Welcome!

News Feed Item

AB SCIEX Next-Generation Proteomics Platform Transforms Proteomics Research

AB SCIEX, a global leader in life science analytical technologies, today introduced the TripleTOF® 6600 system with SWATH™ Acquisition 2.0 – the company’s revolutionary solution for quantitative proteomics. This high-resolution, accurate-mass system, combined with the new SWATH™ Acquisition 2.0, brings new power to proteomic data challenges for advanced biomarker discovery and systems biology. As the emphasis in proteomics research shifts from cataloguing to comprehensive quantitation, the AB SCIEX solution is uniquely positioned, enabling the quantification of thousands of proteins across large sample sets with a level of data completeness and quantitative accuracy and precision that have only been achievable by “gold-standard,” targeted MRM in the past.

“The TripleTOF 6600 system with SWATH 2.0 truly transforms proteomics research by providing an advanced level of data completeness and quantitative accuracy,” said Rainer Blair, President of AB SCIEX, “The new platform empowers researchers to gain greater insights into biomarkers and disease pathways, which will lead to earlier disease detection and, some day, personalized therapies.”

AB SCIEX SWATH Acquisition incorporates a data-independent acquisition strategy and has re-invigorated the proteomics community’s interest in comprehensive data by fragmenting every detectable peptide in the sample in order to acquire quantitative MS/MS data. This approach has been shown to increase the capacity of targeted proteomics experiments by over 30-fold and reduce study time by as much as 90 percent. Now, with the increased dynamic range of the TripleTOF 6600 System, researchers can more deeply interrogate complex samples. Combined with innovative variable window acquisition and the SWATH 2.0 processing software, a significant improvement in quantitative results has been realized.

Ruedi Aebersold, Ph.D., professor at the Institute of Molecular Biology at the ETH in Zurich, Switzerland, comments, "SWATH has already proven its enormous value as a critical discovery and large-scale quantification workflow. The combination of variable window SWATH acquisition with the increased dynamic range of the TripleTOF 6600 will give biological scientists a more precise and complete view of each sample, potentially leading to biological insights that have never been achieved before.”

Early experiments comparing TripleTOF 6600 System with SWATH 2.0 to other systems have demonstrated the quantification of up to 90 percent more peptides with CVs of less than 20 percent (a threshold often used to determine good limits of quantitation in LC/MS data). These advances in capacity and data completeness are expected to make integration with large-scale biology experiments, such as genomics and transcriptomics, much more accessible.

“To take advantage of the full potential of proteomics in translational research, we need to quantitate thousands of proteins in a single experiment with accuracy,” said Jennifer Van Eyk, Ph.D., Director of the Advanced Clinical Biosystems Institute at Cedars-Sinai Medical center and Director of basic science research in the Barbara Streisand Women’s Heart Center in the Cedars-Sinai Heart Institute and the Erika J. Glazer Chair in Women’s Heart Health. “The TripleTOF and SWATH system has enabled us to do this for the first time and contributed to accelerating my research objectives.”

About AB SCIEX

AB SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to push the limits in their field and address the complex analytical challenges they face. The company's global leadership and world-class service and support in the liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research. With over 25 years of proven innovation, AB SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis. For more information, please go to www.absciex.com.

Follow AB SCIEX on Twitter @ABSCIEX and on Facebook.

© 2014. AB SCIEX. AB Sciex Instruments Are For Research Use Only. Not for use in diagnostic procedures. The trademarks mentioned herein are the property of AB Sciex Pte. Ltd. or their respective owners. AB SCIEXTM is being used under license.

