Welcome!

News Feed Item

Scientists Confirm Breakthrough Nano-Technology in Dental Industry

As reported in the internationally renowned scientific journal, Bone [in press for Aug. 2014], a research team from New York University has confirmed what scientific developers at Intra-Lock® International, Inc. have known for several years: the fractal, nano-rough OSSEAN® surface developed for their dental implants actually changes the cellular genetic expression – or the fate of stem cells – at the nano-level, which in turn induces faster healing of implants.

In other words, the OSSEAN surface plays a critical role in healing at the DNA level. It was shown to favorably enhance osteoblast formation (new bone) and accelerate the mineralization on this newly formed bone.i This is the very first time such mechanism is described in-vivo (in a living host).

According to Thierry M. Giorno, DDS, director of research and development, and CEO of Intra-Lock®, International, Inc., “We’ve suspected for many years that OSSEAN alters the genetic expression of stems cells, forcing them to differentiate into bone; we designed it with that intention. However, this report is very important because it gives us a third-party ‘why’ behind our unparalleled, accelerated healing outcomes.”

The Scientific “Why” for Accelerated Healing

Typically, when an implant is surgically placed, there is a period of cellular “confusion” and chaos around the implant, and usually a little bone resorbs before being formed again. The implant is then at risk from the moment it is inserted through the time when the bone is healed around it – a time period Giorno refers to as “the window of negative opportunity.”

However, the NYU researchers found that bone cells immediately start clustering around the OSSEAN implants and begin accelerated healing, with little confusion whatsoever.

This occurs primarily due to the biomimetic structure of the OSSEAN surface, designed and classified as nano-rough and fractalii. Mimicking nature at the nano-level, the OSSEAN surface repeats a similar structural pattern to that of natural bone over and over, essentially “tricking” the body into accepting the implant as a natural substance and igniting the healing process far sooner than would occur with an artificial substance, which is smooth at the nano-level and without natural-seeming pattern repetition.

Benefits to the Patient

Typically, with an implant of any sort, whether it’s a dental implant in your jaw or a titanium rod in your leg, several weeks will pass before the bone begins to grow around it. During this time lapse, known as the “catabolic phase,” there can be great risk and instability with the implant.

Naturally, compressing the healing time and accelerating the degree of osseointegration – the merging of implant and bone – are highly desirable outcomes, and implants with an OSSEAN can provide a faster healing process, which thereby provides for a higher potential for successful long-term results with the implant.

“If you’ve ever had dental implants, you can appreciate the outcomes the OSSEAN surface provides,” said Giorno. “The healing process has changed forever, and future patients with an OSSEAN surface implant can look forward to reduced complications, overall.”

Looking further into the future, Giorno said, “I believe the effects of OSSEAN can potentially revolutionize the implant industry beyond dentistry and into all types of orthopedics where patients must wait for their bodies to accept a foreign substance. With OSSEAN, the wait is over.”

For more information about OSSEAN® or to request a copy of the Bone journal article, please email [email protected] or call (561) 557-8282.

i. Paulo G. Coelho, Tadahiro Takayama, Daniel Yoo, Ryo Jimbo, Sanjay Karunagaran, Nick Tovar, Malvin N. Janal, Seiichi Yamano, Nanometer-scale features on micrometer-scale surface texturing: A bone histological, gene expression, and nanomechanical study. Bone, Issue 65, Aug. 2014.

ii. Dohan Ehrenfest DM, Del Corso M, Kang BS, Leclercq P, Mazor Z, Horowitz RA, Russe P, Oh HK, Zou DR, Shibli JA, Wang HL, Bernard JP, Sammartino G. Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 4: Resorbable Blasting Media (RBM), Dual Acid-Etched (DAE), Subtractive Impregnated Micro/Nanotextured (SIMN) and related surfaces (Group 2B, other subtractive process). POSEIDO. 2014; 2(1):57-79.

About Intra-Lock® International, Inc.

Intra-Lock® International Inc., headquartered in Boca Raton, Florida, USA, is a leading provider of innovative dental restoration solutions including a wide range of dental implants, bio-materials and prosthetic abutments. Intra-Lock dental implants are biologically driven in design. Their architectures are “site-specific,” which encourages physiologic harmony and ensures an ideal tissue response when compromised bone volume, density and/or extraction site defects are encountered. Intra-Lock’s advanced bioactive surface, OSSEAN®, its ergonomic delivery technology, Drive-Lock™ and its exceptional abutment stability offer a complete solution for dental implant specialists. In addition, Intra-lock’s FDA cleared Intra-Spin™ System is designed to enable an efficient, cost effective and simple chairside protocol for the fabrication of one of the most exciting tools in regenerative medicine, L-PRF (Leukocyte- and Platelet- Rich Fibrin). For more information, please visit our informative website www.intra-lock.com or call (561)557-8282.

