Welcome!

News Feed Item

Tute Genomics Biomarker Discovery Platform to Support Brigham Young University's Alzheimer's Disease Genetics Research

PROVO, UT--(Marketwired - July 22, 2014) - Tute Genomics today announced that its genome annotation and discovery platform will support Brigham Young University's (BYU) efforts to advance Alzheimer's disease genetics research. This collaboration involves analysis and interpretation of next-generation sequencing data from more than 1,000 exomes and genomes to identify new genetic variants associated with the disease.

"Collaboration is the key to discovering novel variants in genomics research, and Tute Genomics is honored to play a role in supporting this important work," said Dr. Kai Wang, President of Tute Genomics, "This is an example of how our platform significantly enhances the ability for researchers to identify disease genes and variants from thousands of genomes."

Dr. John "Keoni" Kauwe is leading a group of scientists from the BYU College of Life Sciences that is leveraging Tute Genomics in a large-scale effort to better understand the genetic basis of Alzheimer's disease. The causes of this brain disease are still not fully understood and traditional treatments have so far proven unsuccessful. Dr. Kauwe's group is looking to utilize Tute Genomics' biomarker discovery platform to identify novel targets that may be used for therapeutic interventions.

"We have been extremely impressed with the Tute platform thus far, and we already have a number of research findings we are evaluating. We are excited to utilize Tute's technology to support our novel approaches to finding genetic variants associated with Alzheimer's disease using exome and whole genome sequence data," said Dr. Kauwe.

The Alzheimer's Genetic Analysis Group is a collaborative effort led by Dr. John Hardy at University College London. Other Principal Investigators in this group include Dr. Kauwe from BYU, Drs. Alison Goate and Carlos Cruchaga at the Washington University School of Medicine, and Dr. Andrew Singleton at the National Institutes of Health. Late last year this group discovered a novel genetic variant that doubles a person's risk of developing the disease later in life. The study included families that had several members with Alzheimer's. The scientists sequenced and compared genes of those individuals affected by the disease and those who were not. They were then able to identify variations in a gene that appeared in affected family members. [1]

Another of their recent studies has helped lift the veil on some of the mystery surrounding the causes of Alzheimer's. The research team analyzed data from more than 25,000 people and reported that a rare genetic mutation in TREM2, a gene with function in the immune and inflammatory response, increases the risk of Alzheimer's disease. [2]

"Dr. Kauwe and the Alzheimer's Genetic Analysis Group are making exciting progress towards understanding the genetic underpinnings of Alzheimer's disease. The first step towards effective treatments and an eventual cure is to fully understand the genetics and neurobiology of the disorder," said Dr. Reid Robison, co-founder and CEO of Tute Genomics.

About Tute Genomics

Tute Genomics is a Utah-based company developing innovative cloud-based solutions to accelerate genetic discovery and enable precision medicine. Tute developed a clinical genome interpretation platform that assists researchers in identifying disease genes and biomarkers, and assists clinicians/labs in performing genetic diagnosis. Given sequencing data on a genome or a panel of genes, Tute can return over 125 annotations on variants and genes, perform family-based, case/control or tumor sample analyses to identify causal disease genes, and generate clinical reports for clinicians to focus on clinically relevant and actionable findings. Tute is built on the expertise that developed ANNOVAR, the most widely used genome annotation & interpretation technology with over 750 scientific citations. To learn more please visit www.tutegenomics.com.

[1] "Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease." Nature. 2014 Jan 23;505(7484):550-4. doi: 10.1038/nature12825.

[2] "TREM2 variants in Alzheimer's disease." New England Journal of Medicine. 2013 Jan 10;368(2):117-27. doi: 10.1056/NEJMoa1211851.

More Stories By Marketwired .

Copyright © 2009 Marketwired. All rights reserved. All the news releases provided by Marketwired are copyrighted. Any forms of copying other than an individual user's personal reference without express written permission is prohibited. Further distribution of these materials is strictly forbidden, including but not limited to, posting, emailing, faxing, archiving in a public database, redistributing via a computer network or in a printed form.

