Welcome!

News Feed Item

Bruker Announces Powerful New Mass Spectrometry Systems and Solutions for Life-Science Research, Clinical Research, Biopharma and Applied Markets

At the 62nd ASMS Conference on Mass Spectrometry and Allied Topics today, Bruker Corporation (NASDAQ:BRKR) today announced mass spectrometry-based product introductions for life-science research and proteomics, for clinical research, for pharma/biopharma/CRO customers, as well as for applied and industrial markets. The new systems and solutions are designed to deliver confident analyses with significantly enhanced performance, productivity and versatility.

impact(TM) II Mass Spectrometer (Photo: Business Wire)

impact(TM) II Mass Spectrometer (Photo: Business Wire)

Major Bruker Innovations at ASMS 2014:

  • New impact II ™ ultra-high resolution QTOF mass spectrometer with industry-leading further performance improvements
  • A breakthrough, new 21 Tesla magnet for ultra-high field Fourier Transform Mass Spectrometry (FTMS), described in a separate joint press release together with NHMFL
  • Opening the next chapter in proteomics, the unique impact II now enables for the first time ever fast, intact protein profiling of over 1,000 proteoforms in a single, less than 30 minute UHPLC-UHR-QTOF run
  • New multi-OMICS platform increasing productivity, versatility, and deeper biological insights, including full MaxQuant software support and new Compass™ PathwayScreener™ software
  • New ToxScreener™ solution for comprehensive forensic toxicology on unknowns
  • European launch of Toxtyper™ 1.1, a robust and easy to use forensic and clinical research solution for routine, fast, push-button toxicology on approximately 900 compounds
  • ASMS debut of new autoflex™ speed MALDI TOF(/TOF) system with Bruker 2 kHz smartbeam™-II laser to enhance productivity in protein analysis, MALDI imaging and MALDI Biotyper applications

The new research capabilities, analytical utility and productivity will be presented in Bruker’s ASMS users’ symposium, breakfast workshops, and hospitality suite with emphasis on the following market/applications areas: systems biology, proteomics and metabolomics; biologics & pharmaceuticals; MALDI molecular imaging for pathology research and drug development; petroleomics, energy and industrial applications; applied markets including food safety, forensics and toxicology; as well as MALDI Biotyper-based clinical microbiology. The following sections describe the new Bruker products in more detail:

impact™ II Mass Spectrometer

The new impact II system is the latest innovation in Bruker’s unique UHR-QTOF (ultra-high resolution Qq-time-of-flight) mass spectrometry product line, now with industry-leading >50,000 Full-Sensitivity Resolution (FSR). It offers further enhanced analytical performance levels for all applications where trace analysis from complex, high-background matrices is a challenge – such as proteomics, biomarker research, identification of impurities, or residue screening.

Due to its industry-leading sensitivity, broad mass-transfer ion optics and fast 50 Gbit/sec sampling technology, a dynamic range of 5 orders of magnitude is achieved at UHPLC speeds, with up to 50 Hz spectrum acquisition. The impact II features industry-leading isotopic pattern accuracy, a prerequisite for automated, reliable molecular formula determination of low abundance compounds in nano- and UHPLC peaks.

The enhanced capabilities and versatility of this novel UHR-QTOF drive more productivity for all accurate mass , high dynamic range applications in academia and industry, including:

  • Faster and cost-effective analysis of sub-units of monoclonal antibodies, which can now be fully isotope resolved.
  • Sustainable identification and quantification performance for in-depth quantitative analysis of proteomics samples, including bottom-up proteomics, glycomics and the identification of PTMs
  • High-throughput proteoform screening of intact proteins with isotopic resolution up to 30 kDa. This unique assay allows the screening of well over 1,000 proteoforms in a single 20-30 min UHPLC-UHR-QTOF run. This breakthrough in proteomics is expected to provide an enabling technology for accelerated biomarker identification and validation, and for faster progress towards clinical proteomics.
  • Deep insight into complex metabolomics samples in targeted and non-target analysis by integrated workflows using ProfileAnalysis™ software plus the new Compass PathwayScreener software to pinpoint biomarkers.
  • Better selectivity and specificity for the new Bruker solution in forensic toxicology, ToxScreener, which comes with accurate mass libraries developed together with leading forensic toxicology laboratories.
  • Unique Instant Expertise™ software for intelligent self-optimizing MS/MS acquisition to establish optimal experimental conditions independent of sample amount or complexity. This translates into higher productivity and expert-caliber results - the first time.

