, presented ...
In his session at 21st Cloud Expo, James Henry, Co-CEO/CTO of Calgary Scientific Inc., introduced you to the challenges, solutions and benefits of training AI systems to solve visual problems with an emphasis on improving AIs with continuous training in the field. He explored applications in several industries and discussed technologies that allow the deployment of advanced visualization solutions to the cloud.
Gemini is Yahoo’s native and search advertising platform. To ensure the quality of a complex distributed system that spans multiple products and components and across various desktop websites and mobile app and web experiences – both Yahoo owned and operated and third-party syndication (supply), with complex interaction with more than a billion users and numerous advertisers globally (demand) – it becomes imperative to automate a set of end-to-end tests 24x7 to detect bugs and regression. In th...
"NetApp is known as a data management leader but we do a lot more than just data management on-prem with the data centers of our customers. We're also big in the hybrid cloud," explained Wes Talbert, Principal Architect at NetApp, in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
"Space Monkey by Vivent Smart Home is a product that is a distributed cloud-based edge storage network. Vivent Smart Home, our parent company, is a smart home provider that places a lot of hard drives across homes in North America," explained JT Olds, Director of Engineering, and Brandon Crowfeather, Product Manager, at Vivint Smart Home, in this SYS-CON.tv interview at @ThingsExpo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
"We work around really protecting the confidentiality of information, and by doing so we've developed implementations of encryption through a patented process that is known as superencipherment," explained Richard Blech, CEO of Secure Channels Inc., in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
High-velocity engineering teams are applying not only continuous delivery processes, but also lessons in experimentation from established leaders like Amazon, Netflix, and Facebook. These companies have made experimentation a foundation for their release processes, allowing them to try out major feature releases and redesigns within smaller groups before making them broadly available. In his session at 21st Cloud Expo, Brian Lucas, Senior Staff Engineer at Optimizely, discussed how by using ne...
Agile has finally jumped the technology shark, expanding outside the software world. Enterprises are now increasingly adopting Agile practices across their organizations in order to successfully navigate the disruptive waters that threaten to drown them. In our quest for establishing change as a core competency in our organizations, this business-centric notion of Agile is an essential component of Agile Digital Transformation. In the years since the publication of the Agile Manifesto, the conn...
While some developers care passionately about how data centers and clouds are architected, for most, it is only the end result that matters. To the majority of companies, technology exists to solve a business problem, and only delivers value when it is solving that problem. 2017 brings the mainstream adoption of containers for production workloads. In his session at 21st Cloud Expo, Ben McCormack, VP of Operations at Evernote, discussed how data centers of the future will be managed, how the p...
"Cloud Academy is an enterprise training platform for the cloud, specifically public clouds. We offer guided learning experiences on AWS, Azure, Google Cloud and all the surrounding methodologies and technologies that you need to know and your teams need to know in order to leverage the full benefits of the cloud," explained Alex Brower, VP of Marketing at Cloud Academy, in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clar...
"MobiDev is a software development company and we do complex, custom software development for everybody from entrepreneurs to large enterprises," explained Alan Winters, U.S. Head of Business Development at MobiDev, in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
SYS-CON Events announced today that CrowdReviews.com has been named “Media Sponsor” of SYS-CON's 22nd International Cloud Expo, which will take place on June 5–7, 2018, at the Javits Center in New York City, NY. CrowdReviews.com is a transparent online platform for determining which products and services are the best based on the opinion of the crowd. The crowd consists of Internet users that have experienced products and services first-hand and have an interest in letting other potential buye...