Welcome!

News Feed Item

AgeneBio Appoints Industry Leaders Patrick LePore as Chairman of the Board and Jerry McLaughlin as President and Chief Executive Officer

Appointments Complete Leadership Team to Advance Development Programs Including a Product Candidate in Phase II/III to Slow the Progression of Alzheimer's Disease

BALTIMORE, MD -- (Marketwired) -- 07/25/14 -- AgeneBio, Inc., a clinical-stage pharmaceutical company developing medicines to restore and preserve patients' cognitive function for a range of debilitating neurodegenerative diseases, today announced the appointment of Patrick LePore as chairman of the board and Jerry McLaughlin as president and chief executive officer. Both appointments are effective immediately.

"Pat and Jerry are distinguished leaders in the pharmaceutical industry and will play integral roles in the development and commercialization of the AgeneBio portfolio by providing strategic guidance as we continue to advance our product pipeline," says Dr. Michela Gallagher, founder and chief scientific officer of AgeneBio.

Mr. LePore has over 30 years of experience in the pharmaceutical industry, most recently as Chairman, CEO and President of Par Pharmaceuticals where he guided the company to a sale to Texas Pacific Group. His industry experience spans both the private and public sectors with board and operational experience in each, making him one of a handful of pharmaceutical executives with in depth knowledge of the brand, generic and pharmaceutical service industries.

"The development of a therapeutic to transform the management of Alzheimer's disease is desperately needed and yet potentially within reach, and I'm thrilled at the prospect of helping AgeneBio achieve that goal," said LePore.

Prior to joining AgeneBio, Mr. McLaughlin served as senior vice president and chief commercial officer of NuPathe Inc. through the company's sale to Teva Pharmaceuticals Industries Ltd. in 2014. At NuPathe, McLaughlin was responsible for preparing the organization for commercialization. In addition, he played an integral role in raising capital, including an initial public offering and corporate development initiatives that led to acquisition by Teva in a competitive M&A process. He has also held a variety of commercial leadership roles at Merck and Endo Pharmaceuticals with extensive experience launching new products, including several for central nervous system indications.

AgeneBio's lead product candidate, AGB101, a tablet taken once a day, is being developed to slow the progression of Alzheimer's disease from the time patients and their family members begin to notice issues with memory. This stage of Alzheimer's, called amnestic mild cognitive impairment, or aMCI, precedes the point where a patient experiences dementia and may be the ideal time to intervene with advancing disease process. There is compelling evidence that the part of the brain critical to creating new memories, the hippocampus, becomes overactive in patients with early Alzheimer's leading to decreased brain function and worsening of Alzheimer's symptoms. AGB101 slows activity in the hippocampus to restore normal brain function.

"The looming challenge of an aging population confronted by Alzheimer's is one of the largest and most frightening public health issues on the horizon, presenting a significant challenge and opportunity for companies like AgeneBio," said McLaughlin. "This is an exciting time to be joining the AgeneBio team as the company prepares to initiate a large-scale Phase II/III clinical trial for AGB101 in 2015."

Pending the results of a two year, large-scale clinical trial expected to be initiated by mid-2015 and subsequent regulatory submission, AGB101 could be the first FDA approved product indicated to slow the progression of Alzheimer's disease while improving patient memory.

About AgeneBio, Inc.

AgeneBio is developing therapeutics with the potential to preserve and restore cognitive function affected by a number of neurodegenerative diseases. AgeneBio's lead product candidate, AGB101, is being developed to slow progression of Alzheimer's disease and improve patient memory. Results from a Phase II study of AGB101 published in 2012 demonstrated restoration of normal brain function and improvement in memory in patients treated with AGB101 compared to placebo. The company is planning to initiate a Phase II/III clinical trial in mid-2015. Pending clinical trial results and FDA approval, AGB101 has the potential to be the first Alzheimer's therapeutic to not only improve memory but also to slow the progression of Alzheimer's disease.

The company also has a novel GABAA a5 small molecule program in late discovery stage with potential to address unmet needs for several diseases of the central nervous system including Alzheimer's disease, autism, and schizophrenia. The technology and patents behind AgeneBio's pipeline were discovered and initially developed by researchers at Johns Hopkins University, including the company's founder and chief scientific officer, Michela Gallagher, PhD.

Media Contact:
Hilary Lefebvre
Email Contact
(212) 300-4929

More Stories By Marketwired .

Copyright © 2009 Marketwired. All rights reserved. All the news releases provided by Marketwired are copyrighted. Any forms of copying other than an individual user's personal reference without express written permission is prohibited. Further distribution of these materials is strictly forbidden, including but not limited to, posting, emailing, faxing, archiving in a public database, redistributing via a computer network or in a printed form.

