Welcome!

News Feed Item

A Better Imager for Identifying Tumors

Before they excise a tumor, surgeons need to determine exactly where the cancerous cells lie. Now, research published today in The Optical Society’s (OSA) journal Optics Letters details a new technique that could give surgeons cheaper and more lightweight tools, such as goggles or hand-held devices, to identify tumors in real time in the operating room.

Near-infrared images of the aperture filter, used in the new dual-mode imager. Only the central regi ...

Near-infrared images of the aperture filter, used in the new dual-mode imager. Only the central region of the filter can transmit visible light, while the outer portion can only transmit the near-infrared light used for fluorescent imaging. Credit: Optics Letters

The new technology, developed by a team at the University of Arizona and Washington University in St. Louis, is a dual-mode imager that combines two systems—near-infrared fluorescent imaging to detect marked cancer cells and visible light reflectance imaging to see the contours of the tissue itself—into one small, lightweight package approximately the size of a quarter in diameter, just 25 millimeters across.

"Dual modality is the path forward because it has significant advantages over single modality," says author Rongguang Liang, associate professor of optical sciences at the University of Arizona.

Interest in multi-modal imaging technology has surged over the last 10 years, says Optics Letters topical editor Brian Applegate of Texas A&M University, who was not involved in the research. People have realized that in order to better diagnose diseases like cancer, he says, you need information from a variety of sources, whether it's fluorescence imaging, optical imaging or biochemical markers.

"By combining different modalities together, you get a much better picture of the tissue," which could help surgeons make sure they remove every last bit of the tumor and as small amount of healthy tissue as possible, Applegate says.

Currently, doctors can inject fluorescent dyes into a patient to help them pinpoint cancer cells. The dyes converge onto the diseased cells, and when doctors shine a light of a particular wavelength onto the cancerous area, the dye glows. In the case of a common dye called indocyanine green (ICG), it glows in near-infrared light. But because the human eye isn't sensitive to near-infrared light, surgeons have to use a special camera to see the glow and identify the tumor's precise location.

Surgeons also need to be able to see the surface of the tissue and the tumor underneath before cutting away, which requires visible light imaging. So researchers have been developing systems that can see in both fluorescent and visible light modes.

The trouble is that the two modes have opposing needs, which makes integration difficult. Because the fluorescent glow tends to be dim, a near-infrared light camera needs to have a wide aperture to collect as much fluorescent light as possible. But a camera with a large aperture has a low depth of field, which is the opposite of what's needed for visible-light imaging.

"The other solution is to put two different imaging systems together side by side," Liang says. "But that makes the device bulky, heavy and not easy to use."

To solve this problem, Liang’s group and that of his colleagues, Samuel Achilefua and Viktor Gruev at Washington University in St. Louis, created the first-of-its-kind dual-mode imaging system that doesn't make any sacrifices.

The new system relies on a simple aperture filter that consists of a disk-shaped region in the middle and a ring-shaped area on the outside. The middle area lets in visible and near-infrared light but the outer ring only permits near-infrared light. When you place the filter in the imaging system, the aperture is wide enough to let in plenty of near-infrared light. But since visible light can't penetrate the outer ring, the visible-sensitive part of the filter has a small enough aperture that the depth of field is large.

Liang’s team is now adapting its filter design for use in lightweight goggle-like devices that a surgeon can wear while operating. They are also developing a similar hand-held instrument.

Paper: “Dual-mode optical imaging system for fluorescence image-guided surgery,” N. Zhu et al., Optics Letters, vol. 39, issue 13, pp. 3830-3832 (2014)

EDITOR’S NOTE: Images are available to members of the media upon request. Contact Lyndsay Meyer, [email protected].

About Optics Letters

Published by The Optical Society (OSA), Optics Letters offers rapid dissemination of new results in all areas of optics with short, original, peer-reviewed communications. Optics Letters covers the latest research in optical science, including optical measurements, optical components and devices, atmospheric optics, biomedical optics, Fourier optics, integrated optics, optical processing, optoelectronics, lasers, nonlinear optics, optical storage and holography, optical coherence, polarization, quantum electronics, ultrafast optical phenomena, photonic crystals, and fiber optics. This journal, edited by Xi-Cheng Zhang of the University of Rochester and published twice each month, is where readers look for the latest discoveries in optics. Visit www.OpticsInfoBase.org/OL.

About OSA

Founded in 1916, The Optical Society (OSA) is the leading professional society for scientists, engineers, students and business leaders who fuel discoveries, shape real-world applications and accelerate achievements in the science of light. Through world-renowned publications, meetings and membership programs, OSA provides quality research, inspired interactions and dedicated resources for its extensive global network of professionals in optics and photonics. For more information, visit www.osa.org.

