|By Marketwired .||
|July 10, 2014 09:39 AM EDT||
HUDSON, NY -- (Marketwired) -- 07/10/14 -- Taconic and Le Centre Européen de Recherche en Biologie et en Médecine - Institut de Génétique et de Biologie Moléculaire et Cellulaire (CERBM-IGBMC) today announced a global cross-licensing agreement to improve access to Cre-ERT technology for inducible gene targeting in genetically engineered rodents. Under the agreement each party will be able to generate, sell and use Cre-ERT mouse lines for Tamoxifen induction experiments. Further, Taconic will play a role in helping companies acquire needed rights from CERBM-IGBMC to perform induction studies in Cre-ERT gene targeted mouse lines. Taconic and CERBM-IGBMC are the only fully licensed service providers of the Cre-ERT technology. Combining the access rights to both patent families is specifically important because it equips researchers to explore gene function in adult mice.
Cre-ERT technology was developed independently by scientists at two organizations: Francis Stewart at the European Molecular Biology Laboratory (EMBL) as well as Pierre Chambon and Daniel Metzger at the CERBM-IGBMC. Taconic is the exclusive commercial license holder of the EMBL patent portfolio broadly covering the use of ligand-dependent site-specific recombinases. The CERBM-IGBMC patents cover methods for performing inducible gene targeting in transgenic mice expressing a Cre-ERT fusion protein. The method employs administration of Tamoxifen to transgenic mice to induce Cre-mediated recombination.
The agreement by Taconic and CERBM-IGBMC to further develop and provide access to Cre-ERT technology addresses key challenges relating to understanding cancer, metabolic disorders, stroke and other diseases. "We are very pleased to partner with CERBM-IGBMC to further develop the effective application of Cre-ERT technology in genetically engineered mouse models," stated Todd Little, President of Taconic. "Cre-ERT technology is a powerful tool for studying gene function and expression in many tissues."
The agreement also enhances both organizations' efforts to bring better, more predictive mouse models to market for use by scientists worldwide. "We have greatly contributed to the development and success of the 'Cre-ERT' technology, and will continue to make it freely available to the academic scientific community," said Professor Chambon at the CERBM-IGBMC. "We are very happy with this agreement, and hope that it will contribute to the generation of several new mouse models of human diseases for use in drug discovery and development," said Dr. Daniel Metzger at the CERBM-IGBMC.
Taconic is a global provider of genetically engineered mouse and rat models and services. As a full-service industry leader, founded in 1952, Taconic helps clients acquire, test, develop, breed, cryopreserve, prepare, and distribute highly relevant research lines worldwide. Headquartered in New York's Hudson River Valley, Taconic operates six breeding facilities and three service laboratories in the U.S. and Europe and maintains over 850 employees committed to technological innovation. Taconic's products and services are used by over 1300 companies and academic research institutions in nearly 50 nations worldwide. Learn more at http://www.taconic.com
About the Centre Européen en Biology et Médecine (CERBM) and the Institute of Genetics and Molecular and Cellular Biology (IGBMC).
The Institute of Genetics and Molecular and Cellular Biology (IGBMC) which was created in 1994 by Pierre Chambon is one of the main European centers of biomedical research that combines, within the CERBM-IGBMC, Units of the INSERM, the CNRS and the University of Strasbourg. Besides four scientific departments, the CERBM-IGBMC includes scientific services and advanced technological platforms, such as the Mouse Clinical Institute (ICS), which are also open to the external scientific community. The objective of the CERBM-IGBMC is to develop multidisciplinary research interfacing biology, genetics, biochemistry, physics and medicine, and also to attract students and post-doctoral fellows from all around the world by offering high-level training in the field of biomedical sciences.
About the Cre-ERT technology
Cre-ERT technology is based on an enzyme called Cre recombinase. This enzyme is able to recombine specific sequences of DNA called loxP. Upon encountering two separate loxP sites flanking a target nucleotide sequence, Cre recombinase deletes this intervening sequence by an irreversible recombination event between the loxP sites. By excision of a loxP flanked (floxed) critical region of a gene, the gene can be conditionally knocked out only after Cre is expressed. The spatial control of the conditional knock-out can be achieved by driving Cre activity under a tissue-specific promoter in transgenic mice. In order to generate an inducible knock-out, the Cre enzyme has been fused to a mutated ligand-binding domain of the human estrogen receptor (ERT). Upon the introduction of the synthetic estrogen receptor antagonist tamoxifen, the Cre-ERT construct enters the nucleus and induces the targeted mutation. ERT binds tamoxifen but not to endogenous estrogens, which allows Cre-ERT to remain cytoplasmic in animals that are not treated with tamoxifen. The temporal control by tamoxifen permits to study gene function at the desired time. This can help to elucidate the gene function in adults which is important for drug discovery and basic research.
All organizations that did not originate this moment have a pre-existing culture as well as legacy technology and processes that can be more or less amenable to DevOps implementation. That organizational culture is influenced by the personalities and management styles of Executive Management, the wider culture in which the organization is situated, and the personalities of key team members at all levels of the organization. This culture and entrenched interests usually throw a wrench in the work...
Apr. 27, 2017 08:15 PM EDT Reads: 703
SYS-CON Events announced today that CollabNet, a global leader in enterprise software development, release automation and DevOps solutions, will be a Bronze Sponsor of SYS-CON's 20th International Cloud Expo®, taking place from June 6-8, 2017, at the Javits Center in New York City, NY. CollabNet offers a broad range of solutions with the mission of helping modern organizations deliver quality software at speed. The company’s latest innovation, the DevOps Lifecycle Manager (DLM), supports Value S...