Note to Editors:

Additional information is available upon request:

  • OSSEAN Fact Sheet
  • OSSEAN Research Backgrounder
  • Dr. Theirry Giorno bio & headshot

More Stories By Business Wire

Copyright © 2009 Business Wire. All rights reserved. Republication or redistribution of Business Wire content is expressly prohibited without the prior written consent of Business Wire. Business Wire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
While some developers care passionately about how data centers and clouds are architected, for most, it is only the end result that matters. To the majority of companies, technology exists to solve a business problem, and only delivers value when it is solving that problem. 2017 brings the mainstream adoption of containers for production workloads. In his session at 21st Cloud Expo, Ben McCormack, VP of Operations at Evernote, will discuss how data centers of the future will be managed, how th...
There is huge complexity in implementing a successful digital business that requires efficient on-premise and cloud back-end infrastructure, IT and Internet of Things (IoT) data, analytics, Machine Learning, Artificial Intelligence (AI) and Digital Applications. In the data center alone, there are physical and virtual infrastructures, multiple operating systems, multiple applications and new and emerging business and technological paradigms such as cloud computing and XaaS. And then there are pe...
Why Federal cloud? What is in Federal Clouds and integrations? This session will identify the process and the FedRAMP initiative. But is it sufficient? What is the remedy for keeping abreast of cutting-edge technology? In his session at 21st Cloud Expo, Rasananda Behera will examine the proposed solutions: Private or public or hybrid cloud Responsible governing bodies How can we accomplish?
SYS-CON Events announced today that MIRAI Inc. will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. MIRAI Inc. are IT consultants from the public sector whose mission is to solve social issues by technology and innovation and to create a meaningful future for people.
SYS-CON Events announced today that Keisoku Research Consultant Co. will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Keisoku Research Consultant, Co. offers research and consulting in a wide range of civil engineering-related fields from information construction to preservation of cultural properties. For more information, vi...
Today most companies are adopting or evaluating container technology - Docker in particular - to speed up application deployment, drive down cost, ease management and make application delivery more flexible overall. As with most new architectures, this dream takes significant work to become a reality. Even when you do get your application componentized enough and packaged properly, there are still challenges for DevOps teams to making the shift to continuous delivery and achieving that reducti...
SYS-CON Events announced today that Massive Networks, that helps your business operate seamlessly with fast, reliable, and secure internet and network solutions, has been named "Exhibitor" of SYS-CON's 21st International Cloud Expo ®, which will take place on Oct 31 - Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. As a premier telecommunications provider, Massive Networks is headquartered out of Louisville, Colorado. With years of experience under their belt, their team of...
Most of the time there is a lot of work involved to move to the cloud, and most of that isn't really related to AWS or Azure or Google Cloud. Before we talk about public cloud vendors and DevOps tools, there are usually several technical and non-technical challenges that are connected to it and that every company needs to solve to move to the cloud. In his session at 21st Cloud Expo, Stefano Bellasio, CEO and founder of Cloud Academy Inc., will discuss what the tools, disciplines, and cultural...
SYS-CON Events announced today that Enroute Lab will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Enroute Lab is an industrial design, research and development company of unmanned robotic vehicle system. For more information, please visit http://elab.co.jp/.
SYS-CON Events announced today that Cedexis will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Cedexis is the leader in data-driven enterprise global traffic management. Whether optimizing traffic through datacenters, clouds, CDNs, or any combination, Cedexis solutions drive quality and cost-effectiveness.
SYS-CON Events announced today that Ryobi Systems will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Ryobi Systems Co., Ltd., as an information service company, specialized in business support for local governments and medical industry. We are challenging to achive the precision farming with AI. For more information, visit http:...
Today traditional IT approaches leverage well-architected compute/networking domains to control what applications can access what data, and how. DevOps includes rapid application development/deployment leveraging concepts like containerization, third-party sourced applications and databases. Such applications need access to production data for its test and iteration cycles. Data Security? That sounds like a roadblock to DevOps vs. protecting the crown jewels to those in IT.
What is the best strategy for selecting the right offshore company for your business? In his session at 21st Cloud Expo, Alan Winters, U.S. Head of Business Development at MobiDev, will discuss the things to look for - positive and negative - in evaluating your options. He will also discuss how to maximize productivity with your offshore developers. Before you start your search, clearly understand your business needs and how that impacts software choices.
21st International Cloud Expo, taking place October 31 - November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA, will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy. Me...
Real IoT production deployments running at scale are collecting sensor data from hundreds / thousands / millions of devices. The goal is to take business-critical actions on the real-time data and find insights from stored datasets. In his session at @ThingsExpo, John Walicki, Watson IoT Developer Advocate at IBM Cloud, will provide a fast-paced developer journey that follows the IoT sensor data from generation, to edge gateway, to edge analytics, to encryption, to the IBM Bluemix cloud, to Wa...