Latest Stories
In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, provided an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life sett...
We are always online. We access our data, our finances, work, and various services on the Internet. But we live in a congested world of information in which the roads were built two decades ago. The quest for better, faster Internet routing has been around for a decade, but nobody solved this problem. We’ve seen band-aid approaches like CDNs that attack a niche's slice of static content part of the Internet, but that’s it. It does not address the dynamic services-based Internet of today. It does...
The WebRTC Summit New York, to be held June 6-8, 2017, at the Javits Center in New York City, NY, announces that its Call for Papers is now open. Topics include all aspects of improving IT delivery by eliminating waste through automated business models leveraging cloud technologies. WebRTC Summit is co-located with 20th International Cloud Expo and @ThingsExpo. WebRTC is the future of browser-to-browser communications, and continues to make inroads into the traditional, difficult, plug-in web ...
20th Cloud Expo, taking place June 6-8, 2017, at the Javits Center in New York City, NY, will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy.
WebRTC is the future of browser-to-browser communications, and continues to make inroads into the traditional, difficult, plug-in web communications world. The 6th WebRTC Summit continues our tradition of delivering the latest and greatest presentations within the world of WebRTC. Topics include voice calling, video chat, P2P file sharing, and use cases that have already leveraged the power and convenience of WebRTC.
Without lifecycle traceability and visibility across the tool chain, stakeholders from Planning-to-Ops have limited insight and answers to who, what, when, why and how across the DevOps lifecycle. This impacts the ability to deliver high quality software at the needed velocity to drive positive business outcomes. In his general session at @DevOpsSummit at 19th Cloud Expo, Phil Hombledal, Solution Architect at CollabNet, discussed how customers are able to achieve a level of transparency that e...
"We're a cybersecurity firm that specializes in engineering security solutions both at the software and hardware level. Security cannot be an after-the-fact afterthought, which is what it's become," stated Richard Blech, Chief Executive Officer at Secure Channels, in this SYS-CON.tv interview at @ThingsExpo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
The Internet of Things (IoT) promises to simplify and streamline our lives by automating routine tasks that distract us from our goals. This promise is based on the ubiquitous deployment of smart, connected devices that link everything from industrial control systems to automobiles to refrigerators. Unfortunately, comparatively few of the devices currently deployed have been developed with an eye toward security, and as the DDoS attacks of late October 2016 have demonstrated, this oversight can ...
Fact is, enterprises have significant legacy voice infrastructure that’s costly to replace with pure IP solutions. How can we bring this analog infrastructure into our shiny new cloud applications? There are proven methods to bind both legacy voice applications and traditional PSTN audio into cloud-based applications and services at a carrier scale. Some of the most successful implementations leverage WebRTC, WebSockets, SIP and other open source technologies. In his session at @ThingsExpo, Da...
Kubernetes is a new and revolutionary open-sourced system for managing containers across multiple hosts in a cluster. Ansible is a simple IT automation tool for just about any requirement for reproducible environments. In his session at @DevOpsSummit at 18th Cloud Expo, Patrick Galbraith, a principal engineer at HPE, discussed how to build a fully functional Kubernetes cluster on a number of virtual machines or bare-metal hosts. Also included will be a brief demonstration of running a Galera MyS...
Internet-of-Things discussions can end up either going down the consumer gadget rabbit hole or focused on the sort of data logging that industrial manufacturers have been doing forever. However, in fact, companies today are already using IoT data both to optimize their operational technology and to improve the experience of customer interactions in novel ways. In his session at @ThingsExpo, Gordon Haff, Red Hat Technology Evangelist, will share examples from a wide range of industries – includin...
Unless your company can spend a lot of money on new technology, re-engineering your environment and hiring a comprehensive cybersecurity team, you will most likely move to the cloud or seek external service partnerships. In his session at 18th Cloud Expo, Darren Guccione, CEO of Keeper Security, revealed what you need to know when it comes to encryption in the cloud.
Organizations planning enterprise data center consolidation and modernization projects are faced with a challenging, costly reality. Requirements to deploy modern, cloud-native applications simultaneously with traditional client/server applications are almost impossible to achieve with hardware-centric enterprise infrastructure. Compute and network infrastructure are fast moving down a software-defined path, but storage has been a laggard. Until now.
We're entering the post-smartphone era, where wearable gadgets from watches and fitness bands to glasses and health aids will power the next technological revolution. With mass adoption of wearable devices comes a new data ecosystem that must be protected. Wearables open new pathways that facilitate the tracking, sharing and storing of consumers’ personal health, location and daily activity data. Consumers have some idea of the data these devices capture, but most don’t realize how revealing and...
"We are an all-flash array storage provider but our focus has been on VM-aware storage specifically for virtualized applications," stated Dhiraj Sehgal of Tintri in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.