Apr. 27, 2017 08:00 PM EDT Reads: 1,113
The Internet of Things is clearly many things: data collection and analytics, wearables, Smart Grids and Smart Cities, the Industrial Internet, and more. Cool platforms like Arduino, Raspberry Pi, Intel's Galileo and Edison, and a diverse world of sensors are making the IoT a great toy box for developers in all these areas. In this Power Panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists discussed what things are the most important, which will have the most profound e...
Apr. 27, 2017 07:45 PM EDT Reads: 2,298
Multiple data types are pouring into IoT deployments. Data is coming in small packages as well as enormous files and data streams of many sizes. Widespread use of mobile devices adds to the total. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists will look at the tools and environments that are being put to use in IoT deployments, as well as the team skills a modern enterprise IT shop needs to keep things running, get a handle on all this data, and deli...
Apr. 27, 2017 07:30 PM EDT Reads: 2,466
Automation is enabling enterprises to design, deploy, and manage more complex, hybrid cloud environments. Yet the people who manage these environments must be trained in and understanding these environments better than ever before. A new era of analytics and cognitive computing is adding intelligence, but also more complexity, to these cloud environments. How smart is your cloud? How smart should it be? In this power panel at 20th Cloud Expo, moderated by Conference Chair Roger Strukhoff, pane...
Apr. 27, 2017 07:30 PM EDT Reads: 2,275
The explosion of new web/cloud/IoT-based applications and the data they generate are transforming our world right before our eyes. In this rush to adopt these new technologies, organizations are often ignoring fundamental questions concerning who owns the data and failing to ask for permission to conduct invasive surveillance of their customers. Organizations that are not transparent about how their systems gather data telemetry without offering shared data ownership risk product rejection, regu...
Apr. 27, 2017 07:15 PM EDT Reads: 1,617
SYS-CON Events announced today that Progress, a global leader in application development, has been named “Bronze Sponsor” of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Enterprises today are rapidly adopting the cloud, while continuing to retain business-critical/sensitive data inside the firewall. This is creating two separate data silos – one inside the firewall and the other outside the firewall. Cloud ISVs oft...
Apr. 27, 2017 07:00 PM EDT Reads: 294
The age of Digital Disruption is evolving into the next era – Digital Cohesion, an age in which applications securely self-assemble and deliver predictive services that continuously adapt to user behavior. Information from devices, sensors and applications around us will drive services seamlessly across mobile and fixed devices/infrastructure. This evolution is happening now in software defined services and secure networking. Four key drivers – Performance, Economics, Interoperability and Trust ...
Apr. 27, 2017 06:45 PM EDT Reads: 736
SYS-CON Events announced today that Grape Up will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place on Oct. 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Grape Up is a software company specializing in cloud native application development and professional services related to Cloud Foundry PaaS. With five expert teams that operate in various sectors of the market across the U.S. and Europe, Grape Up works with a variety of customers from emergi...
Apr. 27, 2017 06:45 PM EDT Reads: 2,206
@ThingsExpo has been named the Most Influential ‘Smart Cities - IIoT' Account and @BigDataExpo has been named fourteenth by Right Relevance (RR), which provides curated information and intelligence on approximately 50,000 topics. In addition, Right Relevance provides an Insights offering that combines the above Topics and Influencers information with real time conversations to provide actionable intelligence with visualizations to enable decision making. The Insights service is applicable to eve...
Apr. 27, 2017 06:30 PM EDT Reads: 2,817
DevOps is often described as a combination of technology and culture. Without both, DevOps isn't complete. However, applying the culture to outdated technology is a recipe for disaster; as response times grow and connections between teams are delayed by technology, the culture will die. A Nutanix Enterprise Cloud has many benefits that provide the needed base for a true DevOps paradigm.
Apr. 27, 2017 06:00 PM EDT Reads: 1,035
Building a cross-cloud operational model can be a daunting task. Per-cloud silos are not the answer, but neither is a fully generic abstraction plane that strips out capabilities unique to a particular provider. In his session at 20th Cloud Expo, Chris Wolf, VP & Chief Technology Officer, Global Field & Industry at VMware, will discuss how successful organizations approach cloud operations and management, with insights into where operations should be centralized and when it’s best to decentraliz...
Apr. 27, 2017 06:00 PM EDT Reads: 788
Cybersecurity is a critical component of software development in many industries including medical devices. However, code is not always written to be robust or secure from the unknown or the unexpected. This gap can make medical devices susceptible to cybersecurity attacks ranging from compromised personal health information to life-sustaining treatment. In his session at @ThingsExpo, Clark Fortney, Software Engineer at Battelle, will discuss how programming oversight using key methods can incre...
Apr. 27, 2017 05:30 PM EDT Reads: 3,961
The goal of Continuous Testing is to shift testing left to find defects earlier and release software faster. This can be achieved by integrating a set of open source functional and performance testing tools in the early stages of your software delivery lifecycle. There is one process that binds all application delivery stages together into one well-orchestrated machine: Continuous Testing. Continuous Testing is the conveyor belt between the Software Factory and production stages. Artifacts are ...
Apr. 27, 2017 05:15 PM EDT Reads: 1,278
In recent years, containers have taken the world by storm. Companies of all sizes and industries have realized the massive benefits of containers, such as unprecedented mobility, higher hardware utilization, and increased flexibility and agility; however, many containers today are non-persistent. Containers without persistence miss out on many benefits, and in many cases simply pass the responsibility of persistence onto other infrastructure, adding additional complexity.
Apr. 27, 2017 04:30 PM EDT Reads: 2,293