These features ensure that the impact II delivers the fastest time-to-success for customers across a broad applications ranging from small molecule identification and characterization; to food safety, forensic and toxicology screening, metabolomics, pharmaceuticals, and bottom-up proteomics, proteoform screening to antibody analysis.

Multi-OMICS Knowledge Generation Platform

Bruker is driving the quest for deeper insights and taking ‘omics’ knowledge generation to new heights with the new additions improving productivity and versatility in areas such as bottom-up proteomics, glycomics, quantitative proteomics, intact protein analysis, post-translational modifications and metabolomics.

“We have been using the Impact since almost a year for routine shot-gun bottom-up proteomics. In combination with the CaptiveSpray nanoBooster, the instrument has provided an excellent level of sustainable performance, being capable of delivering untouched performance for over 6-8 weeks of 24/7 use. This is of tremendous importance for the success of our label-free measurement campaigns,” said Professor Alain Van Dorsselaer, LSMBO in Strassbourg, France.

To strengthen its bioinformatics platform, Bruker has collaborated with developers in the group of Professor Matthias Mann to add support for Bruker UHR-QTOF data to the state-of-the-art quantitative proteomics MaxQuant software designed for analyzing large mass-spectrometric data sets. It is specifically aimed at high-resolution MS data. Several labeling techniques as well as label-free data processing workflows are supported and in addition MaxQuant enables researchers to utilize the full potential of mass spectrometry driven proteomics in multi-OMICS approaches.

In metabolomics there is an increasing need for efficient data processing tools, and Bruker has strengthened its bioinformatics offering with Compass™ PathwayScreener software to provide a new layer of insight into metabolomics samples. With the new Compass PathwayScreener, users can get twice the results, performing pathway-driven, targeted metabolomics analysis on the same dataset used for non-targeted data mining. The PathwayScreener workflow can be integrated with Bruker’s market-leading multi-OMICS bioinformatics platform ProfileAnalysis™ for non-targeted metabolomics and label free proteomics studies.

Professor Jörn Kalinowski, at the Center for Biotechnology in Bielefeld, Germany, stated: “Using Compass PathwayScreener we were able to elucidate novel influences of mutants on metabolic networks in Corynebacterium glutamicum.”

In addition, Bruker is collaborating with the University of Alberta to facilitate the development of high-resolution tandem MS libraries for improved workflows in metabolomics. Professor Liang Li explained: “As a co-PI of the Human Metabolome Database (HMDB) project, my laboratory generated the original MS/MS spectral library of about 800 human metabolites using low-resolution triple quadrupole mass spectrometry. We are delighted to collaborate with Bruker to produce a new Human Metabolite MS/MS spectral library with much improved spectral quality. This library, along with an automated acquisition and processing strategy, allows users to identify metabolites very quickly with high confidence.”

Dr. Ole Vorm, the Bruker Daltonics Vice President for the Life-Science Research & Proteomics business unit, commented: “The new products deliver outstanding and robust performance in a very accessible and cost-effective platform. We are conscious of enhancing the reach and capabilities of UHF-QTOF and nano-ESI such that we make this innovative technology readily available and accessible - also for biologists who may not be mass-spec experts. Finally, our proteomics customers are excited about our breakthrough, rapid proteoform screening technology on the impact II, as well as its about 50% higher resolution for bottom-up proteomics, at full sensitivity and under UHPLC fast analysis conditions.”

ToxScreener, a Forensic Toxicology Solution based on Accurate Mass, High Dynamic Range LC-MS/MS

The ToxScreener, a new accurate mass, high dynamic range forensic toxicology solution for Bruker QTOF systems, incorporates broadband CID (bbCID) acquisition to provide a rapid and reliable way for scientists to confidently screen for hundreds or even thousands of known or previously unknown compounds of forensic relevance, delivering the highest degree of confidence, and data that is defensible in court.

The ToxScreener enables forensic toxicologists to keep up with the detection and identification of both the ‘traditional, established’ drugs of abuse, as well to detect new designer drugs that are rapidly emerging across the globe. At the heart of the ToxScreener, is a high quality, accurate mass database covering drugs of forensic relevance allowing users to attain enhanced levels of confirmation for conclusive identification compared to alternative screening techniques. The Bruker ToxScreener bbCID accurate mass forensic database was developed in close collaboration with toxicologists at the forensic institutes at the universities of Freiburg, Germany and Helsinki, Finland.