More Stories By Business Wire

Copyright © 2009 Business Wire. All rights reserved. Republication or redistribution of Business Wire content is expressly prohibited without the prior written consent of Business Wire. Business Wire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, provided an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life settle...
The cloud era has reached the stage where it is no longer a question of whether a company should migrate, but when. Enterprises have embraced the outsourcing of where their various applications are stored and who manages them, saving significant investment along the way. Plus, the cloud has become a defining competitive edge. Companies that fail to successfully adapt risk failure. The media, of course, continues to extol the virtues of the cloud, including how easy it is to get there. Migrating...
Blockchain. A day doesn’t seem to go by without seeing articles and discussions about the technology. According to PwC executive Seamus Cushley, approximately $1.4B has been invested in blockchain just last year. In Gartner’s recent hype cycle for emerging technologies, blockchain is approaching the peak. It is considered by Gartner as one of the ‘Key platform-enabling technologies to track.’ While there is a lot of ‘hype vs reality’ discussions going on, there is no arguing that blockchain is b...
No hype cycles or predictions of a gazillion things here. IoT is here. You get it. You know your business and have great ideas for a business transformation strategy. What comes next? Time to make it happen. In his session at @ThingsExpo, Jay Mason, an Associate Partner of Analytics, IoT & Cybersecurity at M&S Consulting, presented a step-by-step plan to develop your technology implementation strategy. He also discussed the evaluation of communication standards and IoT messaging protocols, data...
ChatOps is an emerging topic that has led to the wide availability of integrations between group chat and various other tools/platforms. Currently, HipChat is an extremely powerful collaboration platform due to the various ChatOps integrations that are available. However, DevOps automation can involve orchestration and complex workflows. In his session at @DevOpsSummit at 20th Cloud Expo, Himanshu Chhetri, CTO at Addteq, will cover practical examples and use cases such as self-provisioning infra...
You know you need the cloud, but you’re hesitant to simply dump everything at Amazon since you know that not all workloads are suitable for cloud. You know that you want the kind of ease of use and scalability that you get with public cloud, but your applications are architected in a way that makes the public cloud a non-starter. You’re looking at private cloud solutions based on hyperconverged infrastructure, but you’re concerned with the limits inherent in those technologies.
Coca-Cola’s Google powered digital signage system lays the groundwork for a more valuable connection between Coke and its customers. Digital signs pair software with high-resolution displays so that a message can be changed instantly based on what the operator wants to communicate or sell. In their Day 3 Keynote at 21st Cloud Expo, Greg Chambers, Global Group Director, Digital Innovation, Coca-Cola, and Vidya Nagarajan, a Senior Product Manager at Google, discussed how from store operations and ...
In his session at 21st Cloud Expo, Raju Shreewastava, founder of Big Data Trunk, provided a fun and simple way to introduce Machine Leaning to anyone and everyone. He solved a machine learning problem and demonstrated an easy way to be able to do machine learning without even coding. Raju Shreewastava is the founder of Big Data Trunk (www.BigDataTrunk.com), a Big Data Training and consulting firm with offices in the United States. He previously led the data warehouse/business intelligence and B...
"IBM is really all in on blockchain. We take a look at sort of the history of blockchain ledger technologies. It started out with bitcoin, Ethereum, and IBM evaluated these particular blockchain technologies and found they were anonymous and permissionless and that many companies were looking for permissioned blockchain," stated René Bostic, Technical VP of the IBM Cloud Unit in North America, in this SYS-CON.tv interview at 21st Cloud Expo, held Oct 31 – Nov 2, 2017, at the Santa Clara Conventi...
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, whic...
The need for greater agility and scalability necessitated the digital transformation in the form of following equation: monolithic to microservices to serverless architecture (FaaS). To keep up with the cut-throat competition, the organisations need to update their technology stack to make software development their differentiating factor. Thus microservices architecture emerged as a potential method to provide development teams with greater flexibility and other advantages, such as the abili...
Product connectivity goes hand and hand these days with increased use of personal data. New IoT devices are becoming more personalized than ever before. In his session at 22nd Cloud Expo | DXWorld Expo, Nicolas Fierro, CEO of MIMIR Blockchain Solutions, will discuss how in order to protect your data and privacy, IoT applications need to embrace Blockchain technology for a new level of product security never before seen - or needed.
Leading companies, from the Global Fortune 500 to the smallest companies, are adopting hybrid cloud as the path to business advantage. Hybrid cloud depends on cloud services and on-premises infrastructure working in unison. Successful implementations require new levels of data mobility, enabled by an automated and seamless flow across on-premises and cloud resources. In his general session at 21st Cloud Expo, Greg Tevis, an IBM Storage Software Technical Strategist and Customer Solution Architec...
The use of containers by developers -- and now increasingly IT operators -- has grown from infatuation to deep and abiding love. But as with any long-term affair, the honeymoon soon leads to needing to live well together ... and maybe even getting some relationship help along the way. And so it goes with container orchestration and automation solutions, which are rapidly emerging as the means to maintain the bliss between rapid container adoption and broad container use among multiple cloud host...
Blockchain is a shared, secure record of exchange that establishes trust, accountability and transparency across business networks. Supported by the Linux Foundation's open source, open-standards based Hyperledger Project, Blockchain has the potential to improve regulatory compliance, reduce cost as well as advance trade. Are you curious about how Blockchain is built for business? In her session at 21st Cloud Expo, René Bostic, Technical VP of the IBM Cloud Unit in North America, discussed the b...