More Stories By Business Wire

Copyright © 2009 Business Wire. All rights reserved. Republication or redistribution of Business Wire content is expressly prohibited without the prior written consent of Business Wire. Business Wire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Fifty billion connected devices and still no winning protocols standards. HTTP, WebSockets, MQTT, and CoAP seem to be leading in the IoT protocol race at the moment but many more protocols are getting introduced on a regular basis. Each protocol has its pros and cons depending on the nature of the communications. Does there really need to be only one protocol to rule them all? Of course not. In his session at @ThingsExpo, Chris Matthieu, co-founder and CTO of Octoblu, walk you through how Oct...
As ridesharing competitors and enhanced services increase, notable changes are occurring in the transportation model. Despite the cost-effective means and flexibility of ridesharing, both drivers and users will need to be aware of the connected environment and how it will impact the ridesharing experience. In his session at @ThingsExpo, Timothy Evavold, Executive Director Automotive at Covisint, will discuss key challenges and solutions to powering a ride sharing and/or multimodal model in the a...
SYS-CON Events announced today that Tintri Inc., a leading producer of VM-aware storage (VAS) for virtualization and cloud environments, will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Tintri VM-aware storage is the simplest for virtualized applications and cloud. Organizations including GE, Toyota, United Healthcare, NASA and 6 of the Fortune 15 have said “No to LUNs.” With Tintri they mana...
"My role is working with customers, helping them go through this digital transformation. I spend a lot of time talking to banks, big industries, manufacturers working through how they are integrating and transforming their IT platforms and moving them forward," explained William Morrish, General Manager Product Sales at Interoute, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
More and more companies are looking to microservices as an architectural pattern for breaking apart applications into more manageable pieces so that agile teams can deliver new features quicker and more effectively. What this pattern has done more than anything to date is spark organizational transformations, setting the foundation for future application development. In practice, however, there are a number of considerations to make that go beyond simply “build, ship, and run,” which changes ho...
Kubernetes is a new and revolutionary open-sourced system for managing containers across multiple hosts in a cluster. Ansible is a simple IT automation tool for just about any requirement for reproducible environments. In his session at @DevOpsSummit at 18th Cloud Expo, Patrick Galbraith, a principal engineer at HPE, discussed how to build a fully functional Kubernetes cluster on a number of virtual machines or bare-metal hosts. Also included will be a brief demonstration of running a Galera M...
According to Forrester Research, every business will become either a digital predator or digital prey by 2020. To avoid demise, organizations must rapidly create new sources of value in their end-to-end customer experiences. True digital predators also must break down information and process silos and extend digital transformation initiatives to empower employees with the digital resources needed to win, serve, and retain customers.
If you’re responsible for an application that depends on the data or functionality of various IoT endpoints – either sensors or devices – your brand reputation depends on the security, reliability, and compliance of its many integrated parts. If your application fails to deliver the expected business results, your customers and partners won't care if that failure stems from the code you developed or from a component that you integrated. What can you do to ensure that the endpoints work as expect...
In this strange new world where more and more power is drawn from business technology, companies are effectively straddling two paths on the road to innovation and transformation into digital enterprises. The first path is the heritage trail – with “legacy” technology forming the background. Here, extant technologies are transformed by core IT teams to provide more API-driven approaches. Legacy systems can restrict companies that are transitioning into digital enterprises. To truly become a lea...
IoT is fundamentally transforming the auto industry, turning the vehicle into a hub for connected services, including safety, infotainment and usage-based insurance. Auto manufacturers – and businesses across all verticals – have built an entire ecosystem around the Connected Car, creating new customer touch points and revenue streams. In his session at @ThingsExpo, Macario Namie, Head of IoT Strategy at Cisco Jasper, will share real-world examples of how IoT transforms the car from a static p...
Cloud computing is being adopted in one form or another by 94% of enterprises today. Tens of billions of new devices are being connected to The Internet of Things. And Big Data is driving this bus. An exponential increase is expected in the amount of information being processed, managed, analyzed, and acted upon by enterprise IT. This amazing is not part of some distant future - it is happening today. One report shows a 650% increase in enterprise data by 2020. Other estimates are even higher....
From wearable activity trackers to fantasy e-sports, data and technology are transforming the way athletes train for the game and fans engage with their teams. In his session at @ThingsExpo, will present key data findings from leading sports organizations San Francisco 49ers, Orlando Magic NBA team. By utilizing data analytics these sports orgs have recognized new revenue streams, doubled its fan base and streamlined costs at its stadiums. John Paul is the CEO and Founder of VenueNext. Prior ...
One of biggest questions about Big Data is “How do we harness all that information for business use quickly and effectively?” Geographic Information Systems (GIS) or spatial technology is about more than making maps, but adding critical context and meaning to data of all types, coming from all different channels – even sensors. In his session at @ThingsExpo, William (Bill) Meehan, director of utility solutions for Esri, will take a closer look at the current state of spatial technology and ar...
The Internet of Things can drive efficiency for airlines and airports. In their session at @ThingsExpo, Shyam Varan Nath, Principal Architect with GE, and Sudip Majumder, senior director of development at Oracle, will discuss the technical details of the connected airline baggage and related social media solutions. These IoT applications will enhance travelers' journey experience and drive efficiency for the airlines and the airports. The session will include a working demo and a technical d...
Businesses are struggling to manage the information flow and interactions between all of these new devices and things jumping on their network, and the apps and IT systems they control. The data businesses gather is only helpful if they can do something with it. In his session at @ThingsExpo, Chris Witeck, Principal Technology Strategist at Citrix, will discuss how different the impact of IoT will be for large businesses, expanding how IoT will allow large organizations to make their legacy ap...