Professor Ilkka Ojanperä of the Laboratory of Forensic Toxicology at the University of Helsinki, said: “We have applied the bbCID concept using Bruker LC-TOF-MS for general forensic drug screening in urine since 2010. In 2013, we switched to the newest UHPLC-UHR-QTOF mass spectrometry technology to attain enhanced sensitivity for drugs-of-abuse and designer drug forensic screening, covering critical low concentration compounds like THC acid, buprenorphine, LSD, and synthetic cannabinoids. This approach has been well received amongst our customers, being an even bigger success than we expected, such that immunological methods in our laboratory have now been replaced by the Bruker QTOF bbCID workflow. The bbCID concept has been carefully validated against spectral library comparison, and it has proven to deliver equal confidence, but with a much higher efficiency, significantly increasing our productivity. Our forensic screening method has now been accredited by the Finnish Accreditation Service.”

High-throughput, Robust Toxtyper 1.1 Solution Automatically Analyzes for 900 Known Toxicology Target Compounds in 12 Minutes

The new Toxtyper 1.1 routine analytical solution includes novel library identification algorithms and reporting with a high-quality library update to over 900 target compounds. In addition, the Toxtyper 1.1 workflow now also comes with a targeted drugs-of-abuse sub-library. Key technologies to achieve robust and reliable toxicology identification performance include continuous, zero-delay positive/negative ion switching, high MS/MS specificity and novel, on-the-fly MS3 confirmation. The new Toxtyper 1.1 search algorithms now also are fully compatible with the recently published “Maurer/Wissenbach/Weber LC-MSn library of Drugs, Poisons and their Metabolites”, an ion trap library which holds over 1,000 parent compounds and 2,700 metabolites.

Novel software tools for automated assignment of structures to fragment ions offer additional metabolites identification and structure verification by MSn. Toxtyper 1.1 now supports sample preparation SOPs for high sensitivity detection of drugs in urine and serum. Toxtyper is a Research Use Only solution presently available only in Europe in selected countries. For more information on the amaZon speed mass spectrometer, please visit www.bruker.com

ASMS Debut of autoflex™ speed MALDI-TOF(/TOF) with 2 kHz Smartbeam™ Laser

The updated autoflex speed mass spectrometer incorporates of numerous advancements to further enhance data quality, acquisition speed, class-leading mass and dynamic range, all with robust and efficient performance. It further extends the applications of MALDI TOF/TOF in protein sequencing, biomarker discovery, polymer analysis, lipid and glycan analysis, molecular imaging, as well as in high-throughput MALDI Biotyper microbiological identification. The autoflex speed incorporates the patented smartbeam™-II laser, now with up to 2 kHz repetition rate and true-pixel image resolution at 20 µm, along with other features that enhance its capabilities including:

  • Unique FAST-SRM mode for single reaction monitoring in imaging drugs and metabolites in tissue.
  • Expanded high-resolution mass range for polymers and top-down, intact protein sequencing for long sequence readouts.
  • FlashDetector™ technology to increase resolution and prevent signal saturation for complex samples
  • Self-cleaning Ion Source cleans the source in minutes to improve up-time with minimal operator maintenance.
  • Optimized software packages for numerous applications e.g. protein, peptide or polymer analysis, as well as MALDI imaging, clinical research and the MALDI Biotyper IVD-CE workflow.

About Bruker Corporation

Bruker Corporation is a leading provider of high-performance scientific instruments and solutions for molecular and materials research, as well as for industrial and applied analysis. For more information about Bruker Corporation (NASDAQ:BRKR), please visit www.bruker.com.