Latest Stories
The many IoT deployments around the world are busy integrating smart devices and sensors into their enterprise IT infrastructures. Yet all of this technology – and there are an amazing number of choices – is of no use without the software to gather, communicate, and analyze the new data flows. Without software, there is no IT. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, Dave McCarthy, Director of Products at Bsquare Corporation; Alan Williamson, Principal...
Businesses and business units of all sizes can benefit from cloud computing, but many don't want the cost, performance and security concerns of public cloud nor the complexity of building their own private clouds. Today, some cloud vendors are using artificial intelligence (AI) to simplify cloud deployment and management. In his session at 20th Cloud Expo, Ajay Gulati, Co-founder and CEO of ZeroStack, will discuss how AI can simplify cloud operations. He will cover the following topics: why clou...
Video experiences should be unique and exciting! But that doesn’t mean you need to patch all the pieces yourself. Users demand rich and engaging experiences and new ways to connect with you. But creating robust video applications at scale can be complicated, time-consuming and expensive. In his session at @ThingsExpo, Zohar Babin, Vice President of Platform, Ecosystem and Community at Kaltura, discussed how VPaaS enables you to move fast, creating scalable video experiences that reach your aud...
Cloud Expo, Inc. has announced today that Andi Mann returns to 'DevOps at Cloud Expo 2017' as Conference Chair The @DevOpsSummit at Cloud Expo will take place on June 6-8, 2017, at the Javits Center in New York City, NY. "DevOps is set to be one of the most profound disruptions to hit IT in decades," said Andi Mann. "It is a natural extension of cloud computing, and I have seen both firsthand and in independent research the fantastic results DevOps delivers. So I am excited to help the great t...
Rapid innovation, changing business landscapes, and new IT demands force businesses to make changes quickly. In the eyes of many, containers are at the brink of becoming a pervasive technology in enterprise IT to accelerate application delivery. In this presentation, attendees learned about the: The transformation of IT to a DevOps, microservices, and container-based architecture What are containers and how DevOps practices can operate in a container-based environment A demonstration of how ...
WebRTC is the future of browser-to-browser communications, and continues to make inroads into the traditional, difficult, plug-in web communications world. The 6th WebRTC Summit continues our tradition of delivering the latest and greatest presentations within the world of WebRTC. Topics include voice calling, video chat, P2P file sharing, and use cases that have already leveraged the power and convenience of WebRTC.
"At ROHA we develop an app called Catcha. It was developed after we spent a year meeting with, talking to, interacting with senior citizens watching them use their smartphones and talking to them about how they use their smartphones so we could get to know their smartphone behavior," explained Dave Woods, Chief Innovation Officer at ROHA, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
In this strange new world where more and more power is drawn from business technology, companies are effectively straddling two paths on the road to innovation and transformation into digital enterprises. The first path is the heritage trail – with “legacy” technology forming the background. Here, extant technologies are transformed by core IT teams to provide more API-driven approaches. Legacy systems can restrict companies that are transitioning into digital enterprises. To truly become a lead...
Without lifecycle traceability and visibility across the tool chain, stakeholders from Planning-to-Ops have limited insight and answers to who, what, when, why and how across the DevOps lifecycle. This impacts the ability to deliver high quality software at the needed velocity to drive positive business outcomes. In his general session at @DevOpsSummit at 19th Cloud Expo, Phil Hombledal, Solution Architect at CollabNet, discussed how customers are able to achieve a level of transparency that e...
"Venafi has a platform that allows you to manage, centralize and automate the complete life cycle of keys and certificates within the organization," explained Gina Osmond, Sr. Field Marketing Manager at Venafi, in this SYS-CON.tv interview at DevOps at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, provided an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life sett...
Get deep visibility into the performance of your databases and expert advice for performance optimization and tuning. You can't get application performance without database performance. Give everyone on the team a comprehensive view of how every aspect of the system affects performance across SQL database operations, host server and OS, virtualization resources and storage I/O. Quickly find bottlenecks and troubleshoot complex problems.
20th Cloud Expo, taking place June 6-8, 2017, at the Javits Center in New York City, NY, will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy.
Application transformation and DevOps practices are two sides of the same coin. Enterprises that want to capture value faster, need to deliver value faster – time value of money principle. To do that enterprises need to build cloud-native apps as microservices by empowering teams to build, ship, and run in production. In his session at @DevOpsSummit at 19th Cloud Expo, Neil Gehani, senior product manager at HPE, discussed what every business should plan for how to structure their teams to delive...
"We analyze the video streaming experience. We are gathering the user behavior in real time from the user devices and we analyze how users experience the video streaming," explained Eric Kim, Founder and CEO at Streamlyzer, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.