More Stories By Business Wire

Copyright © 2009 Business Wire. All rights reserved. Republication or redistribution of Business Wire content is expressly prohibited without the prior written consent of Business Wire. Business Wire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Peak 10, Inc., has announced the implementation of IT service management, a business process alignment initiative based on the widely adopted Information Technology Infrastructure Library (ITIL) framework. The implementation of IT service management enhances Peak 10’s current service-minded approach to IT delivery by propelling the company to deliver higher levels of personalized and prompt service. The majority of Peak 10’s operations employees have been trained and certified in the ITIL frame...
As the rapid adoption of containers continues, companies are finding that they lack the operational tools to understand the behavior of applications deployed in these containers, and how to identify issues in their application infrastructure. For example, how are multiple containers within an application impacting each other’s performance? If an application’s service is degraded, which container is to blame? In the case of an application outage, what was the root cause of the outage?
SYS-CON Events announced today that DatacenterDynamics has been named “Media Sponsor” of SYS-CON's 18th International Cloud Expo, which will take place on June 7–9, 2016, at the Javits Center in New York City, NY. DatacenterDynamics is a brand of DCD Group, a global B2B media and publishing company that develops products to help senior professionals in the world's most ICT dependent organizations make risk-based infrastructure and capacity decisions.
SYS-CON Events announced today TMCnet has been named “Media Sponsor” of SYS-CON's 18th International Cloud Expo, which will take place on June 7–9, 2016, at the Javits Center in New York City, NY, and the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Technology Marketing Corporation (TMC) is the world's leading business-to-business and integrated marketing media company, servicing niche markets within the com...
Between the mockups and specs produced by analysts, and resulting applications built by developers, there exists a gulf where projects fail, costs spiral, and applications disappoint. Methodologies like Agile attempt to address this with intensified communication, with partial success but many limitations. In his session at 18th Cloud Expo, Charles Kendrick, CTO & Chief Architect at Isomorphic Software, will present a revolutionary model enabled by new technologies. Learn how business and devel...
Unless you don’t use the internet, don’t live in California, or haven’t been paying attention to the recent news… you should be aware that self-driving cars are on their way to becoming a reality. I have seen them – they are real. If you believe in the future reality of self-driving cars, then continue reading on. If you don’t believe in the future possibilities, then I am not sure what to do to convince you other than discuss the very real changes that will roll out with the consumer producti...
If there is anything we have learned by now, is that every business paves their own unique path for releasing software- every pipeline, implementation and practices are a bit different, and DevOps comes in all shapes and sizes. Software delivery practices are often comprised of set of several complementing (or even competing) methodologies – such as leveraging Agile, DevOps and even a mix of ITIL, to create the combination that’s most suitable for your organization and that maximize your busines...
In the rush to compete in the digital age, a successful digital transformation is essential, but many organizations are setting themselves up for failure. There’s a common misconception that the process is just about technology, but it’s not. It’s about your business. It shouldn’t be treated as an isolated IT project; it should be driven by business needs with the committed involvement of a range of stakeholders.
Struggling to keep up with increasing application demand? Learn how Platform as a Service (PaaS) can streamline application development processes and make resource management easy.
New Relic, Inc. has announced a set of new features across the New Relic Software Analytics Cloud that offer IT operations teams increased visibility, and the ability to diagnose and resolve performance problems quickly. The new features further IT operations teams’ ability to leverage data and analytics, as well as drive collaboration and a common, shared understanding between teams. Software teams are under pressure to resolve performance issues quickly and improve availability, as the comple...
The IoT has the potential to create a renaissance of manufacturing in the US and elsewhere. In his session at 18th Cloud Expo, Florent Solt, CTO and chief architect of Netvibes, will discuss how the expected exponential increase in the amount of data that will be processed, transported, stored, and accessed means there will be a huge demand for smart technologies to deliver it. Florent Solt is the CTO and chief architect of Netvibes. Prior to joining Netvibes in 2007, he co-founded Rift Technol...
SYS-CON Events announced today that Enzu, a leading provider of cloud hosting solutions, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Enzu’s mission is to be the leading provider of enterprise cloud solutions worldwide. Enzu enables online businesses to use its IT infrastructure to their competitive advantage. By offering a suite of proven hosting and management services, Enzu wants companies to foc...
Many private cloud projects were built to deliver self-service access to development and test resources. While those clouds delivered faster access to resources, they lacked visibility, control and security needed for production deployments. In their session at 18th Cloud Expo, Steve Anderson, Product Manager at BMC Software, and Rick Lefort, Principal Technical Marketing Consultant at BMC Software, will discuss how a cloud designed for production operations not only helps accelerate developer...
Join IBM June 8 at 18th Cloud Expo at the Javits Center in New York City, NY, and learn how to innovate like a startup and scale for the enterprise. You need to deliver quality applications faster and cheaper, attract and retain customers with an engaging experience across devices, and seamlessly integrate your enterprise systems. And you can't take 12 months to do it.
This is not a small hotel event. It is also not a big vendor party where politicians and entertainers are more important than real content. This is Cloud Expo, the world's longest-running conference and exhibition focused on Cloud Computing and all that it entails. If you want serious presentations and valuable insight about Cloud Computing for three straight days, then register now for Cloud Expo.